Edward A Miao

Summary

Affiliation: Institute for Systems Biology
Country: USA

Publications

  1. pmc Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA
    J Clin Immunol 30:502-6. 2010
  2. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
  3. pmc Pseudomonas aeruginosa activates caspase 1 through Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 105:2562-7. 2008
  4. pmc Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 107:3076-80. 2010
  5. pmc Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98103, USA
    J Immunol 185:818-21. 2010
  6. ncbi Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Nat Immunol 7:569-75. 2006
  7. pmc Generation of a Listeria vaccine strain by enhanced caspase-1 activation
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98109, USA
    Eur J Immunol 41:1934-40. 2011
  8. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
  9. pmc The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection
    Jayant V Rajan
    Institute for Systems Biology, 1441 34th Avenue N, Seattle, WA 98104, USA
    J Virol 85:4167-72. 2011
  10. pmc Activation of the NLRP3 inflammasome by intracellular poly I:C
    Jayant V Rajan
    Institute for Systems Biology, Seattle, WA 98103, USA
    FEBS Lett 584:4627-32. 2010

Collaborators

Detail Information

Publications14

  1. pmc Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA
    J Clin Immunol 30:502-6. 2010
    ..Cytokine production by innate immune cells is initiated by signaling downstream of pattern recognition receptors, including Toll-like receptors...
  2. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
    ..This demonstrates that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system...
  3. pmc Pseudomonas aeruginosa activates caspase 1 through Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 105:2562-7. 2008
    ..Thus, Ipaf-dependent detection of cytosolic flagellin is a conserved mechanism by which macrophages detect the presence of pathogens that use T3SS...
  4. pmc Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 107:3076-80. 2010
    ..Furthermore, the specific detection of the virulence machinery permits the discrimination between pathogenic and nonpathogenic bacteria...
  5. pmc Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98103, USA
    J Immunol 185:818-21. 2010
    ..We now use biochemical and genetic approaches to demonstrate that the third detector senses bacterial DNA and identify it as Aim2, a receptor that has previously been shown to detect viral DNA...
  6. ncbi Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Nat Immunol 7:569-75. 2006
    ....
  7. pmc Generation of a Listeria vaccine strain by enhanced caspase-1 activation
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98109, USA
    Eur J Immunol 41:1934-40. 2011
    ..monocytogenes-based vaccine. Moreover, the attenuated strains with embedded flagellin or PrgJ adjuvants represent attractive vectors for vaccines aimed at eliciting T-cell responses...
  8. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
    ..Thus, these data identify IL-1 alpha-IL-1RI as a key pathway allowing for the activation of proinflammatory responses to the virus, independently of its genomic nucleic acid recognition...
  9. pmc The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection
    Jayant V Rajan
    Institute for Systems Biology, 1441 34th Avenue N, Seattle, WA 98104, USA
    J Virol 85:4167-72. 2011
    ..These findings indicate that the NLRP3 inflammasome may be a common pathway for RNA virus detection, but its precise role in the host response may be variable...
  10. pmc Activation of the NLRP3 inflammasome by intracellular poly I:C
    Jayant V Rajan
    Institute for Systems Biology, Seattle, WA 98103, USA
    FEBS Lett 584:4627-32. 2010
    ..This detection is independent of the other poly I:C sensors: TLR3 and MDA5. These results suggest a mechanism by which cytosolic dsRNA produced during viral infection could activate the NLRP3 inflammasome...
  11. ncbi TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Semin Immunopathol 29:275-88. 2007
    ..Thus, TLR5 responds more generally to flagellated bacteria, while Ipaf responds to bacteria that express both flagellin and virulence factors...
  12. pmc NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis
    T Eoin West
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America International Respiratory and Severe Illness Center, University of Washington, Seattle, Washington, United States of America Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 8:e3178. 2014
    ..Our results show that NLRC4 and TLR5, key components of two flagellin sensing pathways, each contribute to host defense in respiratory melioidosis...
  13. ncbi Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton
    Edward A Miao
    Department of Microbiology, University of Washington, HSB K 140, Box 357710, Seattle, WA 98195 7710, USA
    Mol Microbiol 48:401-15. 2003
    ..However, a third intracellular virulence factor, spvB, which ADP-ribosylates actin, strongly inhibited VAP formation in HeLa cells, suggesting a more subtle effect for SspH2 and SseI on the actin cytoskeleton...
  14. pmc Transcription of the SsrAB regulon is repressed by alkaline pH and is independent of PhoPQ and magnesium concentration
    Edward A Miao
    Department of Microbiology, Health Sciences Building, University of Washington, Seattle, WA 98195, USA
    J Bacteriol 184:1493-7. 2002
    ..0 or at a lower pH, suggesting that alkaline pH represses SsrAB activation. In addition, the PhoPQ two-component system, which is also activated intracellularly, was not required for activation of SsrAB...