Ronnie C Mease

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Radionuclide based imaging of prostate cancer
    Ronnie C Mease
    Russell H Morgan Department of Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Curr Top Med Chem 10:1600-16. 2010
  2. pmc ⁶⁴Cu-labeled inhibitors of prostate-specific membrane antigen for PET imaging of prostate cancer
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21287, United States
    J Med Chem 57:2657-69. 2014
  3. pmc 2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, Maryland, USA
    Clin Cancer Res 17:7645-53. 2011
  4. pmc Effect of chelators on the pharmacokinetics of (99m)Tc-labeled imaging agents for the prostate-specific membrane antigen (PSMA)
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    J Med Chem 56:6108-21. 2013
  5. pmc Synthesis and biological evaluation of low molecular weight fluorescent imaging agents for the prostate-specific membrane antigen
    Ying Chen
    Russell H Morgan Department of Radiology, Brain Science Institute, Johns Hopkins Medical School, Baltimore, MD 21231, USA
    Bioconjug Chem 23:2377-85. 2012
  6. pmc 68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21231, USA
    J Med Chem 53:5333-41. 2010
  7. pmc A modular strategy to prepare multivalent inhibitors of prostate-specific membrane antigen (PSMA)
    Sangeeta Ray Banerjee
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, MD, USA
    Oncotarget 2:1244-53. 2011
  8. pmc A low molecular weight PSMA-based fluorescent imaging agent for cancer
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
    Biochem Biophys Res Commun 390:624-9. 2009
  9. pmc [(18)F]Fluorobenzoyllysinepentanedioic Acid Carbamates: New Scaffolds for Positron Emission Tomography (PET) Imaging of Prostate-Specific Membrane Antigen (PSMA)
    Xing Yang
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, United States
    J Med Chem 59:206-18. 2016
  10. pmc Radioiodinated DPA-713 imaging correlates with bactericidal activity of tuberculosis treatments in mice
    Alvaro A Ordonez
    Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Antimicrob Agents Chemother 59:642-9. 2015

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Radionuclide based imaging of prostate cancer
    Ronnie C Mease
    Russell H Morgan Department of Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Curr Top Med Chem 10:1600-16. 2010
    ..In addition, the high selectivity and rapid localization of many of the new agents under development portends promise for a greater use of radionuclide imaging for prostate cancer detection, characterization, and treatment monitoring...
  2. pmc ⁶⁴Cu-labeled inhibitors of prostate-specific membrane antigen for PET imaging of prostate cancer
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21287, United States
    J Med Chem 57:2657-69. 2014
    ..That could be due to the higher stability of [(64)Cu]CB-TE2A as compared with [(64)Cu]NOTA, [(64)Cu]PCTA, [(64)Cu]Oxo-DO3A, and [(64)Cu]DOTA chelates in vivo. ..
  3. pmc 2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, Maryland, USA
    Clin Cancer Res 17:7645-53. 2011
    ..PSMA is upregulated in prostate cancer epithelia and in the neovasculature of most solid tumors...
  4. pmc Effect of chelators on the pharmacokinetics of (99m)Tc-labeled imaging agents for the prostate-specific membrane antigen (PSMA)
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    J Med Chem 56:6108-21. 2013
    ..These results suggest that choice of chelator is an important pharmacokinetic consideration in the development of (99m)Tc-labeled radiopharmaceuticals targeting PSMA. ..
  5. pmc Synthesis and biological evaluation of low molecular weight fluorescent imaging agents for the prostate-specific membrane antigen
    Ying Chen
    Russell H Morgan Department of Radiology, Brain Science Institute, Johns Hopkins Medical School, Baltimore, MD 21231, USA
    Bioconjug Chem 23:2377-85. 2012
    ..Compounds 2 and 3 provide useful scaffolds for targeting of PSMA+ tissues in vivo and should be useful for preparing NIR dye conjugates designed specifically for clinical intraoperative optical imaging devices...
  6. pmc 68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21231, USA
    J Med Chem 53:5333-41. 2010
    ..Both compounds delineated tumor clearly by small animal PET. The urea series of imaging agents for PSMA can be radiolabeled with (68)Ga, a cyclotron-free isotope useful for clinical PET studies, with maintenance of target specificity...
  7. pmc A modular strategy to prepare multivalent inhibitors of prostate-specific membrane antigen (PSMA)
    Sangeeta Ray Banerjee
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, MD, USA
    Oncotarget 2:1244-53. 2011
    ..isogenic PSMA-negative PC3-flu tumors in vivo. The click chemistry approach affords a convenient strategy toward multivalent PSMA inhibitors of enhanced affinity and superior pharmacokinetics for imaging...
  8. pmc A low molecular weight PSMA-based fluorescent imaging agent for cancer
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
    Biochem Biophys Res Commun 390:624-9. 2009
    ..PSMA-negative PC3-flu tumors in vivo. YC-27 3 may be useful for study of PSMA-expressing tissue in preclinical models or for intraoperative guidance...
  9. pmc [(18)F]Fluorobenzoyllysinepentanedioic Acid Carbamates: New Scaffolds for Positron Emission Tomography (PET) Imaging of Prostate-Specific Membrane Antigen (PSMA)
    Xing Yang
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, United States
    J Med Chem 59:206-18. 2016
    ..Prolonged tumor-specific uptake demonstrated by [(18)F]24, which did not reach equilibrium during the 4 h study period, suggests carbamates as alternative scaffolds for mitigating dose to nontarget tissues. ..
  10. pmc Radioiodinated DPA-713 imaging correlates with bactericidal activity of tuberculosis treatments in mice
    Alvaro A Ordonez
    Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Antimicrob Agents Chemother 59:642-9. 2015
    ..03). These studies provide proof of concept for application of a novel noninvasive imaging biomarker to monitor tuberculosis treatments, with the potential for application for humans. ..
  11. pmc Biodistribution, tumor detection, and radiation dosimetry of 18F-DCFBC, a low-molecular-weight inhibitor of prostate-specific membrane antigen, in patients with metastatic prostate cancer
    Steve Y Cho
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland 21287 0014, USA
    J Nucl Med 53:1883-91. 2012
    ..Here, we describe the initial clinical experience and radiation dosimetry of (18)F-DCFBC in men with metastatic PCa...
  12. pmc Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies
    Haofan Wang
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Bioorg Med Chem Lett 20:392-7. 2010
    ..A novel conformational change of amino acids in the S1' pharmacophore pocket was observed in the X-ray crystal structure of GCPII complexed with 32d...
  13. pmc Structural optimization, biological evaluation, and application of peptidomimetic prostate specific antigen inhibitors
    Maya B Kostova
    Department of Oncology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231, USA
    J Med Chem 56:4224-35. 2013
    ..Biodistribution of (125)I labeled peptides showed low levels of uptake into tumors compared to other normal tissues...
  14. pmc PET imaging in prostate cancer: focus on prostate-specific membrane antigen
    Ronnie C Mease
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, MD 21287, USA
    Curr Top Med Chem 13:951-62. 2013
    ..These early clinical results suggest that PET/CT using PSMA-targeted agents, especially with compounds of low molecular weight, will make valuable contributions to the management of PCa...
  15. pmc Imaging of carbonic anhydrase IX with an 111In-labeled dual-motif inhibitor
    Xing Yang
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 6:33733-42. 2015
    ..The dual targeting strategy to engage CAIX enabled specific detection of ccRCC in this xenograft model, with pharmacokinetics surpassing those of previously described radionuclide-based probes against CAIX. ..
  16. pmc Comparison of Prostate-Specific Membrane Antigen-Based 18F-DCFBC PET/CT to Conventional Imaging Modalities for Detection of Hormone-Naïve and Castration-Resistant Metastatic Prostate Cancer
    Steven P Rowe
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
    J Nucl Med 57:46-53. 2016
    ....
  17. pmc Heterobivalent agents targeting PSMA and integrin-αvβ3
    Hassan M Shallal
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, United States
    Bioconjug Chem 25:393-405. 2014
    ..HtBv agents 9 and 10 may enable dual-targeted imaging of malignant cells and tissues in an effort to address heterogeneity that confounds many cancer-targeted imaging agents. ..
  18. doi request reprint Radiochemical synthesis and in vivo evaluation of [18F]AZ11637326: an agonist probe for the α7 nicotinic acetylcholine receptor
    Hayden T Ravert
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, MD 21287 0014, USA
    Nucl Med Biol 40:731-9. 2013
    ..We describe our attempt to synthesize an α7 nAChR-selective radiotracer for positron emission tomography (PET)...
  19. pmc Initial Evaluation of [(18)F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer
    Zsolt Szabo
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Cancer Research Bldg 2, Room 492, 1550 Orleans St, Baltimore, MD, 21231, USA
    Mol Imaging Biol 17:565-74. 2015
    ..Here we present initial safety, biodistribution, and radiation dosimetry results with [(18)F]DCFPyL, a second-generation fluorine-18-labeled small-molecule PSMA inhibitor, in patients with prostate cancer...
  20. pmc AEG-1 promoter-mediated imaging of prostate cancer
    Akrita Bhatnagar
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Cancer Res 74:5772-81. 2014
    ..Our results offer a preclinical proof of concept that rationalizes clinical evaluation in patients with advanced prostate cancer...
  21. pmc High-throughput screen identifies novel inhibitors of cancer biomarker α-methylacyl coenzyme A racemase (AMACR/P504S)
    Brice A P Wilson
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mol Cancer Ther 10:825-38. 2011
    ..This report shows the first high-throughput screen for the discovery of novel AMACR inhibitors, characterizes the first nonsubstrate-based inhibitors, and validates that AMACR is a viable chemotherapeutic target in vitro...
  22. pmc Imaging Enterobacteriaceae infection in vivo with 18F-fluorodeoxysorbitol positron emission tomography
    Edward A Weinstein
    Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Sci Transl Med 6:259ra146. 2014
    ..coli infections were detected in real time. Together, these data show that (18)F-FDS is a candidate imaging probe for translation to human clinical cases of known or suspected infections owing to Enterobacteriaceae. ..
  23. pmc Radiohalogenated prostate-specific membrane antigen (PSMA)-based ureas as imaging agents for prostate cancer
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    J Med Chem 51:7933-43. 2008
    ..Because of the many radiohalogenated moieties that can be attached via the epsilon amino group, the intermediate Lys-C(O)-Glu is an attractive template upon which to develop new imaging agents for prostate cancer...