Evan D Morris

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint ntPET: a new application of PET imaging for characterizing the kinetics of endogenous neurotransmitter release
    Evan D Morris
    Indiana University School of Medicine, Indianapolis, USA
    Mol Imaging 4:473-89. 2005
  2. doi request reprint Initial comparison of ntPET with microdialysis measurements of methamphetamine-induced dopamine release in rats: support for estimation of dopamine curves from PET data
    Evan D Morris
    Biomedical Engineering Department, Indiana University Purdue University, Indianapolis, IN, USA
    Mol Imaging Biol 10:67-73. 2008
  3. ncbi request reprint Positron emission tomography displacement sensitivity: predicting binding potential change for positron emission tomography tracers based on their kinetic characteristics
    Evan D Morris
    Biomedical Engineering Department, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    J Cereb Blood Flow Metab 27:606-17. 2007
  4. pmc When what you see isn't what you get: alcohol cues, alcohol administration, prediction error, and human striatal dopamine
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA
    Alcohol Clin Exp Res 33:139-49. 2009
  5. ncbi request reprint Dopamine D(2) receptor availability is associated with subjective responses to alcohol
    Karmen K Yoder
    Department of Radiology, Division of Research, Section of Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46206, USA
    Alcohol Clin Exp Res 29:965-70. 2005
  6. pmc A linear model for estimation of neurotransmitter response profiles from dynamic PET data
    Marc D Normandin
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
    Neuroimage 59:2689-99. 2012
  7. ncbi request reprint Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 31:965-73. 2007
  8. pmc A rat head holder for simultaneous scanning of two rats in small animal PET scanners: design, construction, feasibility testing and kinetic validation
    Tee Ean Cheng
    Biomedical Engineering Department, Purdue School of Engineering and Technology, Indianapolis, IN 46202, USA
    J Neurosci Methods 176:24-33. 2009
  9. ncbi request reprint Change in binding potential as a quantitative index of neurotransmitter release is highly sensitive to relative timing and kinetics of the tracer and the endogenous ligand
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Nucl Med 45:903-11. 2004
  10. pmc What were they thinking? Cognitive states may influence [11C]raclopride binding potential in the striatum
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, United States
    Neurosci Lett 430:38-42. 2008

Research Grants

Detail Information

Publications19

  1. ncbi request reprint ntPET: a new application of PET imaging for characterizing the kinetics of endogenous neurotransmitter release
    Evan D Morris
    Indiana University School of Medicine, Indianapolis, USA
    Mol Imaging 4:473-89. 2005
    ..Finally, we applied the ntPET method to small-animal imaging data in order to produce the first noninvasive assay of the time-varying release of dopamine in the rat striatum following alcohol...
  2. doi request reprint Initial comparison of ntPET with microdialysis measurements of methamphetamine-induced dopamine release in rats: support for estimation of dopamine curves from PET data
    Evan D Morris
    Biomedical Engineering Department, Indiana University Purdue University, Indianapolis, IN, USA
    Mol Imaging Biol 10:67-73. 2008
    ..The method is entirely translatable to human PET imaging...
  3. ncbi request reprint Positron emission tomography displacement sensitivity: predicting binding potential change for positron emission tomography tracers based on their kinetic characteristics
    Evan D Morris
    Biomedical Engineering Department, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    J Cereb Blood Flow Metab 27:606-17. 2007
    ..The values are in good agreement with the PDS-predicted rank order of sensitivity to displacement...
  4. pmc When what you see isn't what you get: alcohol cues, alcohol administration, prediction error, and human striatal dopamine
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA
    Alcohol Clin Exp Res 33:139-49. 2009
    ..This study assessed the distinct effects of alcohol-related cues and alcohol administration on striatal DA release in healthy humans...
  5. ncbi request reprint Dopamine D(2) receptor availability is associated with subjective responses to alcohol
    Karmen K Yoder
    Department of Radiology, Division of Research, Section of Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46206, USA
    Alcohol Clin Exp Res 29:965-70. 2005
    ..Here, we examined the relationship between dopamine D2 receptors in the nucleus accumbens and scores of perceived "high" and "intoxication" during an intravenous (IV) alcohol infusion...
  6. pmc A linear model for estimation of neurotransmitter response profiles from dynamic PET data
    Marc D Normandin
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
    Neuroimage 59:2689-99. 2012
    ..These results demonstrate that lp-ntPET is a computationally efficient, linear variant of ntPET that can be applied to PET data from single or multiple scan designs to estimate the time course of neurotransmitter activation...
  7. ncbi request reprint Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 31:965-73. 2007
    ..Our approach was to identify voxels that exhibited alcohol-induced DA responses within the striatum, and to determine the relationships between DA responses and alcohol-related behavior...
  8. pmc A rat head holder for simultaneous scanning of two rats in small animal PET scanners: design, construction, feasibility testing and kinetic validation
    Tee Ean Cheng
    Biomedical Engineering Department, Purdue School of Engineering and Technology, Indianapolis, IN 46202, USA
    J Neurosci Methods 176:24-33. 2009
    ..To reduce imaging costs, we designed a head holder for scanning two rats simultaneously in small animal PET scanners. Our goals were (i) to maintain high sensitivity and (ii) to minimize repositioning error between scans...
  9. ncbi request reprint Change in binding potential as a quantitative index of neurotransmitter release is highly sensitive to relative timing and kinetics of the tracer and the endogenous ligand
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Nucl Med 45:903-11. 2004
    ..We sought to characterize the sensitivity of deltaBP to changes in endogenous DA concentration and to elucidate possible biases in deltaBP with respect to timing of task-induced or drug-induced increases in DA...
  10. pmc What were they thinking? Cognitive states may influence [11C]raclopride binding potential in the striatum
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, United States
    Neurosci Lett 430:38-42. 2008
    ..Our findings suggest that even slight differences in cognitive states between groups can have an effect on BP(ND), presumably mediated by changes in endogenous dopamine concentration...
  11. ncbi request reprint Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia
    Karmen K Yoder
    Department of Radiology, Division of Research, Section of Imaging Science, 950 W Walnut St, Research Institute 2, Room E124, Indianapolis, IN 46202, USA
    Schizophr Res 71:371-5. 2004
    ..Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS...
  12. ncbi request reprint Temporal resolution of ntPET using either arterial or reference region-derived plasma input functions
    Marc D Normandin
    Weldon Sch of Biomed Eng, Purdue Univ, West Lafayette, IN 47907, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2005-8. 2006
    ..When a sufficiently robust response is anticipated and knowledge of absolute timing is not necessary, the REF method is an appropriate alternative to ART, which is more demanding experimentally...
  13. pmc Comparison of standardized uptake values with volume of distribution for quantitation of [(11)C]PBR28 brain uptake
    Karmen K Yoder
    Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis IN Center for Neuroimaging, Indiana University School of Medicine, Indianapolis IN Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN Electronic address
    Nucl Med Biol 42:305-8. 2015
    ..The primary goal of this study was to determine the relationship between SUV and VT...
  14. ncbi request reprint Estimation of local receptor density, B'max, and other parameters via multiple-injection positron emission tomography experiments
    Evan D Morris
    Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Methods Enzymol 385:184-213. 2004
  15. ncbi request reprint A supervised method for calculating perfusion/diffusion mismatch volume in acute ischemic stroke
    Judy R James
    Department of Biomedical Engineering, Indiana University Purdue University, IUPUI Indianapolis, IN, USA
    Comput Biol Med 36:1268-87. 2006
    ..Clinical data show that raters using our tool are consistent, fast (15min per subject) and indistinguishable from an expert using manual segmentation...
  16. pmc Estimating neurotransmitter kinetics with ntPET: a simulation study of temporal precision and effects of biased data
    Marc D Normandin
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    Neuroimage 39:1162-79. 2008
    ..The REF formulation of ntPET proved to be robust to many plausible model violations and under most circumstances is an appropriate alternative to ART...
  17. ncbi request reprint Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
  18. ncbi request reprint Nonparametric extraction of transient changes in neurotransmitter concentration from dynamic PET data
    Cristian C Constantinescu
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 46907, USA
    IEEE Trans Med Imaging 26:359-73. 2007
    ..Our results indicate that the method is robust enough for application to voxel-by-voxel data...
  19. ncbi request reprint Measuring the in vivo binding parameters of [18F]-fallypride in monkeys using a PET multiple-injection protocol
    Bradley T Christian
    Department of PET Nuclear Medicine, Kettering Medical Center, Dayton, OH, USA
    J Cereb Blood Flow Metab 24:309-22. 2004
    ....

Research Grants1

  1. Temporal Response of Dopamine to Alcohol Imaged via PET
    Evan Morris; Fiscal Year: 2007
    ..The methods to be developed will easily translate to human imaging studies. [unreadable] [unreadable] [unreadable]..