Tammy J Sajdyk
Affiliation: Indiana University
- Neuropeptide Y-Y2 receptors mediate anxiety in the amygdalaTammy J Sajdyk
Indiana University Medical Center, Indianapolis, IN 46202, USA
Pharmacol Biochem Behav 71:419-23. 2002..These findings support the hypothesis that Y2 receptors are involved in the regulation of the anxiety response...
- Interactions between NPY and CRF in the amygdala to regulate emotionalityTammy J Sajdyk
Department of Psychiatry, Indiana University Medical School, 791 Union Drive, Rm M119, Indianapolis, IN 46202, USA
Neuropeptides 38:225-34. 2004....
- Neuropeptide Y in the amygdala induces long-term resilience to stress-induced reductions in social responses but not hypothalamic-adrenal-pituitary axis activity or hyperthermiaTammy J Sajdyk
Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Neurosci 28:893-903. 2008..These studies suggest one putative physiologic mechanism underlying stress resilience and could identify novel targets for development of therapies that can augment the ability to cope with stress...
- The role of neuropeptide Y in the amygdala on corticotropin-releasing factor receptor-mediated behavioral stress responses in the ratTammy J Sajdyk
Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, IN 46202, USA
Stress 9:21-8. 2006..These results provide further support that an interaction between NPY and CRF within the BLA may be critical for maintaining a normal homeostatic emotional state...
- From anxiety to autism: spectrum of abnormal social behaviors modeled by progressive disruption of inhibitory neuronal function in the basolateral amygdala in Wistar ratsWilliam A Truitt
Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 4620, USA
Psychopharmacology (Berl) 191:107-18. 2007..Social behaviors are disrupted in several psychiatric disorders. The amygdala is a key brain region involved in social behaviors, and amygdala pathology has been implicated in disease states ranging from social anxiety disorder to autism...
- Angiotensin II's role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panicPhilip L Johnson
Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, United States
Prog Neuropsychopharmacol Biol Psychiatry 44:248-56. 2013..Overall these results are the first to implicate A-II and AT1rs as putative neurotransmitter-receptors in NaLac induced panic-like responses in UCN/BLA-primed rats...
- Measurement of panic-like responses following intravenous infusion of sodium lactate in panic-prone ratsTammy J Sajdyk
Indiana University Medical Center, Indianapolis, Indiana, USA
Curr Protoc Neurosci . 2003..A clinically relevant test, the sodium lactate challenge, is utilized to assess parallels between the human condition and this rat model...
- Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamusAnantha Shekhar
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Neurosci 26:9205-15. 2006..Thus, these results implicate A-II pathways and the A-II receptors in the hypothalamus as putative substrates for sodium lactate-induced panic-like responses in vulnerable subjects...
- Neonatal amygdala lesions: co-occurring impact on social/fear-related behavior and cocaine sensitization in adult ratsR Andrews Chambers
Laboratory for Translational Neuroscience of Dual Diagnosis and Development, Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Behav Neurosci 121:1316-27. 2007..NAMLs may provide models for understanding a shared neurobiological basis for and complex interactions among psychiatric symptoms, drug exposure history, and addiction vulnerability...
- NPY Y1 receptors differentially modulate GABAA and NMDA receptors via divergent signal-transduction pathways to reduce excitability of amygdala neuronsAndrei I Molosh
Department of Psychiatry, Institute of Psychiatric Research, Indiana University, Indianapolis, IN, USA
Neuropsychopharmacology 38:1352-64. 2013..This multipathway regulation of NMDA- and GABAA-mediated currents may be important for NPY plasticity and stress resilience in the amygdala...
- The amygdala, panic disorder, and cardiovascular responsesAnantha Shekhar
Department of Psychiatry, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
Ann N Y Acad Sci 985:308-25. 2003..These results suggest that the BLA has a significant role in regulating anxiety, autonomic responses, and the development of anxiety disorders...
- Project development teams: a novel mechanism for accelerating translational researchTammy J Sajdyk
Dr Sajdyk is translational sciences research officer and research navigator, Indiana Clinical and Translational Sciences Institute, Indiana University, Indianapolis, Indiana Dr Sors is chief scientific liaison, Bindley Bioscience Center, and research navigator, Purdue University, West Lafayette, Indiana Mr Hunt is associate director of tracking and evaluation, Indiana Clinical and Translational Sciences Institute, Indiana University, Indianapolis, Indiana Ms Murray is translational research administrator and special projects coordinator, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana Ms Deford is director of grants business management, Office of Research, University of Notre Dame, South Bend, Indiana Dr Shekhar is director, Indiana Clinical and Translational Sciences Institute, assistant vice president for research, Indiana University, and Professor of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana Dr Denne is director, Project Development Team Program, and professor of pediatrics, Indiana University School of Medicine, Indianapolis, Indiana
Acad Med 90:40-6. 2015....
- Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptorDonald R Gehlert
Neuroscience Division DC0510, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 0510, United States
Eur J Pharmacol 509:145-53. 2005..These results provide further support for the CRF1 receptor in anxiety-like behavior and suggest this pathway is quiescent in unstressed animals...
- Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disordersDonald G Rainnie
Department of Psychiatry and Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 24:3471-9. 2004....
- Role of Amygdalar CRF Receptors in Regulating AnxietyTammy Sajdyk; Fiscal Year: 2005..Thus, the study will provide a greater understanding of the underlying neurobiology of pathological anxiety, in particular panic disorder. ..