Anna Kottgen

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels
    Tamra E Meyer
    Human Genetics Center and Division of Epidemiology, The University of Texas Health Science Center at Houston, School of Public Health, Houston, Texas, USA
    PLoS Genet 6:. 2010
  2. pmc Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study
    Mark Bi
    School of Biological Sciences, University of Nebraska at Lincoln, Lincoln, Nebraska, United States of America
    PLoS ONE 5:e11690. 2010
  3. pmc The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Endocr Disord 10:9. 2010
  4. pmc Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 9:49. 2008
  5. pmc Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate
    Adrienne Tin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Hum Genet 58:461-6. 2013
  6. pmc Prevalence of kidney disease in anaemia differs by GFR-estimating method: the Third National Health and Nutrition Examination Survey (1988-94)
    Michelle M Estrella
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Nephrol Dial Transplant 25:2542-8. 2010
  7. pmc A urate gene-by-diuretic interaction and gout risk in participants with hypertension: results from the ARIC study
    Mara A McAdams-Demarco
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument St, Suite B 319, Baltimore, MD 21287, USA
    Ann Rheum Dis 72:701-6. 2013
  8. pmc Comparison of serum concentrations of β-trace protein, β2-microglobulin, cystatin C, and creatinine in the US population
    Stephen P Juraschek
    Departments of Epidemiology and Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Clin J Am Soc Nephrol 8:584-92. 2013
  9. pmc Multiple loci associated with indices of renal function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 41:712-7. 2009
  10. pmc Age, gender, and race effects on cystatin C levels in US adolescents
    Darcy Groesbeck
    Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Clin J Am Soc Nephrol 3:1777-85. 2008

Detail Information

Publications33

  1. pmc Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels
    Tamra E Meyer
    Human Genetics Center and Division of Epidemiology, The University of Texas Health Science Center at Houston, School of Public Health, Houston, Texas, USA
    PLoS Genet 6:. 2010
    ..Follow-up studies of newly implicated genomic loci may provide additional insights into the regulation and homeostasis of human serum magnesium levels...
  2. pmc Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study
    Mark Bi
    School of Biological Sciences, University of Nebraska at Lincoln, Lincoln, Nebraska, United States of America
    PLoS ONE 5:e11690. 2010
    ..In addition, we examined the association of rs780094 with incident diabetes, coronary heart disease (CHD), and stroke over up mean follow-up times of 8, 15, and 15 years, respectively...
  3. pmc The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Endocr Disord 10:9. 2010
    ..We therefore aimed to investigate the association between the transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism and retinal microvascular phenotypes in the Atherosclerosis Risk in Communities (ARIC) Study (1993-1995)...
  4. pmc Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 9:49. 2008
    ..The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants provides a list of SNPs showing the strongest associations with renal traits which need to be verified in independent study samples...
  5. pmc Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate
    Adrienne Tin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Hum Genet 58:461-6. 2013
    ..However, careful attention must be paid to the correlation of systematic errors and inconsistent associations when different biomarkers or methods are used to measure the quantitative trait. ..
  6. pmc Prevalence of kidney disease in anaemia differs by GFR-estimating method: the Third National Health and Nutrition Examination Survey (1988-94)
    Michelle M Estrella
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Nephrol Dial Transplant 25:2542-8. 2010
    ..Serum cystatin C is purportedly a more sensitive marker of kidney disease and a better predictor of mortality than serum creatinine. However, studies suggest that extrarenal factors also influence cystatin C levels...
  7. pmc A urate gene-by-diuretic interaction and gout risk in participants with hypertension: results from the ARIC study
    Mara A McAdams-Demarco
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument St, Suite B 319, Baltimore, MD 21287, USA
    Ann Rheum Dis 72:701-6. 2013
    ..To test for a urate gene-by-diuretic interaction on incident gout...
  8. pmc Comparison of serum concentrations of β-trace protein, β2-microglobulin, cystatin C, and creatinine in the US population
    Stephen P Juraschek
    Departments of Epidemiology and Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Clin J Am Soc Nephrol 8:584-92. 2013
    ..This study compares the distribution of all four markers in the general population and their associations with possible determinants of GFR...
  9. pmc Multiple loci associated with indices of renal function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 41:712-7. 2009
    ..Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease...
  10. pmc Age, gender, and race effects on cystatin C levels in US adolescents
    Darcy Groesbeck
    Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Clin J Am Soc Nephrol 3:1777-85. 2008
    ....
  11. pmc High-normal albuminuria and risk of heart failure in the community
    Saul Blecker
    Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Kidney Dis 58:47-55. 2011
    ..Albuminuria has been associated with cardiovascular risk, but the relationship of high-normal albuminuria to subsequent heart failure has not been well established...
  12. pmc Incident gout in women and association with obesity in the Atherosclerosis Risk in Communities (ARIC) Study
    Janet W Maynard
    Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Med 125:717.e9-717.e17. 2012
    ..We hypothesized that women with early- and mid-adult life obesity, as well as high mid-adult life waist-to-hip ratios, and high weight gain during adulthood, experience a greater incidence of gout...
  13. pmc TCF7L2 variants associate with CKD progression and renal function in population-based cohorts
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Soc Nephrol 19:1989-99. 2008
    ..In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes...
  14. pmc Obesity and younger age at gout onset in a community-based cohort
    Mara A McAdams DeMarco
    Johns Hopkins University, 2024 East Monument Street, Baltimore, MD 21287, USA
    Arthritis Care Res (Hoboken) 63:1108-14. 2011
    ..We examined whether obesity is related to age at gout onset and quantified the risk of incident gout by obesity status in the Campaign Against Cancer and Heart Disease (CLUE II) study, a longitudinal community-based cohort...
  15. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    ..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
  16. pmc Race differences in access to health care and disparities in incident chronic kidney disease in the US
    Kira Evans
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Nephrol Dial Transplant 26:899-908. 2011
    ..The contribution of race differences in access to health care to disparities in chronic kidney disease (CKD) incidence in the United States is unknown...
  17. pmc Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele
    Adrienne Tin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Hum Mol Genet 20:4056-68. 2011
    ..Our data support the importance of multi-ethnic GWAS in the identification of novel risk loci as well as functional variants...
  18. pmc Kidney function estimated from serum creatinine and cystatin C and peripheral arterial disease in NHANES 1999-2002
    Elizabeth Selvin
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    Eur Heart J 30:1918-25. 2009
    ..Serum cystatin C, a novel marker of kidney function, is reported to be superior to serum creatinine as a risk factor for atherosclerotic disease, but associations may vary across vascular beds...
  19. pmc Trefoil factor 3 predicts incident chronic kidney disease: a case-control study nested within the Atherosclerosis Risk in Communities (ARIC) study
    Brad C Astor
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, 2024 East Monument Street, Baltimore, MD 21287, USA
    Am J Nephrol 34:291-7. 2011
    ..Urinary levels of trefoil factor 3 (TFF3) are associated with acute kidney injury in animal models, but the association of TFF3 levels with incident CKD in humans is unknown...
  20. pmc Correlates of kidney stone disease differ by race in a multi-ethnic middle-aged population: the ARIC study
    Saloua Akoudad
    Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA
    Prev Med 51:416-20. 2010
    ..To identify correlates of kidney stone disease in white and African American men and women in a population-based longitudinal study starting in four US communities, and to assess differences in correlates across racial groups...
  21. pmc Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study
    Nrupen A Bhavsar
    Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 60:233-40. 2012
    ....
  22. pmc Reliability and sensitivity of the self-report of physician-diagnosed gout in the campaign against cancer and heart disease and the atherosclerosis risk in the community cohorts
    Mara A McAdams
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21224, USA
    J Rheumatol 38:135-41. 2011
    ..We evaluated the reliability and sensitivity of the self-report of physician-diagnosed gout in the Campaign Against Cancer and Heart Disease (CLUE II) and the Atherosclerosis Risk in the Community (ARIC) cohorts...
  23. pmc ABCG transporters and disease
    Owen M Woodward
    Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    FEBS J 278:3215-25. 2011
    ..We focus on the recent discovery of mutations in ABCG2 causing hyperuricemia and gout, which has led to the identification of urate as a physiological substrate for ABCG2...
  24. pmc Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
    Santhi K Ganesh
    National Human Genome Research Institute, Division of Intramural Research, Bethesda, MD, USA
    Nat Genet 41:1191-8. 2009
    ..This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures...
  25. pmc Defining incident chronic kidney disease in the research setting: The ARIC Study
    Lori D Bash
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21201, USA
    Am J Epidemiol 170:414-24. 2009
    ..3, confidence interval: 4.4, 8.9). Associations with gender differed in direction and magnitude across definitions. Case definition can impact relative risk estimates for CKD risk factors...
  26. pmc Physical Function, Hyperuricemia, and Gout in Older Adults
    Bridget Teevan Burke
    Johns Hopkins University, Baltimore, Maryland
    Arthritis Care Res (Hoboken) 67:1730-8. 2015
    ..Gout prevalence is high in older adults and those affected are at risk of physical disability, yet it is unclear whether they have worse physical function...
  27. pmc Genetic loci for serum magnesium among African-Americans and gene-environment interaction at MUC1 and TRPM6 in European-Americans: the Atherosclerosis Risk in Communities (ARIC) study
    Adrienne Tin
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    BMC Genet 16:56. 2015
    ..Literature search identified the influence of progesterone on MUC1 expression and insulin on TRPM6 expression...
  28. ncbi Reduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) study
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21287, USA
    J Am Soc Nephrol 18:1307-15. 2007
    ..In summary, middle-aged adults with moderately/severely reduced kidney function are at high risk for developing HF...
  29. pmc Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
    Owen M Woodward
    Department of Physiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:10338-42. 2009
    ..Our study completes the chain of evidence from association to causation and supports the common disease-common variant hypothesis in the etiology of gout...
  30. pmc The association of podocin R229Q polymorphism with increased albuminuria or reduced estimated GFR in a large population-based sample of US adults
    Anna Kottgen
    Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 52:868-75. 2008
    ....
  31. pmc Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations
    Robert B Scharpf
    550 N, Broadway, Suite 1101, Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    BMC Genet 15:81. 2014
    ..Whether copy number polymorphisms (CNPs) contribute to uric acid levels is unknown...
  32. doi Serum cystatin C in the United States: the Third National Health and Nutrition Examination Survey (NHANES III)
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Am J Kidney Dis 51:385-94. 2008
    ..However, information for serum cystatin C levels in the general population, specifically across a wide age range and different ethnicities, is lacking...
  33. ncbi SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function
    Man Li
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland
    J Am Soc Nephrol . 2016
    ..This study expands the number of loci associated with kidney function and identifies novel genes with potential roles in kidney formation...