Edward J Fuchs

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Quantitative assessment of altered rectal mucosal permeability due to rectally applied nonoxynol-9, biopsy, and simulated intercourse
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5554, USA
    J Infect Dis 207:1389-96. 2013
  2. ncbi request reprint Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
    J Infect Dis 195:703-10. 2007
  3. doi request reprint Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with fosamprenavir-ritonavir in opioid-dependent subjects
    Ying Jun Cao
    Division of Clinical Pharmacology, Johns Hopkins University, Baltimore, Maryland 21287 5554, USA
    Pharmacotherapy 28:863-74. 2008
  4. pmc Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging
    Ying J Cao
    Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Br J Clin Pharmacol 74:1013-22. 2012
  5. pmc Isoosmolar enemas demonstrate preferential gastrointestinal distribution, safety, and acceptability compared with hyperosmolar and hypoosmolar enemas as a potential delivery vehicle for rectal microbicides
    Francisco J Leyva
    1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
    AIDS Res Hum Retroviruses 29:1487-95. 2013
  6. pmc Distribution of cell-free and cell-associated HIV surrogates in the colon after simulated receptive anal intercourse in men who have sex with men
    Nicolette A Louissaint
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 59:10-7. 2012
  7. doi request reprint Topical microbicides to prevent HIV: clinical drug development challenges
    Craig W Hendrix
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, USA
    Annu Rev Pharmacol Toxicol 49:349-75. 2009
  8. pmc Plasma and intracellular ribavirin concentrations are not significantly altered by abacavir in hepatitis C virus-infected patients
    Edward J Fuchs
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Antimicrob Chemother 71:1597-600. 2016
  9. pmc Biphasic elimination of tenofovir diphosphate and nonlinear pharmacokinetics of zidovudine triphosphate in a microdosing study
    Jianmeng Chen
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 61:593-9. 2012
  10. ncbi request reprint Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin
    Ying Jun Cao
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Clin Pharmacol 48:176-83. 2008

Collaborators

Detail Information

Publications12

  1. pmc Quantitative assessment of altered rectal mucosal permeability due to rectally applied nonoxynol-9, biopsy, and simulated intercourse
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5554, USA
    J Infect Dis 207:1389-96. 2013
    ..Microbicide toxicity may reduce the efficacy of topical preexposure prophylaxis for human immunodeficiency virus (HIV) transmission. Noninvasive quantitative measures of microbicide toxicity would usefully inform microbicide development...
  2. ncbi request reprint Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
    J Infect Dis 195:703-10. 2007
    ..To inform the development of rectal microbicide formulation, we evaluated the effects of hyperosmolar gels on the rectal mucosa...
  3. doi request reprint Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with fosamprenavir-ritonavir in opioid-dependent subjects
    Ying Jun Cao
    Division of Clinical Pharmacology, Johns Hopkins University, Baltimore, Maryland 21287 5554, USA
    Pharmacotherapy 28:863-74. 2008
    ..To compare steady-state pharmacokinetics and pharmacodynamics of methadone enantiomers when coadministered with fosamprenavir 700 mg-ritonavir 100 mg twice/day...
  4. pmc Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging
    Ying J Cao
    Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Br J Clin Pharmacol 74:1013-22. 2012
    ..These methods are needed to develop rationally rectal microbicides to target and prevent HIV infection...
  5. pmc Isoosmolar enemas demonstrate preferential gastrointestinal distribution, safety, and acceptability compared with hyperosmolar and hypoosmolar enemas as a potential delivery vehicle for rectal microbicides
    Francisco J Leyva
    1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
    AIDS Res Hum Retroviruses 29:1487-95. 2013
    ..The isoosmolar enema was superior or similar to the other enemas in all categories and is a good candidate for further development as a rectal microbicide vehicle...
  6. pmc Distribution of cell-free and cell-associated HIV surrogates in the colon after simulated receptive anal intercourse in men who have sex with men
    Nicolette A Louissaint
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 59:10-7. 2012
    ..Describing the distribution and clearance of HIV surrogates within the gastrointestinal tract to inform rectal microbicide development...
  7. doi request reprint Topical microbicides to prevent HIV: clinical drug development challenges
    Craig W Hendrix
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, USA
    Annu Rev Pharmacol Toxicol 49:349-75. 2009
    ..These efforts have also advanced the development of numerous methodological approaches to obtain the knowledge needed to improve microbicide development...
  8. pmc Plasma and intracellular ribavirin concentrations are not significantly altered by abacavir in hepatitis C virus-infected patients
    Edward J Fuchs
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Antimicrob Chemother 71:1597-600. 2016
    ..The objective of this study was to evaluate the effects of abacavir on intracellular ribavirin triphosphate and plasma ribavirin trough concentrations...
  9. pmc Biphasic elimination of tenofovir diphosphate and nonlinear pharmacokinetics of zidovudine triphosphate in a microdosing study
    Jianmeng Chen
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 61:593-9. 2012
    ..To evaluate the prediction of microdosing for active intracellular drug metabolites, we compared the PK profile of 2 antiretroviral drugs, zidovudine (ZDV) and tenofovir (TFV), in microdose and standard dosing regimens...
  10. ncbi request reprint Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin
    Ying Jun Cao
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Clin Pharmacol 48:176-83. 2008
    ..91-9.9) for desipramine. We conclude that our quantitative analysis along with the split ejaculate method is sensitive, reproducible, and applicable for the assessment of pharmacokinetics of the accessory glands of the male genital tract...
  11. pmc CYP3A5 genotype impacts maraviroc concentrations in healthy volunteers
    Yanhui Lu
    Department of Pharmacology and Molecular Sciences Y L, C W H, N N B, and Division of Clinical Pharmacology, Department of Medicine E J F, C W H, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Drug Metab Dispos 42:1796-802. 2014
    ..001). In conclusion, the lower maraviroc concentrations in the homozygous wild-type group indicate that maraviroc may be underdosed in people homozygous for the CYP3A5*1 allele, including almost one-half of African Americans. ..
  12. ncbi request reprint Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with amprenavir in opioid-dependent subjects
    Craig W Hendrix
    Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
    Pharmacotherapy 24:1110-21. 2004
    ..To investigate the steady-state pharmacokinetics of methadone enantiomers when coadministered with amprenavir...