C L Marcus

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Secondary narcolepsy in children with brain tumors
    Carole L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, USA
    Sleep 25:435-9. 2002
  2. ncbi request reprint Pathophysiology of childhood obstructive sleep apnea: current concepts
    C L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Park 316, Johns Hopkins University, Baltimore, 600 N Wolfe Street, Baltimore, MD, USA
    Respir Physiol 119:143-54. 2000
  3. ncbi request reprint Sleep-disordered breathing in children
    C L Marcus
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Curr Opin Pediatr 12:208-12. 2000
  4. ncbi request reprint Response to inspiratory resistive loading during sleep in normal children and children with obstructive apnea
    C L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland 21287 2533, USA
    J Appl Physiol (1985) 87:1448-54. 1999
  5. ncbi request reprint Blood pressure in children with obstructive sleep apnea
    C L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 157:1098-103. 1998
  6. ncbi request reprint Natural history of primary snoring in children
    C L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Pediatr Pulmonol 26:6-11. 1998
  7. ncbi request reprint Developmental changes in response to subatmospheric pressure loading of the upper airway
    C L Marcus
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland 21287 2533, USA
    J Appl Physiol (1985) 87:626-33. 1999
  8. ncbi request reprint Obstructive sleep apnea syndrome: differences between children and adults
    C L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287 2533, USA
    Sleep 23:S140-1. 2000
  9. ncbi request reprint Effect of sleep deprivation on driving safety in housestaff
    C L Marcus
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Sleep 19:763-6. 1996
  10. pmc Effect of sleep stage on breathing in children with central hypoventilation
    Jingtao Huang
    Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Appl Physiol (1985) 105:44-53. 2008

Collaborators

  • Ann C Halbower
  • R D Chervin
  • THORNTON B MASON
  • Stuart F Quan
  • Susan Redline
  • Rohit Budhiraja
  • Sergio Tufik
  • E Mignot
  • Timothy F Hoban
  • Lee J Brooks
  • Reena Mehra
  • Madeleine Grigg-Damberger
  • Merrill S Wise
  • R Arens
  • D Gozal
  • Jingtao Huang
  • Eliot S Katz
  • Preetam Bandla
  • M Cecilia Melendres
  • Ian M Colrain
  • Laurie Karamessinis
  • Janita M Lutz
  • Patricia Galster
  • John M Samuel
  • John Samuel
  • Michelle E Pepe
  • Michael S Schwartz
  • Howard B Panitch
  • Michelle Pepe
  • William H Trescher
  • John M Maris
  • Yael P Mosse
  • Paul R Gallagher
  • Maria Cecilia Lopes
  • Brian Schultz
  • Gustavo A Moreira
  • Nadav Traeger
  • Janita Lutz
  • Ma Cecilia S Melendres
  • Tat Kong Wong
  • Manisha B Witmans
  • Avram R Gold
  • Lucila B Fernandes Do Prado
  • Ronald F Abi-Raad
  • Ruth M Bradford
  • Ruth Bradford
  • Andrea Kelly
  • Ronnie F Abi-Raad
  • Laurie R Karamessinis
  • Ignacio E Tapia
  • I M Colrain
  • Joanne Elliott
  • David P White
  • Karen Verfaille
  • Xianqun Luan
  • Luiz E Nery
  • Avrum N Pollock
  • Eric D Rubin
  • Tai Shing Lau
  • Cheryl Black
  • Sally L Davidson Ward
  • Thomas G Keens
  • Richard Thompson
  • Xianbin Li
  • Mary G Greene
  • Gerald M Loughlin
  • John Carroll
  • Kathryn A Carson
  • Morris S Gold
  • Francis Dipalo

Detail Information

Publications37

  1. ncbi request reprint Secondary narcolepsy in children with brain tumors
    Carole L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, USA
    Sleep 25:435-9. 2002
    ..In view of the good response to treatment, we recommend that all children with excessive daytime sleepiness and hypothalamic damage be evaluated for narcolepsy...
  2. ncbi request reprint Pathophysiology of childhood obstructive sleep apnea: current concepts
    C L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Park 316, Johns Hopkins University, Baltimore, 600 N Wolfe Street, Baltimore, MD, USA
    Respir Physiol 119:143-54. 2000
    ..We speculate that OSAS occurs in those children lacking the compensatory upper airway neuromotor responses...
  3. ncbi request reprint Sleep-disordered breathing in children
    C L Marcus
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Curr Opin Pediatr 12:208-12. 2000
    ..Polysomnography is invaluable for the evaluation of sleep-disordered breathing. Advances in diagnosis and management can alleviate much of the morbidity previously associated with sleep-related respiratory disorders...
  4. ncbi request reprint Response to inspiratory resistive loading during sleep in normal children and children with obstructive apnea
    C L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland 21287 2533, USA
    J Appl Physiol (1985) 87:1448-54. 1999
    ..Despite compensatory changes in respiratory timing, normal children have a decrease in minute ventilation in response to IRL during sleep. However, arousal occurs before gas-exchange abnormalities...
  5. ncbi request reprint Blood pressure in children with obstructive sleep apnea
    C L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 157:1098-103. 1998
    ..001 for diastole and p < 0.01 for systole), but did not differ significantly between rapid eye movement (REM) and non-REM sleep. We conclude that childhood OSAS is associated with systemic diastolic hypertension...
  6. ncbi request reprint Natural history of primary snoring in children
    C L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Pediatr Pulmonol 26:6-11. 1998
    ..Parental concern about children's breathing patterns during sleep is a poor predictor of polysomnographic abnormalities. However, because many patients were lost to follow-up in this study, further prospective studies are needed...
  7. ncbi request reprint Developmental changes in response to subatmospheric pressure loading of the upper airway
    C L Marcus
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland 21287 2533, USA
    J Appl Physiol (1985) 87:626-33. 1999
    ..This is associated with increased body mass index, even in nonsnoring, nonobese subjects. Ventilatory drive during sleep plays a role in modulating upper airway responses...
  8. ncbi request reprint Obstructive sleep apnea syndrome: differences between children and adults
    C L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287 2533, USA
    Sleep 23:S140-1. 2000
    ..Measurements of the upper airway pressure-flow characteristics can be useful in evaluating upper airway function in patients with OSAS as well as the normal population...
  9. ncbi request reprint Effect of sleep deprivation on driving safety in housestaff
    C L Marcus
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Sleep 19:763-6. 1996
    ..We speculate that current HS work schedules may place some HS at risk for injury to themselves and others. Further study, using prospectively objective measures is indicated...
  10. pmc Effect of sleep stage on breathing in children with central hypoventilation
    Jingtao Huang
    Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Appl Physiol (1985) 105:44-53. 2008
    ..The hypoventilation in CHS is more severe during NREM than REM sleep. We speculate that this may be due to increased excitatory inputs to the respiratory system during REM sleep...
  11. pmc Sleep-disordered breathing, behavior, and cognition in children before and after adenotonsillectomy
    Ronald D Chervin
    Sleep Disorders Center, Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
    Pediatrics 117:e769-78. 2006
    ....
  12. pmc Subjective sleepiness and polysomnographic correlates in children scheduled for adenotonsillectomy vs other surgical care
    Ronald D Chervin
    Sleep Disorders Center, Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Sleep 29:495-503. 2006
    ....
  13. pmc Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury
    Ann C Halbower
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e301. 2006
    ..We hypothesized that childhood OSA is associated with neuropsychological performance dysfunction, and with neuronal metabolite alterations in the brain, indicative of neuronal injury in areas corresponding to neuropsychological function...
  14. ncbi request reprint The scoring of respiratory events in sleep: reliability and validity
    Susan Redline
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
    J Clin Sleep Med 3:169-200. 2007
    ....
  15. ncbi request reprint The visual scoring of sleep and arousal in infants and children
    Madeleine Grigg-Damberger
    Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM 87131 0001, USA
    J Clin Sleep Med 3:201-40. 2007
    ..We need research comparing clinical outcomes with PSG measures to better inform clinicians and families exactly what meaning a PSG has in evaluating a child's suspected sleep disorder...
  16. ncbi request reprint The significance of ASDA arousals in children
    Maria Cecilia Lopes
    Department of Psychobiology, Federal University of Sao Paulo, Brazil
    Sleep Med 9:3-8. 2007
    ..The aim of this review is to discuss the application of conventional and unconventional markers of sleep disruption in children...
  17. pmc Relationship between REM density, duty cycle, and obstructive sleep apnea in children
    Laurie Karamessinis
    The Sleep Center, The Children s Hospital ofPhiladelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Sleep 30:837-43. 2007
    ..We speculate that the increase in the duty cycle is a compensatory response to increased upper airway loads during sleep, and that this may lead to ventilatory or upper airway muscle fatigue...
  18. pmc Respiratory-related evoked potentials during sleep in children
    M Cecilia Melendres
    Johns Hopkins School of Medicine, Baltimore, MD, USA
    Sleep 31:55-61. 2008
    ..However, there have been no data on RREP during sleep in children. We thus examined children during sleep to determine whether early RREP components would be maintained during all sleep..
  19. pmc Cortical processing of respiratory afferent stimuli during sleep in children with the obstructive sleep apnea syndrome
    Jingtao Huang
    The Sleep Center Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep 31:403-10. 2008
    ..We hypothesized that children with OSAS have blunted RREP responses compared to normal children during sleep...
  20. pmc Cortical processing of respiratory occlusion stimuli in children with central hypoventilation syndrome
    Jingtao Huang
    The Sleep Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Am J Respir Crit Care Med 178:757-64. 2008
    ..The ability of patients with central hypoventilation syndrome (CHS) to produce and process mechanoreceptor signals is unknown...
  21. pmc Puberty and upper airway dynamics during sleep
    Preetam Bandla
    Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, PA 19104, USA
    Sleep 31:534-41. 2008
    ..We hypothesized that the upper airway response to subatmospheric pressure loading decreased with increasing pubertal Tanner stage in males but remained stable during puberty in females...
  22. ncbi request reprint Adherence to and effectiveness of positive airway pressure therapy in children with obstructive sleep apnea
    Carole L Marcus
    Division of Pulmonary Medicine, Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 117:e442-51. 2006
    ..The objective of this study was to determine adherence and effectiveness of PAP (both continuous [CPAP] and bilevel [BPAP] pressure) in children with obstructive apnea...
  23. pmc Influence of airway pressure on genioglossus activity during sleep in normal children
    Eliot S Katz
    Division of Pediatric Pulmonology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Respir Crit Care Med 173:902-9. 2006
    ..This suggests that additional determinants of airway patency are active, such as neuromuscular compensation...
  24. ncbi request reprint Acoustic arousal responses in children with obstructive sleep apnea
    Gustavo A Moreira
    Department of Pediatrics, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Pediatr Pulmonol 40:300-5. 2005
    ..However, further studies evaluating arousal to both respiratory and nonrespiratory stimuli in the same subjects are needed...
  25. ncbi request reprint Body position and obstructive sleep apnea in children
    Lucila B Fernandes Do Prado
    Department of Neurology and Internal Medicine, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, Brazil
    Sleep 25:66-71. 2002
    ..However, the relationship between sleep position and obstructive apnea in children is unknown. The objective of this study was to evaluate the relationship between obstructive apnea and body position during sleep in children...
  26. ncbi request reprint Upper airway collapsibility during sleep in upper airway resistance syndrome
    Avram R Gold
    Division of Pulmonary Critical Care Medicine, SUNY Stony Brook, School of Medicine, DVA Medical Center, Northport, NY 11768, USA
    Chest 121:1531-40. 2002
    ..To compare upper airway collapsibility during sleep between patients with upper airway resistance syndrome (UARS), normal subjects, and patients with obstructive sleep apnea/hypopnea syndrome (OSA/H)...
  27. ncbi request reprint Night-to-night variability of polysomnography in children with suspected obstructive sleep apnea
    Eliot S Katz
    Eudowood Divison of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    J Pediatr 140:589-94. 2002
    ..To determine whether a single polysomnographic night was a valid measure of obstructive sleep apnea syndrome (OSAS) in children with symptoms of sleep-disordered breathing...
  28. ncbi request reprint Pulse transit time as a measure of arousal and respiratory effort in children with sleep-disordered breathing
    Eliot S Katz
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Pediatr Res 53:580-8. 2003
    ..8 events/h) than primary snoring (2.2 events/h) (p < 0.05). We conclude that, in children, PTT arousals are a more sensitive measure of obstructive events than visible EEG arousals...
  29. ncbi request reprint Letter to the editor regarding our previous publication: "Secondary narcolepsy in children with brain tumors," SLEEP 2002; 25:435-439
    Carole L Marcus
    Sleep 26:228. 2003
  30. ncbi request reprint Obstructive hypopneas in children and adolescents: normal values
    Manisha B Witmans
    Am J Respir Crit Care Med 168:1540. 2003
  31. ncbi request reprint Tolerance of esophageal pressure monitoring during polysomnography in children
    Ronald D Chervin
    Sleep Disorders Center Department of Neurology, University of Michigan, Ann Arbor, MI 48109 0117, USA
    Sleep 26:1022-6. 2003
    ..To assess tolerance of esophageal pressure monitoring (EPM) among 5- to 13-year-old children during research polysomnography at study entry and again 1 year later...
  32. ncbi request reprint Developmental changes in upper airway dynamics
    Carole L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287 2533, USA
    J Appl Physiol (1985) 97:98-108. 2004
    ..Infants appear to have a different pattern of upper airway activation than older children. We speculate that the pharyngeal airway responses present in normal children are a compensatory response for a relatively narrow upper airway...
  33. ncbi request reprint Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathing
    Ma Cecilia S Melendres
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatrics 114:768-75. 2004
    ..Furthermore, we hypothesized that overnight polysomnographic parameters correlated with sleepiness and hyperactivity...
  34. ncbi request reprint Reliability of scoring arousals in normal children and children with obstructive sleep apnea syndrome
    Tat Kong Wong
    Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong
    Sleep 27:1139-45. 2004
    ..However, the validity and reliability of scoring these shorter arousals have never been verified. Based on studies in adults, we hypothesized that interscorer agreement for scoring arousals shorter than 3 seconds was poor...
  35. ncbi request reprint Upper airway dynamic responses in children with the obstructive sleep apnea syndrome
    Carole L Marcus
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287, USA
    Pediatr Res 57:99-107. 2005
    ..Further, we speculate that this compensatory response is lacking in children with OSAS, most likely due to either habituation to chronic respiratory abnormalities during sleep or to mechanical damage to the upper airway...
  36. ncbi request reprint Polysomnographic values in children 2-9 years old: additional data and review of the literature
    Nadav Traeger
    Division of Pulmonary Medicine and Sleep Disorders Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Pediatr Pulmonol 40:22-30. 2005
    ..We also confirm previous data on the frequency distribution of sleep stages, SpO2, and relative rarity of respiratory events in this age group...
  37. doi request reprint Rapid eye movement latency in children and adolescents
    Thornton B A Mason
    Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pediatr Neurol 39:162-9. 2008
    ..Healthy children exhibited rapid eye movement latencies significantly longer than adults. Normal control patients demonstrated significantly longer rapid eye movement latency than obstructive sleep apnea syndrome and narcolepsy patients...