Christopher Cox

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc Genital herpes evaluation by quantitative TaqMan PCR: correlating single detection and quantity of HSV-2 DNA in cervicovaginal lavage fluids with cross-sectional and longitudinal clinical data
    Bulbulgul Aumakhan
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Virol J 7:328. 2010
  2. pmc Survival attributable to an exposure
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Stat Med 28:3276-93. 2009
  3. doi request reprint The generalized F distribution: an umbrella for parametric survival analysis
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E7642, Baltimore, MD 21205, USA
    Stat Med 27:4301-12. 2008
  4. ncbi request reprint Model-based estimation of the attributable risk in case-control and cohort studies
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, E7642, MD 21205, USA
    Stat Methods Med Res 15:611-25. 2006
  5. ncbi request reprint Parametric survival analysis and taxonomy of hazard functions for the generalized gamma distribution
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Stat Med 26:4352-74. 2007
  6. pmc Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study
    Gypsyamber D'Souza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 48:491-9. 2008
  7. pmc The differential effect of ultraviolet light exposure on cataract rate across regions of the lens
    Alison G Abraham
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Invest Ophthalmol Vis Sci 51:3919-23. 2010
  8. pmc Effect of tuberculosis on the survival of HIV-infected men in a country with low tuberculosis incidence
    Hugo Lopez-Gatell
    Directorate of Epidemiology, Ministry of Health, Mexico, Mexico
    AIDS 22:1869-73. 2008
  9. pmc Carotid intima-media thickness in children with CKD: results from the CKiD study
    Tammy M Brady
    Department of Pediatrics, Division of Pediatric Nephrology, Johns Hopkins University, Baltimore, MD 21287, USA
    Clin J Am Soc Nephrol 7:1930-7. 2012
  10. ncbi request reprint Unsafe Sexual Behavior Among Gay/Bisexual Men in the Era of Combination Antiretroviral Therapy (cART)
    Pamela J Surkan
    Social and Behavioral Intervention Program, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St, Room E5523, Baltimore, MD, 21205 2179, USA
    AIDS Behav . 2016

Detail Information

Publications44

  1. pmc Genital herpes evaluation by quantitative TaqMan PCR: correlating single detection and quantity of HSV-2 DNA in cervicovaginal lavage fluids with cross-sectional and longitudinal clinical data
    Bulbulgul Aumakhan
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Virol J 7:328. 2010
    ....
  2. pmc Survival attributable to an exposure
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Stat Med 28:3276-93. 2009
    ..We apply these methods to assess the effect of introducing highly active antiretroviral therapy for the treatment of clinical AIDS at the population level...
  3. doi request reprint The generalized F distribution: an umbrella for parametric survival analysis
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E7642, Baltimore, MD 21205, USA
    Stat Med 27:4301-12. 2008
    ..We also discuss fitting the GF with an alternative parameterization using standard statistical software and refine a description of the hazard functions for death after a diagnosis of clinical AIDS in four different eras of HIV therapy...
  4. ncbi request reprint Model-based estimation of the attributable risk in case-control and cohort studies
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, E7642, MD 21205, USA
    Stat Methods Med Res 15:611-25. 2006
    ..Examples show that for even fairly complex models, the computations are practical using standard statistical software. The bootstrap provides an easily implemented alternative to the delta method for the computation of standard errors...
  5. ncbi request reprint Parametric survival analysis and taxonomy of hazard functions for the generalized gamma distribution
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Stat Med 26:4352-74. 2007
    ..Description of standard statistical software (Stata, SAS and S-Plus) for the computations is included and available at http://statepi.jhsph.edu/software...
  6. pmc Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study
    Gypsyamber D'Souza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 48:491-9. 2008
    ..To examine the incidence and risk factors for anal cancer in a multicenter cohort of human immunodeficiency virus (HIV) positive and HIV-negative men who have sex with men followed between 1984 and 2006 (Multicenter AIDS Cohort Study)...
  7. pmc The differential effect of ultraviolet light exposure on cataract rate across regions of the lens
    Alison G Abraham
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Invest Ophthalmol Vis Sci 51:3919-23. 2010
    ..Further, it has been hypothesized that the lower nasal region of the lens is the most susceptible to damage by environmental ultraviolet light exposure...
  8. pmc Effect of tuberculosis on the survival of HIV-infected men in a country with low tuberculosis incidence
    Hugo Lopez-Gatell
    Directorate of Epidemiology, Ministry of Health, Mexico, Mexico
    AIDS 22:1869-73. 2008
    ..2-4.7). Results underscore the importance of avoiding TB by using preventive interventions such as treatment of latent TB infection, particularly in populations with a large prevalence of HIV/TB co-infected individuals...
  9. pmc Carotid intima-media thickness in children with CKD: results from the CKiD study
    Tammy M Brady
    Department of Pediatrics, Division of Pediatric Nephrology, Johns Hopkins University, Baltimore, MD 21287, USA
    Clin J Am Soc Nephrol 7:1930-7. 2012
    ..Children with CKD are known to be at increased cardiovascular risk. This study sought to identify cardiovascular risk factors associated with increased cIMT in children with CKD...
  10. ncbi request reprint Unsafe Sexual Behavior Among Gay/Bisexual Men in the Era of Combination Antiretroviral Therapy (cART)
    Pamela J Surkan
    Social and Behavioral Intervention Program, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St, Room E5523, Baltimore, MD, 21205 2179, USA
    AIDS Behav . 2016
    ..Serosorting was associated with UIAI (OR 6.11, p-value < 0.0001) and URAI (OR 6.80, p-value < 0.0001). Findings suggest that negative attitudes about HIV transmission are sustained among older men who have sex with men...
  11. pmc Cochlear function among HIV-seropositive and HIV-seronegative men and women
    Peter Torre
    1School of Speech, Language, and Hearing Sciences, San Diego State University, San Diego, CA 2Epidemiology and Statistics Program, National Institute on Deafness and Other Communication Disorders NIDCD, National Institutes of Health NIH, Bethesda, MD 3Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 4Department of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, WA, District of Columbia and 5Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD
    Ear Hear 35:56-62. 2014
    ..The aim of the present study was to collect measures of cochlear function in a large sample of adults with, or at risk for, HIV infection, to evaluate associations between HIV status, HIV treatment, and cochlear function...
  12. pmc Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatus
    Ned Sacktor
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurovirol 16:335-41. 2010
    ..Mild neurocognitive changes over time among older HIV+ individuals are likely to reflect age associated pathophysiological mechanisms including cerebrovascular risk factors...
  13. pmc Methods for characterizing differences in longitudinal glomerular filtration rate changes between children with glomerular chronic kidney disease and those with nonglomerular chronic kidney disease
    Christopher B Pierce
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Am J Epidemiol 174:604-12. 2011
    ..Generalized gamma models captured heterogeneity of effect more richly and provided a better fit to the data than did conventional lognormal models...
  14. pmc The relationship between methamphetamine and popper use and risk of HIV seroconversion in the multicenter AIDS cohort study
    Michael W Plankey
    Department of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, Washington, DC 20007, USA
    J Acquir Immune Defic Syndr 45:85-92. 2007
    ..The association between methamphetamine use and HIV seroconversion for men who have sex with men (MSM) was examined using longitudinal data from the Multicenter AIDS Cohort Study...
  15. ncbi request reprint Prospective study of attitudinal and relationship predictors of sexual risk in the multicenter AIDS cohort study
    David G Ostrow
    David Ostrow and Associates, Chicago MACS Howard Brown Health Center and Northwestern University School of Medicine, 5455 N Sheridan Rd, Suite 1207, Chicago, IL 60640, USA
    AIDS Behav 12:127-38. 2008
    ..We conclude that HIV prevention efforts should target modifiable attitudes (reduced concern about HIV and safer sex fatigue) and increases in sexual risk-taking of MSM, particularly among HIV+ men having sex with serodiscordant partners...
  16. pmc Is susceptibility to prenatal methylmercury exposure from fish consumption non-homogeneous? Tree-structured analysis for the Seychelles Child Development Study
    Li Shan Huang
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotoxicology 28:1237-44. 2007
    ..The regression tree results support previous analyses of outcomes in this cohort. However, this analysis raises the intriguing possibility that an effect may be non-homogeneous among children with different backgrounds and IQ levels...
  17. doi request reprint Consistency of initial antiretroviral therapy with HIV treatment guidelines in a US cohort of HIV-infected women
    Jennifer Cocohoba
    Department of Clinical Pharmacy, University of California San Francisco School of Pharmacy, San Francisco, CA 94143, USA
    J Acquir Immune Defic Syndr 47:377-83. 2008
    ..HIV treatment guidelines define optimal initial antiretroviral therapy (ART)...
  18. pmc Association between living with children and adherence to highly active antiretroviral therapy in the Women's Interagency HIV Study
    Daniel J Merenstein
    Georgetown University Medical Center, Department of Family Medicine, 417 Kober Cogan Hall, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    Pediatrics 121:e787-93. 2008
    ..The purpose of this work was to evaluate whether living with children adversely affects adherence to highly active antiretroviral therapy in HIV-infected women...
  19. pmc Incidence and risk factors for verrucae in women
    Jacqueline C Dolev
    University of California, San Francisco, California 94122, USA
    AIDS 22:1213-9. 2008
    ..To describe the incidence and risk factors for verrucae in HIV-infected and uninfected women...
  20. ncbi request reprint Folate-related genes and omphalocele
    James L Mills
    Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA
    Am J Med Genet A 136:8-11. 2005
    ..This variant causes reduced enzyme activity, thus suggesting a mechanism by which multivitamins with folic acid might prevent omphalocele. Additional investigation is required...
  21. pmc Association between prenatal exposure to methylmercury and visuospatial ability at 10.7 years in the seychelles child development study
    Philip W Davidson
    University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotoxicology 29:453-9. 2008
    ..04), but not when the single outlier was removed (p=0.07). In a population whose exposure to MeHg is from fish consumption, we continue to find no consistent adverse association between MeHg and visual motor coordination...
  22. ncbi request reprint Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study
    Gary J Myers
    Department of Neurology, National Institute for Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, USA
    Lancet 361:1686-92. 2003
    ..The most common form of prenatal exposure is maternal fish consumption, but whether such exposure harms the fetus is unknown. We aimed to identify adverse neurodevelopmental effects in a fish-consuming population...
  23. ncbi request reprint Methylmercury and neurodevelopment: longitudinal analysis of the Seychelles child development cohort
    Philip W Davidson
    The Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA
    Neurotoxicol Teratol 28:529-35. 2006
    ..These findings suggest that the associations observed between MeHg and developmental outcomes may vary with developmental stage...
  24. ncbi request reprint Prenatal methyl mercury exposure from fish consumption and child development: a review of evidence and perspectives from the Seychelles Child Development Study
    Philip W Davidson
    University of Rochester School of Medicine and Dentistry, USA
    Neurotoxicology 27:1106-9. 2006
    ..This suggests that the association between prenatal exposure and child development may be more complex than originally believed. This paper reviews the SCDS main cohort study results and presents our current interpretations...
  25. ncbi request reprint Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects
    Anne Parle-McDermott
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 80:463-8. 2003
    ..002; H532R, P</=0.001; V671I, P=0.006). In conclusion, common variants in the mutase gene do not appear to be risk factors for NTDs but their allele frequencies are significantly different between ethnic groups...
  26. ncbi request reprint Using measurement error models to assess effects of prenatal and postnatal methylmercury exposure in the Seychelles Child Development Study
    Li Shan Huang
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, USA
    Environ Res 93:115-22. 2003
    ..Our reanalysis indicated that adjustment for measurement errors in explanatory variables had no appreciable effect on the original results...
  27. ncbi request reprint Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia
    Bruno M Polliotti
    Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York 11713, USA
    Obstet Gynecol 101:1266-74. 2003
    ..To determine whether alterations in second-trimester maternal serum cytokine concentrations can identify women at risk for developing severe, early-onset preeclampsia...
  28. ncbi request reprint Low vitamin B-12 concentrations in patients without anemia: the effect of folic acid fortification of grain
    James L Mills
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Clin Nutr 77:1474-7. 2003
    ..It is unclear, however, what proportion of people with low vitamin B-12 concentrations do not have anemia and whether the proportion is increasing...
  29. ncbi request reprint Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects
    Anne Parle-McDermott
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    J Hum Genet 48:190-3. 2003
    ..Our findings do not support a role for the 1298A-->C polymorphism in NTDs (OR 0.85 (95% CI 0.49-1.47), p= 0.55), nor do we observe a combined effect with the 677C-->T polymorphism...
  30. pmc Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter
    Richard L Canfield
    Division of Nutritional Sciences, College of Human Ecology, Cornell University, Ithaca, NY 14853, USA
    N Engl J Med 348:1517-26. 2003
    ..483 micromol per liter), little is known about children's neurobehavioral functioning at lead concentrations below this level...
  31. ncbi request reprint Use of thrombolytic therapy for acute myocardial infarction: effects of gender and age on treatment rates
    Karen L Kaplan
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Thromb Thrombolysis 13:21-6. 2002
    ..This study was undertaken to determine the relative rates of treatment of women vs. men and the elderly vs. younger subjects and to examine factors that might explain differences in treatment frequency...
  32. ncbi request reprint Depressive disorders and symptoms in older primary care patients: one-year outcomes
    Jeffrey M Lyness
    Laboratory of Depression and Medical Comorbidity, Program in Geriatrics and Neuropsychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Geriatr Psychiatry 10:275-82. 2002
    ..Depressive conditions had considerable rates of persistence, yet the outcome was not uniformly poor. Longer-term naturalistic study is needed, as are treatment studies targeting those at highest risk of recurrence or chronicity...
  33. ncbi request reprint Long-term mortality in the United States cohort of pituitary-derived growth hormone recipients
    James L Mills
    National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, 6100 Building Room 7B03, Bethesda, MD 20892, USA
    J Pediatr 144:430-6. 2004
    ..We investigated whether they were at increased risk of death from other conditions, particularly preventable conditions...
  34. ncbi request reprint Follow-up to Farm Family Health and Hazard Survey
    William S Beckett
    J Occup Environ Med 46:314-5. 2004
  35. ncbi request reprint Social support, depression, and functional disability in older adult primary-care patients
    Linda A Travis
    Laboratory of Depression and Medical Comorbidity, Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Geriatr Psychiatry 12:265-71. 2004
    ..The authors asked whether social support and depression are independently associated with functional disability and examined the potential role of social support as a moderator in the depression-functional disability association...
  36. ncbi request reprint Prospective identification of pregnant women drinking four or more standard drinks (> or = 48 g) of alcohol per day
    Sofia Aros
    Department of Pediatrics, School of Medicine, University of Chile, San Borja Arriaran Clinical Hospital, Santiago, Chile
    Subst Use Misuse 41:183-97. 2006
    ..We identified specific interview questions that may help screen for alcohol use of 48 g/day or more in pregnant women...
  37. ncbi request reprint Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery
    Anne M Molloy
    Department of Clinical Medicine and the National Human Genome Research Institute, The National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 82:836-42. 2005
    ..Choline, via betaine, is an important folate-independent source of methyl groups for remethylating homocysteine in liver...
  38. ncbi request reprint Screening for new MTHFR polymorphisms and NTD risk
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet A 138:99-106. 2005
    ..This is the first NTD association study of both R594Q and the novel P39P. The association with NTD risk reported for these SNPs is driven by the linkage disequilibrium with the A222V (677C->T) NTD risk factor...
  39. ncbi request reprint Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 85:220-7. 2005
    ..The frequencies of I22M and K350R differed significantly between the two groups (p = 0.0005 and p = 0.0001, respectively). Our findings do not support an important role for these MTRR variants in NTDs...
  40. ncbi request reprint Respiratory syncytial virus infection in elderly and high-risk adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    N Engl J Med 352:1749-59. 2005
    ..Data on the epidemiology and clinical effects in community-dwelling elderly persons and high-risk adults can help in assessing the need for vaccine development...
  41. ncbi request reprint Exploring nonlinear association between prenatal methylmercury exposure from fish consumption and child development: evaluation of the Seychelles Child Development Study nine-year data using semiparametric additive models
    Li Shan Huang
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Environ Res 97:100-8. 2005
    ..We conclude that this reanalysis supports the primary linear analysis, showing little evidence for a prenatal adverse effect...
  42. ncbi request reprint Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles
    Anthony P Pietropaoli
    Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Inhal Toxicol 16:59-72. 2004
    ..Additional studies are required to confirm these findings in normal subjects, compare them with additional susceptible patient populations, and determine their pathophysiologic mechanisms...
  43. ncbi request reprint Prenatal exposure to methylmercury and child development: influence of social factors
    Philip W Davidson
    Strong Center for Developmental Disabilities, Department of Pediatrics, Box 671, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurotoxicol Teratol 26:553-9. 2004
    ..We performed a similar analysis of the 66-month evaluations to determine if the modifying influences of social and environmental factors were consistent with those previously observed...
  44. ncbi request reprint Impaired decision-making ability in subjects with Alzheimer's disease and willingness to participate in research
    Scott Y H Kim
    Department of Psychiatry, University of Rochester School of Medicne and Dentistry, NY 14642, USA
    Am J Psychiatry 159:797-802. 2002
    ..The authors examined the effects of cognitive and decisional impairment on willingness to participate in research among persons with Alzheimer's disease...