Richard A Cone
Affiliation: Johns Hopkins University
- Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouseThomas R Moench
ReProtect, Inc, Baltimore, MD 21286 USA
BMC Infect Dis 10:331. 2010..However, excipients have not previously been tested in susceptibility models...
- Barrier properties of mucusRichard A Cone
Biophysics Department, Johns Hopkins University, and ReProtect, Inc, Baltimore MD, USA
Adv Drug Deliv Rev 61:75-85. 2009..These viruses are smaller than the mucus mesh spacing, and have surfaces that do not stick to mucus. They form a useful model for developing NP for mucosal drug delivery...
- Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmissionRichard A Cone
Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Infect Dis 6:90. 2006....
- Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse modelStuart S Olmsted
Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Infect Dis 5:79. 2005....
- Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiotaDeirdre E O'Hanlon
Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 8:e80074. 2013....
- Human monoclonal antibody stability and activity at vaginal pHPhilip E Castle
Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
J Reprod Immunol 56:61-76. 2002..Taken together, our data and empirical calculations suggest that vaginally applied human MAbs are likely to remain stable and active throughout the duration they are likely to reside in the vagina...
- Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatisSharon L Achilles
The Johns Hopkins University, Baltimore, Maryland, USA
Sex Transm Dis 29:655-64. 2002..Microbicides are being developed for woman-controlled protection against sexually transmitted diseases (STDs)...
- Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccinesKevin J Whaley
Mapp Biopharmaceutical, Inc, San Diego, CA 92121, USA
Antiviral Res 88:S55-66. 2010..This article forms part of a special supplement covering several presentations on novel microbicide formulations from the symposium on "Recent Trends in Microbicide Formulations" held on 25 and 26 January 2010, Arlington, VA...
- Enhanced vaginal drug delivery through the use of hypotonic formulations that induce fluid uptakeLaura M Ensign
Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21231, USA
Biomaterials 34:6922-9. 2013..Hypotonic formulations for vaginal drug delivery via MPP may significantly improve prevention and treatment of reproductive tract diseases and disorders...
- Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivoQingguo Xu
Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA
J Control Release 167:76-84. 2013..These findings will help guide the development of nanoparticle-based therapeutics for the treatment of vision-threatening ocular diseases...
- Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilliDeirdre E O'Hanlon
Mucosal Protection Laboratory, Thomas C, Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Infect Dis 10:120. 2010..However, cervicovaginal fluid (CVF) and semen have significant H2O2-blocking activity...
- In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxideDeirdre E O'Hanlon
Mucosal Protection Laboratory, Thomas C Jenkins Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
BMC Infect Dis 11:200. 2011..Here we used conditions more like those in vivo to compare the effects of physiologically plausible concentrations of H2O2 and lactic acid on a broad range of BV-associated bacteria and vaginal lactobacilli...
- Rapid fluctuation of the vaginal microbiota measured by Gram stain analysisRebecca M Brotman
Department of Epidemiology and Preventive Medicine, Institute for Genome Sciences, University of Maryland School of Medicine, BioPark Building II, 801 West Baltimore Street, Baltimore, MD 21201, USA
Sex Transm Infect 86:297-302. 2010..The aetiology of bacterial vaginosis (BV) remains unknown...
- Diffusion of Immunoglobulin G in Shed Vaginal Epithelial Cells and in Cell-Free Regions of Human Cervicovaginal MucusYing Ying Wang
Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 11:e0158338. 2016....
- Evaluation of microbicide gel adherence monitoring methodsThomas R Moench
ReProtect, Inc, Baltimore, MD, USA
Sex Transm Dis 39:335-40. 2012....
- Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agentKristen V Khanna
Johns Hopkins School of Hygiene and Public Health, Department of Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Clin Invest 109:205-11. 2002....
- A self-sampling method to obtain large volumes of undiluted cervicovaginal secretionsElizabeth R Boskey
Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA
Sex Transm Dis 30:107-9. 2003..A convenient method for self-sampling these secretions outside a clinical setting can facilitate such studies of reproductive health...