B Musicki

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Transnitrosylation: A Factor in Nitric Oxide-Mediated Penile Erection
    Biljana Musicki
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA Electronic address
    J Sex Med 13:808-14. 2016
  2. pmc Targeting NADPH oxidase decreases oxidative stress in the transgenic sickle cell mouse penis
    Biljana Musicki
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 9:1980-7. 2012
  3. pmc Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysis
    Biljana Musicki
    Johns Hopkins Hospital Urology, Baltimore, MD 21287, USA
    J Sex Med 5:552-61. 2008
  4. pmc Endothelial nitric oxide synthase regulation in female genital tract structures
    Biljana Musicki
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 6:247-53. 2009
  5. ncbi request reprint Endothelial dysfunction in diabetic erectile dysfunction
    B Musicki
    Department of Urology, Johns Hopkins University, SOM, Baltimore, MD 21287, USA
    Int J Impot Res 19:129-38. 2007
  6. pmc Post-translational regulation of endothelial nitric oxide synthase (eNOS) by estrogens in the rat vagina
    Biljana Musicki
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 7:1768-77. 2010
  7. ncbi request reprint Age-related changes in phosphorylation of endothelial nitric oxide synthase in the rat penis
    Biljana Musicki
    Johns Hopkins Hospital, Brady Urological Institute, Baltimore, MD 21287, USA
    J Sex Med 2:347-55; discussion 355-7. 2005
  8. pmc Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase
    Biljana Musicki
    Department of Urology, Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 7:3023-32. 2010
  9. doi request reprint Post-translational inactivation of endothelial nitric oxide synthase in the transgenic sickle cell mouse penis
    Biljana Musicki
    The Johns Hopkins University, Department of Urology, Baltimore, MD 21287, USA
    J Sex Med 8:419-26. 2011
  10. ncbi request reprint Phosphorylated endothelial nitric oxide synthase mediates vascular endothelial growth factor-induced penile erection
    Biljana Musicki
    Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Biol Reprod 70:282-9. 2004

Research Grants

Detail Information

Publications31

  1. pmc Transnitrosylation: A Factor in Nitric Oxide-Mediated Penile Erection
    Biljana Musicki
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA Electronic address
    J Sex Med 13:808-14. 2016
    ..However, the impact of S-nitrosylation on erectile function and in NO regulation and oxidative stress in the penis remains poorly understood...
  2. pmc Targeting NADPH oxidase decreases oxidative stress in the transgenic sickle cell mouse penis
    Biljana Musicki
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 9:1980-7. 2012
    ....
  3. pmc Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysis
    Biljana Musicki
    Johns Hopkins Hospital Urology, Baltimore, MD 21287, USA
    J Sex Med 5:552-61. 2008
    ..Diet and exercise affect endothelial function in the penis, but the molecular mechanisms underlying their effects are not understood...
  4. pmc Endothelial nitric oxide synthase regulation in female genital tract structures
    Biljana Musicki
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 6:247-53. 2009
    ..However, the role of endothelial NO synthase (eNOS) and the mechanisms that regulate eNOS in female genital tract structures are largely unknown...
  5. ncbi request reprint Endothelial dysfunction in diabetic erectile dysfunction
    B Musicki
    Department of Urology, Johns Hopkins University, SOM, Baltimore, MD 21287, USA
    Int J Impot Res 19:129-38. 2007
    ..Considering recent advances in the field of vascular biology and diabetes, the emphasis in this review is placed on the mechanisms of hyperglycemia-induced endothelial dysfunction in the pathophysiology of diabetes-associated ED...
  6. pmc Post-translational regulation of endothelial nitric oxide synthase (eNOS) by estrogens in the rat vagina
    Biljana Musicki
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 7:1768-77. 2010
    ..Although vascular effects of estrogens are attributed to an increase in endothelial NO production, the mechanisms of endothelial NO synthase (eNOS) regulation by estrogens in the vagina are largely unknown...
  7. ncbi request reprint Age-related changes in phosphorylation of endothelial nitric oxide synthase in the rat penis
    Biljana Musicki
    Johns Hopkins Hospital, Brady Urological Institute, Baltimore, MD 21287, USA
    J Sex Med 2:347-55; discussion 355-7. 2005
    ....
  8. pmc Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase
    Biljana Musicki
    Department of Urology, Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 7:3023-32. 2010
    ....
  9. doi request reprint Post-translational inactivation of endothelial nitric oxide synthase in the transgenic sickle cell mouse penis
    Biljana Musicki
    The Johns Hopkins University, Department of Urology, Baltimore, MD 21287, USA
    J Sex Med 8:419-26. 2011
    ..However, the mechanism of decreased eNOS function/activation in the penis in association with SCD is not known...
  10. ncbi request reprint Phosphorylated endothelial nitric oxide synthase mediates vascular endothelial growth factor-induced penile erection
    Biljana Musicki
    Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Biol Reprod 70:282-9. 2004
    ..The data provide a molecular explanation for VEGF stimulatory effect on penile erection, which involves phosphorylated eNOS (Serine 1177) mediation...
  11. ncbi request reprint Erection capability is potentiated by long-term sildenafil treatment: role of blood flow-induced endothelial nitric-oxide synthase phosphorylation
    Biljana Musicki
    Department of Urology, Johns Hopkins Hospital, Marburg 405, 600 North Wolfe St, Baltimore, MD 21287, USA
    Mol Pharmacol 68:226-32. 2005
    ....
  12. pmc Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction
    Biljana Musicki
    Department of Urology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:11870-5. 2005
    ..In vivo penile erection paradigm supports the physiologic relevance of O-GlcNAc modification in vascular disorders associated with diabetes...
  13. pmc Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection
    K Joseph Hurt
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:4061-6. 2002
    ..Our findings support a model in which rapid, brief activation of neuronal NOS initiates the erectile process, whereas PI3-kinase/Akt-dependent phosphorylation and activation of eNOS leads to sustained NO production and maximal erection...
  14. pmc Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Sex Med 6:2494-504. 2009
    ..Priapism is a poorly understood disease process with little information on the etiology and pathophysiology of this erectile disorder. One group of patients with a high prevalence of priapism is men with sickle-cell disease...
  15. pmc eNOS-uncoupling in age-related erectile dysfunction
    J M Johnson
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Int J Impot Res 23:43-8. 2011
    ..These findings suggest that aging induces eNOS uncoupling in the penis, resulting in increased oxidative stress and ED...
  16. doi request reprint Serum biomarker measurements of endothelial function and oxidative stress after daily dosing of sildenafil in type 2 diabetic men with erectile dysfunction
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 181:245-51. 2009
    ..We investigated changes in serum biomarkers of vascular function after short-term, continuous sildenafil dosing in men with type 2 diabetes with erectile dysfunction...
  17. pmc Alternatively spliced neuronal nitric oxide synthase mediates penile erection
    K Joseph Hurt
    Department of Urology, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:3440-3. 2006
    ..Thus, alternatively spliced forms of nNOS are major mediators of penile erection and so may be targets for therapeutic intervention...
  18. pmc Attenuated RhoA/Rho-kinase signaling in penis of transgenic sickle cell mice
    Trinity J Bivalacqua
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 76:510.e7-12. 2010
    ..Therefore, the objective of the present study was to evaluate the molecular changes in RhoA and ROCK in an established transgenic sickle cell mouse model of priapism...
  19. pmc Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Hospital, Baltimore, MD 21287, United States
    Eur Urol 51:1732-40. 2007
    ....
  20. ncbi request reprint In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: no tachyphylaxis effect
    Biljana Musicki
    Department of Urology and Division of Cardiology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Urol 174:1493-6. 2005
    ....
  21. ncbi request reprint The nitric oxide signaling pathway in the penis
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, MD 21287 2411, USA
    Curr Pharm Des 11:3987-94. 2005
    ..The purpose of this review is to highlight the latest areas of investigation related to the science of nitric oxide in the penis, as a gateway for considering novel therapeutic strategies for erectile disorders now and in the future...
  22. ncbi request reprint eNOS function and dysfunction in the penis
    Biljana Musicki
    Johns Hopkins Hospital, Department of Urology, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Exp Biol Med (Maywood) 231:154-65. 2006
    ....
  23. ncbi request reprint Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Urology 67:1043-8. 2006
    ..We explored the use of PDE5 inhibitors to treat recurrent priapism, based on the hypothesis that the erection regulatory function of PDE5 would be regularized by this treatment and protect against further episodes...
  24. ncbi request reprint Nitric oxide/redox-based signalling as a therapeutic target for penile disorders
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 2411, USA
    Expert Opin Ther Targets 10:445-57. 2006
    ..The next line of pharmaceuticals for disorders of the penis, in general, may well spawn from an integrative understanding of the complex regulatory interactions influenced by, as well as influencing nitric oxide signalling in this organ...
  25. ncbi request reprint Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism
    Arthur L Burnett
    Johns Hopkins University Urology, Baltimore, MD, USA
    J Sex Med 3:1077-84. 2006
    ..Recurrent ischemic priapism is an enigmatic erectile disorder in need of improved clinical interventions to avert its known, potentially serious complications...
  26. pmc Posttranslational modification of constitutive nitric oxide synthase in the penis
    Biljana Musicki
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, 600 N Wolfe Avenue, Marburg 143, Baltimore, MD 21287, USA
    J Androl 30:352-62. 2009
    ..This communication reviews the role of eNOS and nNOS in erectile physiology and discusses the alterations in eNOS and nNOS via posttranslation modification in various vascular diseases of the penis...
  27. pmc Mechanistic link between erectile dysfunction and systemic endothelial dysfunction in type 2 diabetic rats
    B Musicki
    Department of Urology, The Johns Hopkins School of Medicine, The James Buchanan Brady Urological Institute, Baltimore, MD, USA
    Andrology 4:977-83. 2016
    ..These molecular changes contribute to T2DM ED, while vascular function in the systemic vasculature remains preserved. ..
  28. ncbi request reprint Functional differentiation of the placental syncytiotrophoblast: Effect of estrogen on chorionic somatomammotropin expression during early primate pregnancy
    Biljana Musicki
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Studies in Reproduction, The University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:4316-23. 2003
    ....
  29. doi request reprint Constitutive NOS uncoupling and NADPH oxidase upregulation in the penis of type 2 diabetic men with erectile dysfunction
    B Musicki
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Andrology . 2017
    ..Our description of molecular factors contributing to the pathogenesis of T2DM-associated ED at the human level is relevant to advancing clinically therapeutic approaches to restore erectile function in T2DM patients...
  30. ncbi request reprint Endothelial nitric oxide synthase gene therapy for erectile dysfunction
    Trinity J Bivalacqua
    Department of Urology, Tulane Health Sciences Center, 1430 Tulane Avenue SL42, New Orleans, LA 70112, USA
    Curr Pharm Des 11:4059-67. 2005
    ..Putative gene therapy interventions to restore eNOS expression and subsequent endothelial function may represent an exciting new therapeutic strategy for the future treatment of ED...
  31. ncbi request reprint Lack of effects of postnatal exposure to a mixture of aryl hydrocarbon-receptor agonists on the development of methylnitrosourea-induced mammary tumors in sprague-dawley rats
    Daniel Desaulniers
    Environmental and Occupational Toxicology Division, Health CanadaOttawa, Ontario, Canada
    J Toxicol Environ Health A 67:1457-75. 2004
    ..In conclusion, postnatal exposure to the mixture of AhR agonists had no significant effects on the development of MNU-initiated mammary tumors...

Research Grants2

  1. Posttranslational Regulation of eNOS by Estrogen in the Vagina and Clitoris
    Biljana Musicki; Fiscal Year: 2007
    ..At the same time it may advance treatments for multiple disease states associated with endothelial dysfunction and alterations in hormonal milieu. [unreadable] [unreadable] [unreadable]..
  2. eNOS-Protein Interaction in the Penis
    Biljana Musicki; Fiscal Year: 2007
    ..At the same time, it may suggest a specific eNOS regulatory pathway as a possible new molecular target for treating ED. [unreadable] [unreadable] [unreadable]..