Sara A DiVall
Affiliation: Johns Hopkins University
- The influence of endocrine disruptors on growth and development of childrenSara A DiVall
Department of Pediatrics, Division of Endocrinology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Curr Opin Endocrinol Diabetes Obes 20:50-5. 2013..This review describes the most recent data about the effects of endocrine disrupting compounds (EDCs) on infant and early childhood growth and reproductive tract development as well as controversies in the field...
- Divergent roles of growth factors in the GnRH regulation of puberty in miceSara A DiVall
Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21212, USA
J Clin Invest 120:2900-9. 2010..These studies define the role of IGF-1R signaling in the coordination of somatic development with reproductive maturation and provide insight into the mechanisms regulating pubertal timing in anabolic states...
- Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulinSara A DiVall
Division of Endocrinology, Department of Pediatrics, Johns Hopkins University, 600 N Wolfe Street, Park 211, Baltimore, MD 21287, United States
Mol Cell Endocrinol 270:64-72. 2007..Thus, Egr-1 binds the GnRH promoter at a site between -67 and -76bp from the transcriptional start site to mediate the insulin-induced increase in GnRH gene transcription...
- Endocrinology of female pubertySara A DiVall
Division of Pediatric Endocrinology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Curr Opin Endocrinol Diabetes Obes 16:1-4. 2009....
- Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptorKathryn J Brothers
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Cell Metab 12:295-305. 2010....
- Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female miceSara A DiVall
Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 10:e0119995. 2015..These results suggest that in the obese state, insulin receptor signaling in GnRH neurons increases GnRH pulsatile secretion and consequent LH secretion, contributing to reproductive dysfunction. ..
- Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor alpha (ESR1)Surya P Singh
Divisions of Pediatric Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Biol Reprod 81:488-96. 2009....
- Conditional knockout of the androgen receptor in gonadotropes reveals crucial roles for androgen in gonadotropin synthesis and surge in female miceSheng Wu
Pediatrics Department S W, Y C, T F, S A D, A W, Johns Hopkins School of Medicine, Baltimore, Maryland 21286 Department of Pathology and Laboratory Medicine C C, University of Rochester Medical Center, Rochester, New York 14642 and Department of Urology and Pathology S Y, University of Rochester, Rochester, New York 14642
Mol Endocrinol 28:1670-81. 2014..Overall the pituitary AR contributes to the elaboration of the LH surge and normal reproductive function by regulating LH/FSH expression and secretion. ..
- Pubertal development and menarcheSara A DiVall
Division of Endocrinology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Ann N Y Acad Sci 1135:19-28. 2008..A multidisciplinary focus is required to elucidate the complex mechanisms involved in the initiation and progression of puberty...
- Insulin regulation of GnRH gene expression through MAP kinase signaling pathwaysHelen H Kim
University of Chicago, Department of Obstetrics and Gynecology, 5839 South Maryland Avenue MC5053, Chicago, IL 60637, USA
Mol Cell Endocrinol 242:42-9. 2005..Our studies suggest that insulin may regulate reproductive function by direct effects on the GnRH neurons and specifically by stimulating GnRH gene expression...
- The Role of Egr-1 in GnRH NeuronsSara DiVall; Fiscal Year: 2005..Protein-DNA binding studies will be performed on candidate regions of the GnRH promoter. This could define a link between nutritional status and reproductive competency at a molecular level. ..