A Joseph Tector

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: studies in the dog-to-pig model
    A Joseph Tector
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Liver Transpl 8:153-9. 2002
  2. pmc Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival
    A Joseph Tector
    Department of Surgery, Transplantation Section, Gastroenterology Division, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Ann Surg 244:439-50. 2006
  3. ncbi request reprint Promising early results with immunosuppression using rabbit anti-thymocyte globulin and steroids with delayed introduction of tacrolimus in adult liver transplant recipients
    A Joseph Tector
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Liver Transpl 10:404-7. 2004
  4. doi request reprint Crossmatch-positive liver transplantation in patients receiving thymoglobulin-rituximab induction
    Chandrashekhar A Kubal
    1 Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 2 Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 3 Transplant Immunology Laboratory, Methodist Hospital, Indiana University School of Medicine, Indianapolis, IN 4 Transplant Division, Department of Surgery, University of Virginia, Charlottesville, VA 5 Address correspondence to Chandrashekhar A Kubal, M D, Ph D, Transplant Division, Department of Surgery, Indiana University School of Medicine, 550 North University Boulevard, Room 4601, Indianapolis, IN
    Transplantation 97:56-63. 2014
  5. doi request reprint Immortalized porcine liver sinusoidal endothelial cells: an in vitro model of xenotransplantation-induced thrombocytopenia
    Zheng Yu Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Xenotransplantation 19:249-55. 2012
  6. doi request reprint Differences in human and porcine platelet oligosaccharides may influence phagocytosis by liver sinusoidal cells in vitro
    Leela L Paris
    Xenoimmunology Laboratory, Department of Surgery, Transplant Institute, Indiana University School of Medicine, Indiana University Health, Indianapolis, IN 46202, USA
    Xenotransplantation 19:31-9. 2012
  7. doi request reprint Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths
    MICHAEL O'CONNOR
    Transplant Division, Department of Surgery, Indiana University, School of Medicine, Indianapolis, IN 46202, USA
    J Pediatr Surg 46:1057-63. 2011
  8. doi request reprint Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation
    Andrew J Lutz
    Department of Surgery, IU Health Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Xenotransplantation 20:27-35. 2013
  9. doi request reprint Primary porcine Kupffer cell phagocytosis of human platelets involves the CD18 receptor
    Ray K Chihara
    Department of Surgery, Indiana University Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transplantation 92:739-44. 2011
  10. doi request reprint No difference in clinical transplant outcomes for local and imported liver allografts
    Richard S Mangus
    Clarian Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Liver Transpl 15:640-7. 2009

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: studies in the dog-to-pig model
    A Joseph Tector
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Liver Transpl 8:153-9. 2002
    ..In brief, the hemorrhage that accompanies liver xenotransplantation occurs because of a decrease in the number and function of circulating platelets in the recipient...
  2. pmc Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival
    A Joseph Tector
    Department of Surgery, Transplantation Section, Gastroenterology Division, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Ann Surg 244:439-50. 2006
    ..This study compares the graft/patient survival from standard (SD) and ECD for our transplant population between 2001 and 2005...
  3. ncbi request reprint Promising early results with immunosuppression using rabbit anti-thymocyte globulin and steroids with delayed introduction of tacrolimus in adult liver transplant recipients
    A Joseph Tector
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Liver Transpl 10:404-7. 2004
    ..RATG induction therapy is associated with good patient and graft survival, a low incidence of rejection, and minimal side effects. In addition, RATG induction is safe in patients transplanted for HCV...
  4. doi request reprint Crossmatch-positive liver transplantation in patients receiving thymoglobulin-rituximab induction
    Chandrashekhar A Kubal
    1 Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 2 Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 3 Transplant Immunology Laboratory, Methodist Hospital, Indiana University School of Medicine, Indianapolis, IN 4 Transplant Division, Department of Surgery, University of Virginia, Charlottesville, VA 5 Address correspondence to Chandrashekhar A Kubal, M D, Ph D, Transplant Division, Department of Surgery, Indiana University School of Medicine, 550 North University Boulevard, Room 4601, Indianapolis, IN
    Transplantation 97:56-63. 2014
    ..Positive crossmatch (CM) in liver transplantation (LT) is associated with worse outcomes. Role of induction immunosuppression in this setting remains to be studied...
  5. doi request reprint Immortalized porcine liver sinusoidal endothelial cells: an in vitro model of xenotransplantation-induced thrombocytopenia
    Zheng Yu Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Xenotransplantation 19:249-55. 2012
    ..Porcine iLSEC would enable continued study of xenotransplantation-induced thrombocytopenia in vitro with fewer animals sacrificed...
  6. doi request reprint Differences in human and porcine platelet oligosaccharides may influence phagocytosis by liver sinusoidal cells in vitro
    Leela L Paris
    Xenoimmunology Laboratory, Department of Surgery, Transplant Institute, Indiana University School of Medicine, Indiana University Health, Indianapolis, IN 46202, USA
    Xenotransplantation 19:31-9. 2012
    ..Analysis of these receptor carbohydrate-binding domains and surface carbohydrates on human and porcine platelets may shed light on the mechanism of xenotransplantation-induced thrombocytopenia...
  7. doi request reprint Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths
    MICHAEL O'CONNOR
    Transplant Division, Department of Surgery, Indiana University, School of Medicine, Indianapolis, IN 46202, USA
    J Pediatr Surg 46:1057-63. 2011
    ..This study applies laboratory liver function testing, including APRI, to monitor liver dysfunction over time for short-gut infants, with further analysis of at-risk subpopulations...
  8. doi request reprint Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation
    Andrew J Lutz
    Department of Surgery, IU Health Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Xenotransplantation 20:27-35. 2013
    ..Clinical xenotransplantation is not possible because humans possess antibodies that recognize antigens on the surface of pig cells. Galα-1,3-Gal (Gal) and N-glycolylneuraminic acid (Neu5Gc) are two known xenoantigens...
  9. doi request reprint Primary porcine Kupffer cell phagocytosis of human platelets involves the CD18 receptor
    Ray K Chihara
    Department of Surgery, Indiana University Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transplantation 92:739-44. 2011
    ..We sought to identify the role of KC CD18 in liver xenograft-induced thrombocytopenia...
  10. doi request reprint No difference in clinical transplant outcomes for local and imported liver allografts
    Richard S Mangus
    Clarian Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Liver Transpl 15:640-7. 2009
    ..In conclusion, liver allografts rejected for use by a large number of transplant centers can still be successfully used without early graft function or long-term survival being affected...
  11. doi request reprint Fibronectin from alpha 1,3-galactosyltransferase knockout pigs is a xenoantigen
    Ray K Chihara
    Indiana University School of Medicine, Indianapolis, Indiana
    J Surg Res 184:1123-33. 2013
    ..N-glycolylneuraminic acid (Neu5Gc), similar to galactose α1,3-galactose, is an antigenic carbohydrate found in pigs. We evaluated human antibody reactivity and performed initial antigenic epitope characterization of Fn from GTKO pigs...
  12. doi request reprint Impact of positive flow cytometry crossmatch on outcomes of intestinal/multivisceral transplantation: role anti-IL-2 receptor antibody
    Chandrashekhar A Kubal
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Transplantation 95:1160-6. 2013
    ..This study reports the impact of positive flow cytometry crossmatch on clinical outcomes after intestinal/MV transplantation and the use of anti-interleukin (IL)-2 receptor antibody as a maintenance immunosuppressant...
  13. doi request reprint ASGR1 expressed by porcine enriched liver sinusoidal endothelial cells mediates human platelet phagocytosis in vitro
    Leela L Paris
    Department of Surgery, Indiana University School of Medicine, IU Health Transplant Institute, Indianapolis, IN 46202, USA
    Xenotransplantation 18:245-51. 2011
    ..Recently, it was discovered that porcine liver sinusoidal endothelial cells (LSEC) bind and phagocytose human platelets. We examined the role of ASGR1 in binding and removing human platelets by the pig liver endothelium...
  14. doi request reprint Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gut
    Richard S Mangus
    Department of Surgery, Transplant Section, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    J Pediatr Surg 45:1266-73. 2010
    ..This study applies APRI scoring to parenteral nutrition-dependant, short-gut infants to determine hepatic fibrosis progression...
  15. doi request reprint Immunogenicity of Renal Microvascular Endothelial Cells From Genetically Modified Pigs
    Zheng Yu Wang
    1 Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 2 Department of Surgery, Indiana University Health, Indianapolis, IN 3 IU Health Transplant Institute, Indianapolis, IN
    Transplantation 100:533-7. 2016
    ..It is important to examine rejection pathways at an organ-specific level. The object of this study is to evaluate the human preformed antibody reactivity against DKO renal microvascular endothelial cells (RMEC) in vitro...
  16. doi request reprint Efficient selection of Gal-knockout pig cells for somatic cell nuclear transfer
    Luz M Reyes
    Department of Surgery, Transplant Surgery Section, Indiana University School of Medicine, Indianapolis, Indiana
    J Surg Res 184:e37-42. 2013
    ..The objective of this work was to generate a highly efficient system to select Gal-DKO cells to be used in SCNT without affecting the efficiency in production of Gal-null pigs...
  17. doi request reprint Immunosuppression induction with rabbit anti-thymocyte globulin with or without rituximab in 1000 liver transplant patients with long-term follow-up
    Richard S Mangus
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Liver Transpl 18:786-95. 2012
    ..05), and DCD (HR = 1.55, P = 0.11). rATG-based induction immunosuppression can be safely used in adult LT recipients with excellent survival and low rejection rates and without increases in immunosuppression-related side effects...
  18. ncbi request reprint Induction immunosuppression with rabbit antithymocyte globulin in pediatric liver transplantation
    Ashesh Shah
    Surgery, Indiana University, Indianapolis, IN, USA
    Liver Transpl 12:1210-4. 2006
    ..In conclusion, our data suggest that RATG induction with steroid and tacrolimus maintenance therapy is safe, easy to use, and effective in the prevention of rejection...
  19. doi request reprint Severe hypernatremia in deceased liver donors does not impact early transplant outcome
    Richard S Mangus
    Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN, USA
    Transplantation 90:438-43. 2010
    ..The purported mechanism for this effect is undefined. This study analyzes early graft function for donor livers procured from patients with severe hypernatremia...
  20. pmc Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers
    James Russell Butler
    1 Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    Transplantation 100:571-6. 2016
    ....
  21. doi request reprint Reduced human platelet uptake by pig livers deficient in the asialoglycoprotein receptor 1 protein
    Leela L Paris
    Department of Surgery, Indiana School of Medicine, Indianapolis, IN, USA
    Xenotransplantation 22:203-10. 2015
    ..Human platelets are bound by the asialoglycoprotein receptor (ASGR) on pig sinusoidal endothelial cells and phagocytosed. Inactivation of the ASGR1 gene in donor pigs may prevent xenotransplantation-induced thrombocytopenia...
  22. pmc De novo malignancy post-liver transplantation: a single center, population controlled study
    Hemant Chatrath
    Internal Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Transplant 27:582-90. 2013
    ..With the growing numbers of liver transplant recipients, it is increasingly important to understand the risks of de novo malignancy after liver transplantation...
  23. doi request reprint Multivisceral transplantation: expanding indications and improving outcomes
    Richard S Mangus
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    J Gastrointest Surg 17:179-86; discussion p.186-7. 2013
    ..This study reviews the changing indications and outcomes for this procedure over a 7-year period at a university medical center...
  24. doi request reprint Outcomes of pancreas allografts procured simultaneously with an isolated intestine allograft: single-center and national data
    Jonathan A Fridell
    Department of Surgery, Indiana University School of Medicine, 550 N University Blvd 4258, Indianapolis, IN 46202, USA
    Transplantation 94:84-8. 2012
    ..This study reports the transplant outcomes for pancreas allografts procured simultaneously with an intestine graft...
  25. ncbi request reprint Current status of small bowel and multivisceral transplantation
    Rodrigo M Vianna
    Intestinal and Multivisceral Transplantation, Transplant Surgery Section, Indiana University School of Medicine, Indiana University Hospital 4601, 550 N University Blvd, Indianapolis, IN 46202, USA
    Adv Surg 42:129-50. 2008
    ..Early referral for isolated intestinal transplant will reduce the need for simultaneous multiorgan transplants and increase the residual organs available for patients in need of (primarily) liver transplantation...
  26. doi request reprint Safe inclusion of the entire pancreas as a component of the multivisceral graft
    Rodrigo Vianna
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transplantation 86:114-6. 2008
    ..We reviewed our experience with multivisceral grafts that included the entire pancreas...
  27. ncbi request reprint Steroid withdrawal for pancreas after kidney transplantation in recipients on maintenance prednisone immunosuppression
    Jonathan A Fridell
    Department of Surgery, Indiana University School of Medicine, Indianapolis, 46202, USA
    Transplantation 82:389-92. 2006
    ....
  28. doi request reprint Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in extended criteria liver donors
    Richard S Mangus
    Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Liver Transpl 14:365-73. 2008
    ..These findings persisted for both SCD and ECD livers. Given the lower cost per donor for HTK, this preservation solution may be preferable for general use...
  29. ncbi request reprint Comparison of histidine-tryptophan-ketoglutarate solution (HTK) and University of Wisconsin solution (UW) in adult liver transplantation
    Richard S Mangus
    Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Liver Transpl 12:226-30. 2006
    ..There were no significant differences between HTK and UW in this population when comparing 1 month graft function and first-year graft and patient survival...
  30. doi request reprint Prognosis after recurrence of hepatocellular carcinoma in liver transplantation: predictors for successful treatment and survival
    Shunji Nagai
    Division of Transplant Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Transplant 29:1156-63. 2015
    ..006, hazard ratio = 3.29). Underlying patient conditions and nutritional status, represented by ALC and albumin, are important to successful cancer treatment and strong prognostic markers for survival after HCC recurrence. ..
  31. doi request reprint The fate of human platelets exposed to porcine renal endothelium: a single-pass model of platelet uptake in domestic and genetically modified porcine organs
    James R Butler
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
    J Surg Res 200:698-706. 2016
    ..As this process continues to eliminate immunologic barriers to clinical xenotransplantation, the relationship between human platelets and pig organs must be considered...
  32. doi request reprint Cytomegalovirus Infection After Intestinal/Multivisceral Transplantation: A Single-Center Experience With 210 Cases
    Shunji Nagai
    1 Division of Transplant Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    Transplantation 100:451-60. 2016
    ..The aim of this study is to analyze risk factors for posttransplant CMV infection and to assess the efficacy and validity of our prophylaxis and treatment regimens in intestinal transplantation...
  33. doi request reprint Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response
    James R Butler
    Department of Surgery, Indiana University School of Medicine, Indianapolis IN USA
    Transpl Immunol 35:47-51. 2016
    ..The response was tested in the presence and absence of clinically available immunomodifiers...
  34. doi request reprint Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection
    Ping Li
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Xenotransplantation 22:20-31. 2015
    ..Coexpression of multiple unique single-guide RNA can modify several genetic loci in a single step. We describe a process for increasing the efficiency of selecting cells with multiple genetic modifications...
  35. doi request reprint Prospective Monitoring of Donor-specific Anti-HLA Antibodies After Intestine/Multivisceral Transplantation: Significance of De Novo Antibodies
    Chandrashekhar Kubal
    1 Transplant Division, Department of Surgery, Indiana University School of Medicine, IN, Indiana 2 Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 3 Department of Transplant Immunology, Indiana University School of Medicine, Indianapolis, IN
    Transplantation 99:e49-56. 2015
    ..Presence of circulating donor-specific antibodies (DSA) may be associated with worse clinical outcomes after intestine/multivisceral transplantation...
  36. doi request reprint Mild to moderate pulmonary hypertension in liver transplantation
    Richard S Mangus
    Transplant Division, Department of Surgery, Indiana University, School of Medicine, Indianapolis, Indiana Electronic address
    J Surg Res 184:1150-6. 2013
    ..Patients with pulmonary hypertension (PHTN) are at increased risk for worse outcomes post-liver transplant (LT). This study evaluated LT outcomes and complications for a large number of LT patients with mild to moderate PHTN...
  37. doi request reprint Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases
    Ping Li
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Surg Res 181:e39-45. 2013
    ..ZFN-treated LDC were used as nuclear donors to produce fetuses and piglets via SCNT. All cloned fetuses and piglets showed biallelic knockout of GGTA1 gene...
  38. doi request reprint Identification of human preformed antibody targets in GTKO pigs
    Christopher Burlak
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Xenotransplantation 19:92-101. 2012
    ..This study examined the potential reactivity of human preformed IgG and IgM antibodies toward antigens in the GTKO pig liver...
  39. doi request reprint Multivisceral transplantation for diffuse portomesenteric thrombosis
    Rodrigo M Vianna
    Department of Surgery, Division of Transplantation, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Ann Surg 255:1144-50. 2012
    ..To evaluate the clinical outcomes of multivisceral transplantation (MVT) in the setting of diffuse thrombosis of the portomesenteric venous system...
  40. doi request reprint Evaluation of response after stereotactic body radiotherapy for hepatocellular carcinoma
    Tracy R Price
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 118:3191-8. 2012
    ..Stereotactic body radiotherapy (SBRT) is a noninvasive, effective therapy in the management of liver malignancies. The authors evaluated radiological response in 26 patients with HCC treated with SBRT at Indiana University...
  41. doi request reprint Stereotactic body radiotherapy for primary hepatocellular carcinoma
    David L Andolino
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Radiat Oncol Biol Phys 81:e447-53. 2011
    ..To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of primary hepatocellular carcinoma (HCC)...
  42. ncbi request reprint Intravenous interferon during the anhepatic phase of liver retransplantation and prevention of recurrence of cholestatic hepatitis C virus
    Paul Y Kwo
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5121, USA
    Liver Transpl 13:1710-3. 2007
    ..The role of anhepatic administration of interferon deserves further examination, and this combination may provide a solution in a subset of patients with an otherwise poor prognosis...
  43. doi request reprint Creating class I MHC-null pigs using guide RNA and the Cas9 endonuclease
    Luz M Reyes
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202
    J Immunol 193:5751-7. 2014
    ..Although these animals have reduced levels of CD4(-)CD8(+) T cells in peripheral blood, the pigs appear healthy and are developing normally. These pigs are a promising reagent for immunological research. ..
  44. doi request reprint Minimal Improvement in Glomerular Filtration Rate in the First Year After Liver Transplantation
    Richard S Mangus
    1 Department of Surgery, Transplant Section, Indiana University School of Medicine, Indianapolis, IN
    Transplantation 99:1855-61. 2015
    ..This study examines the change in glomerular filtration rate (GFR, mL/min per m) in the first year after LT, with subgroup analysis by baseline GFR, model for end-stage liver disease (MELD), age, sex, race, and diabetes/hypertension...
  45. doi request reprint Donor management parameters and organ yield: single center results
    George Ryne Marshall
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
    J Surg Res 191:208-13. 2014
    ..This study evaluates organ yield outcomes for a large number of patients managed by the Indiana Organ Procurement Organization...
  46. pmc N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens
    Christopher Burlak
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Xenotransplantation 20:277-91. 2013
    ..There remains, however, a significant portion of human antibody binding...
  47. pmc Erythrocytes from GGTA1/CMAH knockout pigs: implications for xenotransfusion and testing in non-human primates
    Zheng Yu Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Xenotransplantation 21:376-84. 2014
    ..In this study, we characterized erythrocytes from domestic and genetically modified pigs, baboons, chimpanzees, and humans for binding of human and baboon natural antibody, and complement-mediated lysis...
  48. doi request reprint Post-transplant critical care outcomes for pediatric multivisceral and intestinal transplant patients
    Courtney M Rowan
    Department of Pediatric Pulmonary, Critical Care and Allergy, Riley Hospital for Children, Indiana University Health, Indianapolis, IN 46202 5225, USA
    Pediatr Transplant 16:788-95. 2012
    ....
  49. doi request reprint Portal Vein Thrombosis Is a Risk Factor for Poor Early Outcomes After Liver Transplantation: Analysis of Risk Factors and Outcomes for Portal Vein Thrombosis in Waitlisted Patients
    Marwan Ghabril
    1 Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 2 Transplant Surgery, Indiana University School of Medicine, Indianapolis, IN
    Transplantation 100:126-33. 2016
    ..The objectives of this study were to determine the impact of PVT on post-LT patient and graft survival, waitlist outcomes, and the factors associated with PVT...
  50. doi request reprint Post-transplant persistent lymphopenia is a strong predictor of late survival in isolated intestine and multivisceral transplantation
    Shunji Nagai
    Division of Transplant Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Transpl Int 28:1195-204. 2015
    ..Infection leading to mortality occurred more frequently in the persistent lymphopenia group (43% vs. 24%). Trend of post-transplant ALC may be a strong predictive marker for long-term outcome in 1-year survivors after IIT/MVT...
  51. doi request reprint The fate of human platelets perfused through the pig liver: implications for xenotransplantation
    Christopher Burlak
    Department of Surgery, Clarian Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Xenotransplantation 17:350-61. 2010
    ..Studies in pig and baboon liver xenografts revealed the main obstacle to be a lethal thrombocytopenia that occurred within minutes to hours of transplantation...
  52. doi request reprint Gene targeting and cloning in pigs using fetal liver derived cells
    Sanjeev K Waghmare
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Surg Res 171:e223-9. 2011
    ..The goal of this study was to test the feasibility of using fetal liver-derived cells (FLDC) to perform gene targeting, and create a genetic knockout pig...
  53. pmc The need for xenotransplantation as a source of organs and cells for clinical transplantation
    Burcin Ekser
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Int J Surg 23:199-204. 2015
    ..The physiologic compatibilities and incompatibilities of the pig and the human are briefly reviewed. ..
  54. doi request reprint Utility of pre-procurement bedside liver biopsy in the deceased extended-criteria liver donor
    Richard S Mangus
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
    Clin Transplant 28:1358-64. 2014
    ..This study reports the clinical and financial outcomes for this management strategy...
  55. doi request reprint Intestine and multivisceral transplantation: current status and future directions
    Chandrashekhar A Kubal
    Transplant Division, Department of Surgery, Indiana University School of Medicine, 550 N University Blvd, Room 4601, Indianapolis, IN, 46202 5250, USA
    Curr Gastroenterol Rep 17:427. 2015
    ..Although acute and chronic rejection are major problems, long-term survivors have excellent quality of life and remain free of parenteral nutrition...
  56. ncbi request reprint Portal versus systemic drainage of small bowel allografts: comparative assessment of survival, function, rejection, and bacterial translocation
    Thierry Berney
    Liver Gastrointestinal Transplantation, Department of Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
    J Am Coll Surg 195:804-13. 2002
    ..Comparisons in animal models have not demonstrated a clear advantage of one technique over the other, but clinical data are lacking...
  57. ncbi request reprint Epidemiology of acute liver failure
    Mouen Khashab
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 675 West Walnut, IB 327, Indianapolis, IN 46202, USA
    Curr Gastroenterol Rep 9:66-73. 2007
    ..Liver support systems show potential for the treatment of ALF, but their role needs validation in large multicenter randomized trials...
  58. doi request reprint Current status of pig liver xenotransplantation
    Burcin Ekser
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Int J Surg 23:240-6. 2015
    ....
  59. pmc Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation
    Whayoung Lee
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA Department of Surgery, Indiana University School of Medicine, Indianapolis, IN National Swine Resource and Research Center, Columbia, MO and Revivicor, Blacksburg, VA
    Cornea 35:105-13. 2016
    ....
  60. doi request reprint Recent advances in genome editing and creation of genetically modified pigs
    James R Butler
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Int J Surg 23:217-22. 2015
    ..Herein we review the available methods of genetic engineering that have been successfully employed to create genetically modified pigs. ..
  61. pmc Clinical lung xenotransplantation--what donor genetic modifications may be necessary?
    David K C Cooper
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Xenotransplantation 19:144-58. 2012
    ..The optimistic view would be that if experimental pig lung xenotransplantation could be successfully managed, it is likely that clinical application of this and all other forms of xenotransplantation would become more feasible...
  62. doi request reprint Laparoscopic incisional hernia repair after solid-organ transplantation
    Peter T Kennealey
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Arch Surg 144:228-33; discussion 233. 2009
    ..Laparoscopic incisional hernia repair (LIHR) is efficacious in transplant recipients...
  63. ncbi request reprint Hepatic sinusoidal endothelium upregulates IL-1alpha, IFN-gamma, and iNOS in response to discordant xenogeneic islets in an in vitro model of xenoislet transplantation
    Michael Tan
    Department of Surgery, McGill University Health Centre, Montreal, Canada
    J Surg Res 102:229-36. 2002
    ..We have characterized the initial response of hepatic endothelium to xenogeneic islets by measuring the expression of Il-1alpha, TNF-alpha, IFN-gamma, and iNOS in an in vitro dog-to-pig model of xenoislet transplantation...