Jonathan B Orens

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint The course of neurofibromatosis type 1 on immunosuppression after lung transplantation: report of 2 cases
    Christian A Merlo
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Heart Lung Transplant 23:774-6. 2004
  2. ncbi request reprint A review of lung transplant donor acceptability criteria
    Jonathan B Orens
    Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 22:1183-200. 2003
  3. pmc The effect of lung-size mismatch on mechanical ventilation tidal volumes after bilateral lung transplantation
    Rebecca Dezube
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine Baltimore, Baltimore, MD, USA
    Interact Cardiovasc Thorac Surg 16:275-81. 2013
  4. doi request reprint Parameters of donor-recipient size mismatch and survival after bilateral lung transplantation
    Michael Eberlein
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Heart Lung Transplant 31:1207-1213.e7. 2012
  5. doi request reprint Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome
    Michael Eberlein
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Chest 141:451-60. 2012
  6. pmc Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients
    Matthew R Pipeling
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 204:1663-71. 2011
  7. ncbi request reprint Impact of donor lung organisms on post-lung transplant pneumonia
    Pramod N Bonde
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 25:99-105. 2006
  8. pmc Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection
    Matthew R Pipeling
    Division of Pulmonary and Critical Care Medicine, Department of Pathology and Medical Microbiology, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA
    J Immunol 181:546-56. 2008
  9. doi request reprint The effect of lung size mismatch on complications and resource utilization after bilateral lung transplantation
    Michael Eberlein
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Heart Lung Transplant 31:492-500. 2012
  10. pmc Severe acute kidney injury according to the RIFLE (risk, injury, failure, loss, end stage) criteria affects mortality in lung transplantation
    George J Arnaoutakis
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Heart Lung Transplant 30:1161-8. 2011

Detail Information

Publications42

  1. ncbi request reprint The course of neurofibromatosis type 1 on immunosuppression after lung transplantation: report of 2 cases
    Christian A Merlo
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Heart Lung Transplant 23:774-6. 2004
    ....
  2. ncbi request reprint A review of lung transplant donor acceptability criteria
    Jonathan B Orens
    Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 22:1183-200. 2003
  3. pmc The effect of lung-size mismatch on mechanical ventilation tidal volumes after bilateral lung transplantation
    Rebecca Dezube
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine Baltimore, Baltimore, MD, USA
    Interact Cardiovasc Thorac Surg 16:275-81. 2013
    ..We describe the relationship between donor-recipient lung-size mismatch and postoperative mechanical ventilation tidal volumes according to recipient- and donor-predicted body weights in a cohort of bilateral lung transplant patients...
  4. doi request reprint Parameters of donor-recipient size mismatch and survival after bilateral lung transplantation
    Michael Eberlein
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Heart Lung Transplant 31:1207-1213.e7. 2012
    ..The purpose of this study was to investigate the relationship between donor-recipient height, gender and predicted estimates of total lung capacity (pTLC) mismatches and post-transplant survival...
  5. doi request reprint Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome
    Michael Eberlein
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Chest 141:451-60. 2012
    ..Size mismatch between donor lungs and a recipient thorax could affect the major determinants of maximal expiratory airflow: airway resistance, propensity of airways to collapse, and lung elastic recoil...
  6. pmc Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients
    Matthew R Pipeling
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 204:1663-71. 2011
    ..However, the correlates of immune control during chronic CMV infection remain incompletely understood...
  7. ncbi request reprint Impact of donor lung organisms on post-lung transplant pneumonia
    Pramod N Bonde
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 25:99-105. 2006
    ....
  8. pmc Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection
    Matthew R Pipeling
    Division of Pulmonary and Critical Care Medicine, Department of Pathology and Medical Microbiology, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA
    J Immunol 181:546-56. 2008
    ..Moreover, we show intercompartmental phenotypic differences in CMV-specific memory responses during the transition to chronic infection...
  9. doi request reprint The effect of lung size mismatch on complications and resource utilization after bilateral lung transplantation
    Michael Eberlein
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Heart Lung Transplant 31:492-500. 2012
    ..0, was associated with improved long-term survival after lung transplantation (LTx) but could be associated with increased post-operative complications and higher resource utilization...
  10. pmc Severe acute kidney injury according to the RIFLE (risk, injury, failure, loss, end stage) criteria affects mortality in lung transplantation
    George J Arnaoutakis
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Heart Lung Transplant 30:1161-8. 2011
    ..Using the RIFLE criteria, we examined the effect of AKI on outcomes and cost in LTx...
  11. doi request reprint Impact of U.S. Lung Allocation Score on survival after lung transplantation
    Christian A Merlo
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Heart Lung Transplant 28:769-75. 2009
    ..The impact of this change on patient outcomes is unknown. The purpose of the study was to examine early mortality after lung transplantation under the LAS system...
  12. ncbi request reprint Persistent cytomegalovirus-specific memory responses in the lung allograft and blood following primary infection in lung transplant recipients
    Oksana A Shlobin
    Department of Pulmonary and Critical Care Medicine, Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 176:2625-34. 2006
    ..02) compared with those who failed to develop CMV immunity. Together, our data reveal immunologic heterogeneity in D(+)R(-) LTRs, with the development and persistence of primary CMV responses that may provide clinical benefit...
  13. doi request reprint Lung allocation in the United States
    Michael Eberlein
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Clin Chest Med 32:213-22. 2011
    ..Better understanding of pretransplant factors that influence long-term posttransplant outcomes of the individual patient will be instrumental in improving the LAS system in the future...
  14. doi request reprint General overview of lung transplantation and review of organ allocation
    Jonathan B Orens
    Johns Hopkins Hospital, Baltimore, Maryland, USA
    Proc Am Thorac Soc 6:13-9. 2009
    ..Details of the advances in this fascinating field are included in the several articles in this issue...
  15. ncbi request reprint International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation
    Jonathan B Orens
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 25:745-55. 2006
  16. doi request reprint The impact of center volume on survival in lung transplantation: an analysis of more than 10,000 cases
    Eric S Weiss
    Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 88:1062-70. 2009
    ..Whether center volume influences outcomes in lung transplantation is unknown. We reviewed United Network for Organ Sharing data to examine the effect of center volume on short-term mortality...
  17. ncbi request reprint Lung transplantation in scleroderma compared with idiopathic pulmonary fibrosis and idiopathic pulmonary arterial hypertension
    Lionel Schachna
    Johns Hopkins University, Baltimore, Maryland 21224, USA
    Arthritis Rheum 54:3954-61. 2006
    ..This study was undertaken to evaluate whether patients with systemic sclerosis (scleroderma), a systemic autoimmune rheumatic disorder, would receive similar benefit from this intervention...
  18. ncbi request reprint Impact of secondary pulmonary hypertension on lung transplant outcome
    Torin P Fitton
    Division of Cardiac Surgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287 4618, USA
    J Heart Lung Transplant 24:1254-9. 2005
    ..Although previous studies have suggested that SPH does not adversely affect outcome, no study has assessed the impact of the degree of SPH...
  19. doi request reprint Insurance status is an independent predictor of long-term survival after lung transplantation in the United States
    Jeremiah G Allen
    Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Heart Lung Transplant 30:45-53. 2011
    ..The United Network for Organ Sharing (UNOS) database provides a large cohort of lung transplant (LTx) recipients in which to evaluate the effect of insurance on survival...
  20. doi request reprint Candidate selection, overall results, and choosing the right operation
    Christian A Merlo
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Semin Respir Crit Care Med 31:99-107. 2010
    ..Improved outcomes are seen through early referrals to a specialized center and vigilant evaluation to select the most appropriate candidates for lung transplantation...
  21. ncbi request reprint Pulmonary resection following lung transplantation
    Torin P Fitton
    The Johns Hopkins Medical Institution, Baltimore, MD, USA
    Ann Thorac Surg 76:1680-5; discussion 1685-6. 2003
    ..We reviewed our experience to evaluate and discern any variables affecting outcome of pulmonary resections performed following lung transplantation...
  22. ncbi request reprint Tracheostomy following lung transplantation predictors and outcomes
    Siddharth A Padia
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Transplant 3:891-5. 2003
    ..81%) did not exist (p = 0.89). Although tracheostomy is more likely in sicker patients, it is not associated with poor long-term outcomes...
  23. doi request reprint Supranormal expiratory airflow after bilateral lung transplantation is associated with improved survival
    Michael Eberlein
    M D Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 1830 E Monument Street, 5th Floor, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 183:79-87. 2011
    ..These FVLs usually have supranormal expiratory and normal inspiratory flow rates (SUPRA pattern)...
  24. ncbi request reprint Mediastinal mass due to Aspergillus fumigatus after lung transplantation: a case report
    Oksana Anatolia Shlobin
    Department of Pulmonary and Critical Care Medicine, Johns Hopkins Medical Institutes, Baltimore, Maryland 21230, USA
    J Heart Lung Transplant 24:1991-4. 2005
    ..This case highlights the challenges in the prevention and treatment of invasive aspergillosis in lung transplant recipients...
  25. pmc Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: case study and review of the literature
    Mary Y Armanios
    Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Neuro Oncol 6:259-63. 2004
    ..The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed GBM. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission...
  26. pmc Pluripotent allospecific CD8+ effector T cells traffic to lung in murine obliterative airway disease
    Erin E West
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Respir Cell Mol Biol 34:108-18. 2006
    ....
  27. doi request reprint Domperidone for delayed gastric emptying in lung transplant recipients with and without gastroesophageal reflux
    Anne O Lidor
    Johns Hopkins University, Baltimore, Maryland
    Prog Transplant 24:27-32. 2014
    ..No adverse effects were observed in any patients treated with domperidone. Results indicate that domperidone can be used safely and may improve symptoms related to delayed gastric emptying in lung transplant recipients. ..
  28. doi request reprint Guidelines for the selection of lung-transplant candidates
    Pali D Shah
    Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Organ Transplant 17:467-73. 2012
    ..Because of the limited availability of donor lungs and limited post-transplant survival of recipients, selection of candidates that are most likely to benefit from transplantation is of utmost importance...
  29. ncbi request reprint Albuterol improves impaired mucociliary clearance after lung transplantation
    Beth L Laube
    Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2533, USA
    J Heart Lung Transplant 26:138-44. 2007
    ..We hypothesized that impairment of MCC is evident soon after lung transplantation and that the defect in MCC can be improved by inhaled beta(2)-adrenergic receptor agonists...
  30. pmc Lung transplantation in telomerase mutation carriers with pulmonary fibrosis
    Leann L Silhan
    Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Eur Respir J 44:178-87. 2014
    ..While these findings need to be expanded to other cohorts, caution should be exercised when approaching the transplant evaluation and management of this subset of pulmonary fibrosis patients...
  31. doi request reprint Impact of nutritional state on lung transplant outcomes: the weight of the evidence
    Pali Shah
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Heart Lung Transplant 32:755-6. 2013
    ..This article reviews the study presented by Chamogeorgakis et al. to discuss how it furthers our understanding of the impact of nutritional status on transplant-related outcomes and consider areas for future investigation. ..
  32. ncbi request reprint The predictive value and inter-observer variability of donor chest radiograph interpretation in lung transplantation
    J Scott Bolton
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Eur J Cardiothorac Surg 23:484-7. 2003
    ..We sought to clarify the role donor chest radiographs and donor lung acceptability...
  33. ncbi request reprint The utility of cytopathology testing in lung transplant recipients
    Tracy J Wanner
    The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Heart Lung Transplant 24:870-4. 2005
    ..We hypothesized that cytopathology specimens have no additional diagnostic yield beyond that of microbiology and histopathology testing in the routine care of our lung transplant patients...
  34. ncbi request reprint Distal intestinal obstruction syndrome after surgery in cystic fibrosis
    Michael P Boyle
    Chest 124:2408-9. 2003
  35. ncbi request reprint Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study
    Susan G Gerhardt
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Respir Crit Care Med 168:121-5. 2003
    ..05). In addition, the absolute FEV1 increased by 0.50 L (range -0.18 to 1.36 L). These data suggest a potential role for maintenance macrolide therapy in the treatment of bronchiolitis obliterans syndrome in lung transplant recipients...
  36. ncbi request reprint Are there more lungs available than currently meet the eye?
    Andrew C Chang
    Am J Respir Crit Care Med 174:624-5. 2006
  37. ncbi request reprint Surrogate markers and risk factors for chronic lung allograft dysfunction
    Michael E Bowdish
    University of Southern California, Los Angeles, CA, USA
    Am J Transplant 4:1171-8. 2004
    ....
  38. ncbi request reprint Indications for lung transplant referral: physician attitudes
    Sean M Studer
    J Heart Lung Transplant 21:716-7. 2002
  39. ncbi request reprint Cadaveric donor selection and management
    Sean M Studer
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Semin Respir Crit Care Med 27:492-500. 2006
    ..This article summarizes the approach to identification of potential lung donors, optimal donor management, and the clinical importance of various donor factors upon recipient outcomes...
  40. ncbi request reprint Pulmonary eosinophilia following lung transplantation for sarcoidosis in two patients
    Susan G Gerhardt
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
    Chest 123:629-32. 2003
    ..It is known that peripheral eosinophilia is a marker for pulmonary allograft rejection, but its potential in the pathogenesis of BOS is unclear...
  41. ncbi request reprint Cadaveric donor selection and management
    Sean M Studer
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, Pittsburg, PA 15213, USA
    Respir Care Clin N Am 10:459-71. 2004
    ..Until that time, the limited data regarding criteria for donor acceptability must be incorporated into practice to maximize the overall benefits of lung transplantation...
  42. ncbi request reprint Thoracic organ transplantation in the United States, 1994-2003
    Mark L Barr
    University of Southern California, Los Angeles, CA, USA
    Am J Transplant 5:934-49. 2005
    ..A goal of the policy is to minimize deaths on the waiting list...