Michela Gallagher

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Episodic memory on the path to Alzheimer's disease
    Michela Gallagher
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Curr Opin Neurobiol 21:929-34. 2011
  2. ncbi request reprint Functions of the amygdala and related forebrain areas in attention and cognition
    M Gallagher
    Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Ann N Y Acad Sci 877:397-411. 1999
  3. ncbi request reprint Aging and hippocampal/cortical circuits in rodents
    Michela Gallagher
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Alzheimer Dis Assoc Disord 17:S45-7. 2003
  4. ncbi request reprint Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment
    Michela Gallagher
    Department of Psychology and Brain Sciences, Johns Hopkins University, 102 Ames Hall, 3400 North Charles St, Baltimore, MD 21218, USA
    Exp Gerontol 38:71-7. 2003
  5. ncbi request reprint Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline
    J L Bizon
    Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Eur J Neurosci 18:215-9. 2003
  6. pmc Mindspan: lessons from rat models of neurocognitive aging
    Michela Gallagher
    Department of Psychological and Brain Sciences, Johns Hopkins University, Ames Hall, 3400 North Charles Street, Baltimore, MD 21218, USA
    ILAR J 52:32-40. 2011
  7. pmc Bridging neurocognitive aging and disease modification: targeting functional mechanisms of memory impairment
    M Gallagher
    Department of Psychological and Brain Science, Johns Hopkins University, Baltimore, MD 21218, USA
    Curr Alzheimer Res 7:197-9. 2010
  8. pmc A role for alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid GluR1 phosphorylation in the modulatory effects of appetitive reward cues on goal-directed behavior
    Hans S Crombag
    Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, The Johns Hopkins University, Baltimore, MD, USA
    Eur J Neurosci 27:3284-91. 2008
  9. pmc Central, but not basolateral, amygdala is critical for control of feeding by aversive learned cues
    Gorica D Petrovich
    Department of Psychology, Boston College, Chestnut Hill, Massachusetts 02467 3807, USA
    J Neurosci 29:15205-12. 2009
  10. ncbi request reprint Encoding predicted outcome and acquired value in orbitofrontal cortex during cue sampling depends upon input from basolateral amygdala
    Geoffrey Schoenbaum
    Department of Psychology, Johns Hopkins University, 25 Ames Hall, 3400 North Charles Street, Baltimore, MD 21218, USA
    Neuron 39:855-67. 2003

Research Grants

  1. NEUROGENETICS AND BEHAVIOR CENTER
    Michela Gallagher; Fiscal Year: 2007
  2. COGNITIVE ASSESSMENTS IN THE MOUSE
    Michela Gallagher; Fiscal Year: 2002
  3. ESTROGEN EFFECTS ON AGE RELATED COGNITIVE DECLINE
    Michela Gallagher; Fiscal Year: 2002
  4. ASSOCIATIVE FUNCTIONS OF THE BASOLATERAL AMYGDALA
    Michela Gallagher; Fiscal Year: 2009

Collaborators

Detail Information

Publications83

  1. pmc Episodic memory on the path to Alzheimer's disease
    Michela Gallagher
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Curr Opin Neurobiol 21:929-34. 2011
    ....
  2. ncbi request reprint Functions of the amygdala and related forebrain areas in attention and cognition
    M Gallagher
    Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Ann N Y Acad Sci 877:397-411. 1999
    ..These lines of behavioral research have revealed that sub-systems in the basal forebrain and amygdala serve adaptive functions beyond the domains of motivation and emotion to include attention and cognition...
  3. ncbi request reprint Aging and hippocampal/cortical circuits in rodents
    Michela Gallagher
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Alzheimer Dis Assoc Disord 17:S45-7. 2003
  4. ncbi request reprint Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment
    Michela Gallagher
    Department of Psychology and Brain Sciences, Johns Hopkins University, 102 Ames Hall, 3400 North Charles St, Baltimore, MD 21218, USA
    Exp Gerontol 38:71-7. 2003
    ..Aged rats with cognitive impairment exhibited no loss of neurons in the hippocampus. Current research is focused on the functional alterations in neurons by methods which assess transcriptional mechanisms and signaling pathways...
  5. ncbi request reprint Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline
    J L Bizon
    Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Eur J Neurosci 18:215-9. 2003
    ..These effects of aging were not, however, predictive of cognitive status. In particular, the pronounced decrease in new cell production during aging did not distinguish among rats that varied over a wide range of cognitive abilities...
  6. pmc Mindspan: lessons from rat models of neurocognitive aging
    Michela Gallagher
    Department of Psychological and Brain Sciences, Johns Hopkins University, Ames Hall, 3400 North Charles Street, Baltimore, MD 21218, USA
    ILAR J 52:32-40. 2011
    ....
  7. pmc Bridging neurocognitive aging and disease modification: targeting functional mechanisms of memory impairment
    M Gallagher
    Department of Psychological and Brain Science, Johns Hopkins University, Baltimore, MD 21218, USA
    Curr Alzheimer Res 7:197-9. 2010
    ....
  8. pmc A role for alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid GluR1 phosphorylation in the modulatory effects of appetitive reward cues on goal-directed behavior
    Hans S Crombag
    Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, The Johns Hopkins University, Baltimore, MD, USA
    Eur J Neurosci 27:3284-91. 2008
    ....
  9. pmc Central, but not basolateral, amygdala is critical for control of feeding by aversive learned cues
    Gorica D Petrovich
    Department of Psychology, Boston College, Chestnut Hill, Massachusetts 02467 3807, USA
    J Neurosci 29:15205-12. 2009
    ..Those findings together with the current results show a double dissociation between amygdalar subsystems that control food consumption by appetitive and aversive learned cues...
  10. ncbi request reprint Encoding predicted outcome and acquired value in orbitofrontal cortex during cue sampling depends upon input from basolateral amygdala
    Geoffrey Schoenbaum
    Department of Psychology, Johns Hopkins University, 25 Ames Hall, 3400 North Charles Street, Baltimore, MD 21218, USA
    Neuron 39:855-67. 2003
    ..The results provide a neural substrate for representing acquired value and features of the predicted outcome during cue sampling, disruption of which could account for deficits in goal-directed behavior after damage to this system...
  11. pmc Hilar interneuron vulnerability distinguishes aged rats with memory impairment
    Amy M Spiegel
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, 21218
    J Comp Neurol 521:3508-23. 2013
    ..Together these findings confirm the vulnerability of hippocampal interneurons to normal aging and highlight that the integrity of a specific subpopulation in the hilus is coupled with age-related memory impairment...
  12. pmc Potential adaptive function for altered long-term potentiation mechanisms in aging hippocampus
    Katica Boric
    Mind Brain Institute and Department of Neurosciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 28:8034-9. 2008
    ....
  13. ncbi request reprint Different roles for orbitofrontal cortex and basolateral amygdala in a reinforcer devaluation task
    Charles L Pickens
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 23:11078-84. 2003
    ..In contrast, the OFC seems essential for one or more of these latter processes...
  14. ncbi request reprint Amygdalar and prefrontal pathways to the lateral hypothalamus are activated by a learned cue that stimulates eating
    Gorica D Petrovich
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 25:8295-302. 2005
    ..Our results indicate that a cue that has acquired the ability to promote eating in sated rats (CS+) strongly activates a functional network formed by direct pathways from the BL/BM and orbitomedial prefrontal cortex to the LHA...
  15. pmc Encoding changes in orbitofrontal cortex in reversal-impaired aged rats
    Geoffrey Schoenbaum
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St, HSF 2 Rm S251, Baltimore, MD 21201, USA
    J Neurophysiol 95:1509-17. 2006
    ..These altered features of neural encoding could provide a basis for cognitive inflexibility associated with normal aging...
  16. pmc Rat orbitofrontal cortex separately encodes response and outcome information during performance of goal-directed behavior
    Tomoyuki Furuyashiki
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 28:5127-38. 2008
    ..These data demonstrate a broader role of OFC information processing in goal-directed behavior, beyond its widely recognized role in outcome expectancy...
  17. pmc Medial prefrontal cortex is necessary for an appetitive contextual conditioned stimulus to promote eating in sated rats
    Gorica D Petrovich
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 27:6436-41. 2007
    ..The current findings suggest a critical role for vmPFC in the brain network that mediates control of conditioned motivation to eat perhaps by a mechanism akin to appetite or craving...
  18. pmc Integrity of mGluR-LTD in the associative/commissural inputs to CA3 correlates with successful aging in rats
    Sunggu Yang
    The Mind Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 33:12670-8. 2013
    ..Age-unimpaired rats, in contrast, had intact mGluR LTD. These findings indicate that the integrity of mGluR-LTD at A/C → CA3 inputs may play a crucial role in maintaining the performance of CA3 circuitry in aging...
  19. pmc A necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learning
    Hans S Crombag
    Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, Johns Hopkins University, Baltimore, MD 21218, USA
    Behav Brain Res 191:178-83. 2008
    ..Our findings provide novel evidence for a molecular mechanism in a form of appetitive incentive learning critical in regulating normal motivated behavior, as well as maladaptive forms such as addiction and eating disorders...
  20. ncbi request reprint Amygdalo-hypothalamic circuit allows learned cues to override satiety and promote eating
    Gorica D Petrovich
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 22:8748-53. 2002
    ....
  21. pmc Rapid encoding of new information alters the profile of plasticity-related mRNA transcripts in the hippocampal CA3 region
    Rebecca P Haberman
    Department of Psychological and Brain Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 105:10601-6. 2008
    ..Furthermore, siRNA inhibition of nlgn1 within the CA3 subregion impaired spatial memory performance, pointing to mechanisms of synaptic remodeling as a basis for rapid encoding of new information in long-term memory...
  22. pmc Lesions of orbitofrontal cortex impair rats' differential outcome expectancy learning but not conditioned stimulus-potentiated feeding
    Michael A McDannald
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 25:4626-32. 2005
    ....
  23. ncbi request reprint Rapid associative encoding in basolateral amygdala depends on connections with orbitofrontal cortex
    Michael P Saddoris
    Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, 25 Ames Hall, Baltimore, Maryland 21218, USA
    Neuron 46:321-31. 2005
    ..These findings support a role for OFC in facilitating the encoding of information about expected outcomes in ABL...
  24. pmc The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value
    Alexander W Johnson
    Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, Johns Hopkins University, Baltimore, MD 21218, USA
    Eur J Neurosci 28:997-1002. 2008
    ....
  25. ncbi request reprint NMDA receptor-independent long-term depression correlates with successful aging in rats
    Hey Kyoung Lee
    Department of Neuroscience, The Mind Brain Institute, Baltimore, Maryland 21218, USA
    Nat Neurosci 8:1657-9. 2005
    ..Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms...
  26. ncbi request reprint Neural encoding in ventral striatum during olfactory discrimination learning
    Barry Setlow
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuron 38:625-36. 2003
    ..The results support a role for ventral striatum in using the learned significance, both appetitive and aversive, of predictive cues to guide behavior...
  27. pmc Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment
    Ming Teng Koh
    Department of Psychological and Brain Sciences, Johns Hopkins University, Ames Hall, 3400 North Charles Street, Baltimore, MD 21218, USA
    Neuropharmacology 64:145-52. 2013
    ..These data suggest a novel approach to improve neural network function in clinical conditions of excess hippocampal activity. This article is part of a Special Issue entitled 'Cognitive Enhancers'...
  28. pmc Prominent hippocampal CA3 gene expression profile in neurocognitive aging
    Rebecca P Haberman
    Department of Psychological and Brain Science, The Johns Hopkins University, 3400 N Charles Street, 104 Ames Hall, Baltimore, MD 21218, United States
    Neurobiol Aging 32:1678-92. 2011
    ....
  29. pmc The central amygdala projection to the substantia nigra reflects prediction error information in appetitive conditioning
    Hongjoo J Lee
    Department of Psychology, The University of Texas, Austin, Texas 78712, USA
    Learn Mem 17:531-8. 2010
    ..These results suggest that the CeA-nigral pathway represents prediction error information during appetitive conditioning...
  30. pmc Interference with reelin signaling in the lateral entorhinal cortex impairs spatial memory
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Learn Mem 96:150-5. 2011
    ..These observations support a role for entorhinal reelin signaling in spatial learning, and suggest that an intact reelin signaling pathway is essential for synaptic integrity in the adult entorhinal cortex...
  31. pmc Role of amygdalo-nigral circuitry in conditioning of a visual stimulus paired with food
    Hongjoo J Lee
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 25:3881-8. 2005
    ..These experiments demonstrate a role for amygdalo-nigral circuitry in learned modulation of attention to signals for biologically significant events...
  32. pmc Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment
    Ming Teng Koh
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuropsychopharmacology 35:1016-25. 2010
    ....
  33. pmc Associatively learned representations of taste outcomes activate taste-encoding neural ensembles in gustatory cortex
    Michael P Saddoris
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 29:15386-96. 2009
    ..Such representations may provide outcome-specific information for guiding goal-directed behavior...
  34. pmc Orbitofrontal lesions impair use of cue-outcome associations in a devaluation task
    Charles L Pickens
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Behav Neurosci 119:317-22. 2005
    ..Gallagher, P. C. Holland, & G. Schoenbaum, 2003), these results indicate that the OFC is critical for the maintenance of information about the current incentive value of reinforcers or the use of that information to guide behavior...
  35. ncbi request reprint Role of substantia nigra-amygdala connections in surprise-induced enhancement of attention
    Hongjoo J Lee
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 26:6077-81. 2006
    ..These results show that SNc-CeA communication is critical to mechanisms by which the coding of prediction error by midbrain dopamine neurons is translated into enhancement of attention and learning modulated by the cholinergic system...
  36. pmc Assessing the role of the growth hormone secretagogue receptor in motivational learning and food intake
    Alexander W Johnson
    Neurogenetics and Behavior Center, Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, 21218, USA
    Behav Neurosci 123:1058-65. 2009
    ..These results suggest dissociable functions of GHS-R in its influence over motivational learning and ingestive behavior...
  37. pmc Lesions of orbitofrontal cortex and basolateral amygdala complex disrupt acquisition of odor-guided discriminations and reversals
    Geoffrey Schoenbaum
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Learn Mem 10:129-40. 2003
    ..These findings suggest that OFC and ABL serve partially overlapping roles in the use of incentive information that supports normal discrimination performance...
  38. ncbi request reprint Amygdala central nucleus function is necessary for learning but not expression of conditioned visual orienting
    Michael McDannald
    Johns Hopkins University, 222 Ames Hall, 3400 North Charles St, Baltimore, MD 21218, USA
    Eur J Neurosci 20:240-8. 2004
    ..Specialized roles for components of a circuit for conditioned orienting, which includes the central nucleus, the substantia nigra, and dorsolateral striatum, are discussed...
  39. pmc Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged rats
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Cereb Cortex 21:392-400. 2011
    ..Taken together, these findings suggest that reduced reelin expression, emanating from layer II entorhinal neurons, may contribute to network dysfunction that occurs during memory loss in aging...
  40. pmc Hippocampal lesions interfere with long-trace taste aversion conditioning
    Ming Teng Koh
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, United States
    Physiol Behav 98:103-7. 2009
    ..The results replicate past dissociations of dorsal and ventral hippocampal function, and also suggest that the hippocampus has a less differentiated role in long-trace taste aversion learning...
  41. ncbi request reprint More is less: neurogenesis and age-related cognitive decline in Long-Evans rats
    Jennifer L Bizon
    Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    Sci Aging Knowledge Environ 2005:re2. 2005
    ..These findings imply that the role of neurogenesis might change between youth and old age, and that further work is needed to understand the potential benefits and liabilities that new neurons may afford an aging brain...
  42. pmc Learned contextual cue potentiates eating in rats
    Gorica D Petrovich
    Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles St, Baltimore, MD 21218, United States
    Physiol Behav 90:362-7. 2007
    ..Furthermore, the data suggest that CS-potentiation of eating does not induce a general motivation to eat, akin to hunger, but instead more likely produces a more specific motivational state, akin to craving...
  43. ncbi request reprint Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex
    Se Young Choi
    Mind Brain Institute, Department of Neurosciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 25:11433-43. 2005
    ..This essential requirement places PLC-linked receptors in a unique position to control the induction of LTD and provides a mechanism for gating visual cortical plasticity via extra-retinal inputs in the intact organism...
  44. pmc Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment
    Arnold Bakker
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuron 74:467-74. 2012
    ....
  45. pmc The basolateral amygdala is critical to the expression of pavlovian and instrumental outcome-specific reinforcer devaluation effects
    Alexander W Johnson
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    J Neurosci 29:696-704. 2009
    ..Thus, BLA apparently plays a critical role in maintaining or using sensory associations of reinforcer value when multiple outcomes must be coded but not under single-outcome conditions...
  46. pmc Control of food consumption by learned cues: a forebrain-hypothalamic network
    Gorica D Petrovich
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, United States
    Physiol Behav 91:397-403. 2007
    ..The animal model may be informative for understanding control of eating in humans including maladaptive influences that contribute to overeating...
  47. ncbi request reprint Amygdala-frontal interactions and reward expectancy
    Peter C Holland
    Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Curr Opin Neurobiol 14:148-55. 2004
    ....
  48. pmc Aging reduces total neuron number in the dorsal component of the rodent prefrontal cortex
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Comp Neurol 520:1318-26. 2012
    ..These observations indicate that the dorsal PFC is susceptible to neuron loss with aging in rodent brain and suggest some common basis for vulnerability in cortical circuits across species...
  49. pmc Amygdala central nucleus function is necessary for learning, but not expression, of conditioned auditory orienting
    Frank Groshek
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Behav Neurosci 119:202-12. 2005
    ..Thus, although the central nucleus is critical to the acquisition of information required for conditioned orienting to auditory cues, it is not needed for maintaining this information for later use...
  50. ncbi request reprint Double dissociation of the effects of lesions of basolateral and central amygdala on conditioned stimulus-potentiated feeding and Pavlovian-instrumental transfer
    Peter C Holland
    Johns Hopkins University, 3400 North Charles St, 105 Ames Hall, Baltimore, MD 21218, USA
    Eur J Neurosci 17:1680-94. 2003
    ..Implications of the double dissociation of these two aspects of Pavlovian conditioned incentive motivation for amygdala function in associative learning are considered...
  51. ncbi request reprint Amygdala subsystems and control of feeding behavior by learned cues
    Gorica D Petrovich
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Ann N Y Acad Sci 985:251-62. 2003
    ..In addition, this model may be informative for understanding mechanisms of maladaptive aspects of learned control of eating that contribute to eating disorders and more moderate forms of overeating...
  52. ncbi request reprint The basolateral complex of the amygdala is necessary for acquisition but not expression of CS motivational value in appetitive Pavlovian second-order conditioning
    Barry Setlow
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Eur J Neurosci 15:1841-53. 2002
    ....
  53. pmc Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness
    Alexander W Johnson
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 110:12462-7. 2013
    ..As such, this model should be useful for further preclinical research and drug discovery efforts relevant to the burden of prefrontal dysfunction in neuropsychiatric illness. ..
  54. pmc Characterization of CpG island DNA methylation of impairment-related genes in a rat model of cognitive aging
    Rebecca P Haberman
    Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, MD, USA
    Epigenetics 7:1008-19. 2012
    ....
  55. pmc Age-related memory impairment is associated with disrupted multivariate epigenetic coordination in the hippocampus
    James F Castellano
    Laboratory of Experimental Gerontology, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS ONE 7:e33249. 2012
    ....
  56. ncbi request reprint Teaching old rats new tricks: age-related impairments in olfactory reversal learning
    Geoffrey Schoenbaum
    Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, 25 Ames Hall, Baltimore, MD 21218, USA
    Neurobiol Aging 23:555-64. 2002
    ..These data indicate that rats show independent decline of different brain systems during normal aging and suggest orbitofrontal cortex as one prefrontal area where changes may be localized for further study...
  57. ncbi request reprint Spatial memory in middle-aged female rats: assessment of estrogen replacement after ovariectomy
    Dana R Ziegler
    Department Psychological and Brain Sciences, John Hopkins University, Baltimore, MD 21218, USA
    Brain Res 1052:163-73. 2005
    ....
  58. ncbi request reprint Individual differences in spatial memory among aged rats are related to hippocampal PKCgamma immunoreactivity
    Paul J Colombo
    Department of Psychology, Tulane University, New Orleans, Louisiana 70118, USA
    Hippocampus 12:285-9. 2002
    ..Thus age-related impairments of spatial memory, as well as deficits in the flexible use of previously acquired information, may result from dysregulation of PKCgamma...
  59. ncbi request reprint Different roles for amygdala central nucleus and substantia innominata in the surprise-induced enhancement of learning
    Peter C Holland
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 26:3791-7. 2006
    ..Additional circuitry linking these brain regions may also be important in the maintenance of that information...
  60. ncbi request reprint Lesions of basolateral amygdala impair extinction of CS motivational value, but not of explicit conditioned responses, in Pavlovian appetitive second-order conditioning
    John L Lindgren
    Department of Psychological and Brain Sciences, Duke University, Durham, NC, USA
    Eur J Neurosci 17:160-6. 2003
    ....
  61. pmc Genetic background differences and nonassociative effects in mouse trace fear conditioning
    Dani R Smith
    Neurogenetics and Behavior Center, Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Learn Mem 14:597-605. 2007
    ..They also reveal a final set of parameters that are important for minimizing such nonassociative effects and demonstrate strain differences across performance in mouse contextual and trace fear conditioning...
  62. ncbi request reprint Neural encoding in the orbitofrontal cortex related to goal-directed behavior
    Tomoyuki Furuyashiki
    Johns Hopkins University, Department of Psychological and Brain Sciences, Baltimore, MD 21218, USA
    Ann N Y Acad Sci 1121:193-215. 2007
    ..The significance of this emerging evidence may require studies that address the larger scale network through which OFC integrates expected outcome information with behavioral control...
  63. ncbi request reprint Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory
    Hey Kyoung Lee
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Cell 112:631-43. 2003
    ..The phosphomutant mice show deficits in LTD and LTP and have memory defects in spatial learning tasks. These results demonstrate that phosphorylation of GluR1 is critical for LTD and LTP expression and the retention of memories...
  64. pmc Greater effort boosts the affective taste properties of food
    Alexander W Johnson
    Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Biol Sci 278:1450-6. 2011
    ....
  65. ncbi request reprint The effects of amygdala lesions on conditioned stimulus-potentiated eating in rats
    Peter C Holland
    Department of Psychological and Brain Sciences, Duke University, Box 90086, Durham, NC 27708 0086, USA
    Physiol Behav 76:117-29. 2002
    ..These results are considered in the context of anatomical projections from these amygdalar areas to other brain regions involved in feeding, and the role of amygdala subregions in the acquisition of motivational value in conditioning...
  66. ncbi request reprint Decreased glucocorticoid receptor mRNA and dysfunction of HPA axis in rats after removal of the cholinergic innervation to hippocampus
    Jung Soo Han
    Department of Psychological and Brain Science, Johns Hopkins University, 3400 North Charles Street, MD 21218, USA
    Eur J Neurosci 16:1399-404. 2002
    ..These findings are discussed in terms of their possible relevance to ageing as age-related degeneration of the basal forebrain cholinergic system may contribute to the commonly observed dysfunction of the HPA axis in older animals...
  67. ncbi request reprint Disconnection of the basolateral amygdala complex and nucleus accumbens impairs appetitive pavlovian second-order conditioned responses
    Barry Setlow
    Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Behav Neurosci 116:267-75. 2002
    ..The results suggest that the ABL and accumbens are part of a system critical for processing information about learned motivational value...
  68. pmc Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans
    Takatoshi Hikida
    Department of Psychiatry and Behavioral Sciences, Graduate Program in Cellular and Molecular Medicine, and Division of Neurobiology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 104:14501-6. 2007
    ..DN-DISC1 mice also display several behavioral abnormalities, including hyperactivity, disturbance in sensorimotor gating and olfactory-associated behavior, and an anhedonia/depression-like deficit...
  69. ncbi request reprint Cholinergic system regulation of spatial representation by the hippocampus
    Sami Ikonen
    Department of Neuroscience and Neurology, University and University Hospital of Kuopio, Finland
    Hippocampus 12:386-97. 2002
    ..These results suggest that cholinergic input may determine whether new visual information or a stored representation of the current environment will be actively processed in the hippocampal network...
  70. ncbi request reprint Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and age-related spatial learning impairments
    Daniel A Nicholson
    Department of Cell and Molecular Biology, Feinberg School of Medicine and Institute of Neuroscience, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 24:7648-53. 2004
    ..These findings support the notion that many hippocampal perforated synapses become less efficient in aged learning-impaired rats, which may contribute to cognitive decline during normal aging...
  71. ncbi request reprint Place cells of aged rats in two visually identical compartments
    Iain A Wilson
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627 Harjulantie 1, Kuopio 70211, Finland
    Neurobiol Aging 26:1099-106. 2005
    ..These findings suggest that the hippocampal network of aged rats is able to process changes in internally generated cues without rigidity, but that incomplete processing of external landmark cues may lead to impaired spatial learning...
  72. ncbi request reprint Age-associated alterations of hippocampal place cells are subregion specific
    Iain A Wilson
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio 70211, Finland
    J Neurosci 25:6877-86. 2005
    ..Thus, aged CA3 cells failed to rapidly encode new spatial information compared with young CA3 cells. These data suggest an important and selective contribution of CA3 dysfunction to age-related memory impairment...
  73. pmc Neurocognitive aging: prior memories hinder new hippocampal encoding
    Iain A Wilson
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio 70211, Finland
    Trends Neurosci 29:662-70. 2006
    ..As a result of such reorganization in aged memory-impaired individuals, information that is already stored would become the dominant pattern of the hippocampus to the detriment of the ability to encode new information...
  74. ncbi request reprint Transcriptional mechanisms of hippocampal aging
    P Kay Lund
    Department of Cell and Molecular Physiology, University of North Carolina, 6336 MBRB, 103 Mason Farm Road, CB 7545, Chapel Hill, NC 27599 7545, USA
    Exp Gerontol 39:1613-22. 2004
    ..Results from mRNA assays, in situ hybridization, electromobility shift assays and western immunoblot indicate changes in GR and CREB in AI rats. State of the art future approaches to define downstream transcription targets are described...
  75. ncbi request reprint Aging causes partial loss of basal forebrain but no loss of pontine reticular cholinergic neurons
    Karen A Baskerville
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    Neuroreport 17:1819-23. 2006
    ..This selective loss of cholinergic neurons may, in part, account for the cognitive deficits observed in aging and, considering previous findings in this model, may be related to oxidative stress...
  76. pmc Age-related spatial learning impairment is unrelated to spinophilin immunoreactive spine number and protein levels in rat hippocampus
    Michael E Calhoun
    Fishberg Department of Neuroscience, Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029 6574, United States
    Neurobiol Aging 29:1256-64. 2008
    ....
  77. pmc Learning strategy selection in the water maze and hippocampal CREB phosphorylation differ in two inbred strains of mice
    Jin Young Sung
    Graduate Program in Neuroscience and Institute for Brain Science and Technology IBST, Inje University, Daejeon 305 804, South Korea
    Learn Mem 15:183-8. 2008
    ..These findings indicate that pCREB, specifically associated with place/spatial training, is closely tied to differences in spatial/place strategy preference between C57BL/6 and DBA/2 mice...
  78. ncbi request reprint Muscarinic receptor-mediated GTP-Eu binding in the hippocampus and prefrontal cortex is correlated with spatial memory impairment in aged rats
    Hai Yan Zhang
    Roena Kulynych Center for Memory and Cognition Research, Department of Internal Medicine Gerontology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurobiol Aging 28:619-26. 2007
    ..These data demonstrate that muscarinic signaling is severely impaired as a consequence of normal aging in a manner that is closely associated with age-related cognitive decline...
  79. pmc Cognitive aging: a common decline of episodic recollection and spatial memory in rats
    R Jonathan Robitsek
    Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 28:8945-54. 2008
    ....
  80. ncbi request reprint Cognitive aging and the hippocampus: how old rats represent new environments
    Iain A Wilson
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio 70211, Finland
    J Neurosci 24:3870-8. 2004
    ..These observations help to reconcile previously divergent characterizations of spatial representation in aged rats and suggest a model of cognitive aging and hippocampal function...
  81. ncbi request reprint A specific amyloid-beta protein assembly in the brain impairs memory
    Sylvain Lesne
    Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 440:352-7. 2006
    ..We propose that Abeta*56 impairs memory independently of plaques or neuronal loss, and may contribute to cognitive deficits associated with Alzheimer's disease...
  82. ncbi request reprint SGS742: the first GABA(B) receptor antagonist in clinical trials
    Wolfgang Froestl
    Neuroscience Research, Novartis Pharma AG, WKL 136 5 25, CH 4002 Basel, Switzerland
    Biochem Pharmacol 68:1479-87. 2004
    ..A second Phase II clinical trial in 280 Alzheimer's disease patients is underway...

Research Grants4

  1. NEUROGENETICS AND BEHAVIOR CENTER
    Michela Gallagher; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. COGNITIVE ASSESSMENTS IN THE MOUSE
    Michela Gallagher; Fiscal Year: 2002
    ..The models will be developed using F1 hybrids of C57B/6 129svImJ mice and comparisons with the inbred parent strains will also be made. ..
  3. ESTROGEN EFFECTS ON AGE RELATED COGNITIVE DECLINE
    Michela Gallagher; Fiscal Year: 2002
    ..Therefore, the data will be of importance in the understanding of age related changes in cognitive function and will have important clinical relevance. ..
  4. ASSOCIATIVE FUNCTIONS OF THE BASOLATERAL AMYGDALA
    Michela Gallagher; Fiscal Year: 2009
    ..As such, the work has important implications for clinical disorders of impulse and behavioral control. ..