Kim A Lennox
Affiliation: Integrated DNA Technologies
- A direct comparison of anti-microRNA oligonucleotide potencyKim A Lennox
Integrated DNA Technologies, 1710 Commercial Park, Coralville, Iowa 52241, USA
Pharm Res 27:1788-99. 2010..This study objectively evaluates the in vitro potency of different anti-miRNA oligonucleotides (AMOs) using various design and modification strategies described in the literature as well as some novel modification strategies...
- Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotidesKim A Lennox
Integrated DNA Technologies, Inc, Coralville, IA 52241, USA
Nucleic Acids Res 44:863-77. 2016..A mixed-modality approach combining ASOs and RNAi reagents improved knockdown efficacy, particularly for those lncRNAs that localize to both nuclear and cytoplasmic compartments. ..
- Characterization of modified antisense oligonucleotides in Xenopus laevis embryosKim A Lennox
Integrated DNA Technologies, Coralville, IA 52241, USA
Oligonucleotides 16:26-42. 2006..However, at 400 nM, both of these compounds led to significant degradation of survivin mRNA, even when up to three mismatches were present in the heteroduplex...