Trinity J Bivalacqua

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Mini Review: Pathophysiology of Erectile Dysfunction
    Hotaka Matsui
    The James Buchanan Brady Urological Institute, 600 N Wolfe Street Marburg 409, Baltimore, Maryland, 21287, USA
    Curr Drug Targets . 2015
  2. pmc Anatomic extent of pelvic lymph node dissection: impact on long-term cancer-specific outcomes in men with positive lymph nodes at time of radical prostatectomy
    Trinity J Bivalacqua
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Urology 82:653-8. 2013
  3. doi request reprint New insights into the pathophysiology of sickle cell disease-associated priapism
    Trinity J Bivalacqua
    Department of Urology, Johns Hopkins Medical Institutions, The James Buchanan Brady Urological Institute, Marburg, Baltimore, MD 21287, USA
    J Sex Med 9:79-87. 2012
  4. pmc Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction
    Trinity J Bivalacqua
    Department of Urology, The Johns Hopkins Medical Institution, The James Buchanan Brady Urological Institute, Baltimore, Maryland 21287, USA
    J Urol 181:899-906. 2009
  5. doi request reprint The use of gene transfer technology to study the pathophysiology of erectile dysfunction
    Trinity J Bivalacqua
    The Brady Urological Institute, Department of Urology, Johns Hopkins Hospital, Baltimore, MD, USA
    J Sex Med 5:268-75. 2008
  6. doi request reprint Application of Evicel to cavernous nerves of the rat does not influence erectile function in vivo
    Trinity J Bivalacqua
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 72:1169-73. 2008
  7. pmc Attenuated RhoA/Rho-kinase signaling in penis of transgenic sickle cell mice
    Trinity J Bivalacqua
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 76:510.e7-12. 2010
  8. ncbi request reprint Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1alpha
    Trinity J Bivalacqua
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    BJU Int 99:1488-94. 2007
  9. pmc Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
    PLoS ONE 8:e68028. 2013
  10. ncbi request reprint Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy
    Trinity J Bivalacqua
    Johns Hopkins Hospital, Brady Urological Institute, Baltimore, MD, USA
    J Sex Med 2:187-97; discussion 197-8. 2005

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Mini Review: Pathophysiology of Erectile Dysfunction
    Hotaka Matsui
    The James Buchanan Brady Urological Institute, 600 N Wolfe Street Marburg 409, Baltimore, Maryland, 21287, USA
    Curr Drug Targets . 2015
    ..ED is often associated with systemic diseases, such as diabetes and cardiovascular diseases. In this review, we will review the molecular mechanisms of ED and known mechanisms behind ED associated with systemic diseases...
  2. pmc Anatomic extent of pelvic lymph node dissection: impact on long-term cancer-specific outcomes in men with positive lymph nodes at time of radical prostatectomy
    Trinity J Bivalacqua
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Urology 82:653-8. 2013
    ..To evaluate the impact of an extended pelvic lymph node (LN) dissection (EPLND) on the oncologic outcomes of men with LN-positive prostate cancer...
  3. doi request reprint New insights into the pathophysiology of sickle cell disease-associated priapism
    Trinity J Bivalacqua
    Department of Urology, Johns Hopkins Medical Institutions, The James Buchanan Brady Urological Institute, Marburg, Baltimore, MD 21287, USA
    J Sex Med 9:79-87. 2012
    ..Priapism is defined as an erectile disorder, in which erection persists uncontrollably without sexual purpose. The precise mechanisms involved in the development of sickle cell disease-associated priapism are ill defined...
  4. pmc Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction
    Trinity J Bivalacqua
    Department of Urology, The Johns Hopkins Medical Institution, The James Buchanan Brady Urological Institute, Baltimore, Maryland 21287, USA
    J Urol 181:899-906. 2009
    ....
  5. doi request reprint The use of gene transfer technology to study the pathophysiology of erectile dysfunction
    Trinity J Bivalacqua
    The Brady Urological Institute, Department of Urology, Johns Hopkins Hospital, Baltimore, MD, USA
    J Sex Med 5:268-75. 2008
    ..Research has led to a better understanding of the biochemical factors and intracellular mechanisms responsible for corporal smooth muscle contraction and relaxation, as well as the influence of endothelial-derived relaxing factors...
  6. doi request reprint Application of Evicel to cavernous nerves of the rat does not influence erectile function in vivo
    Trinity J Bivalacqua
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 72:1169-73. 2008
    ..To evaluate the effect of the fibrin sealant, Evicel, on the neuroregulatory control of penile erections in an experimental rat model...
  7. pmc Attenuated RhoA/Rho-kinase signaling in penis of transgenic sickle cell mice
    Trinity J Bivalacqua
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 76:510.e7-12. 2010
    ..Therefore, the objective of the present study was to evaluate the molecular changes in RhoA and ROCK in an established transgenic sickle cell mouse model of priapism...
  8. ncbi request reprint Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1alpha
    Trinity J Bivalacqua
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    BJU Int 99:1488-94. 2007
    ....
  9. pmc Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
    PLoS ONE 8:e68028. 2013
    ..Thus, sildenafil exerts pleiotropic effects in the penis that extend to diverse erection disorders. ..
  10. ncbi request reprint Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy
    Trinity J Bivalacqua
    Johns Hopkins Hospital, Brady Urological Institute, Baltimore, MD, USA
    J Sex Med 2:187-97; discussion 197-8. 2005
    ....
  11. doi request reprint Pathological and oncologic outcomes for men with positive lymph nodes at radical prostatectomy: The Johns Hopkins Hospital 30-year experience
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Prostate 73:1673-80. 2013
    ..We report the 30-year institutional experience of radical prostatectomy (RP) for men with clinically localized prostate cancer (PC) found to have lymph node (LN) metastases at surgery...
  12. ncbi request reprint Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction
    Liming Jin
    Department of Urology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    FASEB J 20:536-8. 2006
    ..05). Taken together, these data suggest that impaired erectile function during the aging process involves increased RhoA/Rho-kinase signaling, and this pathway may be exploited for the treatment of age-associated ED...
  13. doi request reprint Nightly vs on-demand sildenafil for penile rehabilitation after minimally invasive nerve-sparing radical prostatectomy: results of a randomized double-blind trial with placebo
    Christian P Pavlovich
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    BJU Int 112:844-51. 2013
    ..To clarify the role of phosphodiesterase type 5 (PDE5) inhibitors in post-prostatectomy penile rehabilitation (PPPR). To compare nightly and on-demand use of PDE5 inhibitors after nerve-sparing minimally invasive radical prostatectomy (RP)...
  14. pmc Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Sex Med 6:2494-504. 2009
    ..Priapism is a poorly understood disease process with little information on the etiology and pathophysiology of this erectile disorder. One group of patients with a high prevalence of priapism is men with sickle-cell disease...
  15. ncbi request reprint Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Urology 67:1043-8. 2006
    ..We explored the use of PDE5 inhibitors to treat recurrent priapism, based on the hypothesis that the erection regulatory function of PDE5 would be regularized by this treatment and protect against further episodes...
  16. pmc Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Hospital, Baltimore, MD 21287, United States
    Eur Urol 51:1732-40. 2007
    ....
  17. doi request reprint Urinary outcomes are significantly affected by nerve sparing quality during radical prostatectomy
    Deborah R Kaye
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD
    Urology 82:1348-53. 2013
    ..To assess the effect of nerve sparing (NS) quality on self-reported patient urinary outcomes after radical prostatectomy...
  18. pmc Contemporaneous comparison of open vs minimally-invasive radical prostatectomy for high-risk prostate cancer
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, MD, USA
    BJU Int 112:751-7. 2013
    ....
  19. pmc Trends in immediate perioperative morbidity and delay in discharge after open and minimally invasive radical prostatectomy (RP): a 20-year institutional experience
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA
    BJU Int 112:45-53. 2013
    ..Specifically, it addresses approach-specific morbidities and indicates that MIRP is associated with higher rates of 'off-pathway' discharge, most often due to ileus...
  20. pmc RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction
    Trinity J Bivalacqua
    Department of Urology, Tulane Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 101:9121-6. 2004
    ..Importantly, these data imply that inhibition of RhoA/Rho-kinase improves eNOS protein content and activity thus restoring erectile function in diabetes...
  21. ncbi request reprint Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats
    Trinity J Bivalacqua
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    J Urol 169:1911-7. 2003
    ..We determined whether adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis of streptozotocin induced diabetic rats could improve the impaired erectile response...
  22. pmc Post-translational regulation of endothelial nitric oxide synthase (eNOS) by estrogens in the rat vagina
    Biljana Musicki
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 7:1768-77. 2010
    ..Although vascular effects of estrogens are attributed to an increase in endothelial NO production, the mechanisms of endothelial NO synthase (eNOS) regulation by estrogens in the vagina are largely unknown...
  23. pmc Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
    Jae Hyung Kim
    Anesthesiology, Tower 711, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    J Appl Physiol (1985) 107:1249-57. 2009
    ..We suggest that arginase is a viable target for therapy in age-dependent vascular stiffness...
  24. ncbi request reprint The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocin-induced diabetic rats: preventive versus curative treatment
    Mustafa F Usta
    Department of Urology, Section of Andrology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    J Sex Med 3:242-50; discussion 250-2. 2006
    ..However, it is unknown whether late administration of a putative cross-link breaker, ALT-711, can reverse diabetic ED. We therefore compared ALT-711 and aminoguanidine in their ability to reverse ED in diabetic rats...
  25. doi request reprint Serum biomarker measurements of endothelial function and oxidative stress after daily dosing of sildenafil in type 2 diabetic men with erectile dysfunction
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 181:245-51. 2009
    ..We investigated changes in serum biomarkers of vascular function after short-term, continuous sildenafil dosing in men with type 2 diabetes with erectile dysfunction...
  26. ncbi request reprint Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase
    Trinity J Bivalacqua
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Physiol Heart Circ Physiol 292:H1340-51. 2007
    ..Inhibition of the arginase pathway improves endothelial function in the aging penile circulation, suggesting that the arginase pathway may be exploited to improve erectile dysfunction associated with aging...
  27. pmc Inhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injury
    Johanna L Hannan
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 189:1155-61. 2013
    ..We evaluated whether daily treatment with the ROCK inhibitor Y-27632 (Tocris Bioscience, Ellisville, Missouri) would prevent erectile dysfunction in a rat model of bilateral cavernous nerve injury...
  28. ncbi request reprint Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum
    Somboon Leungwattanakij
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    J Androl 24:239-45. 2003
    ..In theory, cavernous fibrosis may be reduced by employing various vasoactive agents or interventions that increase oxygenation to the corporal tissues during the postoperative period...
  29. pmc Endothelial nitric oxide synthase regulation in female genital tract structures
    Biljana Musicki
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 6:247-53. 2009
    ..However, the role of endothelial NO synthase (eNOS) and the mechanisms that regulate eNOS in female genital tract structures are largely unknown...
  30. ncbi request reprint Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease
    Trinity J Bivalacqua
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Androl 24:S17-37. 2003
  31. pmc Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism
    Hunter C Champion
    Department of Cardiology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:1661-6. 2005
    ..Coupled with the observation that sickle cell disease mice (which show a priapism phenotype) evince dysregulated PDE5A expression/activity, these data suggest that PDE5A dysregulation is a fundamental mechanism for priapism...
  32. doi request reprint Accuracy of urethral frozen section during radical cystectomy for bladder cancer
    Max Kates
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Md Electronic address
    Urol Oncol 34:532.e1-532.e6. 2016
    ..Our objective was to determine the accuracy of urethral frozen section (FS) by analyzing our clinical experience...
  33. doi request reprint Blood Transfusion is Associated with Increased Perioperative Morbidity and Adverse Oncologic Outcomes in Bladder Cancer Patients Receiving Neoadjuvant Chemotherapy and Radical Cystectomy
    Heather J Chalfin
    James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ann Surg Oncol 23:2715-22. 2016
    ..We examined the effect of leukoreduced PBT on oncologic outcomes and perioperative morbidity in radical cystectomy (RC) patients who received NAC, quantifying exposure with a novel dose-index variable...
  34. pmc Subacute Hemolysis in Sickle Cell Mice Causes Priapism Secondary to NO Imbalance and PDE5 Dysregulation
    Nikolai A Sopko
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Sex Med 12:1878-85. 2015
    ....
  35. doi request reprint High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder
    Morgan Cowan
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Mod Pathol 29:511-5. 2016
    ....
  36. pmc Outcomes of men with an elevated prostate-specific antigen (PSA) level as their sole preoperative intermediate- or high-risk feature
    Farzana A Faisal
    Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA
    BJU Int 114:E120-9. 2014
    ....
  37. doi request reprint Radical cystectomy in patients with preexisting three-piece inflatable penile prosthesis
    Robert L Segal
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Sex Med 10:595-8. 2013
    ..There have not been any reports to date on patients undergoing this surgery who have had previous placement of an inflatable penile prosthesis...
  38. doi request reprint Corporal Burnett "Snake" surgical maneuver for the treatment of ischemic priapism: long-term followup
    Robert L Segal
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2162, USA
    J Urol 189:1025-9. 2013
    ..We provide long-term followup on a modification of the Al-Ghorab distal penile corporoglanular shunt surgery for the treatment of ischemic priapism...
  39. doi request reprint Daily phosphodiesterase type 5 inhibitor therapy as rescue for recurrent ischemic priapism after failed androgen ablation
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Hospital, 600 N Wolfe Ave, Marburg 407, Baltimore, MD 21287, USA
    J Androl 32:371-4. 2011
    ..Our treatment of recurrent priapism implicates androgens and both biochemical and neurovascular control mechanisms in the penis...
  40. doi request reprint Post-translational inactivation of endothelial nitric oxide synthase in the transgenic sickle cell mouse penis
    Biljana Musicki
    The Johns Hopkins University, Department of Urology, Baltimore, MD 21287, USA
    J Sex Med 8:419-26. 2011
    ..However, the mechanism of decreased eNOS function/activation in the penis in association with SCD is not known...
  41. ncbi request reprint Endothelial nitric oxide synthase gene therapy for erectile dysfunction
    Trinity J Bivalacqua
    Department of Urology, Tulane Health Sciences Center, 1430 Tulane Avenue SL42, New Orleans, LA 70112, USA
    Curr Pharm Des 11:4059-67. 2005
    ..Putative gene therapy interventions to restore eNOS expression and subsequent endothelial function may represent an exciting new therapeutic strategy for the future treatment of ED...
  42. ncbi request reprint The protective effect of aminoguanidine on erectile function in diabetic rats is not related to the timing of treatment
    Mustafa F Usta
    Department of Urology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    BJU Int 94:429-32. 2004
    ....
  43. ncbi request reprint Poly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury
    Muammer Kendirci
    Department of Urology, School of Medicine, Tulane University, New Orleans, Louisiana, USA
    J Urol 174:2054-9. 2005
    ..Beverly, Massachusetts) in a bilateral cavernous nerve crush injury (BCNCI) model in rats...
  44. pmc Long-term survival after radical prostatectomy for men with high Gleason sum in pathologic specimen
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 76:715-21. 2010
    ..To evaluate the long-term outcomes of patients with high Gleason sum 8-10 at radical prostatectomy (RP) and to identify the predictors of prostate cancer-specific survival (CSS) in this cohort...
  45. ncbi request reprint Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction
    Trinity J Bivalacqua
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Physiol Heart Circ Physiol 292:H1278-90. 2007
    ..These data highlight the potential clinical use of adult stem cell-based therapy for the treatment of ED...
  46. pmc Identification of men with the highest risk of early disease recurrence after radical prostatectomy
    Debasish Sundi
    Brady Institute of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Prostate 74:628-36. 2014
    ..Men destined to have early biochemical recurrence (BCR) following radical prostatectomy (RP) may be optimal candidates for multimodal treatment. Here we identified pre-operative predictors of early BCR within a surgical cohort who recurred...
  47. doi request reprint Erythropoietin promotes erection recovery after nerve-sparing radical retropubic prostatectomy: a retrospective analysis
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Sex Med 5:2392-8. 2008
    ..Erectile dysfunction persists as a major functional complication of nerve-sparing radical prostatectomy...
  48. ncbi request reprint Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism
    Arthur L Burnett
    Johns Hopkins University Urology, Baltimore, MD, USA
    J Sex Med 3:1077-84. 2006
    ..Recurrent ischemic priapism is an enigmatic erectile disorder in need of improved clinical interventions to avert its known, potentially serious complications...
  49. ncbi request reprint Endothelium-specific gene and stem cell-based therapy for erectile dysfunction
    Travis D Strong
    Department of Urology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Asian J Androl 10:14-22. 2008
    ..The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models...
  50. ncbi request reprint Gene transfer of extracellular SOD to the penis reduces O2-* and improves erectile function in aged rats
    Trinity J Bivalacqua
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Am J Physiol Heart Circ Physiol 284:H1408-21. 2003
    ..formation. Gene-transfer of EC-SOD reduces superoxide formation and restores age-associated erectile function and may represent a novel therapeutic target for the treatment of erectile dysfunction...
  51. doi request reprint Early-stage Type 2 Diabetes Mellitus Impairs Erectile Function and Neurite Outgrowth From the Major Pelvic Ganglion and Downregulates the Gene Expression of Neurotrophic Factors
    Hotaka Matsui
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD
    Urology . 2016
    ..To assess neurite sprouting and gene expression of neurotrophic factors, nerve markers, and apoptosis in the major pelvic ganglia (MPGs) of rats with type 2 diabetes mellitus (T2DM) as it relates to erectile function...
  52. doi request reprint A Retrospective Analysis of the Effect on Survival of Time from Diagnosis to Neoadjuvant Chemotherapy to Cystectomy for Muscle Invasive Bladder Cancer
    Jong Chul Park
    Department of Oncology, Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
    J Urol 195:880-5. 2016
    ..We determine the impact of the timing of radical cystectomy from the diagnosis of muscle invasive bladder cancer on survival in patients also treated with neoadjuvant chemotherapy...
  53. pmc Frailty as a marker of adverse outcomes in patients with bladder cancer undergoing radical cystectomy
    Meera R Chappidi
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Md Electronic address
    Urol Oncol 34:256.e1-6. 2016
    ..To investigate the modified frailty index (mFI) as a preoperative predictor of postoperative complications following radical cystectomy (RC) in patients with bladder cancer...
  54. pmc Chronic oral administration of the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) improves erectile function in aged rats
    Robert Segal
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins MedicalInstitutions, Baltimore, Maryland, USA
    J Androl 33:1169-75. 2012
    ..This represents the first documentation of systemic arginase inhibition positively affecting corporal cavernosal function...
  55. doi request reprint Pathologic response in patients receiving neoadjuvant chemotherapy for muscle-invasive bladder cancer: Is therapeutic effect owing to chemotherapy or TURBT?
    Aaron Brant
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Md Electronic address
    Urol Oncol 35:34.e17-34.e25. 2017
    ..We estimated the proportion of patients who received neoadjuvant chemotherapy for muscle-invasive bladder cancer whose tumors were downstaged by transurethral resection...
  56. ncbi request reprint Infectious complications in transfused patients after radical cystectomy
    Jen Jane Liu
    Department of Urology, Oregon Health and Science University, Portland, Oregon, USA
    Can J Urol 23:8342-7. 2016
    ..While it has been suggested that perioperative blood transfusion (PBT) may be associated with adverse oncologic outcomes after RC, no large analyses have assessed whether PBT increases the risk of perioperative infection after RC...
  57. pmc Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice
    Jochen Steppan
    From the Department of Anesthesiology and Critical Care Medicine and Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institution, Baltimore, Maryland Department of Anesthesiology and Pain Medicine, Yonsei University, College of Medicine, Seoul, South Korea and Department of Urology, Johns Hopkins Medical Institution, Baltimore, Maryland
    Anesth Analg 123:652-8. 2016
    ..In this study, we tested the hypothesis that arginase inhibition would improve NO bioavailability and thereby attenuate systemic and pulmonary vascular endothelial dysfunction in transgenic mice with SCD...
  58. doi request reprint Insulin-like growth factor-1 receptor overexpression is associated with outcome in invasive urothelial carcinoma of urinary bladder: a retrospective study of patients treated using radical cystectomy
    Nilda Gonzalez-Roibon
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD
    Urology 83:1444.e1-6. 2014
    ..To assess the insulin-like growth factor-1 receptor (IGF1R) expression in urothelial carcinoma (UC) and its prognostic role in relation to clinicopathologic parameters...
  59. doi request reprint Combined inflatable penile prosthesis-artificial urinary sphincter implantation: no increased risk of adverse events compared to single or staged device implantation
    Robert L Segal
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland Electronic address
    J Urol 190:2183-8. 2013
    ..We assessed patient outcomes for combined vs single device implantation at a single institution...
  60. pmc The impact of preoperative erectile dysfunction on survival after radical prostatectomy
    Misop Han
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    BJU Int 106:1612-7. 2010
    ..The underlying pathology for preoperative ED may adversely affect survival following radical prostatectomy (RP). We examined the association between preoperative ED and survival following RP...
  61. doi request reprint Inhibition of sympathetic neuroeffector transmission in human corpus cavernosum
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    BJU Int 110:856-62. 2012
    ..Overall, our data adds to current knowledge that the NO-independent heme dependent activation of sGC and the RhoA/Rho-kinase signaling pathways play an important role in the regulation of neurogenic contractile activity in HCC tissue...
  62. doi request reprint Is prostate-specific antigen surveillance necessary in men with benign prostate pathology following radical cystoprostatectomy for bladder cancer?
    Trinity J Bivalacqua
    James Buchanan Brady Urologic Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Urol Int 85:466-9. 2010
    ..The purpose of our study was to analyze the postoperative PSA characteristics of men without prostate cancer who underwent a RCP for bladder cancer...
  63. ncbi request reprint Stratification of penile vascular pathologies in patients with Peyronie's disease and in men with erectile dysfunction according to age: a comparative study
    Mustafa F Usta
    Section of Andrology, Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Urol 172:259-62. 2004
    ..Erectile dysfunction (ED) occurs in 20% to 54% of men with Peyronie's disease (PD). We investigated the role of vascular status in the pathophysiology of ED in patients with PD...
  64. ncbi request reprint Vardenafil: a novel type 5 phosphodiesterase inhibitor for the treatment of erectile dysfunction
    Muammer Kendirci
    Tulane University Health Sciences Center, Department of Urology, New Orleans, LA 70112, USA
    Expert Opin Pharmacother 5:923-32. 2004
    ....
  65. pmc Posttranslational modification of constitutive nitric oxide synthase in the penis
    Biljana Musicki
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, 600 N Wolfe Avenue, Marburg 143, Baltimore, MD 21287, USA
    J Androl 30:352-62. 2009
    ..This communication reviews the role of eNOS and nNOS in erectile physiology and discusses the alterations in eNOS and nNOS via posttranslation modification in various vascular diseases of the penis...
  66. doi request reprint Significance of a minor high-grade component in a low-grade noninvasive papillary urothelial carcinoma of bladder
    Leonardo O Reis
    Pathology, Johns Hopkins Medical Institution, Baltimore, MD Urology, Johns Hopkins Medical Institution, Baltimore, MD
    Hum Pathol 47:20-5. 2016
    ..Until such data are available, it is reasonable to keep MG urothelial carcinoma as a distinct grade category with potential management implications. ..
  67. pmc The ratio of CD8 to Treg tumor-infiltrating lymphocytes is associated with response to cisplatin-based neoadjuvant chemotherapy in patients with muscle invasive urothelial carcinoma of the bladder
    Alexander S Baras
    Department of Pathology, Johns Hopkins, Baltimore, MD, USA Department of Urology, Johns Hopkins, Baltimore, MD, USA
    Oncoimmunology 5:e1134412. 2016
    ..These findings highlight the need to predict who will benefit from conventional NAC and the need for plausible alternatives...
  68. pmc ¹⁸F-DCFBC PET/CT for PSMA-Based Detection and Characterization of Primary Prostate Cancer
    Steven P Rowe
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
    J Nucl Med 56:1003-10. 2015
    ..An imaging biomarker able to detect clinically significant high-grade primary prostate cancer reliably would address an unmet clinical need by allowing for risk-adapted patient management...
  69. pmc Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats
    Johanna L Hannan
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Sex Med 11:1442-51. 2014
    ..Bilateral cavernous nerve injury (BCNI) causes profound penile changes such as apoptosis and fibrosis leading to erectile dysfunction (ED). Histone deacetylase (HDAC) has been implicated in chronic fibrotic diseases...
  70. ncbi request reprint Impact of hospital volume on perioperative outcomes and costs of radical cystectomy: analysis of the Maryland Health Services Cost Review Commission database
    Michael A Gorin
    The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Can J Urol 21:7102-7. 2014
    ..The objective of this study was to evaluate the impact of hospital case volume on perioperative outcomes and costs of radical cystectomy (RC) after controlling for differences in patient case mix...
  71. doi request reprint Intraperitoneal effects of extraperitoneal laparoscopic radical prostatectomy
    Trinity J Bivalacqua
    The Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    Urology 72:273-7. 2008
    ..To compare routine radiologic and laboratory findings after extraperitoneal and transperitoneal laparoscopic radical prostatectomy (eLRP, tLRP) and assess relevant clinical correlations...
  72. doi request reprint Open, laparoscopic and robotic radical prostatectomy: optimizing the surgical approach
    Trinity J Bivalacqua
    James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institution, Baltimore, MD, United States
    Surg Oncol 18:233-41. 2009
    ....
  73. pmc Ureteral stents placed at the time of urinary diversion decreases postoperative morbidity
    Jeffrey K Mullins
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA jmulli12 jhmi edu
    Urol Int 88:66-70. 2012
    ..To determine the impact of stenting ureteroenteric anastomoses on postoperative stricture rate and gastrointestinal recovery in continent and noncontinent urinary diversions (UDs)...
  74. doi request reprint Arginase inhibition promotes wound healing in mice
    Sandra L Kavalukas
    Department of Surgery, Sinai Hospital of Baltimore, Baltimore, MD, USA
    Surgery 151:287-95. 2012
    ..In this study, we used a highly potent and specific inhibitor of arginase, namely 2(S)-amino-6-boronohexanoic acid NH4 (ABH) to evaluate the role of arginase function in wound healing...
  75. ncbi request reprint Intralesional interferon-alpha-2B injections for the treatment of Peyronie's disease
    Gerald Dang
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    South Med J 97:42-6. 2004
    ..Intralesional therapies provide an alternative to surgical treatment of Peyronie's disease (PD). This study examines the efficacy of intraplaque injections of interferon-alpha-2B (IFN-alpha-2B) in the treatment of PD...
  76. ncbi request reprint The protective effect of aminoguanidine on erectile function in streptozotocin diabetic rats
    Mustafa F Usta
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    J Urol 170:1437-42. 2003
    ....
  77. ncbi request reprint Nitric oxide/redox-based signalling as a therapeutic target for penile disorders
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 2411, USA
    Expert Opin Ther Targets 10:445-57. 2006
    ..The next line of pharmaceuticals for disorders of the penis, in general, may well spawn from an integrative understanding of the complex regulatory interactions influenced by, as well as influencing nitric oxide signalling in this organ...
  78. doi request reprint Pathological upstaging during radical cystectomy is associated with worse recurrence-free survival in patients with bacillus Calmette-Guerin-refractory bladder cancer
    Thomas J Guzzo
    The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 74:1276-80. 2009
    ..To compare the outcomes of patients who were upstaged to pT2 at the time of radical cystectomy (RC) to those who were correctly staged as T2 before RC...
  79. doi request reprint Xanthogranulomatous pyelonephritis: presentation and management in the era of laparoscopy
    Thomas J Guzzo
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    BJU Int 104:1265-8. 2009
    ....
  80. doi request reprint Irbesartan promotes erection recovery after nerve-sparing radical retropubic prostatectomy: a retrospective long-term analysis
    Robert L Segal
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    BJU Int 110:1782-6. 2012
    ..Further study in the form of prospective, randomized, placebo-controlled clinical trials are necessary to confirm these findings...
  81. doi request reprint Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury
    Giulia Calenda
    Albert Einstein College of Medicine, Bronx, NY, USA
    BJU Int 109:1552-64. 2012
    ....
  82. doi request reprint The presence of circulating tumor cells does not predict extravesical disease in bladder cancer patients prior to radical cystectomy
    Thomas J Guzzo
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Urol Oncol 30:44-8. 2012
    ..The object of this study was to evaluate the ability of CTCs to predict extravesical disease in bladder cancer patients prior to RC...
  83. ncbi request reprint Glucose-6-phosphate dehydrogenase deficiency: an etiology for idiopathic priapism?
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Sex Med 5:237-40. 2008
    ..Efforts to identify the health risk associations for priapism may reveal pathophysiologic mechanisms for the disorder and suggest a scientifically rational approach for correcting it...
  84. ncbi request reprint Patient and partner satisfaction and long-term results after surgical treatment for Peyronie's disease
    Mustafa F Usta
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Urology 62:105-9. 2003
    ..To assess the long-term functional outcome, patient and partner satisfaction, and predictive factors for unfavorable results in men treated with a surgical approach for severe Peyronie's disease...
  85. ncbi request reprint Relationship between the severity of penile curvature and the presence of comorbidities in men with Peyronie's disease
    Mustafa F Usta
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Urol 171:775-9. 2004
    ..We investigated the relationship between penile curvature severity and co-morbidities in men with Peyronie's disease (PD) and assessed whether the severity of curvature had an impact on penile vascular status and/or erectile function...
  86. pmc Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity
    Milena A Gebska
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Rutland Avenue, Baltimore, MD 21205, USA
    Cardiovasc Res 90:353-63. 2011
    ..The role of endothelial PDE5A, however, has not been yet characterized. The present study was undertaken to determine the presence, localization, and potential physiologic significance of PDE5A within vascular endothelial cells...
  87. doi request reprint Common pitfalls in some of the experimental studies in erectile function and dysfunction: a consensus article
    Selim Cellek
    Cranfield Health, Cranfield University, Bedfordshire, UK
    J Sex Med 9:2770-84. 2012
    ..As the field of sexual medicine expanding, the proper conduct of such techniques is becoming an even more important necessity than before...
  88. doi request reprint Outcomes of patients after aborted radical cystectomy for intraoperative findings of metastatic disease
    Thomas J Guzzo
    The Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
    BJU Int 102:1539-43. 2008
    ....
  89. doi request reprint Penile ischemic injury in the exstrophy/epispadias spectrum: new insights and possible mechanisms
    Raimondo M Cervellione
    Division of Pediatric Urology, Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
    J Pediatr Urol 6:450-6. 2010
    ..Partial or complete penile loss following bladder exstrophy and/or epispadias repair has been reported in the literature progressively more frequently...
  90. doi request reprint Priapism: pathogenesis, epidemiology, and management
    Gregory A Broderick
    Department of Urology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    J Sex Med 7:476-500. 2010
    ..A correct diagnosis of priapism is a matter of urgency requiring identification of underlying hemodynamics...
  91. ncbi request reprint Priapism: current principles and practice
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Instituitions, Baltimore, MD, USA
    Urol Clin North Am 34:631-42, viii. 2007
    ..All health care professionals should appreciate the importance of the disorder and be prepared to follow current principles of diagnosis and treatment to reduce or avert its complications...
  92. doi request reprint Priapism: new concepts in medical and surgical management
    Arthur L Burnett
    Division of Sexual Medicine, Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Johns Hopkins Hospital, Marburg 407, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Urol Clin North Am 38:185-94. 2011
    ..All successes in these arenas ensure that afflicted individuals avoid the health burdens of priapism and preserve sexual function...
  93. doi request reprint Smoking knowledge assessment and cessation trends in patients with bladder cancer presenting to a tertiary referral center
    Thomas J Guzzo
    Department of Urology, University of Pennsylvania School of Medicine, Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania 19104, USA
    Urology 79:166-71. 2012
    ..However, little information is available regarding patients' knowledge of the risks of smoking and the role of their urologists in initiating smoking cessation at diagnosis...
  94. ncbi request reprint Role of nitric oxide in mediating vasodilator responses to opioid peptides in the rat
    Hunter C Champion
    Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Clin Exp Pharmacol Physiol 29:229-32. 2002
    ..Moreover, these results demonstrate that the vasodilator responses to these peptides are not due to the release of vasodilator prostaglandins or the opening of KATP channels in the hindquarters vascular bed of the rat...
  95. ncbi request reprint Urethral carcinosarcoma from bladder carcinosarcomatous lesions: analysis of clinicopathological features
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Can J Urol 16:4512-5. 2009
    ..The goal of this case report is to review our current understanding of the pathological and recurrence patterns of patients with CS of the urinary bladder in order to better define postoperative care for patients with CS of the bladder...
  96. ncbi request reprint Priapism: new concepts in the pathophysiology and new treatment strategies
    Trinity J Bivalacqua
    Baltimore, MD 21287, USA
    Curr Urol Rep 7:497-502. 2006
    ..In this review, the proposed pathogenesis of ischemic priapism is reviewed, and a survey regarding novel treatment modalities is given...
  97. ncbi request reprint Localization of peripheral dopamine D1 and D2 receptors in rat and human seminal vesicles
    Jae Seog Hyun
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Androl 23:114-20. 2002
    ....
  98. ncbi request reprint Paraneoplastic polyarthritis from non-small-cell lung cancer metastatic to the bladder
    Trinity J Bivalacqua
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 25:2621-3. 2007
  99. doi request reprint Cystoscopic management of an extruded coil from arteriovenous fistula embolization using arthroscopic instruments
    Edward M Schaeffer
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Endourol 22:1527-9. 2008
    ..We describe one potential complication of transcatheter embolization that involves necrosis of the bladder wall with a novel technique for endoscopic management of an extruded coil in the bladder...
  100. ncbi request reprint Neurohumoral features of myocardial stunning due to sudden emotional stress
    Ilan S Wittstein
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 352:539-48. 2005
    ..Reversible left ventricular dysfunction precipitated by emotional stress has been reported, but the mechanism remains unknown...