Affiliation: Johns Hopkins University
- Toxoplasma gondii strain-dependent effects on mouse behaviourGeetha Kannan
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5371, USA
Folia Parasitol (Praha) 57:151-5. 2010..No differences in parasite antibody titres were seen between PRU- and ME49-infected mice. The present data suggest the effect of T. gondii infection on mouse behaviour is parasite strain-dependent...
- Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondiiLorraine Jones-Brando
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street Blalock 1149, Baltimore, MD 21287 4933, USA
Schizophr Res 62:237-44. 2003..Several medications used to treat schizophrenia and bipolar disorder have the ability to inhibit the in vitro replication of T. gondii...
- In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisininLorraine Jones-Brando
Stanley Division of Developmental Neurovirology, Dept of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 4988, USA
Antimicrob Agents Chemother 50:4206-8. 2006..We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture...
- Transactivation of elements in the human endogenous retrovirus W family by viral infectionChristoffer Nellåker
The Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
Retrovirology 3:44. 2006....
- Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycleJohn G D'Angelo
Department of Chemistry and The Malaria Research Institute, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA
J Antimicrob Chemother 63:146-50. 2009....
- Abnormalities of neurotransmitter and neuropeptide systems in human neuroepithelioma cells infected by three Toxoplasma strainsJianchun Xiao
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA
J Neural Transm (Vienna) 120:1631-9. 2013..No significant effects of type II infection were found in the NNS. These data may have implications for understanding the pathogenesis and heterogeneity of neurologic disturbances in toxoplasmosis. ..
- Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondiiChristopher P Hencken
Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
J Med Chem 53:3594-601. 2010..Some of the new derivatives of artemisinin described here represent effective anti-Toxoplasma trioxanes as well as molecular probes for elucidating the mechanism of action of the DART class of artemisinin derivatives...
- Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and miceRobert H Yolken
Stanley Division of Developmental Neurovirology, Department of Pediatrics
Proc Natl Acad Sci U S A 111:16106-11. 2014..ATCV-1 exposure in mice also resulted in the altered expression of genes within the hippocampus. These genes comprised pathways related to synaptic plasticity, learning, memory formation, and the immune response to viral exposure. ..
- Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controlsEleonora Passeri
Departments of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 North Wolfe St, Baltimore, MD 21287, USA
Microbes Infect 18:153-8. 2016..This approach may aid study of molecular mechanisms underlying individual predisposition to Toxoplasma infection linked to neuropathology of brain disorders. ..
- Differential effects of three canonical Toxoplasma strains on gene expression in human neuroepithelial cellsJianchun Xiao
Stanley Division of Developmental Neurovirology, Johns Hopkins School of Medicine, 600 N Wolfe Street, 1105 Blalock, Baltimore, MD 21287 4933, USA
Infect Immun 79:1363-73. 2011..These observed differences may explain some of the variation in the neurobiological effects of different strains of Toxoplasma on infected individuals...
- Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomersRavit Arav-Boger
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 5:e10370. 2010..Artesunate, an artemisinin-derived monomer, was reported to inhibit Cytomegalovirus (CMV) replication. We aimed to compare the in-vitro anti-CMV activity of several artemisinin-derived monomers and newly synthesized artemisinin dimers...
- Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogsBogdana Krivogorsky
Dept of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Antimicrob Agents Chemother 52:4466-9. 2008..Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics...