Genomes and Genes
Affiliation: Johns Hopkins University
- Detection of microbial translocation in HIV and SIV infection using the Limulus amebocyte lysate assay is masked by serum and plasmaAshwin Balagopal
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 7:e41258. 2012..However, related research has been impeded by inconsistent LPS test results...
- The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS)Daniel Benten
Department of Gastroenterology and Hepatology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
BMC Gastroenterol 11:107. 2011..Translocation of gut-derived bacterial products such as endotoxin is a major problem in liver cirrhosis...
- Clostridium difficile: new therapeutic optionsAshwin Balagopal
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 439, Baltimore, MD 21287, USA
Curr Opin Pharmacol 7:455-8. 2007..difficile disease. For now, vancomycin or metronidazole combined with discontinuation of antibiotics, when feasible, and expert infection control remain the mainstays of C. difficile disease management...
- IL28B and the control of hepatitis C virus infectionAshwin Balagopal
Division of Infectious Diseases, Center for Viral Hepatitis, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Gastroenterology 139:1865-76. 2010..We review the genetic studies that uncovered the association between IL28B and HCV clearance, the biology of IFN-λ3, the clinical implications of the genetic association, and areas of future research...
- Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liverAbraham J Kandathil
Department of Medicine, Johns Hopkins University Baltimore, Maryland
Gastroenterology 145:1404-13.e1-10. 2013..We investigated spatial distribution and determinants of HCV replication in human liver samples...
- HIV, age, and the severity of hepatitis C virus-related liver disease: a cohort studyGregory D Kirk
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Ann Intern Med 158:658-66. 2013..Persons with HIV infection have been reported to develop age-related diseases at younger ages than those without HIV. Whether this finding is related to HIV infection or failure to control for other risk factors is unknown...
- Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitutionAshwin Balagopal
Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
AIDS 23:2397-404. 2009..Although hepatic macrophages (Kupffer cells) clear most microbial translocation products and can be infected by HIV, their fate in HIV progression has not been carefully investigated...
- Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug usersSupriya Munshaw
Department of Medicine, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Hepatology 56:544-54. 2012..6 (7.8-11.4) years after the study period inception (P < 0.05). Laser captured portal tracts were enriched for immune related genes when compared with hepatocytes but precirrhosis livers lost this enrichment...
- Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected AdultsVidya Mave
Johns Hopkins University BJ Medical College Clinical Research Site, Pune, India Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland
J Infect Dis 214:65-72. 2016..Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown...
- Acute Hepatitis C Virus Infection Induces Consistent Changes in Circulating MicroRNAs That Are Associated with Nonlytic Hepatocyte ReleaseRamy El-Diwany
Department of Medicine Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Virol 89:9454-64. 2015..In contrast, miR-494 accumulated intracellularly (P < 0.05). Collectively, these data are inconsistent with necrolytic release of hepatocyte miRNAs into the plasma during acute HCV infection of humans...
- Liver stiffness is associated with monocyte activation in HIV-infected Ugandans without viral hepatitisAndrew D Redd
Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD 21205, USA
AIDS Res Hum Retroviruses 29:1026-30. 2013..Liver stiffness in HIV-infected Ugandans is associated with increased sCD14 indicative of monocyte activation in the absence of viral hepatitis or microbial translocation, and suggests that HIV may be directly involved in liver disease...
- IFNL3 genotype is associated with differential induction of IFNL3 in primary human hepatocytesFuat Kurbanov
Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
Antivir Ther 20:805-14. 2015..The mechanism(s) linking IFNL polymorphisms and HCV control is currently elusive...
- Immunologic Predictors of Liver Transplantation Outcomes in HIV-HCV Co-Infected PersonsAshwin Balagopal
Department of Medicine, Johns Hopkins University, Baltimore, MD, 21205, United States of America
PLoS ONE 10:e0135882. 2015..02-0.68]). IL-10 levels were higher in persons with rejection (HR 2.10 [95%CI 1.01-4.34]). No markers predicted severe recurrent HCV. Monocyte activation pre-LT may be mechanistically linked to graft health in HIV-HCV co-infection...
- Human immunodeficiency virus-related microbial translocation and progression of hepatitis CAshwin Balagopal
Division of Infectious Diseases, Viral Hepatitis Center, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Gastroenterology 135:226-33. 2008..We hypothesized that HIV promotes liver disease by enhancing microbial translocation...
- Continued Elevation of Interleukin-18 and Interferon-γ After Initiation of Antiretroviral Therapy and Clinical Failure in a Diverse Multicountry Human Immunodeficiency Virus CohortAshwin Balagopal
Johns Hopkins University School of Medicine, Baltimore, Maryland
Open Forum Infect Dis 3:ofw118. 2016..b>Conclusions. Continued IL-18 and sCD14 elevations were associated with clinical ART failure. Interferon-γ levels may reflect preserved immune function...
- Sex-Related Differences in Inflammatory and Immune Activation Markers Before and After Combined Antiretroviral Therapy InitiationJyoti S Mathad
Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, New York, NY Johns Hopkins Clinical Trials Unit, Byramjee Jeejeebhoy Government Medical College, Pune, India Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD Division of Infectious Diseases, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA Department of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe Division of Infectious Diseases, Hospital Nossa Senhora de Conceição, Porto Alegre, Brazil Les Centres GHESKIO, Port au Prince, Haiti Department of Medicine, University of North Carolina Lilongwe, Lilongwe, Malawi Research Institute for Health Sciences, Chiang Mai, Thailand Impacta Peru, San Miguel, Peru Durban International Clinical Research Site, Durban University of Technology, Durban, South Africa STD AIDS Clinical Research Laboratory, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil Department of Medicine, University of Witwatersrand, Johannesburg, South Africa National AIDS Research Institute ICMR
J Acquir Immune Defic Syndr 73:123-9. 2016..Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation...