M A Carducci

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer
    Michael A Carducci
    Division of Medical Oncology, Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA
    J Clin Oncol 24:4092-9. 2006
  2. ncbi request reprint Targeting bone metastasis in prostate cancer with endothelin receptor antagonists
    Michael A Carducci
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    Clin Cancer Res 12:6296s-6300s. 2006
  3. pmc Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours
    Wells A Messersmith
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting Blaustein Cancer Research Building, CRB 1M88, 1650 Orleans Street, Baltimore, MD 21231, USA
    Eur J Cancer 43:78-86. 2007
  4. pmc Removing barriers to participation in clinical trials, a conceptual framework and retrospective chart review study
    Norma F Kanarek
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Trials 13:237. 2012
  5. pmc Phase I study of enzastaurin and bevacizumab in patients with advanced cancer: safety, efficacy and pharmacokinetics
    Nwabundo Nwankwo
    Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Invest New Drugs 31:653-60. 2013
  6. pmc Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence
    Shabana Shabbeer
    Prostate Cancer Program, 1650 Orleans Street Room 1M59, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231
    Cancer Prev Res (Phila) 5:229-39. 2012
  7. pmc A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899
    Robert S DiPaola
    Department of Medicine, The Cancer Institute of New Jersey, UMDNJ RWJMS, New Brunswick NJ, USA
    J Transl Med 8:20. 2010
  8. pmc A phase I study of OSI-461 in combination with mitoxantrone in patients with advanced solid tumors potentially responsive to mitoxantrone
    Lee P Resta
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB1 1M59, Baltimore, MD 21231, USA
    Cancer Chemother Pharmacol 67:431-8. 2011
  9. ncbi request reprint A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer
    Michael A Carducci
    Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Cancer 110:1959-66. 2007
  10. ncbi request reprint Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: safety and pharmacokinetics
    Michael A Carducci
    Division of Medical Oncology, The Johns Hopkins Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Oncol 20:2171-80. 2002

Detail Information

Publications128 found, 100 shown here

  1. ncbi request reprint Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer
    Michael A Carducci
    Division of Medical Oncology, Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA
    J Clin Oncol 24:4092-9. 2006
    ..Secondary objectives were maximum-tolerated dose (MTD), pharmacokinetics (PK), toxicity, and response...
  2. ncbi request reprint Targeting bone metastasis in prostate cancer with endothelin receptor antagonists
    Michael A Carducci
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    Clin Cancer Res 12:6296s-6300s. 2006
    ..Further studies of atrasentan and other selective ET-1 antagonists (ZD4054) are ongoing...
  3. pmc Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours
    Wells A Messersmith
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting Blaustein Cancer Research Building, CRB 1M88, 1650 Orleans Street, Baltimore, MD 21231, USA
    Eur J Cancer 43:78-86. 2007
    ..A long half-life and accumulation of BPU and active metabolites were observed, recommending against a continuous administration. Weekly oral BPU therapy should be further tested using an interrupted schedule...
  4. pmc Removing barriers to participation in clinical trials, a conceptual framework and retrospective chart review study
    Norma F Kanarek
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Trials 13:237. 2012
    ..Enrollment in interventional therapeutic clinical trials is a small fraction of all patients who might participate given reasonable access...
  5. pmc Phase I study of enzastaurin and bevacizumab in patients with advanced cancer: safety, efficacy and pharmacokinetics
    Nwabundo Nwankwo
    Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Invest New Drugs 31:653-60. 2013
    ..Given distinct mechanism of actions of enzastaurin and bevacizumab, preclinical studies suggest enhanced antitumor activity in combination. This phase I study assessed the combination's safety and efficacy...
  6. pmc Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence
    Shabana Shabbeer
    Prostate Cancer Program, 1650 Orleans Street Room 1M59, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231
    Cancer Prev Res (Phila) 5:229-39. 2012
    ..When fed before the onset of cancer, that is, in utero, excess methyl donors can have a protective effect on the progression of cancer. Cancer Prev Res; 5(2); 229-39. ©2011 AACR...
  7. pmc A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899
    Robert S DiPaola
    Department of Medicine, The Cancer Institute of New Jersey, UMDNJ RWJMS, New Brunswick NJ, USA
    J Transl Med 8:20. 2010
    ....
  8. pmc A phase I study of OSI-461 in combination with mitoxantrone in patients with advanced solid tumors potentially responsive to mitoxantrone
    Lee P Resta
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB1 1M59, Baltimore, MD 21231, USA
    Cancer Chemother Pharmacol 67:431-8. 2011
    ..To find the maximum tolerated dose (MTD) of OSI-461 in combination with mitoxantrone in patients with advanced solid tumors...
  9. ncbi request reprint A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer
    Michael A Carducci
    Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Cancer 110:1959-66. 2007
    ..The objective of this study was to evaluate the efficacy and safety of atrasentan (Xinlay), a selective endothelin-A receptor antagonist, in patients with metastatic hormone-refractory prostate cancer (HRPC)...
  10. ncbi request reprint Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: safety and pharmacokinetics
    Michael A Carducci
    Division of Medical Oncology, The Johns Hopkins Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Oncol 20:2171-80. 2002
    ..Atrasentan, an endothelin antagonist, binds selectively to the ET(A) receptor. This study evaluated the safety, pharmacokinetics, and maximum-tolerated dose of atrasentan in cancer patients...
  11. ncbi request reprint Multidisciplinary management of advanced prostate cancer: changing perspectives on referring patients and enhancing collaboration between oncologists and urologists in clinical trials
    Michael A Carducci
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, Maryland 21231 1000, USA
    Urology 65:18-22; discussion 22. 2005
    ..Patients with high-risk recurrent or metastatic disease should be informed of clinical trials for which they may be eligible...
  12. ncbi request reprint A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule
    M A Carducci
    Division of Medical Oncology, The Johns Hopkins Oncology Center, 1 M88 Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA
    Clin Cancer Res 7:3047-55. 2001
    ..We conducted a Phase I and pharmacokinetic study of PB by continuous infusion to characterize the maximum tolerated dose, toxicities, pharmacokinetics, and antitumor effects in patients with refractory solid tumors...
  13. ncbi request reprint A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies
    J Gilbert
    Division of Medical Oncology, Department of Oncology, The Johns Hopkins University School of Medicine, 1 M88 Bunting-Blaustein Cancer Research Building, 2650 Orleans Street, Baltimore, MD 21231-1000, USA
    Clin Cancer Res 7:2292-300. 2001
    ..PB may have a role as a cytostatic agent and should be additionally explored in combination with cytotoxics and other novel drugs...
  14. ncbi request reprint Novel therapeutic approaches to advanced prostate cancer
    Andrew J Armstrong
    Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Clin Adv Hematol Oncol 3:271-82. 2005
    ..Clinical advances in meaningful endpoints such as survival and quality of life are eagerly awaited in large-scale trials of active and rationally designed agents...
  15. ncbi request reprint A phase II study of pomegranate extract for men with rising prostate-specific antigen following primary therapy
    M A Carducci
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD Advanced Clinical, Bannockburn, IL Urological Associates of Lancaster, Lancaster, PA South Orange County Medical Research Center, Laguna Hills, CA Lakeside Urology, St Joseph, MI The Urology Group, Cincinnati, OH Urology Enterprises, Marietta, GA University of California, Los Angeles, Beverly Hills, CA Johns Hopkins University, Baltimore, MD
    J Clin Oncol 29:11. 2011
    ..We sought to determine the effects of low (1 gram) or high (3 grams) daily POMx on PSADT in a similar but broader population of men seeking to defer androgen deprivation therapy...
  16. ncbi request reprint Endothelin receptor antagonists in the treatment of prostate cancer
    Lance K Lassiter
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA
    Semin Oncol 30:678-88. 2003
    ....
  17. ncbi request reprint The role of angiotensin system inhibitors (ASIs) in the outcome of sunitinib treatment (tx) in patients (pts) with metastatic renal cell carcinoma (mRCC)
    J J Kim
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD Johns Hopkins Medical Institutions, Baltimore, MD Roswell Park Cancer Institute, Buffalo, NY The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD
    J Clin Oncol 29:e15008. 2011
    ..Pre-clinical and clinical studies in several cancer types have shown that they may inhibit tumor growth. Their effect on the outcome of sunitinib in mRCC is poorly defined...
  18. ncbi request reprint PSA doubling time (PSADT) and serum testosterone (T) during intermittent androgen deprivation (IAD) in patients with biochemically relapsed prostate cancer (BRCP; M0): Potential predictive implications
    V J Sinibaldi
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD Johns Hopkins Medical Institutions, Baltimore, MD
    J Clin Oncol 29:e15006. 2011
    ..e15006 Background: The systemic management of patients with BRPC remains controversial. IAD is commonly employed...
  19. ncbi request reprint Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate
    M A Carducci
    The Johns Hopkins Oncology Center and The Brady Urological Institute, Baltimore, Maryland 21205, USA
    Clin Cancer Res 2:379-87. 1996
    ..These results demonstrate that PB induces cytotoxicity via apoptosis in human prostate cancer, in addition to its differentiating properties...
  20. ncbi request reprint Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: elevation of estradiol as possible mechanism of action
    Mario A Eisenberger
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 1000, USA
    Urology 63:114-9. 2004
    ..To study the safety, pharmacokinetics, biologic activity, and preliminary efficacy of the bispecific 5-alpha-reductase inhibitor (LY320236) in prostate cancer...
  21. ncbi request reprint Safety and efficacy of ketoconazole (K) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Contemporary experience and prognostic indicators
    M A Eisenberger
    Johns Hopkins Medical Institutions, Baltimore, MD Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD
    J Clin Oncol 29:e15007. 2011
    ..e15007 Background: Intracrine conversion of adrenal androgens to testosterone play an important role in CRPC progression. Treatments (tx) that block adrenal steroid synthesis have shown significant clinical benefits in mCRPC...
  22. ncbi request reprint Effect of angiotenstin system inhibitors (ASIs) on the outcome of sunitinib treatment (tx) in patients (pts) with metastatic renal cell carcinoma (mRCC)
    D Keizman
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD Roswell Park Cancer Institute, Buffalo, NY Johns Hopkins University, Baltimore, MD
    J Clin Oncol 29:317. 2011
    ..Preclinical and clinical studies in several cancer types have shown that they may inhibit tumor growth. Their effect on the outcome of sunitinib in mRCC is poorly defined...
  23. ncbi request reprint PSA doubling time (PSADT) and serum testosterone (T) during intermittent androgen deprivation (IAD) in patients with biochemically relapsed prostate cancer (BRCP; M0): Potential predictive implications
    D Keizman
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD
    J Clin Oncol 29:150. 2011
    ..150 Background: The systemic management of patients with BRPC remains controversial. IAD is commonly employed...
  24. pmc Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours
    R Pili
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB1 Room 1M52, Baltimore, MD 21231, USA
    Br J Cancer 106:77-84. 2012
    ....
  25. ncbi request reprint Phase 3 randomized trial evaluating second-line hormonal therapy versus docetaxel-estramustine combination chemotherapy on progression-free survival in asymptomatic patients with a rising prostate-specific antigen level after hormonal therapy for prostate
    Janet R Walczak
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    Urology 62:141-6. 2003
    ....
  26. ncbi request reprint Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentan
    Joel B Nelson
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Urol 169:1143-9. 2003
    ..We examined the effects of atrasentan (endothelin-A receptor antagonist) on bone deposition and resorption markers and on bone scan index...
  27. ncbi request reprint Phase II study of imatinib mesylate in patients with prostate cancer with evidence of biochemical relapse after definitive radical retropubic prostatectomy or radiotherapy
    Gopal K Bajaj
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Urology 69:526-31. 2007
    ..This Phase II study was undertaken to determine the safety and efficacy of imatinib mesylate in men with biochemical relapse of nonmetastatic, androgen-sensitive prostate cancer after local therapy...
  28. ncbi request reprint Costs of treatments for local/regional prostate cancer
    C F Snyder
    Johns Hopkins School of Medicine, Baltimore, Md Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Dana Farber Cancer Institute, Boston, MA Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    J Clin Oncol 27:6527. 2009
    ..6527 Background: Men with prostate cancer have a variety of treatment options, including surgery, radiation, hormonal therapy, combinations thereof, or active surveillance. Treatment choice may have important cost implications...
  29. ncbi request reprint Phase I trial of the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced solid tumors
    E I Heath
    Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
    Cancer Chemother Pharmacol 48:269-74. 2001
    ..The purpose of this trial was to define the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), safety profile, pharmacokinetics and pharmacodynamics of orally administered BAY12-9566 in patients with incurable solid tumors...
  30. ncbi request reprint Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer
    J W Simons
    Johns Hopkins Oncology Center, Brady Urological Institute, and Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 59:5160-8. 1999
    ..No antibodies against prostate-specific antigen were detected. These data suggest that both T-cell and B-cell immune responses to human PCA can be generated by treatment with irradiated, GM-CSF gene-transduced PCA vaccines...
  31. ncbi request reprint Prostate cancer: a practical approach to current management of recurrent disease
    Janet R Walczak
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans St, Baltimore, MD 21231, USA
    Mayo Clin Proc 82:243-9. 2007
    ....
  32. ncbi request reprint Pharmacotherapy of hormone refractory prostate cancer: new developments and challenges
    Eli Rosenbaum
    Division of Medical Oncology, Room 1M 89, Cancer Research Building, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street Baltimore, Maryland 21231, MD 410 502 9746, USA
    Expert Opin Pharmacother 4:875-87. 2003
    ....
  33. ncbi request reprint New drugs in prostate cancer
    Andrew J Armstrong
    Prostate Cancer Research Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Curr Opin Urol 16:138-45. 2006
    ....
  34. ncbi request reprint Early use of chemotherapy in conjunction with radical prostatectomy
    Joshi J Alumkal
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231 1000, USA
    Clin Prostate Cancer 3:144-9. 2004
    ..Although data for this study are not yet mature, these differences in clinical trial design make such studies in adjuvant chemotherapy for patients with high-risk prostate cancer novel and promising...
  35. pmc Phase II, randomized, placebo-controlled trial of neoadjuvant celecoxib in men with clinically localized prostate cancer: evaluation of drug-specific biomarkers
    Emmanuel S Antonarakis
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Clin Oncol 27:4986-93. 2009
    ..We conducted a randomized, double-blind trial to examine the effect of celecoxib on drug-specific biomarkers from prostate tissue obtained at prostatectomy...
  36. ncbi request reprint Phase I trial with a combination of docetaxel and 153Sm- EDTMP in patients (pts) with castration-resistant metastatic prostate cancer (mCRPC)
    M A Eisenberger
    The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
    J Clin Oncol 27:5155. 2009
    ..This study was designed to evaluate toxicity and preliminary efficacy of 2 cycles (12 wks/cycle, C) of concomitant standard dose/schedule of Sm plus Q3 wks schedule of Tax in mCRPC...
  37. ncbi request reprint Safety and efficacy of ketoconazole (K) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Contemporary experience and prognostic indicators
    D Keizman
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD
    J Clin Oncol 29:145. 2011
    ..145 Background: Intracrine conversion of adrenal androgens to testosterone play an important role in CRPC progression. Treatments (tx) that block adrenal steroid synthesis have shown significant clinical benefits in mCRPC...
  38. ncbi request reprint Lipoprotein profile in men with prostate cancer undergoing androgen deprivation therapy
    M Braga-Basaria
    Department of Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
    Int J Impot Res 18:494-8. 2006
    ..Long-term prospective studies are needed to determine the time of onset of changes in these lipoproteins while on ADT and the influence of these changes on cardiovascular mortality...
  39. ncbi request reprint Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy
    Milena Braga-Basaria
    Department of Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
    J Clin Oncol 24:3979-83. 2006
    ..Because male hypogonadism is a risk factor for metabolic syndrome and men with PCa have high cardiovascular mortality, we evaluated the prevalence of metabolic syndrome in men undergoing long-term ADT...
  40. pmc Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor
    Sushant K Kachhap
    Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e11208. 2010
    ..The mechanism behind this downregulation remains unclear. Here we provide evidence that several DNA repair genes are downregulated by HDAC inhibition and provide a mechanism involving the E2F1 transcription factor in the process...
  41. ncbi request reprint Sequence-dependent antitumor effects of differentiation agents in combination with cell cycle-dependent cytotoxic drugs
    Henk M W Verheul
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Cancer Research Building, 1M52, Baltimore, MD 21231, USA
    Cancer Chemother Pharmacol 60:329-39. 2007
    ..In this report we explored the hypotheses that these "cytostatic" agents may have a greater antitumor activity in combination with "cytotoxic" compounds and their biological effect may be sequence-dependent...
  42. pmc Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors
    Antonio Jimeno
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Cancer Research Building I, Baltimore, MD, USA
    Cancer Chemother Pharmacol 61:423-33. 2008
    ....
  43. pmc The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin
    Sushant K Kachhap
    Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 2:e844. 2007
    ..This novel finding of NDRG1 as a recycling protein involved with recycling of E-cadherin will aid in understanding NDRG1 role as a metastasis suppressor protein...
  44. pmc The natural history of men treated with deferred androgen deprivation therapy in whom metastatic prostate cancer developed following radical prostatectomy
    Danil V Makarov
    James Buchanan Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 179:156-61; discussion 161-2. 2008
    ....
  45. doi request reprint Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity
    Charles M Rudin
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, David H Koch Cancer Research Building, Room 544, 1550 Orleans St, Baltimore, MD 21231, USA
    J Clin Oncol 26:1119-27. 2008
    ..To assess the pharmacogenomic and pharmacokinetic determinants of skin rash and diarrhea, the two primary dose-limiting toxicities of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib...
  46. pmc Novel targeted therapeutics for metastatic castration-resistant prostate cancer
    Emmanuel S Antonarakis
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, United States
    Cancer Lett 291:1-13. 2010
    ....
  47. pmc A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors
    Jianqing Lin
    Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Clin Cancer Res 15:6241-9. 2009
    ..The pharmacokinetics, pharmacodynamics, and antineoplastic effects were also studied...
  48. pmc Combining low-dose cyclophosphamide with GM-CSF-secreting prostate cancer immunotherapy enhances antitumor immune effects
    Emmanuel S Antonarakis
    Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, CRB1 191, Baltimore, MD 21231, USA
    Expert Opin Investig Drugs 19:311-4. 2010
    ..These studies provide a rationale for designing clinical trials that combine low-dose cyclophosphamide with GM-CSF-secreting cell-based immunotherapy in patients with prostate and other cancers...
  49. ncbi request reprint Phase II evaluation of docetaxel plus exisulind in patients with androgen independent prostate carcinoma
    Victoria J Sinibaldi
    Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Am J Clin Oncol 29:395-8. 2006
    ....
  50. ncbi request reprint Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies
    Michelle A Rudek
    Division of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    J Clin Oncol 23:3906-11. 2005
    ..To characterize the pharmacokinetic behavior of 5-azacitidine (5-AC), a cytidine nucleoside analog, when given with phenylbutyrate, a histone deaceytlase inhibitor...
  51. ncbi request reprint Phase II evaluation of docetaxel plus one-day oral estramustine phosphate in the treatment of patients with androgen independent prostate carcinoma
    Victoria J Sinibaldi
    Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer 94:1457-65. 2002
    ..To preserve the therapeutic synergism between docetaxel and EMP, they designed a regimen employing higher doses of oral EMP administered on the day of the docetaxel infusion...
  52. ncbi request reprint Differentiation therapy
    Alexander I Spira
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB Room 1M89, Baltimore, MD 21231, USA
    Curr Opin Pharmacol 3:338-43. 2003
    ..Many agents have been studied over the past few years, with many already either in use clinically or showing future promise...
  53. ncbi request reprint Chemotherapy for advanced prostate cancer: results of new clinical trials and future studies
    Andrew J Armstrong
    Prostate Cancer Research Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, CRB 1M88, 1650 Orleans Street, Baltimore, MD 21231, USA
    Curr Oncol Rep 7:220-7. 2005
    ..The role of chemotherapy for advanced disease in the neoadjuvant or adjuvant setting, in biochemically (PSA) relapsed patients, and as second-line therapy for relapsed disease, remains a subject of active clinical investigation...
  54. ncbi request reprint The design of a randomized, placebo-controlled trial of celecoxib in preprostatectomy men with clinically localized adenocarcinoma of the prostate
    Elisabeth I Heath
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Clin Prostate Cancer 1:182-7. 2002
  55. ncbi request reprint Phase I study of docosahexaenoic acid-paclitaxel: a taxane-fatty acid conjugate with a unique pharmacology and toxicity profile
    Antonio C Wolff
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21230 1000, USA
    Clin Cancer Res 9:3589-97. 2003
    ..This Phase I trial examined its toxicity and pharmacokinetics (PKs)...
  56. ncbi request reprint Marimastat in the treatment of patients with biochemically relapsed prostate cancer: a prospective randomized, double-blind, phase I/II trial
    Eli Rosenbaum
    Department of Radiation Oncology and Molecular Sciences, Division of Medical Oncology and Biostatistics and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Clin Cancer Res 11:4437-43. 2005
    ..To evaluate the safety and biological activity of three different doses of marimastat given for 6 months to patients with biochemically relapsed prostate cancer...
  57. ncbi request reprint Simultaneous analysis of docetaxel and the formulation vehicle polysorbate 80 in human plasma by liquid chromatography/tandem mass spectrometry
    Sharyn D Baker
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Anal Biochem 324:276-84. 2004
    ....
  58. ncbi request reprint Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: a randomized, phase II, placebo-controlled trial
    Michael A Carducci
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD
    J Clin Oncol 21:679-89. 2003
    ..To evaluate the efficacy and safety of atrasentan (ABT-627), an endothelin-A receptor antagonist, in the treatment of asymptomatic, hormone-refractory prostatic adenocarcinoma...
  59. ncbi request reprint Factors affecting cytochrome P-450 3A activity in cancer patients
    Sharyn D Baker
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    Clin Cancer Res 10:8341-50. 2004
    ..The purpose is to identify the demographic, physiologic, and inheritable factors that influence CYP3A activity in cancer patients...
  60. ncbi request reprint Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy
    Shehzad Basaria
    Department of Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, and National Institut on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cancer 106:581-8. 2006
    ....
  61. ncbi request reprint Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors
    Wells A Messersmith
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:1270-5. 2006
    ..Preclinical studies have shown synergy between bortezomib and taxanes. We conducted a phase I study combining bortezomib and docetaxel in refractory solid tumor patients...
  62. ncbi request reprint Comparative pharmacokinetics of weekly and every-three-weeks docetaxel
    Sharyn D Baker
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    Clin Cancer Res 10:1976-83. 2004
    ..The comparative pharmacokinetics of docetaxel during weekly and once every 3 weeks (3-weekly) administration schedules were evaluated...
  63. ncbi request reprint A phase I and pharmacokinetic study of short infusions of UCN-01 in patients with refractory solid tumors
    E Claire Dees
    Division of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Baltimore, MD 21231, USA
    Clin Cancer Res 11:664-71. 2005
  64. pmc Future directions in castrate-resistant prostate cancer therapy
    Emmanuel S Antonarakis
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Clin Genitourin Cancer 8:37-46. 2010
    ..The future of CRPC therapy appears brighter than ever before...
  65. ncbi request reprint Association of PTEN loss with outcome of patients (pts) with early high-risk prostate cancer (CaP) treated with adjuvant docetaxel following radical prostatectomy (RP)
    D Keizman
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD James Buchanan Brady Urological Institute, Baltimore, MD Johns Hopkins University School of Medicine, Baltimore, MD Rabin Medical Center, Petah Tikva, Israel
    J Clin Oncol 29:43. 2011
    ..We examined the PTEN status of primary tumors in pts who underwent adjuvant docetaxel tx in a prospective clinical trial...
  66. ncbi request reprint The effect of PSA doubling time (PSADT) and Gleason score on the PSA at the time of initial metastasis in men with biochemical recurrence after prostatectomy
    E S Antonarakis
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD
    J Clin Oncol 29:16. 2011
    ..Here, we describe the PSA at metastasis for those patients who developed metastatic disease...
  67. ncbi request reprint A randomized double blind phase I-II study to determine the tolerability/efficacy of two different doses of lenalidomide (L), CC- 5013, in biochemically relapsed (BR) prostate cancer (PC) patients (pts) (M0) after local treatment (LT)
    V J Sinibaldi
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
    J Clin Oncol 27:5130. 2009
    ..5130 Background: BR following LT is common in PC with no defined standard treatment. Lenalidomide (L) is an immunomodulatory agent with anti-angiogenic and direct antitumor effects...
  68. ncbi request reprint A noncomparative randomized phase II study of two dose levels of itraconazole in men with metastatic castration-resistant prostate cancer (mCRPC): A DOD/PCCTC trial
    E S Antonarakis
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD Karmanos Cancer Institute, Detroit, MI University of Michigan, Ann Arbor, MI Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY The Johns Hopkins University School of Medicine, Baltimore, MD Memorial Sloan Kettering Cancer Center, New York, NY Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD
    J Clin Oncol 29:4532. 2011
    ..4532 Background: The antifungal drug itraconazole inhibits angiogenesis and Hedgehog signaling, and delays tumor growth in murine prostate cancer xenograft models. Unlike ketoconazole, it does not suppress adrenal androgen synthesis...
  69. ncbi request reprint The association of pretreatment (pre-tx) neutrophil to lymphocyte ratio (NLR) with outcome of sunitinib tx in patients (pts) with metastatic renal cell carcinoma (mRCC)
    P Huang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD Johns Hopkins Medical Institutions, Baltimore, MD Roswell Park Cancer Institute, Buffalo, NY The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD
    J Clin Oncol 29:4621. 2011
    ..The NLR, an index of systemic inflammation, is associated with recurrence of non mRCC and poor prognosis in several types of cancer. We set out to assess the association between pre-tx NLR and outcome of sunitinib tx in pts with mRCC...
  70. ncbi request reprint E3803: Updated results on phase II study of a weekly schedule of BMS-247550 for patients with castrate refractory prostate cancer (CRPC)
    G Wilding
    University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI Dana Farber Cancer Institiute, Boston, MA Cancer Institute of New Jersey, New Brunswick, NJ Johns Hopkins Kimmel Cancer Center, Baltimore, MD
    J Clin Oncol 26:5070. 2008
    ..Ixabepilone has been administered using an every 3 week schedule with significant neutropenia observed. Here we assess the activity and toxicity of ixabepilone, administered using a weekly schedule, in men with CRPC...
  71. ncbi request reprint Quality of care for comorbid conditions during the transition to survivorship
    C F Snyder
    The Johns Hopkins University School of Medicine, Baltimore, MD Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD Dana Farber Cancer Institute, Boston, MA The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    J Clin Oncol 29:9004. 2011
    ..non-cancer controls. In this study, we expand on that research and assess the quality of chronic and acute comorbid condition care for cancer survivors vs...
  72. pmc Serial blood-based analysis of AR-V7 in men with advanced prostate cancer
    M Nakazawa
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, USA
    Ann Oncol 26:1859-65. 2015
    ..Here, we conducted serial measurements of AR-V7 and evaluated patterns of longitudinal AR-V7 dynamics over the course of multiple sequential therapies...
  73. ncbi request reprint Combination of phenylbutyrate and 13-cis retinoic acid inhibits prostate tumor growth and angiogenesis
    R Pili
    The Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Cancer Res 61:1477-85. 2001
    ..004 versus single agents). In summary, this study showed an additive inhibitory effect of combination of differentiation agents PB and CRA on prostate tumor growth through a direct effect on both tumor and endothelial cells...
  74. pmc A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias
    K W Pratz
    Division of Hematologic Malignancies, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Leukemia 24:1437-44. 2010
    ..Although sorafenib showed only modest clinical activity as a single agent in this heavily treated population, robust inhibition of FLT3 and ERK suggests that there may be a potential important role in combination therapies...
  75. pmc Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer
    M T Schweizer
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Prostate Cancer Prostatic Dis 16:357-61. 2013
    ..Although many mechanisms for its anticancer activity have been proposed, tumor suppressor gene re-expression through promoter demethylation emerged as one of the more plausible...
  76. ncbi request reprint Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors
    S D Gore
    The Johns Hopkins Oncology Center, Room 288, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Expert Opin Investig Drugs 9:2923-34. 2000
    ....
  77. pmc Fenugreek: a naturally occurring edible spice as an anticancer agent
    Shabana Shabbeer
    Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA
    Cancer Biol Ther 8:272-8. 2009
    ..Thus, these studies add another biologically active agent to our armamentarium of naturally occurring agents with therapeutic potential...
  78. pmc A multiple-loop, double-cube microarray design applied to prostate cancer cell lines with variable sensitivity to histone deacetylase inhibitors
    Madeleine S Q Kortenhorst
    Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA
    Clin Cancer Res 14:6886-94. 2008
    ..In this article, we present our experience with a complex design microarray experiment on resistance mechanisms of histone deacetylase inhibitors (HDACI)...
  79. pmc Preclinical and clinical studies with the multi-kinase inhibitor CEP-701 as treatment for prostate cancer demonstrate the inadequacy of PSA response as a primary endpoint
    Connie Collins
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Biol Ther 6:1360-7. 2007
    ..CEP-701 binds to serum proteins and a preprostatectomy study was performed to assess prostate tissue penetration and clinical response to CEP-701...
  80. ncbi request reprint The natural history of metastatic progression in men with PSA-recurrent prostate cancer after radical prostatectomy: 25-year follow-up
    E S Antonarakis
    Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD Brady Urological Institute, Johns Hopkins, Baltimore, MD
    J Clin Oncol 27:5008. 2009
    ..We now report data reflecting up to 25 years of follow-up...
  81. ncbi request reprint Phase I study of enzastaurin (ENZ) and bevacizumab (BV) in patients with advanced cancer
    L P Resta
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD Eli Lilly and Company, Indianapolis, IN
    J Clin Oncol 26:3529. 2008
    ..BV is a monoclonal antibody that binds VEGF and inhibits angiogenesis. Since ENZ and BV complement each other in inhibiting angiogenesis, we conducted a Phase I study of ENZ and BV in advanced cancer patients (pts)...
  82. ncbi request reprint Phase I safety and pharmacokinetic/pharmacodynamic results of the histone deacetylase inhibitor vorinostat in combination with bevacizumab in patients with kidney cancer
    H J Hammers
    Johns Hopkins University, Baltimore, MD University of Pittsburgh Cancer Institute, Pittsburgh, PA Division of Cancer Treatment and Diagnosis, NCI, Bethesda, MD
    J Clin Oncol 26:16094. 2008
    ..The objective of this Phase I study was to determine the safety, tolerability, and pharmacokinetic (PK)/pharmacodynamic (PD) profiles of the HDAC inhibitor vorinostat in combination with bevacizumab...
  83. pmc The effect of the frequency and duration of PSA measurement on PSA doubling time calculations in men with biochemically recurrent prostate cancer
    C J Paller
    Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Prostate Cancer Prostatic Dis 17:28-33. 2014
    ..This study explores whether PSADT calculations are influenced by frequency/duration of PSA measurements, and whether statistical variability leads investigators to find false significant results...
  84. ncbi request reprint Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies
    W G Nelson
    Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
    Cancer Chemother Pharmacol 46:S67-72. 2000
    ....
  85. doi request reprint Needs assessments can identify scores on HRQOL questionnaires that represent problems for patients: an illustration with the Supportive Care Needs Survey and the QLQ-C30
    Claire F Snyder
    Johns Hopkins School of Medicine, 624 N Broadway, Room 657, Baltimore, MD 21205, USA
    Qual Life Res 19:837-45. 2010
    ..We explored using needs assessments to identify HRQOL scores associated with patient-reported unmet needs...
  86. doi request reprint Relevant content for a patient-reported outcomes questionnaire for use in oncology clinical practice: Putting doctors and patients on the same page
    Claire F Snyder
    Johns Hopkins School of Medicine, 624 N Broadway, Room 657, Baltimore, MD 21205, USA
    Qual Life Res 19:1045-55. 2010
    ..To investigate relevant patient-reported outcome (PRO) domains for oncology clinical practice...
  87. ncbi request reprint Quantification of 5-azacytidine in plasma by electrospray tandem mass spectrometry coupled with high-performance liquid chromatography
    Ming Zhao
    Division of Experimental Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Room 1M87, Baltimore, MD 21231, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 813:81-8. 2004
    ..This method is 50 times more sensitive than previously published assays and successfully allows studies to characterize the pharmacokinetics and pharmacodynamics of 5AC...
  88. ncbi request reprint Advanced prostate cancer: the future
    Andrew J Armstrong
    Prostate Cancer Research Program, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Can J Urol 12:42-7. 2005
    ..Novel approaches including novel cytotoxics, immunotherapy, PSMA targeted monoclonal antibodies are among the broad categories that will be discussed in this brief review...
  89. ncbi request reprint Palliative chemotherapy: historical perspective, applications, and controversies
    Ilene Browner
    Division of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
    Semin Oncol 32:145-55. 2005
    ....
  90. ncbi request reprint A phase II trial of temozolomide and IFN-alpha in patients with advanced renal cell carcinoma
    Usha Sunkara
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231 1000, USA
    J Interferon Cytokine Res 24:37-41. 2004
    ..The combination of TEM/IFN proved quite tolerable. This regimen appears inactive in terms of response in this population with poor prognosis, but the patients with stable disease > or =6 months remain of interest...
  91. ncbi request reprint Final results on phase II study of a weekly schedule of ixabepilone in patients with metastatic castrate-refractory prostate cancer (E3803): A trial of the Eastern Cooperative Oncology Group
    G Liu
    University of Wisconsin Carbone Cancer Center, Madison, WI Dana Farber Cancer Institute, Boston, MA Cancer Institute of New Jersey, New Brunswick, NJ Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD
    J Clin Oncol 29:4529. 2011
    ..Here we report the activity and toxicity of ixabepilone, administered using a weekly schedule, in men with metastatic castrate-resistant prostate cancer (CRPC)...
  92. ncbi request reprint Association of angiotensin II blockers with survival among men with prostate cancer: Results from CaPSURE
    A Bardia
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD University of California, San Francisco, San Francisco, CA Dana Farber Cancer Institute Brigham and Women s Hospital, Boston, MA
    J Clin Oncol 29:4538. 2011
    ....
  93. ncbi request reprint Tolerance of full-dose sorafenib (S) combined with irinotecan (I; weekly, two on, one off) and cetuximab (C) in previously treated patients with advanced colorectal cancer (CRC)
    A Dasari
    University of Colorado Health Science Center, Aurora, CO Johns Hopkins University, Baltimore, MD University of Colorado Denver, Aurora, CO Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD Johns Hopkins University School of Medicine, Baltimore, MD Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD University of Colorado Cancer Center, Aurora, CO
    J Clin Oncol 29:522. 2011
    ....
  94. ncbi request reprint A phase II study of pomegranate extract for men with rising prostate-specific antigen following primary therapy
    C J Paller
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD Johns Hopkins University School of Medicine, Baltimore, MD Advanced Clinical, Bannockburn, IL Pom Wonderful, Los Angeles, CA Urological Associates of Lancaster, Ltd, Lancaster, PA South Orange County Medical Research Center, Laguna Hills, CA Lakeside Urology, St Joseph, MI The Urology Group, Cincinnati, OH Accumed Research Associates, Garden City, NY Urology Enterprises, Marietta, GA University of California, Los Angeles, Los Angeles, CA
    J Clin Oncol 29:4522. 2011
    ..We sought to determine the effects of 1 gram or 3 grams daily POMx on PSADT in a similar but more inclusive population of men seeking to defer androgen deprivation therapy...
  95. pmc A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer
    C J Paller
    Prostate Cancer Research Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Prostate Cancer Prostatic Dis 16:50-5. 2013
    ..This study assesses biological activity of two doses of pomegranate extract (POMx) in men with recurrent prostate cancer, using changes in PSADT as the primary outcome...
  96. ncbi request reprint A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy
    T L DeWeese
    Division of Radiation Oncology, The Johns Hopkins Oncology Center, Baltimore, Maryland 21231-1000, USA
    Cancer Res 61:7464-72. 2001
    ....
  97. pmc Does pre-existing diabetes affect prostate cancer prognosis? A systematic review
    C F Snyder
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Prostate Cancer Prostatic Dis 13:58-64. 2010
    ..20). Diabetes was also associated with receiving radiation therapy, complication rates, recurrence and treatment failure. Our analysis suggests that pre-existing diabetes affects the treatment and outcomes of men with prostate cancer...
  98. ncbi request reprint Asking the right questions: investigating needs assessments and health-related quality-of-life questionnaires for use in oncology clinical practice
    Claire F Snyder
    Division of General Internal Medicine, Johns Hopkins School of Medicine, 624 N Broadway, 6th Floor, Baltimore, MD 21205, USA
    Support Care Cancer 15:1075-85. 2007
    ..We investigated the item content from two health-related quality-of-life (HRQOL) questionnaires and two needs assessments for this purpose...
  99. ncbi request reprint Multiple Molecular pathways explain the anti-proliferative effect of valproic acid on prostate cancer cells in vitro and in vivo
    Shabana Shabbeer
    Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland 21231, USA
    Prostate 67:1099-110. 2007
    ..It is a known Histone Deacetylase Inhibitor (HDACI). We tested VPA, for its anti-proliferative activity in prostate cancer (PCa) cell lines in vitro and in vivo...
  100. pmc Valproic acid causes dose- and time-dependent changes in nuclear structure in prostate cancer cells in vitro and in vivo
    Madeleine S Q Kortenhorst
    Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, James Buchanan Brady Urological Institute, School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Mol Cancer Ther 8:802-8. 2009
    ..Therefore, nuclear structural alterations may serve as a biomarker for histone deacetylase inhibitor treatment...
  101. ncbi request reprint Endothelin-1 as a target for therapeutic intervention in prostate cancer
    E Scott Kopetz
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Invest New Drugs 20:173-82. 2002
    ..Results of ongoing clinical trials are eagerly awaited in order to see if the hypothetical promise of ET antagonism will result in clinical success...