Shau Ku Huang

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis
    Takeshi Hattori
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    BMC Med Genet 11:151. 2010
  2. ncbi request reprint Antigen coupled with Lewis-x trisaccharides elicits potent immune responses in mice
    Shih Chang Hsu
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 119:1522-8. 2007
  3. ncbi request reprint Evidence for asthma susceptibility genes on chromosome 11 in an African-American population
    Shau Ku Huang
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, MD 21224 6801, Baltimore, USA
    Hum Genet 113:71-5. 2003
  4. ncbi request reprint Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 112:382-8. 2003
  5. ncbi request reprint Induction of C-X-C chemokines, growth-related oncogene alpha expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin-17F) involves activation of Raf1-mitogen-activated protein kinase kinase-extracellular signal-regula
    Mio Kawaguchi
    Johns Hopkins University, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 6801, USA
    J Pharmacol Exp Ther 307:1213-20. 2003
  6. pmc Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1
    Yufeng Zhou
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Nat Med 16:1128-33. 2010
  7. ncbi request reprint Endotoxin contamination contributes to the in vitro cytokine-inducing activity of osteopontin preparations
    Satoshi Konno
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Interferon Cytokine Res 25:277-82. 2005
  8. doi request reprint Regulatory role of DC-derived osteopontin in systemic allergen sensitization
    Masatsugu Kurokawa
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
    Eur J Immunol 39:3323-30. 2009
  9. ncbi request reprint Interleukin-10 and Th2 cytokines differentially regulate osteopontin expression in human monocytes and dendritic cells
    Satoshi Konno
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Interferon Cytokine Res 26:562-7. 2006
  10. pmc Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cells
    Shih Chang Hsu
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Biol Chem 285:7903-10. 2010

Research Grants

  1. Role of C-type lectin receptors in food allergy
    Shau Ku Huang; Fiscal Year: 2008

Collaborators

Detail Information

Publications37

  1. pmc Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis
    Takeshi Hattori
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    BMC Med Genet 11:151. 2010
    ..The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis...
  2. ncbi request reprint Antigen coupled with Lewis-x trisaccharides elicits potent immune responses in mice
    Shih Chang Hsu
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 119:1522-8. 2007
    ..Glycoproteins containing Lewis-x (Le(x)) trisaccharides are often associated with the host's adaptive T(H)2-type immunity, but the mechanisms underlying the T(H)2-biased response are at present unclear...
  3. ncbi request reprint Evidence for asthma susceptibility genes on chromosome 11 in an African-American population
    Shau Ku Huang
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, MD 21224 6801, Baltimore, USA
    Hum Genet 113:71-5. 2003
    ..8 cM with a confidence interval spanning the linkage peak. Evidence from both linkage and association analyses suggest that this region of chromosome 11 contains one or more susceptibility genes for asthma in these AA families...
  4. ncbi request reprint Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 112:382-8. 2003
    ....
  5. ncbi request reprint Induction of C-X-C chemokines, growth-related oncogene alpha expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin-17F) involves activation of Raf1-mitogen-activated protein kinase kinase-extracellular signal-regula
    Mio Kawaguchi
    Johns Hopkins University, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 6801, USA
    J Pharmacol Exp Ther 307:1213-20. 2003
    ..Together, these data indicates a role for Raf1-MEK-extracellular signal-regulated kinase 1/2 pathway in ML-1 induced C-X-C chemokine expression, suggesting potential pharmacological targets for modulation...
  6. pmc Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1
    Yufeng Zhou
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Nat Med 16:1128-33. 2010
    ..The Tr1-like cells could transfer tolerance. These results suggest that sugar-modified antigens might be used to induce oral tolerance by targeting SIGNR1 and LPDCs...
  7. ncbi request reprint Endotoxin contamination contributes to the in vitro cytokine-inducing activity of osteopontin preparations
    Satoshi Konno
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Interferon Cytokine Res 25:277-82. 2005
    ..These results suggest the questionable evidence of the ability of OPN to induce several cytokines in human PBMCs and draw attention to the exquisite sensitivity of PBMCs/monocytes to endotoxin contaminants...
  8. doi request reprint Regulatory role of DC-derived osteopontin in systemic allergen sensitization
    Masatsugu Kurokawa
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
    Eur J Immunol 39:3323-30. 2009
    ..These results indicate that DC-derived OPN plays a regulatory role in the development of systemic allergen sensitization, which is mediated, at least in part, through the production of endogenous IL-12...
  9. ncbi request reprint Interleukin-10 and Th2 cytokines differentially regulate osteopontin expression in human monocytes and dendritic cells
    Satoshi Konno
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Interferon Cytokine Res 26:562-7. 2006
    ..These results demonstrate a novel role of IL-10 and Th2 cytokines in the regulation of DC function through their contrasting regulatory activities on the expression of OPN...
  10. pmc Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cells
    Shih Chang Hsu
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Biol Chem 285:7903-10. 2010
    ..These results suggest that allergens are able to interact with DC-SIGN and induce tumor necrosis factor-alpha expression in MDDCs via, in part, Raf-1 signaling pathways...
  11. pmc Functional interaction of cockroach allergens and mannose receptor (CD206) in human circulating fibrocytes
    Ying Ming Tsai
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 8:e64105. 2013
    ..Fibrocytes have been considered to play a role in allergic asthma. Here we sought to investigate the functional interaction of cockroach allergens with CD206 in fibrocytes...
  12. ncbi request reprint Induction of granulocyte-macrophage colony-stimulating factor by a new cytokine, ML-1 (IL-17F), via Raf I-MEK-ERK pathway
    Mio Kawaguchi
    Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224 6801, USA
    J Allergy Clin Immunol 114:444-50. 2004
    ..ML-1 (IL-17F) is a recently discovered cytokine, and its function remains elusive. GM-CSF is a crucial cytokine for the maturation of various cell types and regulates allergic airway inflammation...
  13. pmc Functional effects of TGF-β1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma
    Peisong Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 192:4560-70. 2014
    ..These results suggest that TGF-β1 may be a key promigratory factor in recruiting MSCs to the airways in mouse models of asthma. ..
  14. ncbi request reprint Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein
    Chih Hsing Hung
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6801, USA
    J Allergy Clin Immunol 114:664-70. 2004
    ..Pulmonary Clara cell secretory 10-kd protein (CC10) is a steroid-inducible and potentially anti-inflammatory cytokine, but its direct involvement in the regulation of T-cell responses remains unknown...
  15. ncbi request reprint Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population
    Pei Song Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 115:982-8. 2005
    ..The T-cell immunoglobulin mucin ( TIM ) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases...
  16. pmc Aryl hydrocarbon receptor controls murine mast cell homeostasis
    Yufeng Zhou
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Blood 121:3195-204. 2013
    ..Consequently, AhR-null mast cells responded poorly to stimulation, demonstrating a critical role of AhR signaling in maintaining mast cell homeostasis...
  17. ncbi request reprint Increased expression of osteopontin is associated with long-term bee venom immunotherapy
    Satoshi Konno
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 115:1063-7. 2005
    ..Venom allergen immunotherapy (VIT) is proven to be highly effective for insect allergy, but the mechanisms and the biomarkers associated with clinical efficacy remain elusive...
  18. ncbi request reprint Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 113:489-95. 2004
    ..SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors...
  19. ncbi request reprint Cell surface expression of a specific antigenic site on the catalytic subunit of (Na(+) + K(+))-ATPase
    Allen C Myers
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Biochem Biophys Res Commun 291:111-5. 2002
    ..These results suggest that the KRQPRNPKTDKLVNE region of the (Na(+) + K(+))-ATPase is expressed on the cellular membrane surface...
  20. ncbi request reprint IL-17 cytokine family
    Mio Kawaguchi
    Johns Hopkins University, Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 114:1265-73; quiz 1274. 2004
    ....
  21. ncbi request reprint Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1
    Mio Kawaguchi
    Johns Hopkins Asthma and Allergy Center and Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Biol Chem 277:15229-32. 2002
    ..These findings suggest that ML-1-induced IL-6 and IL-8 production is mediated through the activation of ERK1/2 in both cell types...
  22. pmc Murine mast cells secrete and respond to interleukin-33
    Hui Ying Tung
    1 Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Interferon Cytokine Res 34:141-7. 2014
    ..These results suggest that mouse BMMCs are capable of producing and serving as endogenous sources of IL-33, and that IL-33 plays an important role in regulating mast cell functions. ..
  23. pmc Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium
    Jinshui Fan
    Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Immunol 186:2482-94. 2011
    ..HuR-mediated regulation in airway epithelium appears broader than previously appreciated, coordinating numerous inflammatory genes through multiple posttranscriptional mechanisms...
  24. ncbi request reprint Microarray and gene-clustering analysis
    Tsung Hsien Tsai
    Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 315:165-74. 2006
    ..Although the focus is on Affymetrix oligonucleotide arrays, the techniques described are generally applicable to expression data generated using other array formats...
  25. ncbi request reprint Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response
    Naruhito Oda
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 171:12-8. 2005
    ..These results suggest a role for IL-17F in the induction of neutrophilia in the lungs and in the exacerbation of Ag-induced pulmonary inflammation...
  26. pmc Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities
    Reiko T Lee
    Department of Biology, T he Johns Hopkins University, Baltimore, MD, USA
    Glycobiology 21:512-20. 2011
    ..BDCA-2, dectin-2, Langerin, MCL and mannose receptor did not bind Le(x) at all...
  27. pmc Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells
    Trong Le
    Department of Pediatrics, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 123:217-23. 2009
    ..Immature human blood monocytoid dendritic cells (mDCs) express high-affinity receptors for IgE (Fc epsilon RI), yet their exact function and regulation remain poorly understood...
  28. pmc Posttranscriptional regulation of IL-13 in T cells: role of the RNA-binding protein HuR
    Vincenzo Casolaro
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 121:853-9.e4. 2008
    ..IL-13, a critical cytokine in allergy, is regulated by as-yet-elusive mechanisms...
  29. ncbi request reprint Modulation of antigen-induced anaphylaxis in mice by a traditional chinese medicine formula, Guo Min Kang
    Xiu Min Li
    Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
    Am J Chin Med 37:113-25. 2009
    ..No effect of GMK was observed on the levels of total IgE and plasma histamine in naive mice. These results provide a basis for the modulation effect of GMK and suggest a potential utility of GMK as a prophylactic and therapeutic agent...
  30. ncbi request reprint Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability
    Jing Long Huang
    The Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Hum Mol Genet 13:2691-7. 2004
    ..11q is a strong candidate gene for asthma...
  31. pmc A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Balitmore, USA
    BMC Genet 7:38. 2006
    ..While efficient in screening a region of dense genotyping, this approach does create some problems: high numbers of tests, assimilating thousands of results, and questions about setting priorities on regions with association signals...
  32. ncbi request reprint Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study
    Kuender D Yang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, Kaohsiung, Taiwan
    J Allergy Clin Immunol 120:842-8. 2007
    ..Wheezing episodes are common in young infants. However, the molecular mechanism of wheezing is unclear, and very few therapeutic regimens are effective...
  33. ncbi request reprint Expression of interleukin-17F in a mouse model of allergic asthma
    Shintaro Suzuki
    First Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
    Int Arch Allergy Immunol 143:89-94. 2007
    ..However, its involvement in airway inflammation has not been well understood. To this end, the expression of IL-17F and the inhibitory effects of glucocorticoids on its expression in a mouse model of asthma were examined...
  34. ncbi request reprint Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infection
    Mukesh Kumar
    Division of Allergy and Immunology Joy McCann Culverhouse Airway Disease Center, James A Haley Veterans Administration Hospital and University of South Florida College of Medicine, Tampa, FL 33612, USA
    Hum Gene Ther 13:1415-25. 2002
    ..Together, these results demonstrate the potential of IGT against acute RSV infection...
  35. ncbi request reprint Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis
    Makiko Shimizu
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Yokohama, Japan
    Hum Mol Genet 14:2919-27. 2005
    ..Our findings will contribute to the evaluation of one of the genetic risk factors for AD...
  36. ncbi request reprint Current understanding and therapy of asthma workshop summary
    Kuender D Yang
    Chang Gung Children Hospital at Kaohsiung, Taiwan, ROC
    Cell Mol Immunol 1:436-9. 2004
    ..This article highlights the issues presented and discussed in this ground-breaking symposium emphasizing this important public health problem in the Chinese population...
  37. ncbi request reprint IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity
    Mio Kawaguchi
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 117:795-801. 2006
    ..Upregulated IL17F gene expression has been observed at sites of allergen challenge in the airways of patients with asthma, suggesting that IL-17F is involved in the pathophysiology of asthma...

Research Grants1

  1. Role of C-type lectin receptors in food allergy
    Shau Ku Huang; Fiscal Year: 2008
    ..Moreover, binding and functional assays will be performed to investigate the ability of food allergens to target CLRs and modulate DC functions. [unreadable] [unreadable] [unreadable]..