Affiliation: Johns Hopkins University
- Methods for evaluating the performance of diagnostic tests in the absence of a gold standard: a latent class model approachElizabeth S Garrett
Johns Hopkins University School of Medicine, Division of Biostatistics, Oncology Center, Baltimore, MD 21205, USA
Stat Med 21:1289-307. 2002..These methods are applied to diagnostic criteria for depression using Baltimore's Epidemiologic Catchment Area Study Wave 3 data...
- The continual reassessment method for dose-finding studies: a tutorialElizabeth Garrett-Mayer
Division of Oncology Biostatistics, Johns Hopkins University, Baltimore, MD, USA
Clin Trials 3:57-71. 2006..This paper presents the original CRM, and then some of its modified versions. It also explains the specifications that define a CRM design, along with simulated examples of CRMs and standard designs, for illustration...
- Fixed-dose capecitabine is feasible: results from a pharmacokinetic and pharmacogenetic study in metastatic breast cancerMichelle A Rudek
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, CRB1 1M52, Baltimore, MD 21231, USA
Breast Cancer Res Treat 139:135-43. 2013..BSA was not the main source of pharmacokinetic variability. Fixed-dose capecitabine is feasible, and simplifies dosing...
- Incorporating scientific knowledge into phenotype development: penalized latent class regressionJeannie Marie S Leoutsakos
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, U S A
Stat Med 30:784-98. 2011..Investigation of novel penalty functions may prove fruitful in further refining psychiatric phenotypes...
- Changes in breast density and circulating estrogens in postmenopausal women receiving adjuvant anastrozoleTatiana M Prowell
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cancer Prev Res (Phila) 4:1993-2001. 2011....
- Monitoring of Serum DNA Methylation as an Early Independent Marker of Response and Survival in Metastatic Breast Cancer: TBCRC 005 Prospective Biomarker StudyKala Visvanathan
Kala Visvanathan, Johns Hopkins University School of Medicine and Bloomberg School of Public Health MaryJo S Fackler, Zhe Zhang, Zoila A Lopez Bujanda, Stacie C Jeter, Lori J Sokoll, Leslie M Cope, Christopher B Umbricht, David M Euhus, Saraswati Sukumar, and Antonio C Wolff, Johns Hopkins University School of Medicine, Baltimore, MD Elizabeth Garrett Mayer, Medical University of South Carolina, Charleston, SC Andres Forero, University of Alabama at Birmingham, Birmingham, AL Anna M Storniolo, Indiana University, Bloomington, IN Rita Nanda, University of Chicago, Chicago, IL Nancy U Lin, Dana Farber Cancer Institute, Boston, MA Lisa A Carey, University of North Carolina, Chapel Hill, NC and James N Ingle, Mayo Clinic, Rochester, MN
J Clin Oncol . 2016..004). Conclusion Methylation of this gene panel is a strong predictor of survival outcomes in MBC and may have clinical usefulness in risk stratification and disease monitoring...
- Randomized phase II study of two schedules of flavopiridol given as timed sequential therapy with cytosine arabinoside and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemiaJudith E Karp
Division of Hematologic Malignancies, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21231 1000, USA
Haematologica 97:1736-42. 2012..6 months...
- Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumorsAntonio Jimeno
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
J Clin Oncol 26:4172-9. 2008..We conducted a dose selection study with daily rapamycin (sirolimus) in patients with solid tumors employing a modified continuous reassessment method (mCRM) using real-time pharmacodynamic data as primary dose-estimation parameter...
- Docetaxel metabolism is not altered by imatinib: findings from an early phase study in metastatic breast cancerRoisin M Connolly
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB1 189, Baltimore, MD 21231 1000, USA
Breast Cancer Res Treat 127:153-62. 2011..However, these unexpected pharmacokinetic findings support further investigation of mechanisms underlying docetaxel elimination pathways...
- Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatusAimee R Kreimer
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
J Infect Dis 189:686-98. 2004..8; 95% confidence interval, 3.1-52.7) among HIV-seropositive individuals. HPV type 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral HPV infection...
- Noise, stress, and annoyance in a pediatric intensive care unitWynne E Morrison
Division of Pediatric Anesthesia and Critical Care, Johns Hopkins School of Medicine, Baltimore, MD, USA
Crit Care Med 31:113-9. 2003..To measure and describe hospital noise and determine whether noise can be correlated with nursing stress measured by questionnaire, salivary amylase, and heart rate...
- Symptoms, supportive care needs, and function in cancer patients: how are they related?Claire F Snyder
Johns Hopkins School of Medicine, Baltimore, MD, USA
Qual Life Res 17:665-77. 2008..To explore the associations among symptoms, supportive care needs, and function...
- Concordance of cancer patients' function, symptoms, and supportive care needsClaire F Snyder
Johns Hopkins School of Medicine, 624 N Broadway, Room 657, Baltimore, MD 21205, USA
Qual Life Res 18:991-8. 2009..Although patients' function, symptoms, and supportive care needs are obviously related, a better understanding of these relationships could improve patient management...
- A prostate-specific antigen-activated channel-forming toxin as therapy for prostatic diseaseSimon A Williams
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Natl Cancer Inst 99:376-85. 2007..Prostate-specific antigen (PSA) is a serine protease that is secreted at high levels by the normal and diseased prostate. Therapies that are activated by PSA may prove effective in treating prostatic malignancies...
- Dose-finding study of 153Sm-EDTMP in patients with poor-prognosis osteosarcomaDavid M Loeb
Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
Cancer 115:2514-22. 2009..The purpose of the current study was to determine the maximally tolerated dose of (153)Sm-EDTMP that permits hematopoietic recovery within 6 weeks...