Annette M Jackson
Affiliation: Johns Hopkins University
- The problem of transplanting the sensitized patient: whose problem is it?Annette M Jackson
Immunogenetics Laboratory, Johns Hopkins University School of Medicine, 2041 E Monument Street, Baltimore, MD 21205 2222, USA
Front Biosci 13:1396-412. 2008..Thus, sensitization to HLA antigens is a problem for the patient, the transplant physician, and the histocompatibility laboratory...
- Immunogenetics and immunology in transplantationAndrea A Zachary
Immunogenetics Laboratory, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Immunol Res 47:232-9. 2010..Ongoing studies are investigating the mechanisms underlying the down-regulation of donor HLA-specific antibodies...
- Transplanting the highly sensitized patient: trials and tribulationsHariharan S Iyer
aDivision of Nephrology and Transplantation, Department of Medicine, London Health Sciences Center, The University of Western Ontario, London, Ontario, Canada bDepartment of Medicine cDepartment of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Curr Opin Nephrol Hypertens 22:681-8. 2013..The number of highly sensitized patients on the renal transplant waiting list continues to increase. This review focuses on the options available to these patients and speculates on future directions for incompatible transplantation...
- Endothelial cell antibodies associated with novel targets and increased rejectionAnnette M Jackson
Departments of Medicine
J Am Soc Nephrol 26:1161-71. 2015..Given the growing number of transplant candidates, a better understanding of the antigenic targets, beyond HLA, and mechanisms of immune injury will be essential for improving long-term allograft survival. ..
- A GPS for finding the route to transplantation for the sensitized patientAnnette M Jackson
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Curr Opin Organ Transplant 17:433-9. 2012..Use of these protocols has revealed various factors that influence which route is the most likely to work for a given patient...
- Multiple hyperacute rejections in the absence of detectable complement activation in a patient with endothelial cell reactive antibodyA M Jackson
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
Am J Transplant 12:1643-9. 2012..Cultured splenocytes produced antibodies that bound donor ECs but not lymphocytes. Bortezomib was initiated on POD5. Despite aggressive therapy, the allograft never regained function...
- Clinical relevance and IgG subclass determination of non-HLA antibodies identified using endothelial cell precursors isolated from donor bloodAnnette M Jackson
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Transplantation 92:54-60. 2011..We investigated the relationship between AECAs identified using donor-derived endothelial cell precursors (ECPs) and kidney allograft rejection and function...
- Using donor exchange paradigms with desensitization to enhance transplant rates among highly sensitized patientsRobert A Montgomery
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Curr Opin Organ Transplant 16:439-43. 2011..The options for these patients include: remaining on the deceased-donor list, entering a kidney-paired donation scheme, or undergoing desensitization with high-dose IVIg or plasmapheresis and low-dose IVIg...
- A flow cytometric crossmatch test using endothelial precursor cells isolated from peripheral bloodAnnette M Jackson
Immunogenetics Laboratory, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Methods Mol Biol 1034:319-29. 2013..Isolation of endothelial precursor cells (EPCs) from peripheral blood now allows testing for antibodies reactive with non-HLA endothelial cell antigens...
- Podocyte effacement closely links to suPAR levels at time of posttransplantation focal segmental glomerulosclerosis occurrence and improves with therapyNada Alachkar
1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 2 Department of Medicine, Rush University Medical Center, Chicago, IL 3 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 4 Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 5 Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 6 Department of Medicine, Union Memorial Hospital, Baltimore, MD 7 Address correspondence to Nada Alachkar, M D, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 971, Baltimore, MD 21205 and Jochen Reiser, M D, Ph D, Department of Medicine, Rush University Medical Center, Cohn Research Building, Suite 724, 1735 W Harrison Street, Chicago, IL 60612
Transplantation 96:649-56. 2013..Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS...
- Impact of pronase on flow cytometric crossmatch outcomeSarah J Hetrick
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Hum Immunol 72:330-6. 2011..Treatment with 1 mg/mL of pronase significantly increased reactivity in 20 of 23 tests of T cells (87%, p = 6.0 × 10(-5)). These data indicate that pronase treatment may result in erroneous FCXM results...
- Variable HLA expression on deceased donor lymphocytes: Not all crossmatches are created equalJessica L Badders
Department of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
Hum Immunol 76:795-800. 2015..HLA expression is impacted by multiple factors and should be routinely monitored to ensure crossmatch sensitivity and to reconcile crossmatch strength with solid phase HLA antibody analyses...
- A closer look at rituximab induction on HLA antibody rebound following HLA-incompatible kidney transplantationAnnette M Jackson
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Kidney Int 87:409-16. 2015....