Yun Guan

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Spinal cord stimulation: neurophysiological and neurochemical mechanisms of action
    Yun Guan
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Curr Pain Headache Rep 16:217-25. 2012
  2. doi request reprint Wide-dynamic-range neurons are heterogeneous in windup responsiveness to changes in stimulus intensity and isoflurane anesthesia level in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurosci Res 88:2272-83. 2010
  3. pmc A partial L5 spinal nerve ligation induces a limited prolongation of mechanical allodynia in rats: an efficient model for studying mechanisms of neuropathic pain
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Neurosci Lett 471:43-7. 2010
  4. pmc Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, 720 Rutland Avenue, Ross 350, Baltimore, MD 21205, USA
    Pain 138:318-29. 2008
  5. doi request reprint Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 113:1392-405. 2010
  6. pmc Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats
    Shao Qiu He
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Pain 154:2477-86. 2013
  7. pmc A subpopulation of nociceptors specifically linked to itch
    Liang Han
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:174-82. 2013
  8. pmc Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, Maryland 21205, USA
    Mol Pain 3:29. 2007
  9. pmc Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain
    Jang Su Park
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 4:67. 2008
  10. pmc Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers
    Matthias Ringkamp
    Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e42105. 2012

Collaborators

Detail Information

Publications38

  1. doi request reprint Spinal cord stimulation: neurophysiological and neurochemical mechanisms of action
    Yun Guan
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Curr Pain Headache Rep 16:217-25. 2012
    ....
  2. doi request reprint Wide-dynamic-range neurons are heterogeneous in windup responsiveness to changes in stimulus intensity and isoflurane anesthesia level in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurosci Res 88:2272-83. 2010
    ..We also elucidate the usefulness and potential limitations of two widely used methods for calculating and presenting windup data...
  3. pmc A partial L5 spinal nerve ligation induces a limited prolongation of mechanical allodynia in rats: an efficient model for studying mechanisms of neuropathic pain
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Neurosci Lett 471:43-7. 2010
    ....
  4. pmc Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, 720 Rutland Avenue, Ross 350, Baltimore, MD 21205, USA
    Pain 138:318-29. 2008
    ..Therefore, peripherally acting MOR agonists may represent a promising therapeutic approach for alleviating neuropathic pain...
  5. doi request reprint Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 113:1392-405. 2010
    ..The sites of action and cellular mechanisms by which spinal cord stimulation reduces neuropathic pain remain unclear...
  6. pmc Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats
    Shao Qiu He
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Pain 154:2477-86. 2013
    ..Our findings indicate that animals with neuropathic pain may develop acute tolerance to the antiallodynic effects of peripherally acting opioids after repetitive systemic and local drug administration...
  7. pmc A subpopulation of nociceptors specifically linked to itch
    Liang Han
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:174-82. 2013
    ..These data suggest that MrgprA3 defines a specific subpopulation of DRG neurons mediating itch. Our study opens new avenues for studying itch and developing anti-pruritic therapies...
  8. pmc Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, Maryland 21205, USA
    Mol Pain 3:29. 2007
    ..Our findings suggest that nNOS, especially in the dorsal root ganglion, may participate in the development and/or maintenance of mechanical hypersensitivity after nerve injury...
  9. pmc Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain
    Jang Su Park
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 4:67. 2008
    ..These findings suggest that spinal AMPARs might participate in the central spinal mechanism of persistent inflammatory pain...
  10. pmc Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers
    Matthias Ringkamp
    Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e42105. 2012
    ..These results suggest that loperamide reversal of behavioral signs of neuropathic pain may be mediated, at least in part, by mechanisms independent of opioid receptors, most probably by local anesthetic actions...
  11. ncbi request reprint Changes in AMPA receptor phosphorylation in the rostral ventromedial medulla after inflammatory hyperalgesia in rats
    Yun Guan
    Department of Biomedical Sciences, Dental School and Program in Neuroscience University of Maryland, Rm 5A12, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Neurosci Lett 366:201-5. 2004
    ..These findings provide new evidence linking in vivo AMPA receptor phosphorylation in the RVM pain modulatory circuitry to the enhanced descending pain modulation after inflammation...
  12. pmc Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice
    Zhe Li
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Pain 155:1613-21. 2014
    ....
  13. pmc Suppression of spinal connexin 43 expression attenuates mechanical hypersensitivity in rats after an L5 spinal nerve injury
    Qian Xu
    Department of Clinical Pharmacology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Neurosci Lett 566:194-9. 2014
    ..These findings suggest that in the spinal cord, the enhanced function of astroglial gap junctions, especially those formed by Cx43, may be important to neuropathic pain in SNL rats. ..
  14. doi request reprint Electrical stimulation at distinct peripheral sites in spinal nerve injured rats leads to different afferent activation profiles
    Fei Yang
    Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Neurosci Lett 505:52-7. 2011
    ..Electrical stimulation of different peripheral targets induced distinctive profiles of A-fiber afferent activation, suggesting that the neuronal substrates for the various forms of peripheral neuromodulatory therapies may differ...
  15. pmc Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation
    Fei Yang
    aDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA bThe Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA cHoward Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA dDepartment of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China eNeuromodulation Research, Medtronic Inc, Minneapolis, MN, USA fDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden gDepartment of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    Pain 157:2582-2593. 2016
    ....
  16. pmc Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain
    Vinod Tiwari
    From the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland Vinod Tiwari, F Y, S Q H, R S, B S, Vineeta Tiwari, Y G, S N R Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China C Z, Y W Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Wuhan, China B S Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China T Z The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland X D and Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Baltimore, Maryland X D
    Anesthesiology 124:706-20. 2016
    ..Opioids have long been regarded as the most effective drugs for the treatment of severe acute and chronic pain. Unfortunately, their therapeutic efficacy and clinical utility have been limited because of central and peripheral side effects...
  17. pmc Conventional and kilohertz-frequency spinal cord stimulation produces intensity- and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain
    Ronen Shechter
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 119:422-32. 2013
    ..Spinal cord stimulation (SCS) is a useful neuromodulatory technique for treatment of certain neuropathic pain conditions. However, the optimal stimulation parameters remain unclear...
  18. ncbi request reprint Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain
    Ya Chun Chu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pain 119:113-23. 2005
    ..Our findings suggest that spinal cord nNOS might play a critical role in central mechanisms of the development and/or maintenance of chronic inflammatory pain...
  19. ncbi request reprint Windup in dorsal horn neurons is modulated by endogenous spinal mu-opioid mechanisms
    Yun Guan
    Department ofAnesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:4298-307. 2006
    ..However, MORs may play an important role in endogenous inhibitory mechanisms that regulate the development of spinal neuronal sensitization...
  20. ncbi request reprint Enhanced thermal avoidance in mice lacking the ATP receptor P2X3
    Isao Shimizu
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 408 Biophysics Building, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Pain 116:96-108. 2005
    ..Regardless, this study illustrates the utility of thermal preference assays as part of a comprehensive approach to the analysis of mouse thermosensation...
  21. pmc Electrical stimulation of low-threshold afferent fibers induces a prolonged synaptic depression in lamina II dorsal horn neurons to high-threshold afferent inputs in mice
    Andrei D Sdrulla
    aDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA bThe Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA cHoward Hughes Medical Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA dDepartment of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    Pain 156:1008-17. 2015
    ..However, 50-Hz Aβ-ES failed to induce cell-type-selective inhibition in SG neurons. The physiologic implication of this novel form of synaptic depression for pain modulation by Aβ-ES warrants further investigation. ..
  22. pmc Effects of Combined Electrical Stimulation of the Dorsal Column and Dorsal Roots on Wide-Dynamic-Range Neuronal Activity in Nerve-Injured Rats
    Fei Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuromodulation 18:592-7; discussion 598. 2015
    ..The objective of this study was to determine if applying electrical conditioning stimulation (CS) at both sites provides additive or synergistic benefits...
  23. pmc Electrical stimulation of dorsal root entry zone attenuates wide-dynamic-range neuronal activity in rats
    Fei Yang
    Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Neuromodulation 18:33-40; discussion 40. 2015
    ..However, the mechanisms of action for this therapeutic effect are unclear. Here, we examined whether DREZ stimulation inhibits spinal wide-dynamic-range (WDR) neuronal activity in nerve-injured rats...
  24. pmc Proteome of synaptosome-associated proteins in spinal cord dorsal horn after peripheral nerve injury
    Om V Singh
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proteomics 9:1241-53. 2009
    ..These changes might participate in the central mechanism that underlies the maintenance of neuropathic pain...
  25. pmc Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury
    Chun yi Lee
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
    Eur J Pain 15:669-75. 2011
    ..These temporal and anatomically specific changes in mOR expression following nerve injury are likely to have functional consequences on pain-associated behaviors and opioid analgesia...
  26. pmc Mas-related G-protein-coupled receptors inhibit pathological pain in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:15933-8. 2010
    ..Agonists for these receptors may, therefore, represent a class of antihyperalgesics for treating persistent pain with minimal side effects because of the highly specific expression of their targets...
  27. doi request reprint Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy
    Vineeta Tiwari
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA
    Adv Exp Med Biol 904:87-103. 2016
    ..We will also discuss the limitations and future scope of this receptor family in pain treatment. ..
  28. pmc MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain
    Shao Qiu He
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Pain 155:534-44. 2014
    ....
  29. ncbi request reprint Inflammation-induced upregulation of AMPA receptor subunit expression in brain stem pain modulatory circuitry
    Yun Guan
    Program in Neuroscience, University of Maryland, Baltimore, MD 21201 1586, USA
    Pain 104:401-13. 2003
    ....
  30. pmc TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception
    Una Park
    Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:11425-36. 2011
    ..Thus, TRPV2 is important for perinatal viability but is not essential for heat or mechanical nociception or hypersensitivity in the adult mouse...
  31. pmc Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain
    Hao Jui Weng
    Departments of Neuroscience and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA Department of Dermatology, National Taiwan University Hospital, Taipei City 100, Taiwan
    Neuron 85:833-46. 2015
    ..Our study unveils a context-dependent modulation of the TRPA1-V1 complex, and Tmem100-3Q CPP is a promising pain therapy...
  32. doi request reprint Selective keratinocyte stimulation is sufficient to evoke nociception in mice
    Zixuan Pang
    Departments of aNeurosurgery bBiological Chemistry cNeuroscience dNeurosurgery Pain Research Institute eCenter for Sensory Biology fDepartment of Anesthesiology and Critical Care Medicine gHoward Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA hDepartment of Biology, University of Virginia, Charlottesville, VA, USA
    Pain 156:656-65. 2015
    ..These data provide direct evidence that keratinocyte stimulation is sufficient to evoke acute nociception-related responses. ..
  33. pmc Intrathecal carbenoxolone inhibits neuropathic pain and spinal wide-dynamic range neuronal activity in rats after an L5 spinal nerve injury
    Qian Xu
    Department of Clinical Pharmacology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Neurosci Lett 563:45-50. 2014
    ....
  34. pmc Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain
    Yu Shin Kim
    Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA Department of Neuroscience and Cell Biology, The University of Texas Medical Branch School of Medicine, 301 University Boulevard, Galveston, TX 77555, USA Electronic address
    Neuron 91:1085-96. 2016
    ..Therefore, neuronal coupling represents a new form of neuronal plasticity in the DRG and contributes to pain hypersensitivity by "hijacking" neighboring neurons through gap junctions. ..
  35. pmc Modulating the delicate glial-neuronal interactions in neuropathic pain: promises and potential caveats
    Vinod Tiwari
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States Electronic address
    Neurosci Biobehav Rev 45:19-27. 2014
    ....
  36. pmc Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus
    Qin Liu
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Cell 139:1353-65. 2009
    ..Therefore, Mrgprs may provide molecular access to itch-selective neurons and constitute novel targets for itch therapeutics...
  37. ncbi request reprint Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia
    Wei Guo
    Department of Oral and Craniofacial Biological Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Neurosci 22:6208-17. 2002
    ....
  38. ncbi request reprint Plasticity in excitatory amino acid receptor-mediated descending pain modulation after inflammation
    Yun Guan
    Department of Oral and Craniofacial Biological Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Pharmacol Exp Ther 300:513-20. 2002
    ..There is a time-dependent increase in EAA neurotransmission in the RVM after inflammation and NMDA receptors play an important role in AMPA-produced inhibition...