Genomes and Genes
Pierre Yves Bochud
Affiliation: Institute for Systems Biology
- Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosyPierre Yves Bochud
Institute for Systems Biology, Seattle, WA 98103 8904, USA
J Infect Dis 197:253-61. 2008..The goal of the present study was to assess the effect of Toll-like receptor 2 (TLR2) polymorphisms on susceptibility to and clinical presentation of leprosy...
- Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infectionPierre Yves Bochud
Institute for Systems Biology, Seattle, Washington State, USA
AIDS 21:441-6. 2007..Toll-like receptors (TLRs) have a key role in innate immunity and mutations in the genes encoding these receptors have been associated with increased or decreased susceptibility to infections...
- Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infectionPierre Yves Bochud
Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103, USA
J Infect Dis 196:505-9. 2007..02 and P=.001) rates. An SNP in haplotype 2 (-15607A/G) was also associated with shedding (P=.01) and lesional (P=.008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection...
- Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantationPierre Yves Bochud
Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
N Engl J Med 359:1766-77. 2008..We examined the role of TLR polymorphisms in conferring a risk of invasive aspergillosis among recipients of allogeneic hematopoietic-cell transplants...
- Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individualsSamuel O Pine
Program in Pathobiology, Department of Global Health, University of Washington, Seattle, Washington, USA
AIDS 23:2387-95. 2009..We investigated the impact of TLR single nucleotide polymorphisms (SNPs) on clinical outcome in a seroincident cohort of HIV-1-infected volunteers...
- Pathogenesis of sepsis: new concepts and implications for future treatmentPierre Yves Bochud
Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103 8904, USA
BMJ 326:262-6. 2003
- Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signalingPierre Yves Bochud
Institute for Systems Biology, Seattle, WA 98103 8904, USA
J Immunol 170:3451-4. 2003....
- Innate immunogenetics: a tool for exploring new frontiers of host defencePierre Yves Bochud
Institute for Systems Biology, Seattle, WA, USA
Lancet Infect Dis 7:531-42. 2007..This is likely to open new perspectives for the development of diagnostic, predictive, and preventive management strategies to combat infectious diseases...
- Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based reviewPierre Yves Bochud
The Institute for Systems Biology, Seattle, WA, USA
Crit Care Med 32:S495-512. 2004....
- Reverse transcriptase activity for quantitation of HIV-1 subtype C in plasma: relation to RNA copy number and CD4 T-cell countElizabeth Seyoum
Ethio Netherlands AIDS Research Project ENARP, Ethiopian Health and Nutrition Research Institute EHNRI, Addis Ababa, Ethiopia
J Med Virol 78:161-8. 2006..It is based on a simple technique, can be run in any routine diagnostic laboratory, and is a competitive alternative for use in resource limited settings...
- Alternative approach to blood screening using the ExaVir reverse transcriptase activity assayElizabeth Seyoum
Ethio Netherlands AIDS Research Project ENARP, Ethiopian Health and Nutrition Research Institute EHNRI, Addis Ababa
Curr HIV Res 3:371-6. 2005..This sample was detectable in the fluorimetric version of the test. The detection of RT activity in addition to the currently used markers would seem to have a potential for use in blood screening...
- Diagnosis of tuberculous lymphadenitis in Butajira, rural EthiopiaMohammed Ahmed Yassin
Southern Region Health Bureau, Awassa, Ethiopia
Scand J Infect Dis 35:240-3. 2003..tuberculosis is needed for diagnosis in lymphadenitis cases of this kind. These findings could help to strengthen the diagnostic algorithm suggested by the National TB Control Program...
- Kinetics of sedimentation rate, viral load and TNF-alpha in relation to HIV co-infection in tuberculosisThomas Schön
Department of Medical Microbiology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
Trans R Soc Trop Med Hyg 100:483-8. 2006..Additionally, TNF-alpha and HIV viral load remained elevated in HIV+/Tb+ patients following treatment despite clinical improvement comparable to HIV-/Tb+ patients...
- Evaluation of outpatients with suspected pulmonary tuberculosis in a high HIV prevalence setting in Ethiopia: clinical, diagnostic and epidemiological characteristicsJudith Bruchfeld
Division of Infectious Diseases, Institution of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
Scand J Infect Dis 34:331-7. 2002..Also, increased awareness of, and improved diagnostic tools for, HIV-related pulmonary infections other than PTB are required, together with algorithms for patients with suspected PTB...
- Local nerve damage in leprosy does not lead to an impaired cellular immune response or decreased wound healing in the skinM Ruby Siddiqui
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York, USA
J Infect Dis 186:260-5. 2002..Rather, chronic cutaneous ulceration in leprosy most likely results from repeated trauma associated with loss of sensation...
- [Burnout in Greene-land]Sven Britton
Lakartidningen 104:2446-7. 2007
- [Needle exchange as bribery]Sven Britton
Lakartidningen 104:2133. 2007
- Co-infection of Onchocerca volvulus and intestinal helminths in indigenous and migrant farmers in southwest EthiopiaGenene Mengistu
Armauer Hansen Research Institute, P O Box 1005, Addis Ababa, Ethiopia
Ethiop Med J 40:19-27. 2002..The public health significance of coexistence of the two diseases, and the need for intensive control measures are discussed...
- Treatment of intestinal worms is associated with decreased HIV plasma viral loadDawit Wolday
Armauer Hansen Research Institute, Addis Ababa, Ethiopia
J Acquir Immune Defic Syndr 31:56-62. 2002..We have previously suggested that helminthic infections make the host more susceptible to HIV infection and enhance its progression due to the chronic immune activation they cause...
- Chronic helminth infections may negatively influence immunity against tuberculosis and other diseases of public health importanceDaniel Elias
ACE BioSciences, Unsbjergvej 2A, 5220 Odense SOE, Denmark
Expert Rev Anti Infect Ther 5:475-84. 2007..Understanding such interactions could assist in the design of vaccines against these diseases...
- Are intestinal helminths risk factors for developing active tuberculosis?Daniel Elias
Department of Microbiology and Parasitology, Gondar University, Gondar, Ethiopia
Trop Med Int Health 11:551-8. 2006..To determine the prevalence of intestinal helminth infections in active tuberculosis patients and their healthy household contacts and to assess its association with active TB in an area endemic for both types of infections...
- Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patientsT Mark Doherty
Department of Tuberculosis Immunology, Statens Serum Institute Hvidovre Hospital, Copenhagen, Denmark
J Clin Microbiol 40:704-6. 2002..We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period...