Ling He

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production
    Ling He
    From the Division of Metabolism, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287
    J Biol Chem 291:10562-70. 2016
  2. pmc Potential biomarker of metformin action
    Ling He
    Division of MetabolismDivision of EndocrinologyDepartments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USAKennedy Krieger InstituteBaltimore, Maryland 21287, USA
    J Endocrinol 221:363-9. 2014
  3. pmc Control of Foxo1 gene expression by co-activator P300
    Anne R Wondisford
    From the Division of Metabolism, Department of Pediatrics and
    J Biol Chem 289:4326-33. 2014
  4. pmc Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage
    Ling He
    Division of Metabolism, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Mol Endocrinol 27:1322-32. 2013
  5. pmc Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis
    Ling He
    Division of Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 287:32069-77. 2012
  6. pmc Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
    Ling He
    Division of Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell 137:635-46. 2009
  7. pmc CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice
    Ryan S Miller
    Division of Pediatric Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cell Biol 32:2349-58. 2012
  8. pmc Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions
    Christopher J Romero
    Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cell Biol 32:4258-69. 2012
  9. pmc Current understanding of metformin effect on the control of hyperglycemia in diabetes
    Hongying An
    Divisions of Metabolism and EndocrinologyDepartment of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
    J Endocrinol 228:R97-106. 2016
  10. pmc Controlled Heat Stress Promotes Myofibrillogenesis during Myogenesis
    Qiongyu Guo
    Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 11:e0166294. 2016

Collaborators

Detail Information

Publications11

  1. pmc Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production
    Ling He
    From the Division of Metabolism, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287
    J Biol Chem 291:10562-70. 2016
    ..We propose that aspirin/salicylate may augment metformin's hepatic action to suppress glucose production. ..
  2. pmc Potential biomarker of metformin action
    Ling He
    Division of MetabolismDivision of EndocrinologyDepartments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USAKennedy Krieger InstituteBaltimore, Maryland 21287, USA
    J Endocrinol 221:363-9. 2014
    ..These data suggests that CBP phosphorylation in WBCs may be used as a biomarker of metformin action in the liver. ..
  3. pmc Control of Foxo1 gene expression by co-activator P300
    Anne R Wondisford
    From the Division of Metabolism, Department of Pediatrics and
    J Biol Chem 289:4326-33. 2014
    ..By characterization of Foxo1 gene promoter, P300 regulates the Foxo1 gene expression through the binding to tandem cAMP-response element sites in the proximal promoter region of Foxo1 gene. ..
  4. pmc Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage
    Ling He
    Division of Metabolism, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Mol Endocrinol 27:1322-32. 2013
    ..Our study demonstrates the important and unique role of p300 in glycogen synthesis through maintaining basal gluconeogenesis. ..
  5. pmc Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis
    Ling He
    Division of Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 287:32069-77. 2012
    ..p300(G422S) and hepatic-deleted p300 mice exhibited significant lower blood glucose levels in the fasted and post-prandial states, indicating a role for p300 in maintaining basal HGP...
  6. pmc Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
    Ling He
    Division of Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell 137:635-46. 2009
    ..Our findings point to CBP phosphorylation at Ser436 by metformin as critical for its therapeutic effect, and as a potential target for pharmaceutical intervention...
  7. pmc CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice
    Ryan S Miller
    Division of Pediatric Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cell Biol 32:2349-58. 2012
    ..As CBP can be phosphorylated by other factors, such as insulin, our studies suggest that CBP may act as a key regulator of Lhb expression in the gonadotroph by integrating homeostatic information with GNRH signaling...
  8. pmc Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions
    Christopher J Romero
    Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cell Biol 32:4258-69. 2012
    ..Our data confirm the inhibitory effects of IGF-1 on GH expression at the level of the promoter and provide evidence of CBP's role as a target of IGF-1R signaling...
  9. pmc Current understanding of metformin effect on the control of hyperglycemia in diabetes
    Hongying An
    Divisions of Metabolism and EndocrinologyDepartment of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
    J Endocrinol 228:R97-106. 2016
    ..In this review, we discuss recent advances in the understanding of metformin's suppression of hepatic glucose production and the mechanism related to the improvement of insulin signaling. ..
  10. pmc Controlled Heat Stress Promotes Myofibrillogenesis during Myogenesis
    Qiongyu Guo
    Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 11:e0166294. 2016
    ..This study offers a new perspective to understand and utilize the time and temperature-sensitive effects of hyperthermal therapy on muscle regeneration...
  11. doi request reprint Metformin action: concentrations matter
    Ling He
    Division of Metabolism, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell Metab 21:159-62. 2015
    ....