Hanna Jaaro-Peled

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Gene models of schizophrenia: DISC1 mouse models
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Prog Brain Res 179:75-86. 2009
  2. pmc Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1
    Hanna Jaaro-Peled
    Department of Psychiatry, Johns Hopkins University School of Medicine, United States Electronic address
    Neurosci Res 112:63-69. 2016
  3. pmc Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Mol Genet 22:1574-80. 2013
  4. pmc Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans
    Takatoshi Hikida
    Department of Psychiatry and Behavioral Sciences, Graduate Program in Cellular and Molecular Medicine, and Division of Neurobiology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 104:14501-6. 2007
  5. pmc Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Neurosciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Trends Neurosci 32:485-95. 2009
  6. pmc Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Schizophr Bull 36:301-13. 2010
  7. pmc Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex
    Saurav Seshadri
    Department of Psychiatry, Johns Hopkins University, 600 North Wolfe Street, Meyer 3 166A, Baltimore, Maryland 21287, USA
    Nat Commun 6:10118. 2015
  8. pmc Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits
    Minae Niwa
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuron 65:480-9. 2010
  9. pmc Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1)
    Sandra Zoubovsky
    Department of Psychiatry, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, United States
    Neurosci Res 98:45-9. 2015
  10. pmc Increased stereotypy in conditional Cxcr4 knockout mice
    Tyler Cash-Padgett
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
    Neurosci Res 105:75-9. 2016

Collaborators

Detail Information

Publications15

  1. doi request reprint Gene models of schizophrenia: DISC1 mouse models
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Prog Brain Res 179:75-86. 2009
    ..Third, generation of a DISC1 KO. Fourth, combination of the DISC1 mouse models with other risk factors: crossing with other genetic models such as NRG1/ErbB4 mutants and exposure to environmental risk factors...
  2. pmc Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1
    Hanna Jaaro-Peled
    Department of Psychiatry, Johns Hopkins University School of Medicine, United States Electronic address
    Neurosci Res 112:63-69. 2016
    ..Thus we suggest that DISC1 may be involved in sleep regulation...
  3. pmc Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Mol Genet 22:1574-80. 2013
    ..We hope that this study will also help bridge a major gap in translational psychiatry between basic characterization of animal models and clinico-pharmacological assessment of patients mainly through PET imaging...
  4. pmc Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans
    Takatoshi Hikida
    Department of Psychiatry and Behavioral Sciences, Graduate Program in Cellular and Molecular Medicine, and Division of Neurobiology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 104:14501-6. 2007
    ..DN-DISC1 mice also display several behavioral abnormalities, including hyperactivity, disturbance in sensorimotor gating and olfactory-associated behavior, and an anhedonia/depression-like deficit...
  5. pmc Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Neurosciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Trends Neurosci 32:485-95. 2009
    ..We provide an update on the role of these emerging concepts in understanding the complex time course of SZ from early neurodevelopmental disturbances to later onset and suggest ways of testing these in the future...
  6. pmc Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Schizophr Bull 36:301-13. 2010
    ..Finally, in comparison with the changes in patients and nongenetic models, we will discuss the anatomical and neuropathological manifestation in genetic models for schizophrenia...
  7. pmc Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex
    Saurav Seshadri
    Department of Psychiatry, Johns Hopkins University, 600 North Wolfe Street, Meyer 3 166A, Baltimore, Maryland 21287, USA
    Nat Commun 6:10118. 2015
    ..Our results suggest a mechanism by which cross-talk between DISC1 and NRG1-ErbB4 signalling may contribute to these deficits. ..
  8. pmc Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits
    Minae Niwa
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuron 65:480-9. 2010
    ....
  9. pmc Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1)
    Sandra Zoubovsky
    Department of Psychiatry, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, United States
    Neurosci Res 98:45-9. 2015
    ..Together, our results suggest that haploinsufficiency at the Pcm1 locus can induce a range of neuroanatomical and behavioral phenotypes that support the candidacy of this locus in neuropsychiatric disorders. ..
  10. pmc Increased stereotypy in conditional Cxcr4 knockout mice
    Tyler Cash-Padgett
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
    Neurosci Res 105:75-9. 2016
    ..Stereotypy is observed in many psychiatric conditions, including schizophrenia, autism, and dementia. Thus, the Cxcr4 conditional knockout mice may serve as a model for this symptomatic feature. ..
  11. pmc Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice
    Rana Rais
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Drug Metab Dispos 40:2067-73. 2012
    ..Thus, a potent DAAO inhibitor with a longer half-life should be capable of maintaining high plasma D-serine levels over a sustained period of time and might have therapeutic implications for the treatment of schizophrenia...
  12. pmc Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models
    Chi Ying Lin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurobiol Dis 45:48-56. 2012
    ..We also point out that models in which the metabolic genes are modified are obviously untested from mental illness viewpoints, suggesting the potential to re-address these models with behavioral assays and neurochemical assessments...
  13. pmc Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory
    Michael D Ballinger
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurobiol Dis 82:176-84. 2015
    ..These results suggest that alteration of CB1R-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors. ..
  14. pmc Cell Type-Specific Effects of Mutant DISC1: A Proteomics Study
    Meng Xia
    Departments of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA Preclinical College, Guangxi University of Chinese Medicine, Nanning, PR China
    Mol Neuropsychiatry 2:28-36. 2016
    ..The present study demonstrates that DISC1 variants can perturb distinct molecular pathways in a cell type-specific fashion to contribute to psychiatric disorders through heterogenic effects in diverse brain cells. ..