E S Pizer
Affiliation: Johns Hopkins University
- Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell linesE S Pizer
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Cancer Res 58:4611-5. 1998..The data suggest a direct linkage at a regulatory level, between fatty acid synthesis and DNA synthesis in proliferating tumor cells...
- Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progressionE S Pizer
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Prostate 47:102-10. 2001..FAS expression is low in most normal tissues, but is elevated in many human cancers, including androgen-sensitive and androgen-independent prostate cancer...
- Synthesis and antitumor activity of an inhibitor of fatty acid synthaseF P Kuhajda
Department of Pathology, The Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 97:3450-4. 2000..This development will enable the in vivo study of FAS inhibition in human cancer and other metabolic diseases...
- Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53J N Li
Department of Pathology, Johns Hopkins Medical Institutions, Gerontology Research Center, National Institut on Aging, Baltimore, Maryland 21224, USA
Cancer Res 61:1493-9. 2001..Whereas induction of apoptosis appeared related to accumulation of the substrate, malonyl-CoA, after FAS inhibition, the cytostatic effects were independent of malonyl-CoA accumulation and may have resulted from product depletion...
- Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenograftsE S Pizer
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Cancer Res 60:213-8. 2000..The data suggest that differences in intermediary metabolism render tumor cells susceptible to toxic fluxes in malonyl-CoA, both in vitro and in vivo...
- Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patientsY Wang
Department of Pathology, Johns Hopkins Medical Institutions, 600 N. Wolfe Street/Meyer B-121, Baltimore, MD 21287, USA
Cancer Lett 167:99-104. 2001..39+/-0.35 units/l) compared with healthy subjects (0.27+/-0.02 units/l, P<0.05). Taken together, our data suggest that FAS expression may be a useful tumor marker for breast cancer and play a role in assessing cancer virulence...