L Joseph Wheat

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi State-of-the-art review of pulmonary fungal infections
    L Joseph Wheat
    Indiana University School of Medicine, Indianapolis Department of Veterans Affairs Hospital, USA
    Semin Respir Infect 17:158-81. 2002
  2. ncbi Practice guidelines for the management of patients with histoplasmosis. Infectious Diseases Society of America
    J Wheat
    Department of Medicine and Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Clin Infect Dis 30:688-95. 2000
  3. ncbi Diagnosis of histoplasmosis by antigen detection based upon experience at the histoplasmosis reference laboratory
    L Joseph Wheat
    Indiana University School of Medicine, Indianapolis, IN, USA
    Diagn Microbiol Infect Dis 43:29-37. 2002
  4. pmc Antigen clearance during treatment of disseminated histoplasmosis with itraconazole versus fluconazole in patients with AIDS
    L Joseph Wheat
    Histoplasmosis Reference Laboratory, Indiana University School of Medicine and Veterans Affairs Medical Center, Indianapolis, Indiana 46202 2879, USA
    Antimicrob Agents Chemother 46:248-50. 2002
  5. ncbi Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome
    L J Wheat
    Indiana University School of Medicine, Histoplasmosis Reference Laboratory, and Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Clin Infect Dis 33:1910-3. 2001
  6. ncbi Laboratory diagnosis of histoplasmosis: update 2000
    L J Wheat
    Division of Infectious Diseases, Indiana University School of Medicine, Richard L Roudebush Department of Veterans Affairs Hospital, Histoplasmosis Reference Laboratory, Indianapolis, IN 46202 28790, USA
    Semin Respir Infect 16:131-40. 2001
  7. pmc Clearance of fungal burden during treatment of disseminated histoplasmosis with liposomal amphotericin B versus itraconazole
    L J Wheat
    Indiana University School of Medicine, Histoplasmosis Reference Library and Veterans Affairs Medical Center, Indianapolis 46202 2879, USA
    Antimicrob Agents Chemother 45:2354-7. 2001
  8. ncbi Factors associated with severe manifestations of histoplasmosis in AIDS
    L J Wheat
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Infect Dis 30:877-81. 2000
  9. ncbi Mucosal and invasive fungal infections in HIV/AIDS
    C A Hage
    Indiana University School of Medicine, Indianapolis Department of Veterans Affairs Hospital, USA
    Eur J Med Res 7:236-41. 2002
  10. doi Diagnosis of histoplasmosis by antigen detection in BAL fluid
    Chadi A Hage
    Department of Medicine, Roudebush VA Medical Center, Indiana University, Indianapolis, IN 46202, USA
    Chest 137:623-8. 2010

Detail Information

Publications72

  1. ncbi State-of-the-art review of pulmonary fungal infections
    L Joseph Wheat
    Indiana University School of Medicine, Indianapolis Department of Veterans Affairs Hospital, USA
    Semin Respir Infect 17:158-81. 2002
    ..The lung is the portal of entry for most of these pathogens, and often is prominently involved in the clinical syndrome. This article focuses on the recognition, diagnosis, and management of these important pulmonary mycoses...
  2. ncbi Practice guidelines for the management of patients with histoplasmosis. Infectious Diseases Society of America
    J Wheat
    Department of Medicine and Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Clin Infect Dis 30:688-95. 2000
    ..PARTICIPANTS AND CONSENSUS PROCESS: A working group of 8 experts in this field was convened to develop this guideline. The working group developed and refined the guideline through a series of conference calls...
  3. ncbi Diagnosis of histoplasmosis by antigen detection based upon experience at the histoplasmosis reference laboratory
    L Joseph Wheat
    Indiana University School of Medicine, Indianapolis, IN, USA
    Diagn Microbiol Infect Dis 43:29-37. 2002
    ..This report is based soley upon the experience at the Histoplasmosis Reference Laboratory, and can not be used in interpretation of results of Histoplasma antigen testing done at other laboratories...
  4. pmc Antigen clearance during treatment of disseminated histoplasmosis with itraconazole versus fluconazole in patients with AIDS
    L Joseph Wheat
    Histoplasmosis Reference Laboratory, Indiana University School of Medicine and Veterans Affairs Medical Center, Indianapolis, Indiana 46202 2879, USA
    Antimicrob Agents Chemother 46:248-50. 2002
    ..This study demonstrates that clearance of fungemia is a better measure of antifungal effect than clearance of antigen...
  5. ncbi Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome
    L J Wheat
    Indiana University School of Medicine, Histoplasmosis Reference Laboratory, and Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Clin Infect Dis 33:1910-3. 2001
    ..Cross-resistance to itraconazole was not seen. In conclusion, fluconazole is less active than itraconazole for Histoplasma capsulatum and induces resistance during therapy, which accounted for treatment failure in some patients...
  6. ncbi Laboratory diagnosis of histoplasmosis: update 2000
    L J Wheat
    Division of Infectious Diseases, Indiana University School of Medicine, Richard L Roudebush Department of Veterans Affairs Hospital, Histoplasmosis Reference Laboratory, Indianapolis, IN 46202 28790, USA
    Semin Respir Infect 16:131-40. 2001
    ..Each has certain limitations that must be recognized if they are to be used correctly. The approach to diagnosis of histoplasmosis will be reviewed...
  7. pmc Clearance of fungal burden during treatment of disseminated histoplasmosis with liposomal amphotericin B versus itraconazole
    L J Wheat
    Indiana University School of Medicine, Histoplasmosis Reference Library and Veterans Affairs Medical Center, Indianapolis 46202 2879, USA
    Antimicrob Agents Chemother 45:2354-7. 2001
    ..2 U in the itraconazole group (P = 0.0005). The more rapid clearance of fungemia supports the use of liposomal amphotericin B rather than itraconazole for initial treatment of moderately severe or severe histoplasmosis...
  8. ncbi Factors associated with severe manifestations of histoplasmosis in AIDS
    L J Wheat
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Infect Dis 30:877-81. 2000
    ..2; 95% CI, 0.1-0.6). Findings associated with severe histoplasmosis should be recognized early and the cases managed aggressively...
  9. ncbi Mucosal and invasive fungal infections in HIV/AIDS
    C A Hage
    Indiana University School of Medicine, Indianapolis Department of Veterans Affairs Hospital, USA
    Eur J Med Res 7:236-41. 2002
    ..Finally, new antifungal agents expand our treatment choices. This review updates management of fungal infections in AIDS...
  10. doi Diagnosis of histoplasmosis by antigen detection in BAL fluid
    Chadi A Hage
    Department of Medicine, Roudebush VA Medical Center, Indiana University, Indianapolis, IN 46202, USA
    Chest 137:623-8. 2010
    ..The purpose of this study is to compare the sensitivity of the quantitative antigen detection assay with cytopathology and culture of BAL specimens...
  11. pmc Use of bronchoalveolar lavage to detect galactomannan for diagnosis of pulmonary aspergillosis among nonimmunocompromised hosts
    M Hong Nguyen
    Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Clin Microbiol 45:2787-92. 2007
    ..Given the likelihood of false-positive results, a BAL GM test should not be ordered routinely in this population...
  12. pmc Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay
    Chadi A Hage
    Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, Pulmonary Critical Care Medicine, Indianapolis, Indiana 46202, USA
    Clin Vaccine Immunol 18:661-6. 2011
    ..Antigenuria declines earlier with amphotericin B than with itraconazole...
  13. doi Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay
    Michelle Durkin
    MiraVista Diagnostics, Indianapolis, Indiana 46241, USA
    Clin Infect Dis 47:e69-73. 2008
    ..We have previously shown antigenuria in patients with coccidioidomycosis through use of the Histoplasma antigen enzyme immunoassay (EIA), and now we have developed a specific Coccidioides antigen EIA...
  14. ncbi Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole
    L Joseph Wheat
    MiraVista Diagnostics MiraBella Technologies, 4444 Decatur Boulevard, Indianapolis, IN 46241, USA
    J Antimicrob Chemother 57:1235-9. 2006
    ..To determine the activity of newer triazoles against strains of Histoplasma capsulatum resistant to fluconazole...
  15. pmc Blastomyces dermatitidis antigen detection by quantitative enzyme immunoassay
    Patricia Connolly
    MiraVista Diagnostics, Indianapolis, Indiana, USA
    Clin Vaccine Immunol 19:53-6. 2012
    ..Pretreatment increased the sensitivity for detection of antigenemia. Differentiation of histoplasmosis and blastomycosis is not possible by antigen detection...
  16. pmc Detection of Coccidioides antigenemia following dissociation of immune complexes
    Michelle Durkin
    MiraVista Diagnostics, Indianapolis, Indiana1 MiraBella Technologies, Indianapolis, Indiana 46241, USA
    Clin Vaccine Immunol 16:1453-6. 2009
    ..Specificity of 100% was obtained in healthy subjects, but cross-reactions were seen in 22.2% of patients with histoplasmosis or blastomycosis. EDTA-heat treatment improves the sensitivity for the detection of Coccidioides antigenemia...
  17. pmc Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results
    Lindsey Egan
    MiraVista Diagnostics, 4444 Decatur Blvd, Suite 300, Indianapolis, IN 46241, USA
    Clin Vaccine Immunol 15:726-8. 2008
    ..Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity...
  18. ncbi Safety of discontinuation of maintenance therapy for disseminated histoplasmosis after immunologic response to antiretroviral therapy
    Mitchell Goldman
    Division of Infectious Diseases, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis, Indiana 46202, USA
    Clin Infect Dis 38:1485-9. 2004
    ....
  19. pmc Cryptococcal glucoxylomannan does not exhibit cross-reactivity in the MVista Histoplasma antigen enzyme immunoassay
    David Zhuang
    MiraVista Diagnostics, Indianapolis, Indiana 46241, USA
    Clin Vaccine Immunol 15:392-3. 2008
    ..We tested patient samples, spleens from infected mice, and purified polysaccharides in the MVista Histoplasma antigen enzyme immunoassay and cryptococcal antigen latex agglutination system for cross-reactivity, and none was observed...
  20. doi Histoplasmosis as a cause for a positive Fungitell (1 --> 3)-beta-D-glucan test
    Lindsey Egan
    MiraVista Diagnostics, 4444 Decatur Boulevard, Suite 300, Indianapolis, IN 46241, USA
    Med Mycol 46:93-5. 2008
    ..Therefore, there is a need to conduct confirmatory tests for histoplasmosis in the appropriate clinical setting...
  21. doi Blastomycosis in indiana: digging up more cases
    W Graham Carlos
    Pulmonary Critical Care and Infectious Diseases, Roudebush VA Medical Center and Indiana University, Indianapolis, IN 46202, USA
    Chest 138:1377-82. 2010
    ..We propose that this surge was related to major highway construction around Indianapolis...
  22. ncbi Reduction in false antigenemia in the second generation Histoplasma antigen assay
    L Joseph Wheat
    MiraVista Diagnostics, Indianapolis, Indiana 46241, USA
    Med Mycol 45:169-71. 2007
    ..False-positive results were not observed in serum or urine from healthy subjects. Thus, the second generation assay is less susceptible to false antigenemia caused by anti-rabbit antibodies...
  23. pmc Detection of histoplasma antigen by a quantitative enzyme immunoassay
    Patricia A Connolly
    MiraVista Diagnostics, 4444 Decatur Blvd, Indianapolis, IN 46241, USA
    Clin Vaccine Immunol 14:1587-91. 2007
    ..Sensitivity, specificity, and interassay precision are excellent in the new third-generation quantitative Histoplasma antigen immunoassay...
  24. doi Pulmonary histoplasmosis
    Chadi A Hage
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Semin Respir Crit Care Med 29:151-65. 2008
    ..Detection of antigen in bronchoalveolar lavage fluid may be particularly helpful in certain circumstances. Guidelines for antifungal therapy have been updated and will be discussed for pulmonary syndromes...
  25. pmc Evaluation of the IMMY ALPHA Histoplasma antigen enzyme immunoassay for diagnosis of histoplasmosis marked by antigenuria
    Ann Lemonte
    MiraVista Diagnostics and MiraBella Technologies, 4444 Decatur Blvd, Indianapolis, IN 46241, USA
    Clin Vaccine Immunol 14:802-3. 2007
    ..The specificity was 84% with the IMMY EIA versus 98% with the MVD EIA. The correlation between assays for positive cases was weak (r(2) = 0.430)...
  26. doi Histoplasma capsulatum preferentially induces IDO in the lung
    Chadi A Hage
    Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, Pulmonary Critical Care Medicine, Indianapolis, Indiana 46202, USA
    Med Mycol 51:270-9. 2013
    ..Histoplasma preferentially induces lung IDO, as early as one week after infection. IDO appears to modulate the immune response to Histoplasma infection...
  27. doi Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy
    Chadi A Hage
    Pulmonary Critical Care and Infectious Diseases, Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin Infect Dis 50:85-92. 2010
    ..Prescribers should become aware of the recognition, diagnosis, and treatment of histoplasmosis and educate recipients about decreasing their risk of exposure and both recognizing and reporting signs of early infection...
  28. doi A multicenter evaluation of tests for diagnosis of histoplasmosis
    Chadi A Hage
    Pulmonary Critical Care Medicine, Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin Infect Dis 53:448-54. 2011
    ..The goal of this study was to determine the sensitivity of the current antigen assay in different categories of histoplasmosis...
  29. pmc Investigation of the efficacy of micafungin in the treatment of histoplasmosis using two North American strains of Histoplasma capsulatum
    Chadi A Hage
    Pulmonary Critical Care and Infectious Diseases, Roudebush VA Medical Center and Indiana University, 1481 W 10th St, 111P IU, Indianapolis, IN 46202, USA
    Antimicrob Agents Chemother 55:4447-50. 2011
    ..Micafungin was active in vitro against the mold but not the yeast form but was ineffective in vivo. Micafungin appears to be ineffective in treatment of histoplasmosis...
  30. pmc Histoplasmosis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS): multicenter study of outcomes and factors associated with relapse
    Thein Myint
    From Division of Infectious Diseases TM, RNG, Department of Internal Medicine, and Department of Public Health TNC, University of Kentucky, Lexington, Kentucky Division of Infectious Diseases AMA, Department of Internal Medicine, Emory University, Atlanta, Georgia Division of Infectious Diseases AS, Department of Internal Medicine, University of Southern California, Los Angeles, California Division of Infectious Diseases AF, Department of Internal Medicine, University Medical Center of Southern Nevada, Las Vegas, Nevada Department of Pulmonary and Critical Care Medicine, Thoracic Transplantation CH, Indiana University Health, Indianapolis, Indiana Division of Infectious Disease JWB, Department of Internal Medicine, University of Alabama, Birmingham, Alabama Departmentof Epidemiology MJ, College of Public Health, University of Louisville, Louisville, Kentucky Division of Infectious Disease DMB, Department of Internal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, Missouri and MiraVista Diagnostics MR, LJW, Indianapolis, Indiana
    Medicine (Baltimore) 93:11-8. 2014
    ..0 units in second-generation method), and no CNS histoplasmosis...
  31. ncbi Urine polymerase chain reaction is not as sensitive as urine antigen for the diagnosis of disseminated histoplasmosis
    Yi Wei Tang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Diagn Microbiol Infect Dis 54:283-7. 2006
    ..Thus, positive PCR results in urine specimens correlate with positive culture results, but not with antigenuria. The low sensitivity of this PCR assay in urine limits its use in the diagnosis of disseminated histoplasmosis...
  32. ncbi Differences in histoplasmosis in patients with acquired immunodeficiency syndrome in the United States and Brazil
    Kian Karimi
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Infect Dis 186:1655-60. 2002
    ..Skin lesions are more common in infection with class 5 or 6 organisms than with class 2 Histoplasma capsulatum. The role of genetic differences in the organism as a cause for the clinical differences requires investigation...
  33. doi Detection of Blastomyces dermatitidis antigen in patients with newly diagnosed blastomycosis
    J Ryan Bariola
    Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Diagn Microbiol Infect Dis 69:187-91. 2011
    ..B. dermatitidis antigen was detected in most of the patients with blastomycosis and can be a useful tool for timely diagnosis...
  34. pmc Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay
    L Joseph Wheat
    MiraVista Diagnostics, 4444 Decatur Blvd, Suite 300, Indianapolis, IN 46241, USA
    Clin Vaccine Immunol 14:638-40. 2007
    ..Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results...
  35. pmc Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Infect Dis 47:674-83. 2008
    ..We also discuss potential pitfalls in assessing outcome, such as conflicting clinical, radiological, and/or mycological data and gaps in knowledge...
  36. pmc Development of a highly sensitive and specific blastomycosis antibody enzyme immunoassay using Blastomyces dermatitidis surface protein BAD-1
    Sarah M Richer
    MiraVista Diagnostics, Indianapolis, Indiana, USA
    Clin Vaccine Immunol 21:143-6. 2014
    ..This assay has the potential to aid in the diagnosis of blastomycosis. ..
  37. doi Disseminated histoplasmosis of infancy in one of the twins
    Laura A S Quilter
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Pediatr Infect Dis J 31:990-1. 2012
    ..The report also documents histoplasma antigen concentrations in serum and urine before, during and after completing antifungal therapy...
  38. doi Ileocecal histoplasmosis simulating Crohn disease in a patient with hyperimmunoglobulin E syndrome
    Steven J Steiner
    Division of Pediatric Gastroenterology Hepatology Nutrition, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202 5225, USA
    Pediatr Infect Dis J 28:744-6. 2009
    ..Histopathologic findings of the terminal ileum demonstrated intracellular yeast forms compatible with Histoplasma capsulatum. The patient was treated with oral itraconazole and had a rapid and complete response...
  39. pmc Effect of calcineurin inhibitors on posaconazole blood levels as measured by the MVista microbiological assay
    David Zhuang
    MiraVista Diagnostics and MiraBella Technologies, Indianapolis, IN 46241, USA
    Antimicrob Agents Chemother 52:730-1. 2008
    ..No effect was observed. However, concurrent or recently discontinued treatment with other antifungal drugs caused false-positive results, emphasizing a limitation of microbiological assays for antifungal drug level measurement...
  40. ncbi Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America
    L Joseph Wheat
    MiraVista Diagnostics MiraBella Technologies, Indianapolis, IN 46241, USA
    Clin Infect Dis 45:807-25. 2007
    ..In addition, the panel added recommendations for management of histoplasmosis in children for those aspects that differ from aspects in adults...
  41. ncbi Antifungal therapy for central nervous system histoplasmosis, using a newly developed intracranial model of infection
    Ross R Haynes
    Histoplasmosis Reference Laboratory, Department of Medicine, Indiana University School of Medicine, 1001 W 10th Street, OPW 430, Indianapolis, IN 46202 2879, USA
    J Infect Dis 185:1830-2. 2002
    ..The hypothesis that amphotericin B-fluconazole combination therapy would be superior to amphotericin B monotherapy for treatment of CNS histoplasmosis was not supported by this study...
  42. doi Approach to the diagnosis of the endemic mycoses
    L Joseph Wheat
    MiraBella Technologies and MiraVista Diagnostics, Indianapolis, IN 46241, USA
    Clin Chest Med 30:379-89, viii. 2009
    ..Of note is that isolation of the fungus by culture remains the only method for definitive diagnosis, and the only method for diagnosis in some patients...
  43. ncbi Histoplasmosis
    L Joseph Wheat
    MiraVista Diagnostics, 4444 Decatur Boulevard, Suite 300, Indianapolis, IN 46241, USA
    Infect Dis Clin North Am 17:1-19, vii. 2003
    ..This article provides an up-to-date clinical review of histoplasmosis, focusing on recognition, diagnosis, and management...
  44. ncbi Efficacy and safety of twice-daily versus three-times daily saquinavir soft gelatin capsules as part of triple combination therapy for HIV-1 infection
    L Joseph Wheat
    Indiana University School of Medicine, Indianapolis, Ind, USA
    Antivir Ther 7:199-209. 2002
    ..The objective of this study was to determine whether a triple therapy regimen incorporating twice-daily saquinavir is as effective as a three-times daily regimen...
  45. pmc Histoplasmosis among hospitalized febrile patients in northern Tanzania
    Sarah M Lofgren
    Division of Infectious Diseases and International Health, Department of Medicine, Box 102359, Duke University Medical Center, Durham, NC 27710, USA
    Trans R Soc Trop Med Hyg 106:504-7. 2012
    ..Histoplasmosis is an important cause of febrile illness in Tanzania but is rarely considered in the differential diagnosis. Increased clinician awareness and availability of reliable diagnostic tests may improve patient outcomes...
  46. ncbi Gastrointestinal histoplasmosis
    Charles J Kahi
    Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University Medical Center, UH 4100, 550 N University Boulevard, Indianapolis, IN 46202, USA
    Am J Gastroenterol 100:220-31. 2005
    ..This review will focus on the clinical and histopathologic features of GIH, the approach to diagnosis, and recommendations for treatment...
  47. ncbi Histoplasmosis after treatment with anti-tumor necrosis factor-alpha therapy
    Karen L Wood
    Division of Pulmonary and Critical Care, Department of Medicine, Infectious Disease, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Respir Crit Care Med 167:1279-82. 2003
    ..In summary, patients receiving anti-TNF-alpha therapy are at risk for developing disseminated histoplasmosis. This may be due to a defect in the TH1 arm of cellular immunity...
  48. doi Approach to the diagnosis of invasive aspergillosis and candidiasis
    L Joseph Wheat
    MiraBella Technologies and MiraVista Diagnostics, Indianapolis, IN 46241, USA
    Clin Chest Med 30:367-77, viii. 2009
    ..None of these methods is useful for diagnosis of zygomycosis and certain other less common mold infections. This article focuses on the detection of antigen and beta-D-glucan for diagnosis of invasive aspergillosis and candidiasis...
  49. pmc Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipients
    Cornelius J Clancy
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Clin Microbiol 45:1759-65. 2007
    ..5%, respectively (cutoff, > or = 1.0). In conclusion, BAL GM testing facilitated more-rapid diagnoses of IPA and the institution of antifungal therapy among non-lung solid-organ transplant recipients and helped to rule out IPA...
  50. ncbi Pulmonary histoplasmosis syndromes: recognition, diagnosis, and management
    L Joseph Wheat
    MiraVista Diagnostics, Indianapolis, Indiana, USA
    Semin Respir Crit Care Med 25:129-44. 2004
    ..Several new drugs active against H. capsulatum offer alternatives in patients failing or intolerant of current therapies...
  51. doi Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management
    Chadi A Hage
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
    Semin Respir Crit Care Med 36:729-45. 2015
    ..The preferred agents include liposomal amphotericin B for more severe cases and itraconazole for milder cases and "step-down" therapy following response to amphotericin B. ..
  52. pmc Long-term stability at -20 °C of Aspergillus galactomannan in serum and bronchoalveolar lavage specimens
    L Joseph Wheat
    MiraVista Diagnostics, Indianapolis, Indianapolis, USA
    J Clin Microbiol 52:2108-11. 2014
    ..These findings support the use of frozen serum or BAL specimens stored for at least 5 years in evaluation of diagnostic tests based on detection of galactomannan...
  53. ncbi Improvements in diagnosis of histoplasmosis
    L Joseph Wheat
    MiraVista Diagnostics and MiraBella Technologies, 4444 Decatur Blvd, Indianapolis, IN 46241, USA
    Expert Opin Biol Ther 6:1207-21. 2006
    ..This review provides the background for understanding the role of a battery of diagnostic methods in histoplasmosis. Tests facilitating a rapid diagnosis are expected to improve the outcome in patients with severe disease...
  54. pmc (1,3)-β-d-glucan in cerebrospinal fluid for diagnosis of fungal meningitis associated with contaminated methylprednisolone injections
    Anurag N Malani
    Department of Medicine, Section of Infectious Diseases, St Joseph Mercy Hospital, Ann Arbor, Michigan, USA
    J Clin Microbiol 53:799-803. 2015
    ..Further study on the utility of CSF BDG testing for other types of fungal meningitis is needed. ..
  55. ncbi Histoplasmosis: a review for clinicians from non-endemic areas
    L Joseph Wheat
    MiraVista Diagnostics, Indianapolis, IN 46241, USA
    Mycoses 49:274-82. 2006
    ..This review will address these issues with the goal of providing physicians in non-endemic areas sufficient information to suspect, diagnose, and treat patients with histoplasmosis...
  56. ncbi Cellular immune response in HIV-infected patients with histoplasmosis
    G Matthew Vail
    Indiana University School of Medicine, Histoplasmosis Reference Laboratory, Richard L Roudebush Veterans Administration Hospital, Indianapolis, Indiana, USA
    J Acquir Immune Defic Syndr 29:49-53. 2002
    ..In conclusion, immune responsiveness to H. capsulatum was depressed in HIV-1-infected persons with CD4 counts between 200 and 500 cells/mm(3), but approached normal in those with CD4 counts >500 cells/mm(3)...
  57. pmc Evaluation of reagents for detection of Histoplasma capsulatum antigenuria
    L Joseph Wheat
    Clin Vaccine Immunol 14:1387-8; author reply 1388. 2007
  58. ncbi Safety and efficacy of liposomal amphotericin B compared with conventional amphotericin B for induction therapy of histoplasmosis in patients with AIDS
    Philip C Johnson
    Division of General Medicine, University of Texas Houston Medical School, 6431 Fannin, MSB 1 122, Houston, TX 77030, USA
    Ann Intern Med 137:105-9. 2002
    ..In patients with moderate to severe histoplasmosis associated with AIDS, the preferred treatment has been the deoxycholate formulation of amphotericin B. However, serious side effects are associated with use of amphotericin B...
  59. pmc Detection of Histoplasma capsulatum antigen in Panamanian patients with disseminated histoplasmosis and AIDS
    Maria Eugenia Gutierrez
    Department of Infectious Diseases, Arnulfo Arias Madrid Hospital, Panama City, Panama
    Clin Vaccine Immunol 15:681-3. 2008
    ..We conclude that the MVista Histoplasma antigen EIA is a sensitive method for diagnosis of histoplasmosis in Panama...
  60. pmc Relationship of blood level and susceptibility in voriconazole treatment of histoplasmosis
    Alison Freifeld
    Antimicrob Agents Chemother 51:2656-7. 2007
  61. ncbi Diagnosis of coccidioidomycosis by antigen detection using cross-reaction with a Histoplasma antigen
    Tim Kuberski
    Body Positive, Phoenix, Arizona, USA
    Clin Infect Dis 44:e50-4. 2007
    ..In 2005, patients with coccidioidomycosis were observed to have positive Histoplasma antigen test results...
  62. ncbi Combination therapy for aspergillosis: is it needed, and which combination?
    L Joseph Wheat
    J Infect Dis 187:1831-3. 2003
  63. pmc Plasmalyte as a cause of false-positive results for Aspergillus galactomannan in bronchoalveolar lavage fluid
    Chadi A Hage
    J Clin Microbiol 45:676-7. 2007
  64. ncbi Invalid comparison of the IMMY Histoplasma antigen assay with the "gold standard"
    L Joseph Wheat
    Am J Clin Pathol 129:661-3, author reply 663-5. 2008
  65. ncbi Histoplasmosis among human immunodeficiency virus-infected people in Europe: report of 4 cases and review of the literature
    Spinello Antinori
    Department of Clinical Sciences, Section of Infectious and Tropical Diseases, University of Milan, Milan, Italy
    Medicine (Baltimore) 85:22-36. 2006
    ..5 organs involved. The results of the present report highlight the need to consider the diagnosis of PDH among patients with AIDS in Europe presenting with a febrile illness who have traveled to or who originated from an endemic area...
  66. ncbi Urine antigen detection of blastomycosis in pediatric patients
    Kanokporn Mongkolrattanothai
    Section of Pediatric Infectious Diseases, Department of Pediatrics, University of Chicago, Chicago, IL 61637, USA
    Pediatr Infect Dis J 25:1076-8. 2006
    ..For the first time, we report the effect of therapy on Blastomyces antigen clearance. In our experience, the urine antigen detection for B. dermatitidis is useful for diagnosis and follow up during therapy...
  67. ncbi Outbreak of histoplasmosis in a school party that visited a cave in Belize: role of antigen testing in diagnosis
    Jane A Buxton
    Federal Field Epidemiology Training Program, Laboratory Centre for Disease Control, Health Canada, Ottawa, Ontario, Canada
    J Travel Med 9:48-50. 2002
  68. pmc Production of extracellular proteolytic activity by Histoplasma capsulatum grown in Histoplasma-macrophage medium is limited to restriction fragment length polymorphism class 1 isolates
    Robert Zarnowski
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI 53706, USA
    Diagn Microbiol Infect Dis 59:39-47. 2007
    ..Overall, the feature of extracellular proteolytic activity production enables a convenient and unequivocal identification of RFLP class 1 isolates and, thereby, can be used in H. capsulatum strain differentiation and typing...
  69. pmc Galactoxylomannan does not exhibit cross-reactivity in the platelia Aspergillus enzyme immunoassay
    Magdia De Jesus
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Vaccine Immunol 14:624-7. 2007
    ..Our results revealed no cross-reactions...
  70. ncbi A large histoplasmosis outbreak among high school students in Indiana, 2001
    Shadi Chamany
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS C09, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 23:909-14. 2004
    ..A histoplasmosis outbreak occurred in an Indiana high school in November-December 2001...
  71. ncbi Infliximab does not affect dendritic cells' mediated lymphoproliferative response to Histoplasma capsulatum
    Chadi A Hage
    Clin Infect Dis 41:1685-7; author reply 1687. 2005
  72. pmc Blastomyces antigen detection for monitoring progression of blastomycosis in a pregnant adolescent
    Megan Tarr
    Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA
    Infect Dis Obstet Gynecol 2007:89059. 2007
    ..Urine antigen detection for blastomycosis can be useful for following progression of disease in patients with disseminated blastomycosis in both the intrapartum and postpartum periods...