Michael T McMahon

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Developing MR probes for molecular imaging
    Michael T McMahon
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA The Russell H Morgan Department of Radiology and Radiological Sciences, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Electronic address
    Adv Cancer Res 124:297-327. 2014
  2. pmc New "multicolor" polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI
    Michael T McMahon
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    Magn Reson Med 60:803-12. 2008
  3. pmc Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles
    Assaf A Gilad
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, Neurosection, Baltimore, Maryland 21231, USA
    Magn Reson Med 61:970-4. 2009
  4. pmc Steady pulsed imaging and labeling scheme for noninvasive perfusion imaging
    Jiadi Xu
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 75:238-48. 2016
  5. ncbi request reprint Cancer Therapy: Vaginal Delivery of Paclitaxel via Nanoparticles with Non-Mucoadhesive Surfaces Suppresses Cervical Tumor Growth (Adv. Healthcare Mater. 7/2014)
    Ming Yang
    Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA
    Adv Healthc Mater 3:1120. 2014
  6. pmc MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viability
    Kannie W Y Chan
    The Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Mater 12:268-75. 2013
  7. pmc Human protamine-1 as an MRI reporter gene based on chemical exchange
    Amnon Bar-Shir
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States
    ACS Chem Biol 9:134-8. 2014
  8. pmc Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells
    Xiaolei Song
    1 Division of MR Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA 2 Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Commun 6:6719. 2015
  9. pmc NOrmalized MAgnetization Ratio (NOMAR) filtering for creation of tissue selective contrast maps
    Guanshu Liu
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
    Magn Reson Med 69:516-23. 2013
  10. pmc CEST phase mapping using a length and offset varied saturation (LOVARS) scheme
    Xiaolei Song
    Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 68:1074-86. 2012

Collaborators

Detail Information

Publications58

  1. doi request reprint Developing MR probes for molecular imaging
    Michael T McMahon
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA The Russell H Morgan Department of Radiology and Radiological Sciences, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Electronic address
    Adv Cancer Res 124:297-327. 2014
    ..As part of this comparison, the strengths and weaknesses of each category are discussed. ..
  2. pmc New "multicolor" polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI
    Michael T McMahon
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    Magn Reson Med 60:803-12. 2008
    ....
  3. pmc Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles
    Assaf A Gilad
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, Neurosection, Baltimore, Maryland 21231, USA
    Magn Reson Med 61:970-4. 2009
    ..These initial findings are a first step toward using dual CEST/T2 contrast imaging for studying multiple cellular or molecular targets simultaneously in vivo...
  4. pmc Steady pulsed imaging and labeling scheme for noninvasive perfusion imaging
    Jiadi Xu
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 75:238-48. 2016
    ..A steady pulsed imaging and labeling (SPIL) scheme is proposed to obtain high-resolution multislice perfusion images of mice brain using standard preclinical MRI equipment...
  5. ncbi request reprint Cancer Therapy: Vaginal Delivery of Paclitaxel via Nanoparticles with Non-Mucoadhesive Surfaces Suppresses Cervical Tumor Growth (Adv. Healthcare Mater. 7/2014)
    Ming Yang
    Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA
    Adv Healthc Mater 3:1120. 2014
    ..The MPP platform may hold similar promise for local chemotherapy against tumors at other mucosal surfaces. ..
  6. pmc MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viability
    Kannie W Y Chan
    The Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Mater 12:268-75. 2013
    ..All of the components of these nanosensors are clinical grade and hence this approach should be a translatable and universal modification of hydrogels...
  7. pmc Human protamine-1 as an MRI reporter gene based on chemical exchange
    Amnon Bar-Shir
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States
    ACS Chem Biol 9:134-8. 2014
    ..Live cells expressing the hPRM1 reporter gene, and embedded in three-dimensional culture, also generated higher CEST contrast compared to wild-type live cells. ..
  8. pmc Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells
    Xiaolei Song
    1 Division of MR Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA 2 Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Commun 6:6719. 2015
    ..These results suggest that the mucCEST MRI signal can be used as a label-free surrogate marker to non-invasively assess mucin glycosylation and tumour malignancy. ..
  9. pmc NOrmalized MAgnetization Ratio (NOMAR) filtering for creation of tissue selective contrast maps
    Guanshu Liu
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
    Magn Reson Med 69:516-23. 2013
    ....
  10. pmc CEST phase mapping using a length and offset varied saturation (LOVARS) scheme
    Xiaolei Song
    Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 68:1074-86. 2012
    ....
  11. pmc Developing imidazoles as CEST MRI pH sensors
    Xing Yang
    Russell H Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Contrast Media Mol Imaging 11:304-12. 2016
    ..We have tested several probes based on this scaffold, and demonstrated that these probes could be applied for in vivo detection of kidney pH after intravenous administration. Copyright © 2016 John Wiley & Sons, Ltd. ..
  12. pmc Dynamic glucose enhanced (DGE) MRI for combined imaging of blood-brain barrier break down and increased blood volume in brain cancer
    Xiang Xu
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 74:1556-63. 2015
    ..Recently, natural d-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using d-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown...
  13. pmc Metal ion sensing using ion chemical exchange saturation transfer 19F magnetic resonance imaging
    Amnon Bar-Shir
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Am Chem Soc 135:12164-7. 2013
    ..Through the substrate binding kinetics we were able to amplify the signal of Ca(2+) onto free 5F-BAPTA and thus indirectly detect low Ca(2+) concentrations with high sensitivity. ..
  14. pmc Variable delay multi-pulse train for fast chemical exchange saturation transfer and relayed-nuclear overhauser enhancement MRI
    Jiadi Xu
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA
    Magn Reson Med 71:1798-812. 2014
    ..A new technique, variable delay multi-pulse CEST (VDMP-CEST), is proposed to eliminate the need for recording full Z-spectra and performing asymmetry analysis to obtain CEST contrast...
  15. pmc Time domain removal of irrelevant magnetization in chemical exchange saturation transfer Z-spectra
    Nirbhay N Yadav
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 70:547-55. 2013
    ..To evaluate the possibility of processing Z-spectra using time domain analysis...
  16. pmc In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes
    Guanshu Liu
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Magn Reson Med 67:1106-13. 2012
    ..Being nonmetallic and bioorganic, these diamagnetic chemical exchange saturation transfer liposomes form an attractive novel platform for multicolor imaging in vivo...
  17. pmc Salicylic Acid Conjugated Dendrimers Are a Tunable, High Performance CEST MRI NanoPlatform
    Wojciech G Lesniak
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21287, United States
    Nano Lett 16:2248-53. 2016
    ..5 h and distributed over ∼50% of the tumors. Our results demonstrate that SA modified dendrimers present a promising new nanoplatform for medical applications. ..
  18. pmc CEST theranostics: label-free MR imaging of anticancer drugs
    Yuguo Li
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    Oncotarget 7:6369-78. 2016
    ..v.-injected, drug-loaded liposomes was successfully detected in CT26 mouse tumors. Such label-free CEST MRI theranostics provides a new imaging means, potentially with an immediate clinical impact, to monitor the drug delivery in cancer. ..
  19. pmc MR tracking of transplanted cells with "positive contrast" using manganese oxide nanoparticles
    Assaf A Gilad
    Russell H Morgan Department of Radiology, Division of MR Research, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Magn Reson Med 60:1-7. 2008
    ..Simultaneous imaging of both transplants with opposite contrast offers a method for MR "double labeling" of different cell populations...
  20. ncbi request reprint Artificial reporter gene providing MRI contrast based on proton exchange
    Assaf A Gilad
    The Russell H Morgan Department of Radiology and Radiological Science, Neurosection, Division of MR Research, Traylor Building Rm 217, 720 Rutland Ave, Baltimore, Maryland 21205, USA
    Nat Biotechnol 25:217-9. 2007
    ..This endogenous contrast, based on transfer of radiofrequency labeling from the reporter's amide protons to water protons, can be switched on and off...
  21. pmc Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T
    Craig K Jones
    Division of MR Research, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 77:114-24. 2013
    ....
  22. pmc Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression
    Amnon Bar-Shir
    Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Chem Soc 135:1617-24. 2013
    ..In light of these findings, this new approach can be generalized for designing specific probes for the in vivo imaging of a variety of proteins and enzymes...
  23. pmc Detection of rapidly exchanging compounds using on-resonance frequency-labeled exchange (FLEX) transfer
    Nirbhay N Yadav
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 68:1048-55. 2012
    ..This labeling scheme is particularly suited for studying rapidly exchanging hydroxyl, amine, and imino protons in diamagnetic chemical exchange saturation transfer agents...
  24. pmc Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer
    Kannie W Y Chan
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 68:1764-73. 2012
    ..e. with iodine (CT), radioisotopes (PET/SPECT), or paramagnetic metals (MRI). The goal was to explore the possibility of using simple D-glucose as an infusable biodegradable MRI agent for cancer detection...
  25. pmc Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds
    Jonghoon Choi
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Control Release 156:239-45. 2011
    ....
  26. pmc MRI reporter genes
    Assaf A Gilad
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 49:1905-8. 2008
    ..MRI reporter genes have the advantage that the specific signal can be coregistered with soft-tissue anatomy and functional tissue information and have, therefore, become an active and growing area of scientific interest...
  27. pmc Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients
    Xiang Xu
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States
    Tomography 1:105-114. 2015
    ....
  28. pmc Screening CEST contrast agents using ultrafast CEST imaging
    Xiang Xu
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States Electronic address
    J Magn Reson 265:224-9. 2016
    ....
  29. pmc Natural D-glucose as a biodegradable MRI relaxation agent
    Nirbhay N Yadav
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA
    Magn Reson Med 72:823-8. 2014
    ..Demonstrate applicability of natural D-glucose as a T2 MRI contrast agent...
  30. pmc Liposome-based mucus-penetrating particles (MPP) for mucosal theranostics: demonstration of diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI)
    Tao Yu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Nanomedicine 11:401-5. 2015
    ..Liposomal MPP with optimized PEG content hold promise for drug delivery and imaging at mucosal surfaces...
  31. pmc Multi-echo length and offset VARied saturation (MeLOVARS) method for improved CEST imaging
    Xiaolei Song
    Division of MR Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    Magn Reson Med 73:488-96. 2015
    ..The aim of this study was to develop a technique for rapid collection of chemical exchange saturation transfer images with the saturation varied to modulate signal loss transfer and enhance contrast...
  32. pmc High-throughput screening of chemical exchange saturation transfer MR contrast agents
    Guanshu Liu
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    Contrast Media Mol Imaging 5:162-70. 2010
    ....
  33. pmc A diaCEST MRI approach for monitoring liposomal accumulation in tumors
    Kannie W Y Chan
    Russell H Morgan Department of Radiology and Radiological Sciences, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore 21287, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore 21205, USA Center for Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore 21287, USA Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore 21205, USA
    J Control Release 180:51-9. 2014
    ....
  34. pmc Nuts and bolts of chemical exchange saturation transfer MRI
    Guanshu Liu
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
    NMR Biomed 26:810-28. 2013
    ..The 'Post-processing' section contains a description of the typical image processing employed for B0 /B1 correction, Z-spectral interpolation, frequency-selective detection and improvement of CEST contrast maps...
  35. pmc Monitoring enzyme activity using a diamagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent
    Guanshu Liu
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland 21205, USA
    J Am Chem Soc 133:16326-9. 2011
    ..These data demonstrate the ability to detect enzyme activity based on proton exchange. Consequently, CEST MRI has the potential to follow the kinetics of multiple enzymes in real time in living tissue...
  36. pmc MRI biosensor for protein kinase A encoded by a single synthetic gene
    Raag D Airan
    Russell H Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Magn Reson Med 68:1919-23. 2012
    ....
  37. doi request reprint (15)N Heteronuclear Chemical Exchange Saturation Transfer MRI
    Haifeng Zeng
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland 21205, United States
    J Am Chem Soc 138:11136-9. 2016
    ..In addition to providing a small sensitivity enhancement, this approach can be used to monitor the exchange rates and thus the pH sensitivity of the participating (15)N-bound protons. ..
  38. pmc Salicylic acid analogues as chemical exchange saturation transfer MRI contrast agents for the assessment of brain perfusion territory and blood-brain barrier opening after intra-arterial infusion
    Xiaolei Song
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltmore, MD, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
    J Cereb Blood Flow Metab 36:1186-94. 2016
    ..Hyperosmolar SAA solutions themselves are also capable of opening the BBB, and, when multiple SAA agents were co-injected, their locoregional perfusion could be differentiated. ..
  39. pmc Advances in using MRI probes and sensors for in vivo cell tracking as applied to regenerative medicine
    Amit K Srivastava
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dis Model Mech 8:323-36. 2015
    ..We present here a review of recent advancements in the development of these probes and sensors, and of their functioning, applications and limitations. ..
  40. pmc Diamagnetic chemical exchange saturation transfer (diaCEST) liposomes: physicochemical properties and imaging applications
    Kannie W Y Chan
    The Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 6:111-24. 2014
    ..The unique features of diaCEST liposomes are discussed to provide an overview of the applications currently envisioned for this new technology and to provide an overall insight of their potential...
  41. pmc Achieving 1% NMR polarization in water in less than 1min using SABRE
    Haifeng Zeng
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA Electronic address
    J Magn Reson 246:119-21. 2014
    ..Polarization was achieved in less than 1 min...
  42. pmc Magnetization transfer contrast MRI for non-invasive assessment of innate and adaptive immune responses against alginate-encapsulated cells
    Kannie W Y Chan
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, USA Center of Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Baltimore, MD 21205, USA
    Biomaterials 35:7811-8. 2014
    ..01) existed, which was not observed on MTR imaging. We conclude that MT imaging, which is clinically available, can be applied for non-invasive monitoring of the occurrence of a host immune response against encapsulated cells. ..
  43. pmc Microencapsulated cell tracking
    Dian R Arifin
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 26:850-9. 2013
    ..This has led to a new generation of imaging biomaterials that can render cells visible with multiple imaging modalities...
  44. pmc Indirect detection of labile solute proton spectra via the water signal using frequency-labeled exchange (FLEX) transfer
    Joshua I Friedman
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21201, USA
    J Am Chem Soc 132:1813-5. 2010
    ....
  45. pmc CEST-MRI detects metabolite levels altered by breast cancer cell aggressiveness and chemotherapy response
    Kannie W Y Chan
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 29:806-16. 2016
    ..Copyright © 2016 John Wiley & Sons, Ltd. ..
  46. pmc Optimization of SABRE for polarization of the tuberculosis drugs pyrazinamide and isoniazid
    Haifeng Zeng
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA Electronic address
    J Magn Reson 237:73-8. 2013
    ....
  47. pmc Mesoporous silica-coated hollow manganese oxide nanoparticles as positive T1 contrast agents for labeling and MRI tracking of adipose-derived mesenchymal stem cells
    Taeho Kim
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Am Chem Soc 133:2955-61. 2011
    ..These novel nanoparticles may extend the arsenal of currently available nanoparticle MR contrast agents by providing positive contrast on T(1)-weighted images at high magnetic field strengths...
  48. pmc In vivo high-resolution diffusion tensor imaging of the mouse brain
    Dan Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 83:18-26. 2013
    ..Comparisons between in vivo and ex vivo mouse brain DTI data showed significant differences in brain morphology and tissue contrasts, which indicate the importance of the in vivo DTI-based mouse brain atlas...
  49. pmc Size-induced enhancement of chemical exchange saturation transfer (CEST) contrast in liposomes
    Jason M Zhao
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Am Chem Soc 130:5178-84. 2008
    ..These new theoretical and experimental tools are expected to benefit applications of liposomes to sensing the cellular environment, targeting and imaging biological processes, and optimizing drug delivery properties...
  50. pmc Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): Ph calibration for poly
    Michael T McMahon
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    Magn Reson Med 55:836-47. 2006
    ..9 Hz, ka = 1.21 Hz, kb = 1.92 x 10(9) Hz, and k0 = 106.4 Hz, ka = 25.8 Hz, kb = 5.45 x 10(8) Hz for PLL and SPD-5, respectively, showing the expected predominance of base-catalyzed exchange for these amide protons...
  51. pmc Screening of CEST MR contrast agents
    Xiaolei Song
    Division of MR Research, The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 771:171-87. 2011
    ..In this chapter, we will focus on the methods which can be used in terms of acquisition schemes and hardware to screen these agents through MR imaging...
  52. pmc Establishing the Lysine-rich Protein CEST Reporter Gene as a CEST MR Imaging Detector for Oncolytic Virotherapy
    Christian T Farrar
    From the Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology C T F, and Brain Tumor Research Center, Department of Neurosurgery J S B, A K, G F, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Simches CRPZN 3800, Boston, MA 02114 F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md G L, M T M, A A G, The Russell H Morgan Department of Radiology and Radiological Science G L, M T M, A A G, The Johns Hopkins University, Baltimore, MD Department of Neurosurgery, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands A K, M L M L and Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Md A A G
    Radiology 275:746-54. 2015
    ....
  53. pmc Anthranilic acid analogs as diamagnetic CEST MRI contrast agents that feature an intramolecular-bond shifted hydrogen
    Xiaolei Song
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    Contrast Media Mol Imaging 10:74-80. 2015
    ..This initial IM-SHY library includes the largest reported shifts for N-H protons on small organic diaCEST agents, and should find use as multifrequency MR agents for in vivo applications...
  54. pmc Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth
    Ming Yang
    Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA
    Adv Healthc Mater 3:1044-52. 2014
    ..These results demonstrate the in vivo advantages of polymer-based MPP for treatment of tumors localized to a mucosal surface. ..
  55. ncbi request reprint Porous tantalum and tantalum oxide nanoparticles for regenerative medicine
    Gokhuldass Mohandas
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Acta Neurobiol Exp (Wars) 74:188-96. 2014
    ..Thus, alternative strategies are needed, such as hydrogel or nanofiber scaffolds, which can be loaded with higher concentrations of nanoparticles, to increase the precision of cell deposition and allow tracking under x-ray guidance...
  56. pmc Noninvasive imaging of infection after treatment with tumor-homing bacteria using Chemical Exchange Saturation Transfer (CEST) MRI
    Guanshu Liu
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 70:1690-8. 2013
    ..To develop a noninvasive MRI method for determining the germination and infection of tumor-homing bacteria in bacteriolytic cancer therapy using endogenous CEST contrast...
  57. pmc Cellular and Molecular Imaging Using Chemical Exchange Saturation Transfer
    Michael T McMahon
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute The Russell H Morgan Department of Radiology and Radiological Sciences, Division of MR Research Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
    Top Magn Reson Imaging 25:197-204. 2016
    ....
  58. ncbi request reprint Simultaneous water and lipid suppression for in vivo brain spectroscopy in humans
    Mari A Smith
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 54:691-6. 2005
    ..An example of the use of the dual saturation method in in vivo magnetic resonance spectroscopic imaging of the human brain is presented...