STEPHEN V DESIDERIO

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinase.
    John Bettridge
    Proc Natl Acad Sci U S A 114:1904-1909. 2017
  2. pmc Fine mapping of V(D)J recombinase mediated rearrangements in human lymphoid malignancies
    Eitan Halper-Stromberg
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA
    BMC Genomics 14:565. 2013
  3. pmc Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk
    Theresa Tretter
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Exp Med 198:1863-73. 2003
  4. pmc NetPath: a public resource of curated signal transduction pathways
    Kumaran Kandasamy
    Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
    Genome Biol 11:R3. 2010
  5. pmc The Paf1 complex promotes displacement of histones upon rapid induction of transcription by RNA polymerase II
    Heather A Marton
    Department of Molecular Biology and Genetics and Program in Immunology, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21205, USA
    BMC Mol Biol 9:4. 2008
  6. ncbi request reprint A genome-wide analysis of the acute-phase response and its regulation by Stat3beta
    Stephen Desiderio
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 987:280-4. 2003
  7. doi request reprint Along came a spider: AID escapes a microRNA web
    Stephen Desiderio
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Immunity 28:596-8. 2008
  8. pmc A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement
    Yun Liu
    Department of Molecular Biology and Genetics, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Immunity 27:561-71. 2007
  9. ncbi request reprint Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock
    Joo Yeon Yoo
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Baltimore, MD, USA
    Cell 108:331-44. 2002
  10. pmc Innate and acquired immunity intersect in a global view of the acute-phase response
    Joo Yeon Yoo
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:1157-62. 2003

Research Grants

  1. The Acute Phase Response in Atherosclerosis
    Stephen Desiderio; Fiscal Year: 2006

Collaborators

  • Hao Jiang
  • Akhilesh Pandey
  • Ranjan Sen
  • Sonye K Danoff
  • Li Zhang
  • Heather A Marton
  • Yun Liu
  • John Bettridge
  • Joo Yeon Yoo
  • Eitan Halper-Stromberg
  • Kumaran Kandasamy
  • Ashley E Ross
  • Tanisha A Jackson
  • Chan Hyun Na
  • Theresa Tretter
  • Timothy Fuller
  • Nicolas Giraldo-Castillo
  • Jared Steranka
  • Kathleen H Burns
  • Jean Christophe Renauld
  • Hariprasad Padhukasahasram
  • Roopashree Subbaiah
  • Warren J Leonard
  • Sashi Kanth Gollapudi
  • J Daniel Navarro
  • Harrys K C Jacob
  • Y L Ramachandra
  • B Abdul Rahiman
  • Jon C D Houtman
  • Lavanya Balakrishnan
  • Yashwanth Subbannayya
  • Suresh Mathivanan
  • Renu Goel
  • Toshio Hirano
  • Chris Sander
  • Purvesh Khatri
  • Christian Pecquet
  • Jun Zhong
  • Shyam Mohan
  • Sujay Singh
  • Raja Sekhar
  • Ghantasala S Sameer Kumar
  • S Sujatha Mohan
  • Masato Kubo
  • Vishalakshi Nanjappa
  • Sorin Draghici
  • Shivakumar Keerthikumar
  • Rajesh Raju
  • Osamu Ohara
  • Deepthi Telikicherla
  • Jian Xin Lin
  • T S Keshava Prasad
  • Stefan N Constantinescu
  • Sudhir Gopal Tattikota
  • Gary D Bader
  • Abhilash K Venugopal
  • Tirtha Chakraborty
  • Ramesh Subrahmanyam
  • Harry E Taylor
  • Deva Sharma
  • Dominic I Dordai
  • Milena Vuica
  • Daniel Nathans
  • David L Huso

Detail Information

Publications16

  1. pmc H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinase.
    John Bettridge
    Proc Natl Acad Sci U S A 114:1904-1909. 2017
    ..Thus, engagement of H3K4me3 by the RAG-2 PHD is associated with dynamic conformational changes in RAG-1, consistent with allosteric control by active chromatin...
  2. pmc Fine mapping of V(D)J recombinase mediated rearrangements in human lymphoid malignancies
    Eitan Halper-Stromberg
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA
    BMC Genomics 14:565. 2013
    ..The approach obviates the need for PCR amplification of recombined sequences...
  3. pmc Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk
    Theresa Tretter
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Exp Med 198:1863-73. 2003
    ..Thus, sustained activation of Blk induces responses normally associated with the pre-BCR...
  4. pmc NetPath: a public resource of curated signal transduction pathways
    Kumaran Kandasamy
    Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
    Genome Biol 11:R3. 2010
    ..We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches...
  5. pmc The Paf1 complex promotes displacement of histones upon rapid induction of transcription by RNA polymerase II
    Heather A Marton
    Department of Molecular Biology and Genetics and Program in Immunology, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21205, USA
    BMC Mol Biol 9:4. 2008
    ..The yeast Paf1 protein complex is required for efficient transcription elongation by RNA polymerase II (RNA pol II), but the precise role of the complex has been unclear...
  6. ncbi request reprint A genome-wide analysis of the acute-phase response and its regulation by Stat3beta
    Stephen Desiderio
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 987:280-4. 2003
    ..These findings are accompanied by overexpression and hyperresponsiveness of a subset of lipopolysaccharide (LPS)-inducible genes in liver, suggesting a critical role for Stat3beta in the control of systemic inflammation...
  7. doi request reprint Along came a spider: AID escapes a microRNA web
    Stephen Desiderio
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Immunity 28:596-8. 2008
    ..2008) and Dorsett et al. (2008) report that activation-induced cytidine deaminase in B cells is repressed by microRNA-155. Relief of repression is associated with defective affinity maturation and increased Myc-Igh translocations...
  8. pmc A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement
    Yun Liu
    Department of Molecular Biology and Genetics, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Immunity 27:561-71. 2007
    ..Together, these findings are consistent with the interpretation that recognition of hypermethylated histone H3 K4 promotes efficient V(D)J recombination in vivo...
  9. ncbi request reprint Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock
    Joo Yeon Yoo
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Baltimore, MD, USA
    Cell 108:331-44. 2002
    ..The hepatic response to endotoxin in wild-type mice is accompanied by a transient increase in the ratio of Stat3beta to Stat3alpha. These findings indicate a critical role for Stat3beta in the control of systemic inflammation...
  10. pmc Innate and acquired immunity intersect in a global view of the acute-phase response
    Joo Yeon Yoo
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:1157-62. 2003
    ..Increased expression of genes for innate defense was accompanied by coordinate induction of the MHC class I antigen presentation machinery, illustrating an intersection between innate and adaptive immunity...
  11. pmc Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells
    Ashley E Ross
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Mol Cell Biol 23:5308-19. 2003
    ..These results suggest that the intrinsic RAG-2 NLS functions in the nuclear uptake of RAG-2 following its reexpression in cycling cells...
  12. ncbi request reprint Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins
    Hao Jiang
    Department of Molecular Biology and Genetics, Program in Immunology, Institute for Cell Engineering, and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 279:8478-86. 2004
    ..Intracellular SECs, which are likely to persist in the absence of coding ends, represent potential donors whose transposition is not suppressed by the non-core regions of the RAG proteins...
  13. ncbi request reprint Vascular endothelial growth factor receptor-2: counter-regulation by the transcription factors, TFII-I and TFII-IRD1
    Tanisha A Jackson
    Department of Medicine, The John Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 280:29856-63. 2005
    ..We found that TFII-I is capable of acting at both basal and regulatory sites in one promoter and that the human VEGFR-2 promoter is functionally counter-regulated by TFII-I and TFII-IRD1...
  14. ncbi request reprint Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle
    Hao Jiang
    Department of Molecular Biology and Genetics, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell 18:699-709. 2005
    ..The regulation of antigen receptor gene assembly by Skp2-SCF provides an unexpected and direct mechanistic link between DNA recombination and the cell cycle...
  15. pmc Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex
    Yun Liu
    Department of Molecular Biology and Genetics, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Adv Exp Med Biol 650:157-65. 2009
    ..This chapter will focus on those features of the recombinase itself--and in particular the RAG-2 subunit--that interact with extrinsic factors to establish patterns of temporal control and locus specificity in developing lymphocytes...
  16. doi request reprint Temporal and spatial regulatory functions of the V(D)J recombinase
    Stephen Desiderio
    Department of Molecular Biology and Genetics and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21210, United States
    Semin Immunol 22:362-9. 2010
    ....

Research Grants1

  1. The Acute Phase Response in Atherosclerosis
    Stephen Desiderio; Fiscal Year: 2006
    ..Third, we will test the hypothesis that chronic systemic inflammation promotes development of atherosclerosis by examining the influence of Stat3beta-deficiency on development of atherosclerosis in mouse models. ..