Genomes and Genes
Marilyn S Albert
Affiliation: Johns Hopkins University
- Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotypeMarilyn Albert
Johns Hopkins School of Medicine Neurology 1620 McElderry Street Reed Hall West 1, Baltimore, Maryland 21205 United States
Curr Alzheimer Res 11:773-84. 2014....
- Changes in cognitionMarilyn S Albert
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neurobiol Aging 32:S58-63. 2011..There are recent reports that amyloid accumulation may also be associated with memory performance in cognitively normal individuals...
- Mild cognitive impairment and dementiaMarilyn S Albert
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21212, USA
Annu Rev Clin Psychol 2:379-88. 2006....
- Longitudinal change in cognitive performance among individuals with mild cognitive impairmentMarilyn Albert
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neuropsychology 21:158-69. 2007..Individuals with an APOE epsilon4 allele scored lower on the episodic memory and executive function factors at baseline...
- The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseMarilyn S Albert
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Alzheimers Dement 7:270-9. 2011..Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings...
- A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderlyApril J Ho
Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:8404-9. 2010..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
- Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairmentBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Arch Gen Psychiatry 64:1443-50. 2007....
- Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementiaEric E Smith
Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Arch Neurol 65:94-100. 2008..To determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the development of cognitive decline and dementia...
- Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer diseaseMaija Pihlajamaki
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, MA, USA
Alzheimer Dis Assoc Disord 24:28-36. 2010..Altered fMRI activity of the posteromedial areas of the brain default network may be an early indicator of risk for AD...
- Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysisKim A Celone
Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 26:10222-31. 2006..These data may also provide functional evidence of the interaction between neocortical and medial temporal lobe pathology in early AD...
- Selectivity of executive function deficits in mild cognitive impairmentJason Brandt
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287 7218, USA
Neuropsychology 23:607-18. 2009..Multiple-domain MCI patients had more severe impairments in planning/problem solving and working memory than single-domain patients, leading to the supposition that they, not pure amnestic MCIs, are at highest risk of imminent dementia...
- Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairmentArnold Bakker
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Neuron 74:467-74. 2012....
- Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairmentOzioma C Okonkwo
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Arch Neurol 68:113-9. 2011..To examine the effect of specific cerebrospinal fluid (CSF) profiles on the rate of cognitive decline, disease progression, and risk of conversion to Alzheimer disease (AD) dementia in patients with amnestic mild cognitive impairment (MCI)...
- Medial temporal lobe function and structure in mild cognitive impairmentBradford C Dickerson
Department of Neurology, Gerontology Research Unit, Massachusetts General Hospital, MGH East 149 2691, 149 13th Street, Charlestown, MA 02129, USA
Ann Neurol 56:27-35. 2004..We hypothesize that increased activation in MTL regions reflects a compensatory response to accumulating AD pathology and may serve as a marker for impending clinical decline...
- Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive ChangeAnja Soldan
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
JAMA Neurol 73:698-705. 2016..To optimize observing a treatment effect, such trials need to enroll cognitively normal individuals likely to show cognitive decline over the duration of the trial...
- Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performanceArnold Bakker
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neuroimage Clin 7:688-98. 2015....
- The SIST-M: predictive validity of a brief structured clinical dementia rating interviewOlivia I Okereke
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Alzheimer Dis Assoc Disord 26:225-31. 2012....
- Hippocampal and neocortical activation during repetitive encoding in older personsErin Rand-Giovannetti
Gerontology Research Unit, Department of Psychiatry, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, and Johns Hopkins University, Baltimore, MD 21205, USA
Neurobiol Aging 27:173-82. 2006..Our findings suggest that hippocampal function is preserved in normal aging and that repetition-based memory enhancing techniques may engage primarily neocortical attentional networks...
- The relation of patient dependence to home health aide use in Alzheimer's diseaseRachel K Scherer
Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Department of Neurology, Columbia University Medical Center, 630 West 168th St, P and S Box 16, New York, NY 10032, USA
J Gerontol A Biol Sci Med Sci 63:1005-9. 2008..The objective of this study was to examine whether the Dependence Scale can predict home health aide (HHA) use...
- Changing the trajectory of cognitive decline?Marilyn S Albert
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
N Engl J Med 357:502-3. 2007
- Blood glucose levels and cortical thinning in cognitively normal, middle-aged adultsAlexandra M V Wennberg
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, United States Electronic address
J Neurol Sci 365:89-95. 2016..These findings suggest that glucose levels in the diabetic range are associated with reduced cortical thickness in AD vulnerable regions as early as middle age. ..
- Voxelwise genome-wide association study (vGWAS)Jason L Stein
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
Neuroimage 53:1160-74. 2010..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
- Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulinAleister J Saunders
Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Hum Mol Genet 12:2765-76. 2003..However, the negative case - control studies suggest that any underlying pathogenic polymorphisms have a modest effect, and may operate primarily among individuals with a family history of AD...
- Exploring candidate gene associations with neuropsychological performanceMatthew B McQueen
Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado 80309 0447, USA
Am J Med Genet B Neuropsychiatr Genet 144:987-91. 2007....
- Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer diseaseAdam M Brickman
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Campus Box 16, New York, NY 10032, USA
Arch Neurol 65:1202-8. 2008..To determine if baseline measurements of cerebral atrophy and severity of white matter hyperintensity (WMH) predict the rate of future cognitive decline in patients with Alzheimer disease (AD)...
- Structural magnetic resonance imaging in established and prodromal Alzheimer disease: a reviewMonika Atiya
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston University, Boston, Massachusetts 02129, USA
Alzheimer Dis Assoc Disord 17:177-95. 2003
- Predicting cognitive impairment in high-functioning community-dwelling older persons: MacArthur Studies of Successful AgingJoshua Chodosh
Division of Geriatrics, UCLA School of Medicine, 10945 Le Conte Avenue, Los Angeles, CA 90095, USA
J Am Geriatr Soc 50:1051-60. 2002..To examine whether simple cognitive tests, when applied to cognitively intact older persons, are useful predictors of cognitive impairment 7 years later...
- Achieving and maintaining cognitive vitality with agingHoward M Fillit
Institute for the Study of Aging, Inc, New York, NY 10153, USA
Mayo Clin Proc 77:681-96. 2002..The data presented in this review should interest physicians who provide preventive care management to middle-aged and older individuals who seek to maintain cognitive vitality with aging...
- Detection of very early Alzheimer disease through neuroimagingMarilyn S Albert
Department of Psychiatry, Harvard Medical School, Massachusetts Geneal Hospital, Charlestown, Massachusetts, USA
Alzheimer Dis Assoc Disord 17:S63-5. 2003
- MRI-guided SPECT perfusion measures and volumetric MRI in prodromal Alzheimer diseaseGeorges El Fakhri
Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arch Neurol 60:1066-72. 2003....
- Results of a high-resolution genome screen of 437 Alzheimer's disease familiesDeborah Blacker
Massachusetts General Hospital, Charlestown, MA, USA
Hum Mol Genet 12:23-32. 2003..Although some of these will surely prove to be false positives, these linkage signals should provide a valuable framework for future studies aimed at identifying additional susceptibility genes for late-onset AD...
- Quantitative SPECT leads to improved performance in discrimination tasks related to prodromal Alzheimer's diseaseGeorges El Fakhri
Department of Radiology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Nucl Med 45:2026-31. 2004....
- Differential amygdala habituation to neutral faces in young and elderly adultsMichelle M Wedig
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, 2nd Floor, Charlestown, MA 02129, USA
Neurosci Lett 385:114-9. 2005..We conclude that, in healthy elderly adults, the amygdala retains its adaptive habituation response, but speculate that intrinsic changes in amygdala anatomy during aging may modulate its laterality...
- Association between mind-body and cardiovascular exercises and memory in older adultsAgnes S Chan
Department of Psychology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
J Am Geriatr Soc 53:1754-60. 2005..Older adults who engaged in both types of exercise were also included to examine the combined effects...
- An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interestRahul S Desikan
Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W701, Boston, MA 02118, USA
Neuroimage 31:968-80. 2006....
- Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy agingChristopher M Holland
Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Stroke 39:1127-33. 2008..We sought to determine whether the spatial distribution of WMHs discriminates between different disease groups and healthy aging individuals and whether these distributions are related to local cerebral perfusion patterns...
- Memory decline: the boundary between aging and age-related diseaseMarilyn S Albert
Ann Neurol 51:282-4. 2002