Michael A Jenike
- Clinical practice. Obsessive-compulsive disorderMichael A Jenike
Department of Psychiatry, Massachusetts General Hospital, Boston, USA
N Engl J Med 350:259-65. 2004
- Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorderS Evelyn Stewart
Psychiatric Neurodevelopmental and Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:1027-33. 2007..Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required...
- DBT-enhanced habit reversal treatment for trichotillomania: 3-and 6-month follow-up resultsNancy J Keuthen
Trichotillomania Clinic and Research Unit, Massachusetts General Hospital Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
Depress Anxiety 28:310-3. 2011..Maintenance of gains with cognitive-behavioral treatment for trichotillomania (TTM) has historically been problematic...
- Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorderSabine Wilhelm
Obsessive Compulsive Disorder Clinic, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 165:335-41; quiz 409. 2008..This study examined whether d-cycloserine, a partial agonist at the N-methyl-D-aspartate (NMDA) glutamatergic receptor, enhances the efficacy of behavior therapy for obsessive-compulsive disorder (OCD)...
- Severe obsessive-compulsive disorder with and without comorbid hair pulling: comparisons and clinical implicationsS Evelyn Stewart
McLean Hospital, Boston, Mass, USA
J Clin Psychiatry 66:864-9. 2005..This study determined the prevalence of hair pulling in an inpatient obsessive-compulsive disorder (OCD) population and compared clinical characteristics and treatment response between subgroups with and without comorbid hair pulling...
- Prevalence of symptoms of body dysmorphic disorder and its correlates: a cross-cultural comparisonAntje Bohne
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Psychosomatics 43:486-90. 2002..Body image concerns and preoccupation were significantly greater in American than in German students, although the prevalence of probable body dysmorphic disorder was not...
- Single modality versus dual modality treatment for trichotillomania: sertraline, behavioral therapy, or both?Darin D Dougherty
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
J Clin Psychiatry 67:1086-92. 2006..However, no randomized, controlled studies to date have compared the efficacy of individual SSRI or CBT treatment to the combination of both treatment modalities...
- Connections among symptoms of obsessive-compulsive disorder and posttraumatic stress disorder: a case seriesBeth S Gershuny
Harvard Medical School and Massachusetts General Hospital, Department of Psychiatry, Charlestown, MA 02129, USA
Behav Res Ther 41:1029-41. 2003..Speculations about the function of OCD symptoms in relation to post-traumatic psychopathology are put forth; and theoretical, research, and treatment implications are discussed...
- Cognitive-behavior therapy for self-injurious skin picking. A case seriesThilo Deckersbach
Harvard Medical School, Cognitive Behavior Therapy Program, Obsessive Compulsive Disorder Clinic, Psychiatric Neuroscience Program, Massachusetts General Hospital, USA
Behav Modif 26:361-77. 2002..In the current article, the authors describe the implementation and outcome of cognitive-behavior therapy for three patients with severe self-injurious skin picking, two of which had psychiatric comorbidity...
- A study of parallel implicit and explicit information processing in patients with obsessive-compulsive disorderThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital East, Building 149, 13th Street, 9th Floor, Charlestown, MA 02129, USA
Am J Psychiatry 159:1780-2. 2002..Neuroimaging data suggest that during implicit learning, OCD patients use neural systems normally active during explicit learning to compensate for striatal dysfunction...
- Pharmacotherapy for obsessive-compulsive disorderDarin D Dougherty
Massachusetts General Hospital, Charlestown, MA 02129, USA
J Clin Psychol 60:1195-202. 2004..There is substantially less evidence supporting other alternative strategies. Finally, neurosurgical and device-based approaches for treatment-refractory OCD are reviewed...
- Pilot trial of dialectical behavior therapy-enhanced habit reversal for trichotillomaniaNancy J Keuthen
Massachusetts General Hospital Harvard Medical School, Boston, USA
Depress Anxiety 27:953-9. 2010..Not all hair pullers improve acutely with cognitive-behavioral treatment (CBT) and few maintain their gains over time...
- Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adultsS Evelyn Stewart
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 47:763-72. 2008..Identification of a category-based OCD symptom dimension structure that is validated for use across child, adolescent, and adult age groups is necessary to guide ongoing translational research...
- Latent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorderKevin L Delucchi
Department of Psychiatry, University of California, Box 0984 TRC, San Francisco, CA 94143 0984, USA
Compr Psychiatry 52:334-41. 2011..This study was designed to uncover sets of homogeneous groupings within 1611 individuals with OCD based on symptoms...
- Open-label study of duloxetine for the treatment of obsessive-compulsive disorderDarin D Dougherty
Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA Drs Dougherty, Corse, CHOU, DUFFY, Arulpragasam, and Deckersbach OCD and Related Disorders Program, Massachusetts General Hospital, Boston, MA Drs Dougherty, Jenike, and Keuthen Department of Psychology, Harvard University, Cambridge, MA Dr Chou Department of Neuroscience, Brown University, Providence, RI Dr Duffy
Int J Neuropsychopharmacol 18:. 2015..This study sought to investigate the efficacy of duloxetine for the treatment of obsessive-compulsive disorder (DSM-IV)...
- A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorderScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 139th Street, 9th Floor, Charlestown, MA 02129, USA
Psychiatry Res 122:13-9. 2003..the comparison group. Findings with respect to the caudate nucleus are consistent with both the conceptualization of BDD as an obsessive-compulsive spectrum disorder, and the 'striatal topography model' of obsessive-compulsive disorders...
- A genetic family-based association study of OLIG2 in obsessive-compulsive disorderS Evelyn Stewart
Psychiatric Neuroscience Research Division, and Obsessive Compulsive Disorder Clinic, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Gen Psychiatry 64:209-14. 2007..The gene for oligodendrocyte lineage transcription factor 2 (OLIG2) is an essential regulator in the development of cells that produce white matter (myelin). The OLIG2 gene is also highly expressed in brain regions implicated in OCD...
- Skin picking in German students. Prevalence, phenomenology, and associated characteristicsAntje Bohne
Massachusetts General Hospital, Harvard Medical School, USA
Behav Modif 26:320-39. 2002..6%). About 20% (n = 26) ate the picked tissue afterward. Results suggest SP is an underrecognized problem that occurs on a continuum ranging from mild to severe with generally stable clinical characteristics across cultures...
- Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation studyScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuropsychopharmacology 27:782-91. 2002..Finally, this pattern is sufficiently robust as to be relatively independent of symptomatic state at the time of tracer uptake...
- Comorbid posttraumatic stress disorder: impact on treatment outcome for obsessive-compulsive disorderBeth S Gershuny
OCD Clinic and Research Unit, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, 02129, USA
Am J Psychiatry 159:852-4. 2002..The study tested the effect of comorbid posttraumatic stress disorder (PTSD) on behavior therapy outcome for obsessive-compulsive disorder (OCD)...
- Symptom stability in adult obsessive-compulsive disorder: data from a naturalistic two-year follow-up studyDavid Mataix-Cols
Department of Psychiatry, Imperial College School of Medicine, London, UK
Am J Psychiatry 159:263-8. 2002..This study systematically investigated the temporal stability of individual symptoms and symptom dimensions of OCD in adult patients who were followed prospectively for 2 years...
- Trauma and posttraumatic stress disorder in treatment-resistant obsessive-compulsive disorderBeth S Gershuny
Department of Psychology, Skidmore College, Saratoga Springs, NY 12866, USA
Depress Anxiety 25:69-71. 2008..PTSD may be relatively common in individuals diagnosed with treatment-resistant OCD; and interpersonal traumas, MDD, and BPD may play a relatively strong predictive role in PTSD diagnosis and severity in such OCD patients...
- Outcome predictors for severe obsessive-compulsive patients in intensive residential treatmentS Evelyn Stewart
Obsessive Compulsive Disorder Clinic, Massachusetts General Hospital, 185 Cambridge Street, 2nd floor Simches Building, Boston MA 02114, United States
J Psychiatr Res 40:511-9. 2006..Future research is necessary to elucidate putative relationships between gender and OCD psychopathology, and to understand the interplay of psychosocial factors, OCD severity and treatment outcome...
- Effectiveness of intensive residential treatment (IRT) for severe, refractory obsessive-compulsive disorderS Evelyn Stewart
McLean Hospital, Harvard Medical School, North Belknap 1, 115 Mill Street, Belmont MA 02478, USA
J Psychiatr Res 39:603-9. 2005..No formalized OCD IRT outcome studies have been completed to date in North America...
- Prevalence of body dysmorphic disorder in a German college student sampleAntje Bohne
Massachusetts General Hospital East Harvard Medical School, OCD Clinic, 149 Thirteenth Street, Charlestown, MA 02129, USA
Psychiatry Res 109:101-4. 2002..One student with BDD also reported severe skin picking. In conclusion, BDD is a common psychiatric disorder in college students...
- Prospective long-term follow-up of 44 patients who received cingulotomy for treatment-refractory obsessive-compulsive disorderDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Am J Psychiatry 159:269-75. 2002..Long-term outcome associated with cingulotomy for obsessive-compulsive disorder (OCD) was prospectively assessed. Findings are reported for 18 patients previously described in 1995 and for 26 new patients...
- Visuospatial abilities, memory, and executive functioning in trichotillomania and obsessive-compulsive disorderAntje Bohne
Massachusetts General Hospital Harvard Medical School, OCD Clinic, Charlestown, MA 02129, USA
J Clin Exp Neuropsychol 27:385-99. 2005..Other executive functions, as well as memory and visuospatial abilities were unimpaired in TTM and OCD. Our data suggest that TTM and OCD are characterized by different patterns of neuropsychological dysfunction...