Stuart B Mazzone

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Evidence for differential reflex regulation of cholinergic and noncholinergic parasympathetic nerves innervating the airways
    Stuart B Mazzone
    The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 165:1076-83. 2002
  2. ncbi request reprint Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs
    Stuart B Mazzone
    Johns Hopkins Medical Institutions, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Regul Integr Comp Physiol 283:R86-98. 2002
  3. ncbi request reprint An in vivo guinea pig preparation for studying the autonomic regulation of airway smooth muscle tone
    Stuart B Mazzone
    The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Auton Neurosci 99:91-101. 2002
  4. pmc Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs
    Stuart B Mazzone
    The Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 569:559-73. 2005
  5. pmc Reflex regulation of airway sympathetic nerves in guinea-pigs
    Eun Joo Oh
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Physiol 573:549-64. 2006
  6. ncbi request reprint Vagal afferent nerves regulating the cough reflex
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Physiol Neurobiol 152:223-42. 2006
  7. pmc Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 557:543-58. 2004
  8. ncbi request reprint Nitric oxide-dependent modulation of smooth-muscle tone by airway parasympathetic nerves
    Branko S Kesler
    Department of Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 165:481-8. 2002
  9. pmc Pharmacology of Bradykinin-Evoked Coughing in Guinea Pigs
    Matthew M Hewitt
    The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland G A, N M, B J C University of Pennsylvania, Philadelphia, Pennsylvania M M H University of Queensland, Australia S B M and Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China L Y
    J Pharmacol Exp Ther 357:620-8. 2016
  10. ncbi request reprint Central nervous system control of the airways: pharmacological implications
    Stuart B Mazzone
    The Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    Curr Opin Pharmacol 2:220-8. 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Evidence for differential reflex regulation of cholinergic and noncholinergic parasympathetic nerves innervating the airways
    Stuart B Mazzone
    The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 165:1076-83. 2002
    ..This previously unrecognized complexity of autonomic regulation of airway caliber has potentially important implications for the mechanisms of airways hyperresponsiveness...
  2. ncbi request reprint Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs
    Stuart B Mazzone
    Johns Hopkins Medical Institutions, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Regul Integr Comp Physiol 283:R86-98. 2002
    ..These data, as well as anatomic evidence for afferent nerve subtype convergence in the commissural nucleus of the solitary tract, suggest that airway nociceptors and mechanoreceptors may act synergistically to regulate airway tone...
  3. ncbi request reprint An in vivo guinea pig preparation for studying the autonomic regulation of airway smooth muscle tone
    Stuart B Mazzone
    The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Auton Neurosci 99:91-101. 2002
    ..The results of the study demonstrate the utility of this model for future studies into the neural regulation of bronchomotor tone and the mechanisms of airway obstruction and hyperreactivity associated with disease...
  4. pmc Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs
    Stuart B Mazzone
    The Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 569:559-73. 2005
    ..Tracheal application of these antagonists was without effect. C-fibre activation may thus sensitize the cough reflex via central mechanisms...
  5. pmc Reflex regulation of airway sympathetic nerves in guinea-pigs
    Eun Joo Oh
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Physiol 573:549-64. 2006
    ..This sympathetic nerve-mediated response may serve to oppose airway contraction induced by parasympathetic nerve activation in the airways...
  6. ncbi request reprint Vagal afferent nerves regulating the cough reflex
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Physiol Neurobiol 152:223-42. 2006
    ..Whether these "cough receptors" are the guinea pig equivalent of the irritant receptors described in the extrapulmonary airways of other species is unclear...
  7. pmc Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 557:543-58. 2004
    ..We propose that these airway afferent neurones represent a distinct subtype and that their primary function is regulation of the cough reflex...
  8. ncbi request reprint Nitric oxide-dependent modulation of smooth-muscle tone by airway parasympathetic nerves
    Branko S Kesler
    Department of Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 165:481-8. 2002
    ..These results show that noncholinergic parasympathetic nerves modulate ASM tone. The NO-dependent component of this response is most effective at baseline levels of nerve activity...
  9. pmc Pharmacology of Bradykinin-Evoked Coughing in Guinea Pigs
    Matthew M Hewitt
    The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland G A, N M, B J C University of Pennsylvania, Philadelphia, Pennsylvania M M H University of Queensland, Australia S B M and Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China L Y
    J Pharmacol Exp Ther 357:620-8. 2016
    ..The data suggest that bradykinin induces coughing in guinea pigs by activating B2 receptors on bronchopulmonary C-fibers. We speculate that therapeutics targeting the actions of bradykinin may prove useful in the treatment of cough. ..
  10. ncbi request reprint Central nervous system control of the airways: pharmacological implications
    Stuart B Mazzone
    The Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    Curr Opin Pharmacol 2:220-8. 2002
    ....
  11. ncbi request reprint Reflex mechanisms in gastroesophageal reflux disease and asthma
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Med 115:45S-48S. 2003
    ..It appears possible that synergistic interactions between esophageal nociceptors and airway sensory nerves may precipitate the asthma-like symptoms associated with GERD...
  12. pmc Neural dysfunction following respiratory viral infection as a cause of chronic cough hypersensitivity
    Bradley J Undem
    Department of Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224, USA Electronic address
    Pulm Pharmacol Ther 33:52-6. 2015
    ....
  13. pmc Neuronal modulation of airway and vascular tone and their influence on nonspecific airways responsiveness in asthma
    Brendan J Canning
    Department of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy (Cairo) 2012:108149. 2012
    ....
  14. ncbi request reprint Sensory neural targets for the treatment of cough
    Stuart B Mazzone
    Howard Florey Institute, University of Melbourne, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 34:955-62. 2007
    ....
  15. ncbi request reprint Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging
    Stuart B Mazzone
    The Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia 3010
    Am J Respir Crit Care Med 176:327-32. 2007
    ..Coughing in humans is typically preceded by a desire (or urge) to cough. The neural circuitry involved in sensing airway irritation and generating the urge-to-cough in humans is essentially unknown...
  16. ncbi request reprint Sensory regulation of the cough reflex
    Stuart B Mazzone
    Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Parkville, VIC 3010, Australia
    Pulm Pharmacol Ther 17:361-8. 2004
    ....
  17. pmc Fluorescent styryl dyes FM1-43 and FM2-10 are muscarinic receptor antagonists: intravital visualization of receptor occupancy
    Stuart B Mazzone
    The Howard Florey Institute, University of Melbourne, Australia
    J Physiol 575:23-35. 2006
    ..In addition, these dyes may provide a novel tool for visualizing muscarinic receptor occupancy in living tissue or cell preparations...
  18. ncbi request reprint Na+-K+-2Cl- cotransporters and Cl- channels regulate citric acid cough in guinea pigs
    Stuart B Mazzone
    Howard Florey Institute, University of Melbourne, Parkville 3010, Victoria, Australia
    J Appl Physiol (1985) 101:635-43. 2006
    ..Efflux of intracellular Cl-, in part through calcium-activated Cl- channels, may play an important role in regulating airway afferent neuron activity...
  19. pmc Respiratory actions of vanilloid receptor agonists in the nucleus of the solitary tract: comparison of resiniferatoxin with non-pungent agents and anandamide
    Dominic P Geraghty
    School of Human Life Sciences, University of Tasmania, Locked bag 1 320, Launceston, Tasmania 7250, Australia
    Br J Pharmacol 137:919-27. 2002
    ..However, whereas RTX and PPAHV activate and subsequently desensitize vanilloid receptors on sensory nerve terminals in the cNTS, olvanil and AEA fail to activate despite readily desensitizing responses to RTX in this region...
  20. ncbi request reprint Tachykinin receptor (NK(1), NK(2), NK(3)) binding sites in the rat caudal brainstem following neonatal capsaicin administration
    Dominic P Geraghty
    School of Human Life Sciences, University of Tasmania, Locked Bag 1320, Tasmania 7250, Launceston, Australia
    Brain Res 979:230-4. 2003
    ..The distribution and density of binding sites were similar in vehicle- and capsaicin-pretreated rats, suggesting that sensory neuron ablation by neonatal capsaicin does not affect tachykinin receptor numbers in the rat caudal brainstem...