Yoon Young Jang

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease
    Yong Soon Chun
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Int J Biol Sci 6:796-805. 2010
  2. ncbi request reprint Molecular imaging and stem cell research
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center, JohnsHopkins University School of Medicine, Baltimore, MD 21231, USA
    Mol Imaging 10:111-22. 2011
  3. pmc A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 110:3056-63. 2007
  4. ncbi request reprint Fetal to adult stem cell transition: knocking Sox17 off
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cell 130:403-4. 2007
  5. ncbi request reprint Hematopoietic stem cells convert into liver cells within days without fusion
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Nat Cell Biol 6:532-9. 2004
  6. pmc Liver engraftment potential of hepatic cells derived from patient-specific induced pluripotent stem cells
    Su Mi Choi
    Stem Cell Biology Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Cycle 10:2423-7. 2011
  7. pmc Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells
    Su Mi Choi
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hepatology 57:2458-68. 2013
  8. pmc Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells
    Su Mi Choi
    Stem Cell Biology Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Blood 118:1801-5. 2011
  9. ncbi request reprint Stem cell plasticity: a rare cell, not a rare event
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Stem Cell Rev 1:45-51. 2005
  10. ncbi request reprint Metamorphosis from bone marrow derived primitive stem cells to functional liver cells
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cell Cycle 3:980-2. 2004

Collaborators

Detail Information

Publications24

  1. pmc Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease
    Yong Soon Chun
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Int J Biol Sci 6:796-805. 2010
    ....
  2. ncbi request reprint Molecular imaging and stem cell research
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center, JohnsHopkins University School of Medicine, Baltimore, MD 21231, USA
    Mol Imaging 10:111-22. 2011
    ..In this review, we discuss the application of current imaging modalities for research of hematopoietic stem cells and pluripotent stem cells and the challenges ahead...
  3. pmc A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 110:3056-63. 2007
    ..The ROS-related signaling pathways together with specific characteristics of niche HSCs may serve as targets for beneficial therapies...
  4. ncbi request reprint Fetal to adult stem cell transition: knocking Sox17 off
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cell 130:403-4. 2007
    ..2007) demonstrate in mice that the endodermal transcription factor Sox17 is required for the maintenance of fetal and neonatal but not adult HSCs...
  5. ncbi request reprint Hematopoietic stem cells convert into liver cells within days without fusion
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Nat Cell Biol 6:532-9. 2004
    ..Notably, liver function was restored 2-7 d after transplantation. We conclude that HSCs contribute to the regeneration of injured liver by converting into functional hepatocytes without fusion...
  6. pmc Liver engraftment potential of hepatic cells derived from patient-specific induced pluripotent stem cells
    Su Mi Choi
    Stem Cell Biology Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Cycle 10:2423-7. 2011
    ....
  7. pmc Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells
    Su Mi Choi
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hepatology 57:2458-68. 2013
    ..This highly efficient and cost-effective targeting technology will broadly benefit both basic and translational applications...
  8. pmc Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells
    Su Mi Choi
    Stem Cell Biology Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Blood 118:1801-5. 2011
    ..The ability to reprogram the widely banked patient B-cell lines will offer an unprecedented opportunity to generate human disease models and provide novel drug therapies...
  9. ncbi request reprint Stem cell plasticity: a rare cell, not a rare event
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Stem Cell Rev 1:45-51. 2005
    ..It is important to dissect the relationship between primitive/tissue-specific SCs and regenerative signals...
  10. ncbi request reprint Metamorphosis from bone marrow derived primitive stem cells to functional liver cells
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cell Cycle 3:980-2. 2004
    ..Functional repair should also be demonstrated prior to treatment in patients...
  11. pmc Hematopoietic cells as sources for patient-specific iPSCs and disease modeling
    Zhaohui Ye
    Division of Hematology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Cycle 10:2840-4. 2011
    ..Here we describe the recent advances in generating disease specific human iPSCs from these different types of hematopoietic cells and their potential applications in disease modeling and regenerative medicine...
  12. pmc In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins
    Hua Liu
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Sci Transl Med 3:82ra39. 2011
    ....
  13. pmc Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders
    Zhaohui Ye
    Stem Cell Program, Institute for Cell Engineering, and Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 114:5473-80. 2009
    ..These iPS cells provide a renewable cell source and a prospective hematopoiesis model for investigating MPD pathogenesis...
  14. doi request reprint Efficient and Controlled Generation of 2D and 3D Bile Duct Tissue from Human Pluripotent Stem Cell-Derived Spheroids
    Lipeng Tian
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    Stem Cell Rev 12:500-8. 2016
    ..This new ductal differentiation method will provide a more efficient method of obtaining bile duct cells and tissues, which may facilitate engineering of complete and functional liver tissue in the future. ..
  15. pmc Efficient and allele-specific genome editing of disease loci in human iPSCs
    Cory Smith
    1 Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 2 Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 3 Predoctoral Training Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Ther 23:570-7. 2015
    ..Overall, our results demonstrate the advantages of the CRISPR/Cas9 system in allele-specific genome targeting and in NHEJ-mediated gene disruption. ..
  16. pmc Pluripotent stem cell-based cancer therapy: promise and challenges
    Saul J Sharkis
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Sci Transl Med 4:127ps9. 2012
    ..Here, we discuss the potential therapeutic applications of iPSCs for treating cancer and other diseases and highlight the current barriers restricting their use...
  17. pmc Expression kinetics of hepatic progenitor markers in cellular models of human liver development recapitulating hepatocyte and biliary cell fate commitment
    Pooja Chaudhari
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore 21205, USA Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore 21205, USA Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore 21205, USA
    Exp Biol Med (Maywood) 241:1653-62. 2016
    ....
  18. pmc IFNL3 genotype is associated with differential induction of IFNL3 in primary human hepatocytes
    Fuat Kurbanov
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Antivir Ther 20:805-14. 2015
    ..The mechanism(s) linking IFNL polymorphisms and HCV control is currently elusive...
  19. pmc Roles of reactive oxygen species in the fate of stem cells
    Pooja Chaudhari
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Antioxid Redox Signal 20:1881-90. 2014
    ..Regulation of ROS has a vital role in maintaining "stemness" and differentiation of the stem cells, as well as in progression of stem-cell-associated diseases...
  20. pmc Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes
    Hua Liu
    Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Hepatology 51:1810-9. 2010
    ..In addition, these cells are able to directly differentiate into definitive endoderm, hepatic progenitors, and mature hepatocytes...
  21. doi request reprint Gene correction in patient-specific iPSCs for therapy development and disease modeling
    Yoon Young Jang
    Department of Oncology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Genet 135:1041-58. 2016
    ....
  22. ncbi request reprint Genome editing systems in novel therapies
    Yoon Young Jang
    Department of Oncology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Discov Med 21:57-64. 2016
    ..In this review we discuss the preclinical and clinical studies aiming at translating the genome editing technologies as well as the issues that are important for more successful translation. ..
  23. doi request reprint Determination of Functional Activity of Human iPSC-Derived Hepatocytes by Measurement of CYP Metabolism
    Pooja Chaudhari
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    Methods Mol Biol 1357:383-94. 2016
    ..Herein, we describe the protocol for measurement of different CYP450 enzyme activities in human iPSC-derived hepatocytes. ..
  24. pmc Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
    Hsing Chen Tsai
    The Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Cell 21:430-46. 2012
    ..Low-dose decitabine and azacitidine may have broad applicability for cancer management...