Ashwin Balagopal

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Detection of microbial translocation in HIV and SIV infection using the Limulus amebocyte lysate assay is masked by serum and plasma
    Ashwin Balagopal
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e41258. 2012
  2. pmc The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS)
    Daniel Benten
    Department of Gastroenterology and Hepatology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    BMC Gastroenterol 11:107. 2011
  3. ncbi request reprint Clostridium difficile: new therapeutic options
    Ashwin Balagopal
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 439, Baltimore, MD 21287, USA
    Curr Opin Pharmacol 7:455-8. 2007
  4. pmc IL28B and the control of hepatitis C virus infection
    Ashwin Balagopal
    Division of Infectious Diseases, Center for Viral Hepatitis, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Gastroenterology 139:1865-76. 2010
  5. pmc Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver
    Abraham J Kandathil
    Department of Medicine, Johns Hopkins University Baltimore, Maryland
    Gastroenterology 145:1404-13.e1-10. 2013
  6. pmc HIV, age, and the severity of hepatitis C virus-related liver disease: a cohort study
    Gregory D Kirk
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Ann Intern Med 158:658-66. 2013
  7. pmc Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution
    Ashwin Balagopal
    Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    AIDS 23:2397-404. 2009
  8. pmc Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug users
    Supriya Munshaw
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Hepatology 56:544-54. 2012
  9. pmc Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults
    Vidya Mave
    Johns Hopkins University BJ Medical College Clinical Research Site, Pune, India Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland
    J Infect Dis 214:65-72. 2016
  10. pmc Acute Hepatitis C Virus Infection Induces Consistent Changes in Circulating MicroRNAs That Are Associated with Nonlytic Hepatocyte Release
    Ramy El-Diwany
    Department of Medicine Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Virol 89:9454-64. 2015

Collaborators

Detail Information

Publications16

  1. pmc Detection of microbial translocation in HIV and SIV infection using the Limulus amebocyte lysate assay is masked by serum and plasma
    Ashwin Balagopal
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e41258. 2012
    ..However, related research has been impeded by inconsistent LPS test results...
  2. pmc The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS)
    Daniel Benten
    Department of Gastroenterology and Hepatology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    BMC Gastroenterol 11:107. 2011
    ..Translocation of gut-derived bacterial products such as endotoxin is a major problem in liver cirrhosis...
  3. ncbi request reprint Clostridium difficile: new therapeutic options
    Ashwin Balagopal
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 439, Baltimore, MD 21287, USA
    Curr Opin Pharmacol 7:455-8. 2007
    ..difficile disease. For now, vancomycin or metronidazole combined with discontinuation of antibiotics, when feasible, and expert infection control remain the mainstays of C. difficile disease management...
  4. pmc IL28B and the control of hepatitis C virus infection
    Ashwin Balagopal
    Division of Infectious Diseases, Center for Viral Hepatitis, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Gastroenterology 139:1865-76. 2010
    ..We review the genetic studies that uncovered the association between IL28B and HCV clearance, the biology of IFN-λ3, the clinical implications of the genetic association, and areas of future research...
  5. pmc Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver
    Abraham J Kandathil
    Department of Medicine, Johns Hopkins University Baltimore, Maryland
    Gastroenterology 145:1404-13.e1-10. 2013
    ..We investigated spatial distribution and determinants of HCV replication in human liver samples...
  6. pmc HIV, age, and the severity of hepatitis C virus-related liver disease: a cohort study
    Gregory D Kirk
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Ann Intern Med 158:658-66. 2013
    ..Persons with HIV infection have been reported to develop age-related diseases at younger ages than those without HIV. Whether this finding is related to HIV infection or failure to control for other risk factors is unknown...
  7. pmc Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution
    Ashwin Balagopal
    Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    AIDS 23:2397-404. 2009
    ..Although hepatic macrophages (Kupffer cells) clear most microbial translocation products and can be infected by HIV, their fate in HIV progression has not been carefully investigated...
  8. pmc Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug users
    Supriya Munshaw
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Hepatology 56:544-54. 2012
    ..6 (7.8-11.4) years after the study period inception (P < 0.05). Laser captured portal tracts were enriched for immune related genes when compared with hepatocytes but precirrhosis livers lost this enrichment...
  9. pmc Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults
    Vidya Mave
    Johns Hopkins University BJ Medical College Clinical Research Site, Pune, India Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland
    J Infect Dis 214:65-72. 2016
    ..Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown...
  10. pmc Acute Hepatitis C Virus Infection Induces Consistent Changes in Circulating MicroRNAs That Are Associated with Nonlytic Hepatocyte Release
    Ramy El-Diwany
    Department of Medicine Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Virol 89:9454-64. 2015
    ..In contrast, miR-494 accumulated intracellularly (P < 0.05). Collectively, these data are inconsistent with necrolytic release of hepatocyte miRNAs into the plasma during acute HCV infection of humans...
  11. pmc Liver stiffness is associated with monocyte activation in HIV-infected Ugandans without viral hepatitis
    Andrew D Redd
    Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 29:1026-30. 2013
    ..Liver stiffness in HIV-infected Ugandans is associated with increased sCD14 indicative of monocyte activation in the absence of viral hepatitis or microbial translocation, and suggests that HIV may be directly involved in liver disease...
  12. pmc IFNL3 genotype is associated with differential induction of IFNL3 in primary human hepatocytes
    Fuat Kurbanov
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Antivir Ther 20:805-14. 2015
    ..The mechanism(s) linking IFNL polymorphisms and HCV control is currently elusive...
  13. pmc Immunologic Predictors of Liver Transplantation Outcomes in HIV-HCV Co-Infected Persons
    Ashwin Balagopal
    Department of Medicine, Johns Hopkins University, Baltimore, MD, 21205, United States of America
    PLoS ONE 10:e0135882. 2015
    ..02-0.68]). IL-10 levels were higher in persons with rejection (HR 2.10 [95%CI 1.01-4.34]). No markers predicted severe recurrent HCV. Monocyte activation pre-LT may be mechanistically linked to graft health in HIV-HCV co-infection...
  14. pmc Human immunodeficiency virus-related microbial translocation and progression of hepatitis C
    Ashwin Balagopal
    Division of Infectious Diseases, Viral Hepatitis Center, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Gastroenterology 135:226-33. 2008
    ..We hypothesized that HIV promotes liver disease by enhancing microbial translocation...
  15. pmc Continued Elevation of Interleukin-18 and Interferon-γ After Initiation of Antiretroviral Therapy and Clinical Failure in a Diverse Multicountry Human Immunodeficiency Virus Cohort
    Ashwin Balagopal
    Johns Hopkins University School of Medicine, Baltimore, Maryland
    Open Forum Infect Dis 3:ofw118. 2016
    ..b>Conclusions.  Continued IL-18 and sCD14 elevations were associated with clinical ART failure. Interferon-γ levels may reflect preserved immune function...
  16. pmc Sex-Related Differences in Inflammatory and Immune Activation Markers Before and After Combined Antiretroviral Therapy Initiation
    Jyoti S Mathad
    Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, New York, NY Johns Hopkins Clinical Trials Unit, Byramjee Jeejeebhoy Government Medical College, Pune, India Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD Division of Infectious Diseases, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA Department of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe Division of Infectious Diseases, Hospital Nossa Senhora de Conceição, Porto Alegre, Brazil Les Centres GHESKIO, Port au Prince, Haiti Department of Medicine, University of North Carolina Lilongwe, Lilongwe, Malawi Research Institute for Health Sciences, Chiang Mai, Thailand Impacta Peru, San Miguel, Peru Durban International Clinical Research Site, Durban University of Technology, Durban, South Africa STD AIDS Clinical Research Laboratory, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil Department of Medicine, University of Witwatersrand, Johannesburg, South Africa National AIDS Research Institute ICMR
    J Acquir Immune Defic Syndr 73:123-9. 2016
    ..Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation...