Myoung Sook Kim

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Neurofilament heavy polypeptide regulates the Akt-beta-catenin pathway in human esophageal squamous cell carcinoma
    Myoung Sook Kim
    Head and Neck Cancer Research Division, Department of Otolaryngology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9003. 2010
  2. pmc Cellular transformation by cigarette smoke extract involves alteration of glycolysis and mitochondrial function in esophageal epithelial cells
    Myoung Sook Kim
    Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int J Cancer 127:269-81. 2010
  3. doi request reprint DCC promoter hypermethylation in esophageal squamous cell carcinoma
    Hannah Lui Park
    Department of Otolaryngology, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int J Cancer 122:2498-502. 2008
  4. pmc Differential recognition of response elements determines target gene specificity for p53 and p63
    Motonobu Osada
    Department of Otolaryngology, Division of Head and Neck Surgery, Johns Hopkins University School of Medicine, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Mol Cell Biol 25:6077-89. 2005
  5. pmc ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer
    Jun Wei Liu
    Division of Head and Neck Cancer Research, Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 14:3754-60. 2008
  6. pmc Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation
    Janghee Woo
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Lett 264:54-62. 2008
  7. doi request reprint HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma
    Keishi Yamashita
    Department of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins University, Baltimore, MD 21231, USA
    Mol Cancer Res 6:31-41. 2008
  8. pmc Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer
    Myoung Sook Kim
    Department of Otolaryngology, Head and Neck Cancer Research Institute, Johns Hopkins University, 1550 Orleans Street 5N 03, Baltimore, MD 21231, USA
    Biochem Biophys Res Commun 370:38-43. 2008
  9. pmc Identification of hypermethylated genes associated with cisplatin resistance in human cancers
    Xiaofei Chang
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 70:2870-9. 2010
  10. pmc Pharmacologic unmasking of epigenetically silenced genes in breast cancer
    Kimberly Laskie Ostrow
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Clin Cancer Res 15:1184-91. 2009

Collaborators

Detail Information

Publications37

  1. pmc Neurofilament heavy polypeptide regulates the Akt-beta-catenin pathway in human esophageal squamous cell carcinoma
    Myoung Sook Kim
    Head and Neck Cancer Research Division, Department of Otolaryngology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9003. 2010
    ..Loss of NEFH activates the Akt/beta-catenin pathway and increases glycolysis and mitochondrial dysfunction. Cancer cells with methylated NEFH can be targeted for destruction with specific inhibitors of deregulated downstream pathways...
  2. pmc Cellular transformation by cigarette smoke extract involves alteration of glycolysis and mitochondrial function in esophageal epithelial cells
    Myoung Sook Kim
    Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int J Cancer 127:269-81. 2010
    ....
  3. doi request reprint DCC promoter hypermethylation in esophageal squamous cell carcinoma
    Hannah Lui Park
    Department of Otolaryngology, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int J Cancer 122:2498-502. 2008
    ..We have demonstrated that DCC methylation is a frequent and cancer-specific event in primary ESCCs, suggesting that DCC and associated pathways may represent a new diagnostical therapeutic target...
  4. pmc Differential recognition of response elements determines target gene specificity for p53 and p63
    Motonobu Osada
    Department of Otolaryngology, Division of Head and Neck Surgery, Johns Hopkins University School of Medicine, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Mol Cell Biol 25:6077-89. 2005
    ..Our results indicate that p63 can regulate expression of specific target genes such as those involved in skin, limb, and craniofacial development by preferentially activating distinct p63-specific response elements...
  5. pmc ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer
    Jun Wei Liu
    Division of Head and Neck Cancer Research, Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 14:3754-60. 2008
    ..Prostate cancer is a major cause of cancer death among men and the development of new biomarkers is important to augment current detection approaches...
  6. pmc Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation
    Janghee Woo
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Lett 264:54-62. 2008
    ..These findings altogether indicate that hAQP5 plays an important role in human carcinogenesis and, furthermore, provide an attractive therapeutic target...
  7. doi request reprint HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma
    Keishi Yamashita
    Department of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins University, Baltimore, MD 21231, USA
    Mol Cancer Res 6:31-41. 2008
    ....
  8. pmc Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer
    Myoung Sook Kim
    Department of Otolaryngology, Head and Neck Cancer Research Institute, Johns Hopkins University, 1550 Orleans Street 5N 03, Baltimore, MD 21231, USA
    Biochem Biophys Res Commun 370:38-43. 2008
    ..3%, 2/13). Moreover, methylation status of DFNA5 was correlated with lymph node metastasis in breast cancer patients. Our data implicate DFNA5 promoter methylation as a novel molecular biomarker in human breast cancer...
  9. pmc Identification of hypermethylated genes associated with cisplatin resistance in human cancers
    Xiaofei Chang
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 70:2870-9. 2010
    ....
  10. pmc Pharmacologic unmasking of epigenetically silenced genes in breast cancer
    Kimberly Laskie Ostrow
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Clin Cancer Res 15:1184-91. 2009
    ....
  11. pmc Cysteine dioxygenase 1 is a tumor suppressor gene silenced by promoter methylation in multiple human cancers
    Mariana Brait
    Department of Otolaryngology, Head and Neck Cancer Research Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e44951. 2012
    ..Our data implicate CDO1 as a novel tumor suppressor gene and a potentially valuable molecular marker for human cancer...
  12. ncbi request reprint A novel response element confers p63- and p73-specific activation of the WNT4 promoter
    Motonobu Osada
    Department of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 339:1120-8. 2006
    ..Neither response element alone was able to confer transcriptional activity. It is thus likely that both RE1 and RE2 are necessary in rendering p63/p73-specific activation of the WNT4 promoter...
  13. pmc Role of human aquaporin 5 in colorectal carcinogenesis
    Sung Koo Kang
    The Head and Neck Cancer Research Division, Department of Otolaryngology, The Johns Hopkins University, CRBII, 5M03, 1550 Orleans St, Baltimore, MD 21231, USA
    Am J Pathol 173:518-25. 2008
    ....
  14. pmc The role of PGP9.5 as a tumor suppressor gene in human cancer
    Yutaka Tokumaru
    Department of Otolaryngology, Head and Neck Cancer Research Institute, Johns Hopkins University, Baltimore, MD, USA
    Int J Cancer 123:753-9. 2008
    ..Our data support the notion that PGP9.5 is a tumor suppressor gene that is inactivated by promoter methylation or gene deletion in several types of human cancers...
  15. pmc Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma
    Yiping Huang
    Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int J Cancer 128:2261-73. 2011
    ..Our results indicate that cigarette smoking is a cause of SSBP2 promoter methylation and that SSBP2 harbors a tumor suppressive role in ESCC through inhibition of the Wnt signaling pathway...
  16. ncbi request reprint A promoter methylation pattern in the N-methyl-D-aspartate receptor 2B gene predicts poor prognosis in esophageal squamous cell carcinoma
    Myoung Sook Kim
    Department of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21231, USA
    Clin Cancer Res 13:6658-65. 2007
    ....
  17. ncbi request reprint N-methyl-D-aspartate receptor type 2B is epigenetically inactivated and exhibits tumor-suppressive activity in human esophageal cancer
    Myoung Sook Kim
    Department of Otolaryngology, Head and Neck Cancer Research Division, Institute of Cell Engineering, Johns Hopkins University School of Medicine, 818 Ross Building, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Cancer Res 66:3409-18. 2006
    ..Thus, NMDAR2B promoter methylation is common in ESCC, abrogating gene transcription and leading to cellular resistance to apoptosis...
  18. ncbi request reprint Quantitative hypermethylation of NMDAR2B in human gastric cancer
    Jun Wei Liu
    Department of Otolaryngology, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 121:1994-2000. 2007
    ..Taken together, the above results suggest that NMDAR2B methylation is a common and important biologically relevant event in gastric cancer progression...
  19. pmc Genome-wide promoter analysis uncovers portions of the cancer methylome
    Mohammad Obaidul Hoque
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 68:2661-70. 2008
    ..Identification of a large number of genes with cancer-specific methylation provides new targets for diagnostic and therapeutic intervention, and opens fertile avenues for basic research in tumor biology...
  20. doi request reprint Hypermethylation of MCAM gene is associated with advanced tumor stage in prostate cancer
    Jun Wei Liu
    Department of Otolaryngology, Division of Head and Neck Cancer Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Prostate 68:418-26. 2008
    ....
  21. ncbi request reprint PGP9.5 methylation in diffuse-type gastric cancer
    Keishi Yamashita
    Department of Otolaryngology, Division of Head and Neck Cancer Research, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Cancer Res 66:3921-7. 2006
    ..05). Furthermore, real-time methylation-specific PCR analysis of PGP9.5 showed relatively higher methylation levels in DGC than in IGC. Our data thus implicate a molecular event common in the DGC phenotype compared with IGC...
  22. ncbi request reprint LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer
    Guojun Wu
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 67:4123-9. 2007
    ..Thus, our current study suggests for the first time that lysyl oxidase-like genes can act as tumor suppressor genes and exert their functions through the inhibition of the Ras/ERK signaling pathway in human bladder cancer...
  23. pmc The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors
    Xiaofei Chang
    Department of Otolaryngology Head and Neck Surgery, Division of Head and Neck Cancer Research, Johns Hopkins University, Baltimore, Maryland, USA
    PLoS ONE 8:e68966. 2013
    ..01). ..
  24. pmc Characterization of the methylation patterns in human papillomavirus type 16 viral DNA in head and neck cancers
    Il Seok Park
    Departments of Otolaryngology Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Cancer Prev Res (Phila) 4:207-17. 2011
    ..Our findings also support continued targeting of the E6 and/or E7 antigens through various vaccine strategies against HPV-associated cancers...
  25. ncbi request reprint The effect of aquaporin 5 overexpression on the Ras signaling pathway
    Janghee Woo
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins Medical Institution, Cancer Research Building II, 5M3, 1550 Orleans Street, Baltimore, MD, 21205, USA
    Biochem Biophys Res Commun 367:291-8. 2008
    ..This is the first evidence demonstrating an association between AQP5 and a signaling pathway, namely the Ras signal transduction pathway, which may be the basis of the oncogenic properties seen in AQP-overexpressing cells...
  26. pmc Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma
    Yong Gu Cho
    Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University, 1550 Orleans Street, CRBII Rm 574, Baltimore, MD 21231, USA
    Int J Oncol 39:337-44. 2011
    ..These results demonstrate that cancer-specific methylation and a specific decrease of LIFR expression are a common inactivation event in colon cancer development...
  27. ncbi request reprint Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer
    Jong Chul Park
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21231, USA
    Biochem Biophys Res Commun 365:221-6. 2008
    ..In addition, no non-synonymous mutations related to gene silencing were found. While further analysis is warranted, our results suggest that T has the potential to be a novel candidate TSG in lung cancer...
  28. doi request reprint DNA methylation markers in colorectal cancer
    Myoung Sook Kim
    Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II 5M, Baltimore, MD, 21231, USA
    Cancer Metastasis Rev 29:181-206. 2010
    ..Therefore, the aim of this review is to understand DNA methylation as a driving force in colorectal neoplasia and its emerging value as a molecular marker in the clinic...
  29. ncbi request reprint LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer
    Sunil Upadhyay
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Cancer Res 66:7870-9. 2006
    ..These results suggest that PEA3 stabilization due to LKB1 inactivation could lead to epithelial/mesenchymal transition and greater lung cancer invasion potential...
  30. pmc Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma
    Xiaofei Chang
    Department of Otolaryngology, Head and Neck Cancer Research Division, The Johns Hopkins University, School of Medicine, 1550 Orleans Street, CRB II 5M, Baltimore, MD 21231, USA
    Int J Oncol 38:1129-35. 2011
    ..mRNA expression of HSPB2 in ESCC tissues was significantly down-regulated compared to normal tissues. Our data suggest that promoter methylation of HSPB2 deserves further attention as a novel molecular biomarker in human ESCC...
  31. pmc Downregulation of insulin-like growth factor-binding protein 7 in cisplatin-resistant non-small cell lung cancer
    Jun Okamura
    Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Biol Ther 13:148-55. 2012
    ..These findings suggest a novel molecular mechanism responsible for the tumor suppressive function of IGFBP7 in cisplatin-resistant human lung cancer and could lead to the development of IGFBP7 as a cisplatin-sensitizing agent...
  32. ncbi request reprint Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium
    Janghee Woo
    Department of Otolaryngology, Johns Hopkins University, 1550 Orleans St 574A, Baltimore, MD 21231, USA
    Biochem Biophys Res Commun 366:321-7. 2008
    ..We conclude that AQP5 membrane targeting can include more than one mechanism besides cAMP dependent phosphorylation...
  33. pmc Suprabasin is hypomethylated and associated with metastasis in salivary adenoid cystic carcinoma
    Chunbo Shao
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    PLoS ONE 7:e48582. 2012
    ..ACC is well known for perineural invasion and distant metastasis, but its underlying molecular mechanisms of carcinogenesis are still unclear...
  34. ncbi request reprint PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma
    Diana L Mandelker
    Department of Otolaryngology, Head and Neck Cancer Research, Johns Hopkins University, Baltimore, Maryland 21205 2196, USA
    Cancer Res 65:4963-8. 2005
    ..5 methylation was an independent prognostic factor for ESCC survival (P = 0.03). These results suggest that PGP9.5 promoter methylation could be a clinically applicable marker for ESCC progression...
  35. ncbi request reprint p63-specific activation of the BPAG-1e promoter
    Motonobu Osada
    Department of Otolaryngology, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Invest Dermatol 125:52-60. 2005
    ..This represents a novel molecular mechanism by which target gene induction by p63 is distinguished from induction by other p53 family members...
  36. ncbi request reprint Effects of three-dimensional culture and growth factors on the chondrogenic differentiation of murine embryonic stem cells
    Nathaniel S Hwang
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Clark Hall 106, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Stem Cells 24:284-91. 2006
    ..These findings suggest that EB-PEG hydrogel culture, with an appropriate growth factor, may provide a suitable environment for chondrogenic differentiation of intact ES cell-derived EBs...
  37. ncbi request reprint Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA)
    Myoung Sook Kim
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Cell Res 306:94-102. 2005
    ..Moreover, TSA sensitization to UV-induced apoptosis is p53 dependent. p53 and acetylation of the core histones may thus contribute to UV-induced apoptosis by modulating the formation of DNA lesions on chromatin...