PAUL BOTTOMLEY

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Designing passive MRI-safe implantable conducting leads with electrodes
    Paul A Bottomley
    SurgiVision, Inc, Suite B307, 1101 East 33rd Street, Baltimore, Maryland 21218, USA
    Med Phys 37:3828-43. 2010
  2. pmc High-resolution intravascular magnetic resonance quantification of atherosclerotic plaque at 3T
    Di Qian
    Division of MR Research, Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
    J Cardiovasc Magn Reson 14:20. 2012
  3. pmc Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy study
    Paul A Bottomley
    Division of MR Research, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circulation 119:1918-24. 2009
  4. ncbi request reprint The rise of human in vivo NMR spectroscopy
    P A Bottomley
    Department of Radiology, Johns Hopkins University, Baltimore, MD 21287 0843, USA
    Solid State Nucl Magn Reson 9:29-40. 1997
  5. pmc Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo
    Paul A Bottomley
    Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287 0843, USA
    Magn Reson Med 47:850-63. 2002
  6. ncbi request reprint Noninvasive localized MR quantification of creatine kinase metabolites in normal and infarcted canine myocardium
    P A Bottomley
    Department of Radiology, Division of MR Research, Johns Hopkins University, JHOC 4221, 601 N Caroline St, Baltimore, MD 21287 0843, USA
    Radiology 219:411-8. 2001
  7. pmc Quantitative cardiac 31P spectroscopy at 3 Tesla using adiabatic pulses
    AbdEl Monem El-Sharkawy
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 61:785-95. 2009
  8. pmc Monitoring and correcting spatio-temporal variations of the MR scanner's static magnetic field
    AbdEl Monem El-Sharkawy
    The Department of Electrical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    MAGMA 19:223-36. 2006
  9. ncbi request reprint Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: current applications
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Technol Cancer Res Treat 3:543-50. 2004
  10. pmc Proton, diffusion-weighted imaging, and sodium (23Na) MRI of uterine leiomyomata after MR-guided high-intensity focused ultrasound: a preliminary study
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 29:649-56. 2009

Research Grants

  1. SODIUM IMAGING IN ISCHEMIC HEART DISEASE
    PAUL BOTTOMLEY; Fiscal Year: 2002
  2. Innovative MRI Research Technology
    PAUL BOTTOMLEY; Fiscal Year: 2005
  3. MR Studies of Myocardial Creatine Kinase Metabolism
    PAUL BOTTOMLEY; Fiscal Year: 2007

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Designing passive MRI-safe implantable conducting leads with electrodes
    Paul A Bottomley
    SurgiVision, Inc, Suite B307, 1101 East 33rd Street, Baltimore, Maryland 21218, USA
    Med Phys 37:3828-43. 2010
    ..The purpose of this article is to develop and compare a range of passive implantable "MRI-safe" lead designs...
  2. pmc High-resolution intravascular magnetic resonance quantification of atherosclerotic plaque at 3T
    Di Qian
    Division of MR Research, Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
    J Cardiovasc Magn Reson 14:20. 2012
    ....
  3. pmc Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy study
    Paul A Bottomley
    Division of MR Research, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circulation 119:1918-24. 2009
    ..CK flux is defined as the product of [PCr] and k. CK flux and k have never been measured in human MI...
  4. ncbi request reprint The rise of human in vivo NMR spectroscopy
    P A Bottomley
    Department of Radiology, Johns Hopkins University, Baltimore, MD 21287 0843, USA
    Solid State Nucl Magn Reson 9:29-40. 1997
    ..Both have links to physics at Nottingham, at least in the personalized account that follows. Today, virtually all NMR spectroscopy experiments can be conceived with a localized in vivo spectroscopy counterpart...
  5. pmc Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo
    Paul A Bottomley
    Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287 0843, USA
    Magn Reson Med 47:850-63. 2002
    ..These timesaving FAST methods are enabling because they permit localized measurements of metabolic flux, which were previously impractical due to intolerably long scan times...
  6. ncbi request reprint Noninvasive localized MR quantification of creatine kinase metabolites in normal and infarcted canine myocardium
    P A Bottomley
    Department of Radiology, Division of MR Research, Johns Hopkins University, JHOC 4221, 601 N Caroline St, Baltimore, MD 21287 0843, USA
    Radiology 219:411-8. 2001
    ....
  7. pmc Quantitative cardiac 31P spectroscopy at 3 Tesla using adiabatic pulses
    AbdEl Monem El-Sharkawy
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 61:785-95. 2009
    ..8+/-0.3 s and 5.4+/-0.6 s, respectively. For heart (n=10) the values are 5.8+/-0.5 s (PCr) and 3.1+/-0.6 s (gamma-ATP). The 2TR protocol measurements agreed with those obtained by conventional methods to within 10%...
  8. pmc Monitoring and correcting spatio-temporal variations of the MR scanner's static magnetic field
    AbdEl Monem El-Sharkawy
    The Department of Electrical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    MAGMA 19:223-36. 2006
    ..It is demonstrated that serial field mapping and phased difference imaging correction protocols can substantially compensate for the drift effects observed in the MR thermometry and spectroscopy experiments...
  9. ncbi request reprint Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: current applications
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Technol Cancer Res Treat 3:543-50. 2004
    ..A combination of MR, MRSI, and 23Na sodium MR parameters may be examined in a single MR imaging examination, potentially resulting in improved specificity for radiologic evaluation of malignancy...
  10. pmc Proton, diffusion-weighted imaging, and sodium (23Na) MRI of uterine leiomyomata after MR-guided high-intensity focused ultrasound: a preliminary study
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 29:649-56. 2009
    ..To determine the feasibility of using combined proton (1H), diffusion-weighted imaging (DWI), and sodium (23Na) magnetic resonance imaging (MRI) to monitor the treatment of uterine leiomyomata (fibroids)...
  11. ncbi request reprint Proton magnetic resonance spectroscopic imaging of human breast cancer: a preliminary study
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 19:68-75. 2004
    ..To investigate the diagnostic value of proton magnetic resonance spectroscopic imaging (MRSI) in patients with breast lesions...
  12. pmc Tissue sodium concentration in myocardial infarction in humans: a quantitative 23Na MR imaging study
    Ronald Ouwerkerk
    Division of Magnetic Resonance Research, Department of Radiology, Johns Hopkins University, School of Medicine, 601 N Caroline St, JHOC 4241, Baltimore, MD 21287 0845, USA
    Radiology 248:88-96. 2008
    ....
  13. pmc Optimized quadrature surface coil designs
    Ananda Kumar
    Department of Radiology and Electrical and Computer Engineering, Johns Hopkins University, Division of MR Research, 601 N Caroline Street, JHOC room 4243, Baltimore, MD 21287, USA
    MAGMA 21:41-52. 2008
    ..While the radius of the optimum loop coil for performing MRI at depth d in a sample is known, the optimum geometry for figure-8 and butterfly coils is not...
  14. ncbi request reprint Tissue sodium concentration in human brain tumors as measured with 23Na MR imaging
    Ronald Ouwerkerk
    Department of Radiology, Division of MR Research, Johns Hopkins University School of Medicine, 610 N Caroline St, JHOC 4241, Baltimore, MD 21287 0845, USA
    Radiology 227:529-37. 2003
    ..To use combined proton (1H) and sodium 23 (23Na) magnetic resonance (MR) imaging to noninvasively quantify total tissue sodium concentration and to determine if concentration is altered in malignant human brain tumors...
  15. pmc Deconvolution-interpolation gridding (DING): accurate reconstruction for arbitrary k-space trajectories
    Refaat E Gabr
    Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Magn Reson Med 56:1182-91. 2006
    ..The results demonstrate a stable performance and reduced root mean square (RMS) error for DING in different k-space trajectories...
  16. ncbi request reprint Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI
    Ronald Ouwerkerk
    Division of MR Research, Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD 21287 0845, USA
    Breast Cancer Res Treat 106:151-60. 2007
    ....
  17. ncbi request reprint Measuring human cardiac tissue sodium concentrations using surface coils, adiabatic excitation, and twisted projection imaging with minimal T2 losses
    Ronald Ouwerkerk
    Division of MR Research, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0845, USA
    J Magn Reson Imaging 21:546-55. 2005
    ..To measure tissue sodium concentrations in the human heart with (23)Na MRI using a surface coil, thereby eliminating the effects of inhomogeneous excitation by surface coils and minimizing T(1) and T(2) relaxation...
  18. pmc On restoring motion-induced signal loss in single-voxel magnetic resonance spectra
    Refaat E Gabr
    Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287 0843, USA
    Magn Reson Med 56:754-60. 2006
    ..Constructive averaging should be incorporated as a routine tool for in vivo (1)H MRS...
  19. pmc Triple repetition time saturation transfer (TRiST) 31P spectroscopy for measuring human creatine kinase reaction kinetics
    Michael Schar
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 63:1493-501. 2010
    ..The first 3-T TRiST measurements of creatine kinase k(f) in the human calf (n = 6), chest muscle, and heart (n = 8) are 0.26 +/- 0.04 s(-1), 0.23 +/- 0.03 s(-1), and 0.32 +/- 0.07 s(-1), respectively, consistent with prior 1.5 T values...
  20. pmc Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium
    Craig S Smith
    Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, Baltimore, MD 21287 6568, USA
    Circulation 114:1151-8. 2006
    ..The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery...
  21. pmc ATP flux through creatine kinase in the normal, stressed, and failing human heart
    Robert G Weiss
    Department of Medicine, Cardiology Division, and Department of Radiology, Nuclear Magnetic Resonance Research Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:808-13. 2005
    ..These findings support the pursuit of new therapies that reduce energy demand and/or augment energy transfer in heart failure and indicate that cardiac magnetic resonance can be used to assess their effectiveness...
  22. ncbi request reprint Effects of a pharmacologically-induced shift of hemoglobin-oxygen dissociation on myocardial energetics during ischemia in patients with coronary artery disease
    Samer S Najjar
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Cardiovasc Magn Reson 7:657-66. 2005
    ..We evaluated whether exercise-induced myocardial ischemia can be alleviated in subjects with coronary artery disease (CAD) by enhancing oxygen release with an allosteric modifier of hemoglobin's affinity for oxygen (RSR13)...
  23. pmc The performance of interventional loopless MRI antennae at higher magnetic field strengths
    AbdEl Monem M El-Sharkawy
    Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Med Phys 35:1995-2006. 2008
    ..5 T. The large SNR and FOV gains realized present a major opportunity for high-resolution imaging of vascular pathology and MRI-guided intervention...
  24. pmc Correcting reaction rates measured by saturation-transfer magnetic resonance spectroscopy
    Refaat E Gabr
    Division of MR Research, Department of Radiology, The Johns Hopkins University, JHOC 4221, Baltimore, MD 21287, USA
    J Magn Reson 191:248-58. 2008
    ..5 T. In normal in vivo spectra affected by spillover, the correction increases the mean calculated forward CK reaction rate by 6-16% over traditional and prior correction formulae...
  25. pmc Quantifying in vivo MR spectra with circles
    Refaat E Gabr
    Division of MR Reasearch, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA
    J Magn Reson 179:152-63. 2006
    ..We conclude that CFIT is a stable, accurate alternative to the best existing methods of fitting in vivo data...
  26. pmc Interventional MRI: tapering improves the distal sensitivity of the loopless antenna
    Di Qian
    Division of MR Research, Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 63:797-802. 2010
    ..The manifold improvement in distal signal-to-noise ratio afforded by redistributing the insulation should improve the loopless antenna's utility for interventional MRI...
  27. pmc Lumped-element planar strip array (LPSA) for parallel MRI
    Ray F Lee
    Department of Radiology, New York University, New York, New York 10016, USA
    Magn Reson Med 51:172-83. 2004
    ..Two different decoupling schemes for the LPSA are described. A four-element LPSA prototype was built to test the theory with quantitative measurements on images obtained with parallel and conventional acquisition schemes...
  28. pmc MRI dynamic range and its compatibility with signal transmission media
    Refaat E Gabr
    Division of MR Research, Department of Radiology, Johns Hopkins School of Medicine, 600 N Wolfe St, Park 328, Baltimore, MD, USA
    J Magn Reson 198:137-45. 2009
    ..However, combining analog links with signal compression might make non-coaxial cable signal transmission viable...
  29. pmc A prototype RF dosimeter for independent measurement of the average specific absorption rate (SAR) during MRI
    John P Stralka
    Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Magn Reson Imaging 26:1296-302. 2007
    ..To develop a scanner-independent dosimeter for measuring the average radio frequency (RF) power deposition and specific absorption rates (SAR) for human MRI exposure...
  30. pmc High-energy phosphate transfer in human muscle: diffusion of phosphocreatine
    Refaat E Gabr
    Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Physiol Cell Physiol 301:C234-41. 2011
    ..Thus these first measurements of PCr diffusion in human muscle in vivo support the view that PCr diffusion is not a factor limiting high-energy phosphate transport between the mitochondria and the myofibrils in healthy resting myocytes...
  31. pmc Noise figure limits for circular loop MR coils
    Ananda Kumar
    Department of Radiology, Division of MR Research, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Magn Reson Med 61:1201-9. 2009
    ..The ability to characterize and reliably predict component- and geometry-associated coil losses is key to designing SNR-optimized loop and phased-array detectors...
  32. pmc MRI endoscopy using intrinsically localized probes
    Shashank Sathyanarayana
    Department of Radiology, Division of MR Research, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Med Phys 36:908-19. 2009
    ..The method is demonstrated in a kiwifruit, in intact porcine and rabbit aortas, and in an atherosclerotic human iliac artery specimen, with in-plane resolution as small as 80 microm and 1.5-5 mm slice thickness...
  33. ncbi request reprint The effect of orientation on quantification of muscle creatine by 1H MR spectroscopy
    Fabao Gao
    Cardiology Division, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Magn Reson Imaging 21:561-6. 2003
    ..These observations are consistent with the primary hypothesis that careful water-referenced [CR] quantification, accounting for T2 effects and using the N-CH3 peak at 3.0ppm, is not affected by muscle orientation...
  34. pmc Local planar gradients with order-of-magnitude strength and speed advantage
    Bulent Aksel
    GE Global Research, Niskayuna, New York 12309, USA
    Magn Reson Med 58:134-43. 2007
    ..The gradient system and correction algorithm were implemented in a standard 1.5 T scanner and demonstrated by high-resolution imaging of phantoms and humans...
  35. pmc Large field-of-view real-time MRI with a 32-channel system
    Christopher J Hardy
    GE Global Research Center, Niskayuna, New York 12309, USA
    Magn Reson Med 52:878-84. 2004
    ..The system provides a platform for evaluating the applications of many-channel real-time MRI, and for understanding the factors that optimize the choice of array size...

Research Grants3

  1. SODIUM IMAGING IN ISCHEMIC HEART DISEASE
    PAUL BOTTOMLEY; Fiscal Year: 2002
    ..The availability of thousands of clinical MRI scanners offers a great opportunity for advancing 23Na MRI as a tool for assessing sodium pump function in human heart disease. ..
  2. Innovative MRI Research Technology
    PAUL BOTTOMLEY; Fiscal Year: 2005
    ..The work will be implemented at 1 .5T and will directly and positively benefit 21 other funded research grants at this institution, with broad potential benefit to noninvasive imaging in a wide range of patients and diseases. ..
  3. MR Studies of Myocardial Creatine Kinase Metabolism
    PAUL BOTTOMLEY; Fiscal Year: 2007
    ....