Candace L Kerr

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Pluripotent stem cells from germ cells
    Candace L Kerr
    Institute for Cell Engineering, Department of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Methods Enzymol 419:400-26. 2006
  2. ncbi request reprint Expression of pluripotent stem cell markers in the human fetal testis
    Candace L Kerr
    Institute for Cellular Engineering, Department of Obstetrics and Gynecology, Johns Hopkins University, Broadway Research Building, Suite 771, 733 North Broadway, Baltimore, MD 21205, USA
    Stem Cells 26:412-21. 2008
  3. doi request reprint Expression of pluripotent stem cell markers in the human fetal ovary
    Candace L Kerr
    Institute for Cellular Engineering, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Broadway Research Building Suite 771, 733 N Broadway, MD 21205, USA
    Hum Reprod 23:589-99. 2008
  4. doi request reprint Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury
    Candace L Kerr
    Department of Gynecology and Obstetrics and Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Int J Neurosci 120:305-13. 2010
  5. pmc Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells
    Nikta Pashai
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e39088. 2012
  6. pmc Bone morphogenetic protein 4 mediates human embryonic germ cell derivation
    Marc Hiller
    Department of Gynecology and Obstetrics, Institute for Cellular Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Stem Cells Dev 20:351-61. 2011
  7. doi request reprint Electrophysiological evaluation of sensory and motor pathways after incomplete unilateral spinal cord contusion
    Faith A Bazley
    Departments of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Neurosurg Spine 16:414-23. 2012
  8. pmc MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells
    Brian S Letzen
    Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e10480. 2010
  9. pmc Direct Reprogramming of Human Primordial Germ Cells into Induced Pluripotent Stem Cells: Efficient Generation of Genetically Engineered Germ Cells
    Faith A Bazley
    1 Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    Stem Cells Dev 24:2634-48. 2015
  10. pmc Quantitative temporal proteomic analysis of human embryonic stem cell differentiation into oligodendrocyte progenitor cells
    Raghothama Chaerkady
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proteomics 11:4007-20. 2011

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Pluripotent stem cells from germ cells
    Candace L Kerr
    Institute for Cell Engineering, Department of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Methods Enzymol 419:400-26. 2006
    ..Detailed protocols for EGC derivation and maintenance from human and mouse primordial germ cells (PGCs) will be presented...
  2. ncbi request reprint Expression of pluripotent stem cell markers in the human fetal testis
    Candace L Kerr
    Institute for Cellular Engineering, Department of Obstetrics and Gynecology, Johns Hopkins University, Broadway Research Building, Suite 771, 733 North Broadway, Baltimore, MD 21205, USA
    Stem Cells 26:412-21. 2008
    ..Together, these results suggest that PGCs maintain expression of pluripotent stem cell markers during and after sexual differentiation of the gonad, albeit in very low numbers...
  3. doi request reprint Expression of pluripotent stem cell markers in the human fetal ovary
    Candace L Kerr
    Institute for Cellular Engineering, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Broadway Research Building Suite 771, 733 N Broadway, MD 21205, USA
    Hum Reprod 23:589-99. 2008
    ..Human primordial germ cells (PGCs) can give rise to pluripotent stem cells such as embryonal carcinoma cells (ECCs) and embryonic germ cells (EGCs)...
  4. doi request reprint Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury
    Candace L Kerr
    Department of Gynecology and Obstetrics and Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Int J Neurosci 120:305-13. 2010
    ..The extent of injury and effect of early cell transplant was measured using behavioral and electrophysiological assessments which demonstrated increased neurological responses in rats transplanted with OPCs compared to controls...
  5. pmc Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells
    Nikta Pashai
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e39088. 2012
    ..Together, these findings provide the first glimpse into a unique genomic signature of human germ cells and pluripotent stem cells and provide genes potentially involved in defining different states of germ-line pluripotency...
  6. pmc Bone morphogenetic protein 4 mediates human embryonic germ cell derivation
    Marc Hiller
    Department of Gynecology and Obstetrics, Institute for Cellular Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Stem Cells Dev 20:351-61. 2011
    ..Downstream activators of the BMP4 pathway such as ID1 and phosphorylated SMADs 1 and 5 were also expressed, suggesting a role of this growth factor in EGC pluripotency...
  7. doi request reprint Electrophysiological evaluation of sensory and motor pathways after incomplete unilateral spinal cord contusion
    Faith A Bazley
    Departments of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Neurosurg Spine 16:414-23. 2012
    ..The authors sought to quantify the functional integrity of the bilateral motor and sensory pathways following unilateral SCI by using measurements of motor and somatosensory evoked potentials (MEPs and SSEPs, respectively)...
  8. pmc MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells
    Brian S Letzen
    Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e10480. 2010
    ..Here, we performed a global miRNA analysis to reveal and identify characteristic patterns in the multiple stages leading to OL maturation from hES cells including those targeting factors involved in myelin production...
  9. pmc Direct Reprogramming of Human Primordial Germ Cells into Induced Pluripotent Stem Cells: Efficient Generation of Genetically Engineered Germ Cells
    Faith A Bazley
    1 Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    Stem Cells Dev 24:2634-48. 2015
    ..Their derivation efficiency and survival in culture significantly supersedes that of EGCs, demonstrating their utility as a powerful model for studying factors regulating pluripotency in future studies. ..
  10. pmc Quantitative temporal proteomic analysis of human embryonic stem cell differentiation into oligodendrocyte progenitor cells
    Raghothama Chaerkady
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proteomics 11:4007-20. 2011
    ..Thus, by providing the first extensive proteomic profiling of human ESC differentiation into OPCs, this study provides many novel proteins that are potentially involved in OL development...
  11. pmc Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors
    Angelo H All
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Singapore Institute for Neurotechnology, National University of Singapore, Singapore, Singapore Departments of Orthopedic Surgery, Biomedical Engineering and Medicine, Division of Neurology, National University of Singapore, Singapore, Singapore
    PLoS ONE 10:e0116933. 2015
    ..This is significant as determining the time in which stem cells are injected after SCI may influence their survival and differentiation capacity. ..
  12. pmc A draft map of the human proteome
    Min Sik Kim
    1 McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA 2 Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 509:575-81. 2014
    ..humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease. ..
  13. pmc Potential long-term benefits of acute hypothermia after spinal cord injury: assessments with somatosensory-evoked potentials
    Anil Maybhate
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 40:573-9. 2012
    ..In our experiments, these effects lasted long after the acute hypothermia and were accompanied by potential long-term improvements in motor movement...
  14. doi request reprint The dazzle in germ cell differentiation
    Candace L Kerr
    Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Mol Cell Biol 2:26-9. 2010
    ..Although factors that Dazl influences during this process have been identified, the underlying mechanisms warrant future studies...
  15. ncbi request reprint Embryonic germ cells: when germ cells become stem cells
    Candace L Kerr
    Institute for Cell Engineering, Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Semin Reprod Med 24:304-13. 2006
    ..Transplantation studies have begun in a variety of models in hopes of defining their potential use to treat a wide variety of human conditions, including diabetes and urological and neurological disorders...
  16. ncbi request reprint Characterization of zona pellucida glycoprotein 3 (ZP3) and ZP2 binding sites on acrosome-intact mouse sperm
    Candace L Kerr
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205 2179, USA
    Biol Reprod 66:1585-95. 2002
    ..Finally, we demonstrate that extracellular calcium as well as capacitation and maturation of sperm are required for these sites to bind their respective ligands...