P B Barker

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Single-voxel proton MRS of the human brain at 1.5T and 3.0T
    P B Barker
    Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA
    Magn Reson Med 45:765-9. 2001
  2. ncbi request reprint MRI and proton MRSI in women heterozygous for X-linked adrenoleukodystrophy
    A Fatemi
    Kennedy Krieger Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Neurology 60:1301-7. 2003
  3. ncbi request reprint Quantitation of NAA in the brain by magnetic resonance spectroscopy
    Peter B Barker
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Adv Exp Med Biol 576:183-97; discussion 361-3. 2006
  4. ncbi request reprint Broadband proton decoupling for in vivo brain spectroscopy in humans
    P B Barker
    Department of Radiology, MRI 143C, Johns Hopkins University School of Medicine, 800 N Wolfe St, Baltimore, MD 21287, USA
    Magn Reson Med 45:226-32. 2001
  5. ncbi request reprint Metabolic heterogeneity at the level of the anterior and posterior commissures
    P B Barker
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 43:348-54. 2000
  6. ncbi request reprint Neuroimaging in leukodystrophies
    Peter B Barker
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Child Neurol 19:559-70. 2004
  7. ncbi request reprint Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute stroke
    A E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Neurol 50:561-6. 2001
  8. ncbi request reprint Proton magnetic resonance spectroscopy of choroid plexus tumors in children
    A Horska
    Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 14:78-82. 2001
  9. ncbi request reprint Spectroscopic evidence of cerebral axonopathy in patients with "pure" adrenomyeloneuropathy
    P Dubey
    Departments of Neurogenetics, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, MD, USA
    Neurology 64:304-10. 2005
  10. ncbi request reprint Reperfusion of specific brain regions by raising blood pressure restores selective language functions in subacute stroke
    A E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, USA
    Brain Lang 79:495-510. 2001

Detail Information

Publications80

  1. ncbi request reprint Single-voxel proton MRS of the human brain at 1.5T and 3.0T
    P B Barker
    Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA
    Magn Reson Med 45:765-9. 2001
    ..Spectra in phantoms demonstrated significantly improved resolution at 3T compared to 1.5T, but resolution improvements in in vivo spectra were almost completely offset by increased linewidths at higher field...
  2. ncbi request reprint MRI and proton MRSI in women heterozygous for X-linked adrenoleukodystrophy
    A Fatemi
    Kennedy Krieger Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Neurology 60:1301-7. 2003
    ..To utilize neuroimaging procedures to assess the extent of cerebral involvement in female subjects heterozygous for X-linked adrenoleukodystrophy (X-ALD)...
  3. ncbi request reprint Quantitation of NAA in the brain by magnetic resonance spectroscopy
    Peter B Barker
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Adv Exp Med Biol 576:183-97; discussion 361-3. 2006
  4. ncbi request reprint Broadband proton decoupling for in vivo brain spectroscopy in humans
    P B Barker
    Department of Radiology, MRI 143C, Johns Hopkins University School of Medicine, 800 N Wolfe St, Baltimore, MD 21287, USA
    Magn Reson Med 45:226-32. 2001
    ..The PBAR sequence allows whole brain [(1)H]-[13]C decoupling to be performed at 1.5T with a standard head coil within FDA guidelines for RF power deposition. Magn Reson Med 45:226-232, 2001...
  5. ncbi request reprint Metabolic heterogeneity at the level of the anterior and posterior commissures
    P B Barker
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 43:348-54. 2000
    ..Normal regional variations in the brain spectra should be considered when evaluating pathological conditions...
  6. ncbi request reprint Neuroimaging in leukodystrophies
    Peter B Barker
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Child Neurol 19:559-70. 2004
    ..In the future, anatomic and physiologic magnetic resonance techniques are expected to be integrated into a single examination that will provide a detailed characterization of white-matter diseases in children...
  7. ncbi request reprint Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute stroke
    A E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Neurol 50:561-6. 2001
    ..These results add further evidence for the crucial role of Wernicke's area (Brodmann's area 22) in word comprehension and indicate that the magnitude of delay on PWI may be a gross indicator of tissue dysfunction...
  8. ncbi request reprint Proton magnetic resonance spectroscopy of choroid plexus tumors in children
    A Horska
    Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 14:78-82. 2001
    ....
  9. ncbi request reprint Spectroscopic evidence of cerebral axonopathy in patients with "pure" adrenomyeloneuropathy
    P Dubey
    Departments of Neurogenetics, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, MD, USA
    Neurology 64:304-10. 2005
    ..Histopathology shows cerebral involvement even in pure AMN; however, not much is known about the nature, extent, and clinical relevance of these findings...
  10. ncbi request reprint Reperfusion of specific brain regions by raising blood pressure restores selective language functions in subacute stroke
    A E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, USA
    Brain Lang 79:495-510. 2001
    ....
  11. ncbi request reprint Leukoencephalopathy, cerebral calcifications, and cysts: new observations
    L M Nagae-Poetscher
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 62:1206-9. 2004
    ..Imaging findings favor increased water content rather than a demyelinating process in the pathophysiology of this disease. Clinical features of Coats disease and consanguinity were also encountered...
  12. ncbi request reprint Perfusion-weighted MRI as a marker of response to treatment in acute and subacute stroke
    A E Hillis
    Department of Cognitive Science, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Neuroradiology 46:31-9. 2004
    ....
  13. ncbi request reprint Restoring blood pressure reperfused Wernicke's area and improved language
    A E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 56:670-2. 2001
    ..MR perfusion imaging showed that language gains were accompanied by improved perfusion of Wernicke's area when mean arterial pressure was increased...
  14. ncbi request reprint Proton MR spectroscopic imaging in ataxia-telangiectasia
    D D M Lin
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuropediatrics 37:241-6. 2006
    ....
  15. ncbi request reprint Imaging of acute cerebral ischemia
    N J Beauchamp
    Morgan H Russell Department of Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Radiology 212:307-24. 1999
    ..Magnetic resonance techniques are equally emphasized in that they have the potential to provide a single modality evaluation of tissue viability and vessel patency in an increasingly rapid evaluation...
  16. ncbi request reprint Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats
    R A Knight
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Mich 48202, USA
    Stroke 29:144-51. 1998
    ..As a means of predicting HT, we investigated the role of contrast-enhanced MRI at acute time points in a rat middle cerebral artery occlusion model with reperfusion...
  17. pmc Crossed cerebellar diaschisis in acute stroke detected by dynamic susceptibility contrast MR perfusion imaging
    D D M Lin
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    AJNR Am J Neuroradiol 30:710-5. 2009
    ....
  18. ncbi request reprint Quantitative 1H MR spectroscopic imaging in early Rett syndrome
    A Horska
    Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Neurology 54:715-22. 2000
    ..To determine cerebral regional concentrations of N-acetyl aspartate (NAA), total choline (Cho), and total creatine (Cr) in Rett syndrome (RS) using 1H magnetic resonance spectroscopic imaging (MRSI)...
  19. pmc Can proton MR spectroscopic and perfusion imaging differentiate between neoplastic and nonneoplastic brain lesions in adults?
    R Hourani
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    AJNR Am J Neuroradiol 29:366-72. 2008
    ..Our aims were to investigate whether 1) proton MR spectroscopic imaging ((1)H-MRSI) can aid in differentiating between tumors and nonneoplastic brain lesions, and 2) perfusion MR imaging can improve the classification...
  20. ncbi request reprint Proton MR spectroscopic imaging predicts lesion progression on MRI in X-linked adrenoleukodystrophy
    F S Eichler
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, MD 21205, USA
    Neurology 58:901-7. 2002
    ..However, the significance of these changes is unclear...
  21. ncbi request reprint Quantitative proton MR spectroscopic imaging in acute disseminated encephalomyelitis
    A Bizzi
    Russell C. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    AJNR Am J Neuroradiol 22:1125-30. 2001
    ..This case demonstrates that reduced levels of NAA are not always associated with neuronal loss, irreversible tissue damage, or poor neurologic outcome...
  22. ncbi request reprint Neuroimaging studies in Rett syndrome
    S Naidu
    The Kennedy Krieger Institute and the Johns Hopkins University, Baltimore, MD 21205, USA
    Brain Dev 23:S62-71. 2001
    ..The resulting neuroexcitotoxic injury to the developing brain contributes to the seizures, behavioral disturbance and respiratory irregularities commonly seen in phases 1 and 2 of this disorder...
  23. ncbi request reprint Rapid method for correction of CSF partial volume in quantitative proton MR spectroscopic imaging
    A Horska
    Division of Neuroradiology, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA
    Magn Reson Med 48:555-8. 2002
    ....
  24. ncbi request reprint Diffusion-weighted MRI and proton MR spectroscopic imaging in the study of secondary neuronal injury after intracerebral hemorrhage
    J R Carhuapoma
    Divisions of Neurosciences Critical Care, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 7840, USA
    Stroke 31:726-32. 2000
    ..We report on the feasibility of DWI and (1)H-MRSI in the study of human ICH and present preliminary data on their contribution to understanding perihematoma tissue functional and metabolic profiles...
  25. ncbi request reprint Contrasts in cortical magnesium, phospholipid and energy metabolism between migraine syndromes
    M D Boska
    Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
    Neurology 58:1227-33. 2002
    ..These studies were extended to include multiple brain regions and larger numbers of patients by multislice (31)P MR spectroscopic imaging...
  26. ncbi request reprint Multi-slice proton MR spectroscopy and diffusion-weighted imaging in methylmalonic acidemia: report of two cases and review of the literature
    B C Trinh
    Russell C. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, USA
    AJNR Am J Neuroradiol 22:831-3. 2001
    ..The findings consisted of restricted diffusion and elevated lactate in the globi pallidi, compatible with acute infarction (patient 1) and elevated lactate in CSF (patient 2)...
  27. ncbi request reprint A pilot randomized trial of induced blood pressure elevation: effects on function and focal perfusion in acute and subacute stroke
    A E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Cerebrovasc Dis 16:236-46. 2003
    ..We conducted a pilot, randomized trial to evaluate effects of pharmacologically induced blood pressure elevation on function and perfusion in acute stroke...
  28. ncbi request reprint Diffusion- and perfusion-weighted brain magnetic resonance imaging in patients with neurologic complications after cardiac surgery
    R J Wityk
    Department of Neurology, Johns Hopkins Hospital, Meyer 5 181, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Neurol 58:571-6. 2001
    ..More precise neuroimaging of patients with these complications may lead to a better understanding of the etiology and treatment of these disorders...
  29. pmc Minimal hepatic encephalopathy in children: evaluation with proton MR spectroscopy
    B R Foerster
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    AJNR Am J Neuroradiol 30:1610-3. 2009
    ....
  30. ncbi request reprint Quantitative proton MR spectroscopic imaging of normal human cerebellum and brain stem
    M A Jacobs
    The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 46:699-705. 2001
    ..002) and was also higher in the pons than in the insular cortex (P < 0.05). Quantitative multislice MRSI of the posterior fossa is feasible and significant regional differences in metabolite concentrations were found...
  31. ncbi request reprint Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion
    A E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 125:1094-104. 2002
    ..From these data we conclude that aphasia and neglect due to acute subcortical stroke can be largely explained by cortical hypoperfusion...
  32. pmc Imaging characteristics of oligodendrogliomas that predict grade
    L Khalid
    Russell H Morgan Department of Radiology and Radiological Services, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    AJNR Am J Neuroradiol 33:852-7. 2012
    ..Our aim was to retrospectively evaluate imaging features of oligodendrogliomas that predict tumor grade...
  33. ncbi request reprint Musculoskeletal tumors: use of proton MR spectroscopic imaging for characterization
    Laura M Fayad
    Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Magn Reson Imaging 23:23-8. 2006
    ..To determine the value of multivoxel proton magnetic resonance spectroscopic imaging (MRSI) in distinguishing malignant skeletal tumors from benign tumors and normal bone marrow using the metabolite choline (Cho) as a marker for malignancy...
  34. ncbi request reprint Proton magnetic resonance spectroscopic imaging to differentiate between nonneoplastic lesions and brain tumors in children
    Roula Hourani
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 23:99-107. 2006
    ..To investigate whether in vivo proton magnetic resonance spectroscopic imaging (MRSI) can differentiate between 1) tumors and nonneoplastic brain lesions, and 2) high- and low-grade tumors in children...
  35. ncbi request reprint Noninvasive assessment of brain injury in a canine model of hypothermic circulatory arrest using magnetic resonance spectroscopy
    Christopher J Barreiro
    Division of Cardiac Surgery, Kennedy Krieger Research Institute, Baltimore, Maryland, USA
    Ann Thorac Surg 81:1593-8. 2006
    ..We demonstrated that noninvasive measurement of NAA:Cho with magnetic resonance spectroscopy facilitates assessment of neuronal injury after HCA and allows for evaluation of neuroprotective strategies...
  36. pmc Regional apparent metabolite concentrations in young adult brain measured by (1)H MR spectroscopy at 3 Tesla
    Eva H Baker
    Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Magn Reson Imaging 27:489-99. 2008
    ..To quantify and examine the distribution of brain metabolites in normal young adults using single voxel MR spectroscopy at 3 Tesla (T)...
  37. ncbi request reprint Dynamic MR perfusion and proton MR spectroscopic imaging in Sturge-Weber syndrome: correlation with neurological symptoms
    Doris D M Lin
    Division of Neuroradiology, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Magn Reson Imaging 24:274-81. 2006
    ..To investigate physiological alterations in Sturge-Weber syndrome (SWS) using MR perfusion imaging (PWI) and proton spectroscopic imaging (MRSI), and their association with neurological status...
  38. pmc Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury
    Ann C Halbower
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e301. 2006
    ..We hypothesized that childhood OSA is associated with neuropsychological performance dysfunction, and with neuronal metabolite alterations in the brain, indicative of neuronal injury in areas corresponding to neuropsychological function...
  39. ncbi request reprint Optimized detection of lactate at high fields using inner volume saturation
    Richard A E Edden
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 56:912-7. 2006
    ..The method should be feasible at magnetic fields above 3 Tesla, and may also be applied to other coupled spin systems in which modulation effects are important...
  40. ncbi request reprint Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Toxicol Sci 94:351-8. 2006
    ..This is supported by a significantly decreased, in the parietal cortex, NAA/Cr ratio suggestive of ongoing neuronal degeneration or dysfunction...
  41. pmc Measurement of T1 and T2 in the cervical spinal cord at 3 tesla
    Seth A Smith
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Magn Reson Med 60:213-9. 2008
    ..Since the spinal cord has rostral-caudal symmetry, we expect these findings to be applicable to the whole cord...
  42. pmc 3T MR with diffusion tensor imaging and single-voxel spectroscopy in giant axonal neuropathy
    Christiana Brenner
    Diagnostic Imaging Department, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    J Magn Reson Imaging 28:236-41. 2008
    ..Cerebellar involvement was less evident. The DTI and MRS findings suggest myelin and axonal damage...
  43. doi request reprint Molecular characterization of musculoskeletal tumors by proton MR spectroscopy
    Laura M Fayad
    Department of Radiology and Orthopaedic Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Semin Musculoskelet Radiol 11:240-5. 2007
    ..We demonstrate its potential utility in the evaluation of musculoskeletal lesions through a series of examples...
  44. ncbi request reprint Spatial effects in the detection of gamma-aminobutyric acid: improved sensitivity at high fields using inner volume saturation
    Richard A E Edden
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 58:1276-82. 2007
    ..MEGA-PRESS-IVS is then compared to MEGA-PRESS in a phantom and an average signal increase of 24% is demonstrated in five healthy volunteers...
  45. ncbi request reprint Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders
    Mona A Mohamed
    The Johns Hopkins University School of Medicine, Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, United States
    Psychiatry Res 156:175-9. 2007
    ..Abnormal neuronal metabolism in the right basal ganglia and right thalamus may be indicating lack of response to treatment to selective serotonin reuptake inhibitor...
  46. ncbi request reprint Proton MR spectroscopic imaging of the medulla and cervical spinal cord
    Richard A E Edden
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Magn Reson Imaging 26:1101-5. 2007
    ..To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical spine and medulla at 3.0 Tesla...
  47. ncbi request reprint In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla
    Richard A E Edden
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Magn Reson Med 57:977-82. 2007
    ..White matter concentrations of NAA (6.7 +/- 0.3 mM) and NAAG (2.2 +/- 0.3 mM) were measured in 10 healthy volunteers to demonstrate the method...
  48. ncbi request reprint Characterization of musculoskeletal lesions on 3-T proton MR spectroscopy
    Laura M Fayad
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine and Johns Hopkins Medical Institutions, 601 N Caroline St, JHOC 3171C, Baltimore, MD 21287, USA
    AJR Am J Roentgenol 188:1513-20. 2007
    ..The purpose of our study was to determine the feasibility and value of proton MR spectroscopy at 3 T for characterizing musculoskeletal tumors...
  49. ncbi request reprint Fast method for brain image segmentation: application to proton magnetic resonance spectroscopic imaging
    David Bonekamp
    Division of Neuroradiology, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 54:1268-72. 2005
    ..It is concluded that FSE imaging in conjunction with Eigenimage analysis is a rapid and reliable way of segmenting brain tissue for application to proton MRSI...
  50. ncbi request reprint Early characteristics of Sturge-Weber syndrome shown by perfusion MR imaging and proton MR spectroscopic imaging
    Doris D M Lin
    Department of Radiology and Radiologic Science Johns Hopkins University School of Medicine, Baltimore, MD, USA
    AJNR Am J Neuroradiol 24:1912-5. 2003
    ..The perfusion and subtle metabolic abnormalities are comparable with the extent of the overlying leptomeningeal enhancement, illustrating the early pathophysiological manifestation of this disease...
  51. ncbi request reprint Asymmetry and gender effect in functionally lateralized cortical regions: a proton MRS imaging study
    Lidia M Nagae-Poetscher
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 19:27-33. 2004
    ..to compare metabolite concentrations and ratios in gray matter regions known for their anatomical/functional asymmetry and evaluate gender effect...
  52. ncbi request reprint Proton magnetic resonance spectroscopic imaging of human breast cancer: a preliminary study
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 19:68-75. 2004
    ..To investigate the diagnostic value of proton magnetic resonance spectroscopic imaging (MRSI) in patients with breast lesions...
  53. ncbi request reprint Benign and malignant breast lesions: diagnosis with multiparametric MR imaging
    Michael A Jacobs
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Traylor Bldg, Room 217, 712 Rutland Avenue, Baltimore, MD 21205, USA
    Radiology 229:225-32. 2003
    ..To both develop and use a tissue signature method for the identification and classification of breast lesions and healthy breast tissue with magnetic resonance (MR) imaging...
  54. ncbi request reprint Proton MR spectroscopic imaging in Pelizaeus-Merzbacher disease
    Francesca Pizzini
    Kennedy Krieger Institute, Baltimore, MD, USA
    AJNR Am J Neuroradiol 24:1683-9. 2003
    ..The current study was conducted to characterize the results of proton MR spectroscopic (MRS) imaging in PMD...
  55. ncbi request reprint Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma
    Bayram Cirak
    Division of Pediatric Neurosurgery, Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Childs Nerv Syst 21:404-9. 2005
    ..A pilomyxoid astrocytoma (PmA) is considered to be either a more aggressive variant of a pediatric pilocytic astrocytoma (PA) or a tumor of a separate entity...
  56. ncbi request reprint Quantitative proton MR spectroscopic imaging of the mesial temporal lobe
    Atilla Arslanoglu
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 20:772-8. 2004
    ..To evaluate variations in regional metabolite concentrations in the anterior mesial temporal lobe (ATL), and compare metabolite concentrations between the allocortex and neocortex using quantitative proton MR spectroscopic imaging (MRSI)...
  57. ncbi request reprint Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: current applications
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Technol Cancer Res Treat 3:543-50. 2004
    ..A combination of MR, MRSI, and 23Na sodium MR parameters may be examined in a single MR imaging examination, potentially resulting in improved specificity for radiologic evaluation of malignancy...
  58. ncbi request reprint Combined dynamic contrast enhanced breast MR and proton spectroscopic imaging: a feasibility study
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 21:23-8. 2005
    ..To investigate the feasibility of combined dynamic contrast enhanced (DCE) and magnetic resonance spectroscopy (MRS) in evaluating breast lesions...
  59. ncbi request reprint Magnetic resonance spectroscopy: a new guide for the therapy of adrenoleukodystrophy
    Hugo W Moser
    Neurology 64:406-7. 2005
  60. ncbi request reprint A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia
    Ned Sacktor
    Department of Neurology, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Magn Reson Imaging 21:325-33. 2005
    ..To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia...
  61. ncbi request reprint Scan time reduction in proton magnetic resonance spectroscopic imaging of the human brain
    Xavier Golay
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Magn Reson Med 47:384-7. 2002
    ..Scan time in MRSI is minimized in this method by using FOVs no larger than the dimensions of the object to be imaged. The method may also be combined with other fast MRSI techniques to provide further scan time reductions...
  62. ncbi request reprint Proton MR spectroscopic and diffusion tensor brain MR imaging in X-linked adrenoleukodystrophy: initial experience
    Florian S Eichler
    F M Kirby Research Center for Functional Brain Imaging, Johns Hopkins University, Baltimore, MD, USA
    Radiology 225:245-52. 2002
    ..To compare conventional magnetic resonance (MR) imaging, proton MR spectroscopic imaging, and diffusion tensor (DT) MR imaging findings in patients with X chromosome-linked adrenoleukodystrophy (X-ALD)...
  63. ncbi request reprint Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome
    Florian S Eichler
    Department of Neurogenetics, The Johns Hopkins University, Baltimore, MD, USA
    AJNR Am J Neuroradiol 23:833-7. 2002
    ..Proton MR spectroscopic imaging may be helpful for the diagnosis and investigation of the underlying pathophysiology of reversible posterior leukoencephalopathy syndrome...
  64. ncbi request reprint Quantitative proton magnetic resonance spectroscopic imaging: regional variations in the corpus callosum and cortical gray matter
    Mahaveer N Degaonkar
    Division of Neuroradiology, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Magn Reson Imaging 22:175-9. 2005
    ..To evaluate regional variations of metabolite concentrations in normal adult brain cortical gray matter regions, and the genu and splenium of the corpus callosum, using proton magnetic resonance spectroscopic imaging (MRSI)...
  65. ncbi request reprint In vivo quantitative proton MRSI study of brain development from childhood to adolescence
    Alena Horska
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 15:137-43. 2002
    ..To quantify regional variations in metabolite levels in the developing brain using quantitative proton MR spectroscopic imaging (MRSI)...
  66. ncbi request reprint Quantitative MR spectroscopic imaging of brain lesions in patients with AIDS: correlation with [11C-methyl]thymidine PET and thallium-201 SPECT
    Martin G Pomper
    Department of Radiology, Johns Hopkins University, Baltimore, MD 21287 2182, USA
    Acad Radiol 9:398-409. 2002
    ..The purpose of this study was to examine the metabolic basis for magnetic resonance (MR) spectroscopic imaging findings in focal brain lesions of patients with acquired immunodeficiency syndrome (AIDS)...
  67. ncbi request reprint Change in perfusion in acute nondominant hemisphere stroke may be better estimated by tests of hemispatial neglect than by the National Institutes of Health Stroke Scale
    Argye E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, Meyer 5 185, 600 N Wolfe St, Baltimore, MD 21287, USA
    Stroke 34:2392-6. 2003
    ..We conducted 2 studies to determine whether tests of hemispatial neglect provide a better measure of hypoperfusion and reperfusion than NIHSS in nondominant hemisphere stroke...
  68. ncbi request reprint Proton MR spectroscopy in the diagnostic evaluation of suspected mitochondrial disease
    Doris D M Lin
    Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    AJNR Am J Neuroradiol 24:33-41. 2003
    ..We sought to examine the frequency of detectable elevations of CNS lactate by proton MR spectroscopy in a population of children and young adults with suspected mitochondrial disease...
  69. ncbi request reprint Simultaneous water and lipid suppression for in vivo brain spectroscopy in humans
    Mari A Smith
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 54:691-6. 2005
    ..An example of the use of the dual saturation method in in vivo magnetic resonance spectroscopic imaging of the human brain is presented...
  70. ncbi request reprint A neurologic presentation of familial hemophagocytic lymphohistiocytosis which mimicked septic emboli to the brain
    L Christine Turtzo
    Department of Neurology and Pediatric Neurology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Child Neurol 22:863-8. 2007
    ..His case illustrates the potential for a fulminant neurological presentation of familial hemophagocytic lymphohistiocytosis with widespread lesions in the brain...
  71. ncbi request reprint Diffusion-perfusion MR evaluation and spectroscopy before and after surgical therapy for intracerebral hemorrhage
    J Ricardo Carhuapoma
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    Neurocrit Care 2:23-7. 2005
    ..We postulate that these MRI techniques may help define mechanisms of secondary damage and assess effects of therapeutic interventions in perihematoma tissue after ICH...
  72. ncbi request reprint Diffusion tensor-based imaging reveals occult abnormalities in adrenomyeloneuropathy
    Prachi Dubey
    Department of Neurogenetics and Functional Magnetic Resonance Imaging Kirby Center, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Ann Neurol 58:758-66. 2005
    ..Accompanying abnormalities in genu of corpus callosum indicate that the disease pathology in pure AMN may not be limited to spinal cord long tracts alone, although the involvement of the latter is most prominent and severe...
  73. ncbi request reprint Etiology of perfusion-diffusion magnetic resonance imaging mismatch patterns
    Lucas Restrepo
    Department of Neurology, Johns Hopkins Hospital, Baltimore, MD, USA
    J Neuroimaging 15:254-60. 2005
    ..The authors therefore investigated the etiology of brain ischemia in patients with different DWI/PWI patterns...
  74. ncbi request reprint Anatomy of spatial attention: insights from perfusion imaging and hemispatial neglect in acute stroke
    Argye E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurosci 25:3161-7. 2005
    ..Results help explain conflicting results in the literature and contribute to the understanding of spatial attention and representation in the human brain...
  75. ncbi request reprint Proton MR spectroscopy in hyperhomocysteinemia with elevated blood methionine levels
    L Patricia Franco
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Magn Reson Imaging 23:404-7. 2006
    ..Normal MRSI at presentation was predictive of a positive outcome despite the markedly abnormal initial MRI results...
  76. ncbi request reprint Restoring cerebral blood flow reveals neural regions critical for naming
    Argye E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 26:8069-73. 2006
    ..Results show that identifying areas of reperfusion that are associated with acute improvement of a function can reveal the brain regions essential for that function...
  77. ncbi request reprint Metabolites in ventricular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging
    Lidia M Nagae-Poetscher
    Kennedy Krieger Institute, Baltimore, Maryland, USA
    J Magn Reson Imaging 20:496-500. 2004
    ..These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously...
  78. pmc Diffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differences
    David Bonekamp
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neuroimage 34:733-42. 2007
    ..Our results show that the evaluated DTI protocol is suitable for clinical application in pediatric population...
  79. ncbi request reprint Re-examining the brain regions crucial for orchestrating speech articulation
    Argye E Hillis
    Department of Neurology, Meyer 5 185, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Brain 127:1479-87. 2004
    ..These results illustrate a potential limitation of lesion overlap studies, and illustrate an alternative method for identifying brain-behaviour relationships...
  80. ncbi request reprint Neuroimaging of phakomatoses
    Doris D M Lin
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Semin Pediatr Neurol 13:48-62. 2006
    ....