J C Dekkers

Summary

Affiliation: Iowa State University
Country: USA

Publications

  1. pmc A class of Bayesian methods to combine large numbers of genotyped and non-genotyped animals for whole-genome analyses
    Rohan L Fernando
    Department of Animal Science, Iowa State University, 50011 Ames, Iowa, USA
    Genet Sel Evol 46:50. 2014
  2. pmc Total cost estimation for implementing genome-enabled selection in a multi-level swine production system
    Caitlyn E Abell
    Iowa State University, 109 Kildee Hall, Ames, IA 50011, USA
    Genet Sel Evol 46:32. 2014
  3. pmc Body composition and gene expression QTL mapping in mice reveals imprinting and interaction effects
    Ye Cheng
    Department of Animal Science, Iowa State University, 2255 Kildee, Ames, IA, USA
    BMC Genet 14:103. 2013
  4. pmc Application of genomics tools to animal breeding
    Jack C M Dekkers
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Curr Genomics 13:207-12. 2012
  5. pmc Genome-wide association and genomic prediction for host response to porcine reproductive and respiratory syndrome virus infection
    Nicholas J Boddicker
    Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA
    Genet Sel Evol 46:18. 2014
  6. pmc Genomic selection of purebred animals for crossbred performance in the presence of dominant gene action
    Jian Zeng
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA, USA
    Genet Sel Evol 45:11. 2013
  7. pmc Genome-wide association study of insect bite hypersensitivity in two horse populations in the Netherlands
    Anouk Schurink
    Animal Breeding and Genomics Centre, Wageningen University, P, O, Box 338, Wageningen, 6700 AH, The Netherlands
    Genet Sel Evol 44:31. 2012
  8. pmc Genomic breeding value prediction and QTL mapping of QTLMAS2011 data using Bayesian and GBLUP methods
    Jian Zeng
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, USA
    BMC Proc 6:S7. 2012
  9. pmc Accuracies of genomic breeding values in American Angus beef cattle using K-means clustering for cross-validation
    Mahdi Saatchi
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 43:40. 2011
  10. pmc Persistence of accuracy of genomic estimated breeding values over generations in layer chickens
    Anna Wolc
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska st, 33, 60 637 Poznan, Poland
    Genet Sel Evol 43:23. 2011

Collaborators

Detail Information

Publications67

  1. pmc A class of Bayesian methods to combine large numbers of genotyped and non-genotyped animals for whole-genome analyses
    Rohan L Fernando
    Department of Animal Science, Iowa State University, 50011 Ames, Iowa, USA
    Genet Sel Evol 46:50. 2014
    ..Furthermore, SS-BLUP is expected to perform poorly relative to variable selection models such as BayesB and BayesC as marker densities increase...
  2. pmc Total cost estimation for implementing genome-enabled selection in a multi-level swine production system
    Caitlyn E Abell
    Iowa State University, 109 Kildee Hall, Ames, IA 50011, USA
    Genet Sel Evol 46:32. 2014
    ..The objective of this study was to develop a tool to estimate the cost structure associated with incorporating genome-enabled selection into multi-level commercial breeding programs...
  3. pmc Body composition and gene expression QTL mapping in mice reveals imprinting and interaction effects
    Ye Cheng
    Department of Animal Science, Iowa State University, 2255 Kildee, Ames, IA, USA
    BMC Genet 14:103. 2013
    ..Previously, we found that Myostatin genotype, reciprocal cross, and sex interacted with numerous chromosomal regions to affect growth traits...
  4. pmc Application of genomics tools to animal breeding
    Jack C M Dekkers
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Curr Genomics 13:207-12. 2012
    ....
  5. pmc Genome-wide association and genomic prediction for host response to porcine reproductive and respiratory syndrome virus infection
    Nicholas J Boddicker
    Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA
    Genet Sel Evol 46:18. 2014
    ..Phenotypic data and 60 K SNP genotypes from eight trials of ~200 pigs from different commercial crosses were used to address these objectives...
  6. pmc Genomic selection of purebred animals for crossbred performance in the presence of dominant gene action
    Jian Zeng
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA, USA
    Genet Sel Evol 45:11. 2013
    ..Advantages of incorporating dominance in genomic selection were investigated in a two-way crossbreeding program for a trait with different magnitudes of dominance. Training was carried out only once in the simulation...
  7. pmc Genome-wide association study of insect bite hypersensitivity in two horse populations in the Netherlands
    Anouk Schurink
    Animal Breeding and Genomics Centre, Wageningen University, P, O, Box 338, Wageningen, 6700 AH, The Netherlands
    Genet Sel Evol 44:31. 2012
    ..Therefore, the aim of our study was to identify and quantify genomic associations with insect bite hypersensitivity in Shetland pony mares and Icelandic horses in the Netherlands...
  8. pmc Genomic breeding value prediction and QTL mapping of QTLMAS2011 data using Bayesian and GBLUP methods
    Jian Zeng
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, USA
    BMC Proc 6:S7. 2012
    ..The goal of this study was to apply Bayesian and GBLUP methods to predict genomic breeding values (GEBV), map QTL positions and explore the genetic architecture of the trait simulated for the 15th QTL-MAS workshop...
  9. pmc Accuracies of genomic breeding values in American Angus beef cattle using K-means clustering for cross-validation
    Mahdi Saatchi
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 43:40. 2011
    ..The objective of this study was to estimate marker effects to derive prediction equations for direct genomic values for 16 routinely recorded traits of American Angus beef cattle and quantify corresponding accuracies of prediction...
  10. pmc Persistence of accuracy of genomic estimated breeding values over generations in layer chickens
    Anna Wolc
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska st, 33, 60 637 Poznan, Poland
    Genet Sel Evol 43:23. 2011
    ..The objective of this study was to evaluate the accuracy of GEBV in a closed population of layer chickens and to quantify their persistence over five successive generations using marker or pedigree information...
  11. pmc Breeding value prediction for production traits in layer chickens using pedigree or genomic relationships in a reduced animal model
    Anna Wolc
    Department of Genetics and Animal Breeding, University of Life Sciences in Poznan, Wołyńska st, 33, 60 637 Poznan, Poland
    Genet Sel Evol 43:5. 2011
    ....
  12. pmc Comparison of methods for analysis of selective genotyping survival data
    Joseph P McElroy
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, USA
    Genet Sel Evol 38:637-55. 2006
    ..The results from the research presented herein are directly applicable to interval mapping analyses...
  13. pmc Haplotype inference in crossbred populations without pedigree information
    Albart Coster
    Animal Breeding and Genomics Centre, Wageningen University, Wageningen, The Netherlands
    Genet Sel Evol 41:40. 2009
    ..The sequence of alleles from one parent constitutes one haplotype of an individual. Haplotypes thus reveal allele origin in data of crossbred individuals...
  14. pmc Genomic selection of purebreds for crossbred performance
    Noelia Ibánez-Escriche
    Department of Animal Science, Iowa State University, Ames, IA 50011 3150, USA
    Genet Sel Evol 41:12. 2009
    ..A Bayesian method (Bayes-B) was used to estimate the SNP effects in the crossbred training population and the accuracy of resulting GS breeding values for commercial crossbred performance was validated in the purebred population...
  15. pmc A gene frequency model for QTL mapping using Bayesian inference
    Wei He
    Department of Animal Science, Iowa State University, Ames, IA, USA
    Genet Sel Evol 42:21. 2010
    ..Computer simulation was used to compare the power to detect and accuracy to map QTL by this method with those from least squares analysis using a regression model (LSR)...
  16. pmc Interval mapping of quantitative trait loci with selective DNA pooling data
    Jing Wang
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
    Genet Sel Evol 39:685-709. 2007
    ..With small family sizes, however, the LS-pool method resulted in severely biased estimates of QTL location for distal QTL but this bias was reduced with the ML-pool...
  17. pmc Mapping QTL affecting resistance to Marek's disease in an F6 advanced intercross population of commercial layer chickens
    Eliyahu M Heifetz
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA
    BMC Genomics 10:20. 2009
    ..At the F6 generation, a total of 1615 chicks were produced (98 to 248 per family) and phenotyped for MD resistance measured as survival time in days after challenge with a very virulent plus (vv+) strain of MDV...
  18. pmc Extent and consistency of linkage disequilibrium and identification of DNA markers for production and egg quality traits in commercial layer chicken populations
    Behnam Abasht
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA
    BMC Genomics 10:S2. 2009
    ....
  19. pmc Analysis of porcine transcriptional response to Salmonella enterica serovar Choleraesuis suggests novel targets of NFkappaB are activated in the mesenteric lymph node
    Yanfang Wang
    Department of Animal Science, and Center for Integrated Animal Genomics, Iowa State University, 2255 Kildee Hall, Ames, IA 50010, USA
    BMC Genomics 9:437. 2008
    ..Choleraesuis at acute (8 hours (h), 24 h and 48 h post-inoculation (pi)) and chronic stages (21 days (d) pi)...
  20. pmc Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance
    Jack C M Dekkers
    Department of Animal Science, 225C Kildee Hall, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 36:297-324. 2004
    ..Results show that strategic use of information on over-dominant QTL can enhance crossbred performance without crossbred testing...
  21. ncbi request reprint Prediction of response to marker-assisted and genomic selection using selection index theory
    J C M Dekkers
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011 3150, USA
    J Anim Breed Genet 124:331-41. 2007
    ....
  22. pmc A method to optimize selection on multiple identified quantitative trait loci
    Reena Chakraborty
    Department of Animal Science, 225C Kildee Hall, Iowa State University Ames, IA 50011, USA
    Genet Sel Evol 34:145-70. 2002
    ..The method can be used to develop and evaluate optimal strategies for selection on multiple QTL for a wide range of situations and genetic models...
  23. pmc Optimal selection on two quantitative trait loci with linkage
    Jack C M Dekkers
    Department of Animal Science, 225 Kildee Hall, Iowa State University Ames, IA 50011, USA
    Genet Sel Evol 34:171-92. 2002
    ..These results demonstrate the ability of optimal selection to capitalize on information on the complex genetic basis of quantitative traits that is forthcoming...
  24. pmc Genomic breeding value prediction and QTL mapping of QTLMAS2010 data using Bayesian Methods
    Xiaochen Sun
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
    BMC Proc 5:S13. 2011
    ..We also proposed a novel approach to set significance thresholds for claiming QTL in this specific case by using pedigree-based simulation of genotypes. All analyses were focused on detecting and evaluating QTL with additive effects...
  25. ncbi request reprint Commercial application of marker- and gene-assisted selection in livestock: strategies and lessons
    J C M Dekkers
    Department of Animal Science, Iowa State University, Ames 50011 3150, USA
    J Anim Sci 82:E313-328. 2004
    ..The current attitude toward marker-assisted selection is therefore one of cautious optimism...
  26. ncbi request reprint Marker-assisted selection for commercial crossbred performance
    J C M Dekkers
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames 50011 3150, USA
    J Anim Sci 85:2104-14. 2007
    ....
  27. ncbi request reprint Potential gain from optimizing multigeneration selection on an identified quantitative trait locus
    J C Dekkers
    Department of Animal Science, Iowa State University, Ames, 50011 3150, USA
    J Anim Sci 79:2975-90. 2001
    ....
  28. ncbi request reprint A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. II. Meat and muscle composition
    M Malek
    Department of Animal Science, 2255H Kildee Hall, Iowa State University, Ames, Iowa 50011, USA
    Mamm Genome 12:637-45. 2001
    ....
  29. ncbi request reprint Joint analysis of two breed cross populations in pigs to improve detection and characterization of quantitative trait loci
    J J Kim
    Department of Animal Science, Center for Integrated Animal Genomics, Iowa State University, Ames, 50011, USA
    J Anim Sci 83:1229-40. 2005
    ..Results of this study suggest that joint analysis using a range of QTL models increases the power of QTL mapping and QTL characterization, which helps to identify genes for subsequent marker-assisted selection...
  30. ncbi request reprint Characterization of quantitative trait loci for growth and meat quality in a cross between commercial breeds of swine
    H Thomsen
    Department of Animal Science and the Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
    J Anim Sci 82:2213-28. 2004
    ..The detected QTL and their identified mode of expression will allow further research in these QTL regions and their utilization in marker-assisted improvement of meat quality...
  31. pmc Comparing linkage disequilibrium-based methods for fine mapping quantitative trait loci
    L Grapes
    Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA
    Genetics 166:1561-70. 2004
    ..Thus for populations similar to those simulated here, the IBD-based method is comparable to single-marker regression analysis for fine mapping QTL...
  32. ncbi request reprint A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. I. Growth and body composition
    M Malek
    Department of Animal Science, 2255H Kildee Hall, Iowa State University, Ames, Iowa 50011, USA
    Mamm Genome 12:630-6. 2001
    ..For several QTL the favorable allele originated from the breed with the lower trait mean...
  33. ncbi request reprint Evaluation of linkage disequilibrium measures between multi-allelic markers as predictors of linkage disequilibrium between markers and QTL
    H Zhao
    Department of Animal Science, 239 Kildee Hall, Iowa State University, Ames, IA 50011, USA
    Genet Res 86:77-87. 2005
    ..Therefore, when LD is generated by drift, chi(2') is recommended to quantify the amount and extent of usable LD in a population for QTL mapping and MAS based on multi-allelic markers...
  34. doi request reprint Genomic selection in admixed and crossbred populations
    A Toosi
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames 50011, USA
    J Anim Sci 88:32-46. 2010
    ..Results also showed that haplotype segments with strong linkage disequilibrium are shorter in crossbred and admixed populations than in purebreds, providing opportunities for QTL fine mapping...
  35. pmc Controlling the proportion of false positives in multiple dependent tests
    R L Fernando
    Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA
    Genetics 166:611-9. 2004
    ..For a fixed CWER, we have estimated PFP, FDR, pFDR, and GWER through simulation under a variety of models to illustrate practical and philosophical similarities and differences among the methods...
  36. ncbi request reprint New alleles in calpastatin gene are associated with meat quality traits in pigs
    D C Ciobanu
    Department of Animal Science, Iowa State University, Ames 50011, USA
    J Anim Sci 82:2829-39. 2004
    ....
  37. doi request reprint A calcitonin receptor (CALCR) single nucleotide polymorphism is associated with growth performance and bone integrity in response to dietary phosphorus deficiency
    L S Alexander
    Department of Animal Science, North Carolina State University, Raleigh 27695, USA
    J Anim Sci 88:1009-16. 2010
    ..Understanding the underlying genetic mechanisms that regulate P utilization may lead to novel strategies to produce more environmentally friendly pigs...
  38. ncbi request reprint Computational integration of structural and functional genomics data across species to develop information on the porcine inflammatory gene regulatory pathway
    C K Tuggle
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA
    Dev Biol (Basel) 132:105-13. 2008
    ..Integration of these results and verification of putative target genes will increase our understanding of the porcine response pathways responding to bacterial infection...
  39. pmc Mapping quantitative trait loci affecting susceptibility to Marek's disease virus in a backcross population of layer chickens
    E M Heifetz
    Department of Animal Science, Iowa State University, Ames 50011, USA
    Genetics 177:2417-31. 2007
    ..These QTL could be used in marker-assisted selection (MAS) programs for MDV resistance and as a platform for high-resolution mapping and positional cloning of the resistance genes...
  40. pmc The impact of genetic relationship information on genome-assisted breeding values
    D Habier
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
    Genetics 177:2389-97. 2007
    ..The method of choice was Bayes-B; FR-LS should be investigated further, whereas RR-BLUP cannot be recommended...
  41. ncbi request reprint Correlations among selected pork quality traits
    E Huff-Lonergan
    Department of Animal Science, Iowa State University, Ames 50011, USA
    J Anim Sci 80:617-27. 2002
    ..The correlations yield information that could aid in directing future studies aimed at understanding the underlying biological mechanisms behind the development of many quality traits...
  42. ncbi request reprint Evaluation of linkage disequilibrium measures between multi-allelic markers as predictors of linkage disequilibrium between single nucleotide polymorphisms
    H Zhao
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA
    Genet Res 89:1-6. 2007
    ..Therefore, the LD measure between multi-allelic markers that is best for predicting usable LD in a population depends on the type of markers (i.e. multi-allelic or biallelic) that will eventually be used for QTL mapping or MAS...
  43. ncbi request reprint Evaluation of strategies for selection for lean growth rate in pigs
    P Chen
    Department of Animal Science, Iowa State University, Ames 50011, USA
    J Anim Sci 81:1150-7. 2003
    ..Based on the relative changes in the responses in LGR, selection for estimated LGR based on a nonlinear index or a linear index with updating is recommended for use in the swine industry...
  44. pmc Power and precision of alternate methods for linkage disequilibrium mapping of quantitative trait loci
    H H Zhao
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
    Genetics 175:1975-86. 2007
    ..Thus, for rapid initial screening of samples of adequate size in populations in which drift is the primary force that has created LD, QTL can be detected and mapped by regression on SNP genotypes without recovering haplotypes...
  45. ncbi request reprint Identification of trait loci affecting white meat percentage and other growth and carcass traits in commercial broiler chickens
    J P McElroy
    Department of Animal Science, Iowa State University, Ames 50011, USA
    Poult Sci 85:593-605. 2006
    ..The advantage of using multiple statistical models was evident because QTL were identified with the combined and parent of origin models that were not identified with the line-cross or half-sib models...
  46. ncbi request reprint Integration of structural and functional genomics
    C K Tuggle
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, 2255 Kildee Hall, Ames, IA 50011, USA
    Anim Genet 37:1-6. 2006
    ..The session topics and oral presentations are briefly described for all invited speakers...
  47. doi request reprint The effect of selection for residual feed intake on general behavioral activity and the occurrence of lesions in Yorkshire gilts
    L J Sadler
    Department of Animal Science, Iowa State University, Ames 50011, USA
    J Anim Sci 89:258-66. 2011
    ..Behavioral differences were observed between genetic lines over subsequent rounds, with LRFI gilts becoming less active, but there were no differences in lesion scores...
  48. doi request reprint Identification of genetic markers associated with residual feed intake and meat quality traits in the pig
    B Fan
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Meat Sci 84:645-50. 2010
    ..This study has identified potential genetic markers suitable for MAS in improving RFI, ADG, and meat color traits, but these associations need to be validated in other larger populations...
  49. ncbi request reprint Microsatellite markers associated with resistance to Marek's disease in commercial layer chickens
    J P McElroy
    Department of Animal Science, 2255 Kildee Hall, Iowa State University, Ames, Iowa 50011, USA
    Poult Sci 84:1678-88. 2005
    ..Thus, the present study shows that loci affecting MD resistance can be mapped in commercial layer lines. More comprehensive studies are under way to confirm and extend these results...
  50. ncbi request reprint Selection response and genetic parameters for residual feed intake in Yorkshire swine
    W Cai
    Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA
    J Anim Sci 86:287-98. 2008
    ..05% with P < 0.0001). In conclusion, RFI is a heritable trait, and selection for low RFI has significantly decreased the feed required for a given rate of growth and backfat...
  51. ncbi request reprint Genetic parameters and trends for litter traits in U.S. Yorkshire, Duroc, Hampshire, and Landrace pigs
    P Chen
    Department of Animal Science, Iowa State University, Ames 50011, USA
    J Anim Sci 81:46-53. 2003
    ..This study presents the first set of breed-specific estimates of genetic parameters available from large numbers of field records. It provides information for use in national genetic evaluations...
  52. doi request reprint Integrating comparative expression profiling data and association of SNPs with Salmonella shedding for improved food safety and porcine disease resistance
    J J Uthe
    Department of Animal Science, Iowa State University, Ames, IA 50014, USA
    Anim Genet 42:521-34. 2011
    ..These associations provide new information about the mechanisms of porcine host response to Salmonella and may be useful in improving genetic resistance to this bacterium...
  53. ncbi request reprint Rapid identification of single nucleotide polymorphisms and estimation of allele frequencies using sequence traces from DNA pools
    X Ye
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames 50011, USA
    Poult Sci 85:1165-8. 2006
    ....
  54. ncbi request reprint Review of quantitative trait loci identified in the chicken
    B Abasht
    Department of Animal Science, Iowa State University, Ames 50011, USA
    Poult Sci 85:2079-96. 2006
    ..This information can be helpful in identifying genes or mutations underlying the QTL and in the application of genomic information in marker-assisted breeding programs...
  55. ncbi request reprint Identification of errors and factors associated with errors in data from electronic swine feeders
    D S Casey
    Department of Animal Science, Iowa State University, Ames, 50011, USA
    J Anim Sci 83:969-82. 2005
    ..Results indicate that the frequency of errors in data from electronic swine feeders is substantial, but visits with errors can be identified and their frequency can be decreased by proper feeder management...
  56. pmc Linkage disequilibrium in related breeding lines of chickens
    Cristina Andreescu
    Department of Animal Science, Iowa State University, Ames 50010, USA
    Genetics 177:2161-9. 2007
    ..In conclusion, LD-based correlations are good estimates of line relationships and the relationship between a pair of lines a good predictor of LD consistency between the lines...
  57. pmc Application of the false discovery rate to quantitative trait loci interval mapping with multiple traits
    Hakkyo Lee
    Hankyong National University, Ansung si, Kyonggi, 456 749, Korea
    Genetics 161:905-14. 2002
    ..FDR based on FDRm was recommended for QTL detection in interval mapping because it provides significance tests that are meaningful, yet not overly stringent, such that a more complete picture of QTL is revealed...
  58. ncbi request reprint Tests of candidate genes in breed cross populations for QTL mapping in livestock
    Honghua Zhao
    Department of Animal Science, 225C Kildee Hall, Iowa State University, Ames, Iowa, 50011, USA
    Mamm Genome 14:472-82. 2003
    ..Therefore, while we conclude that candidate gene tests in QTL mapping populations must be interpreted with caution, we now have a clearer picture of the value of candidate gene tests in these populations...
  59. pmc A comparison of alternative methods to compute conditional genotype probabilities for genetic evaluation with finite locus models
    Liviu R Totir
    Department of Animal Science, Iowa State University, Ames, IA 50011 3150, USA
    Genet Sel Evol 35:585-604. 2003
    ..For MCMC methods, a linear relationship can be maintained by sampling genotypes one locus at a time. Out of the three MCMC methods considered, ESIP, performed the best while scalar Gibbs performed the worst...
  60. pmc The effect of using approximate gametic variance covariance matrices on marker assisted selection by BLUP
    Liviu R Totir
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 36:29-48. 2004
    ..1% and 13.5% for Method A, between 1.7% and 23.8% for Method B, and between 7.6% and 28.9% for the exact method. The relative performance of the methods under investigation was not affected by the number of MQTL in the model...
  61. pmc A study on the minimum number of loci required for genetic evaluation using a finite locus model
    Liviu R Totir
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 36:395-414. 2004
    ..For highly heritable traits, models with up to six loci were needed to match the evaluations obtained by BLP...
  62. ncbi request reprint Polar overdominant inheritance of a DLK1 polymorphism is associated with growth and fatness in pigs
    Kwan Suk Kim
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
    Mamm Genome 15:552-9. 2004
    ..Further study in pigs can provide important insights into understanding the molecular regulation of imprinted genes that are associated with human UPD14 and sheep callipyge phenotypes...
  63. ncbi request reprint Investigation of obesity candidate genes on porcine fat deposition quantitative trait loci regions
    Kwan Suk Kim
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011 3150, USA
    Obes Res 12:1981-94. 2004
    ..To investigate possible obesity candidate genes in regions of porcine quantitative trait loci (QTL) for fat deposition and obesity-related phenotypes...
  64. ncbi request reprint Combined line-cross and half-sib QTL analysis of crosses between outbred lines
    Jong Joo Kim
    Department of Animal Science, Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA
    Genet Res 85:235-48. 2005
    ..Fourteen CB QTL were detected only by the combined model. Thus, the combined model can increase power to detect QTL and mapping accuracy and enable characterization of QTL that segregate within breeds...
  65. ncbi request reprint The use of molecular genetics in the improvement of agricultural populations
    Jack C M Dekkers
    Department of Animal Science, Iowa State University, 225 Kildee Hall, Ames, Iowa 50011, USA
    Nat Rev Genet 3:22-32. 2002
    ..The genes and genetic markers that are being discovered can be used to enhance the genetic improvement of breeding stock through marker-assisted selection...
  66. pmc Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
    Xianghai Ye
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 39:73-89. 2007
    ..These results suggest that the myostatin gene has pleiotropic effects on broiler performance...
  67. ncbi request reprint Global transcriptional response of porcine mesenteric lymph nodes to Salmonella enterica serovar Typhimurium
    Yanfang Wang
    Department of Animal Science and Center for Integrated Animal Genomics Iowa State University, Ames, IA 50010, USA
    Genomics 90:72-84. 2007
    ..We propose that such NFkappaB suppression in antigen-presenting cells may be the mechanism by which S. Typhimurium eludes a strong inflammatory response to establish a carrier status in pigs...