Mark Kelley

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells
    Aditi Bapat
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 334:988-98. 2010
  2. pmc Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy
    Mark R Kelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research M R K, J H W, K E P, B J B, R W, M L F, and Department of Pharmacology and Toxicology M R K, C G, K E P, M L F, M R V, Indiana University School of Medicine, Indianapolis, Indiana and ApeX Therapeutics, Indianapolis, Indiana J H W
    J Pharmacol Exp Ther 359:300-309. 2016
  3. pmc N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts
    M L Rinne
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine Indianapolis, IN 46202, USA
    Nucleic Acids Res 33:2859-67. 2005
  4. pmc APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1
    Mark R Kelley
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Curr Mol Pharmacol 5:36-53. 2012
  5. pmc Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase
    Ted M Kremer
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Respir Res 5:16. 2004
  6. ncbi request reprint Disparity between DNA base excision repair in yeast and mammals: translational implications
    Mark R Kelley
    Department of Pediatrics, Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer Res 63:549-54. 2003
  7. pmc DNA repair proteins as molecular targets for cancer therapeutics
    Mark R Kelley
    Department of Pediatrics, Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St R4 W302C, Indianapolis, IN 46202, USA
    Anticancer Agents Med Chem 8:417-25. 2008
  8. ncbi request reprint Genomic structure and characterization of the Drosophila S3 ribosomal/DNA repair gene and mutant alleles
    M R Kelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    DNA Cell Biol 19:149-56. 2000
  9. pmc Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1
    Mark R Kelley
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 980 West Walnut Street, Indianapolis, IN 46202, USA
    Antioxid Redox Signal 14:1387-401. 2011
  10. ncbi request reprint Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1
    M R Kelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Antioxid Redox Signal 3:671-83. 2001

Research Grants

Collaborators

Detail Information

Publications64

  1. pmc Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells
    Aditi Bapat
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 334:988-98. 2010
    ..AR03 is a novel small-molecule inhibitor of Ape1, which may have potential as an oncotherapeutic drug for treating glioblastoma and other cancers...
  2. pmc Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy
    Mark R Kelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research M R K, J H W, K E P, B J B, R W, M L F, and Department of Pharmacology and Toxicology M R K, C G, K E P, M L F, M R V, Indiana University School of Medicine, Indianapolis, Indiana and ApeX Therapeutics, Indianapolis, Indiana J H W
    J Pharmacol Exp Ther 359:300-309. 2016
    ..Together, these data suggest that the second-generation compound APX2009 is effective in preventing or reversing platinum-induced CIPN while not affecting the anticancer activity of platins...
  3. pmc N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts
    M L Rinne
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine Indianapolis, IN 46202, USA
    Nucleic Acids Res 33:2859-67. 2005
    ....
  4. pmc APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1
    Mark R Kelley
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Curr Mol Pharmacol 5:36-53. 2012
    ..It also discusses APE1's altered expression in many cancers and the therapeutic potential of selective inhibition of redox regulation, which is the subject of intense preclinical studies...
  5. pmc Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase
    Ted M Kremer
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Respir Res 5:16. 2004
    ..The base excision repair pathway is one of the most important cellular protection mechanisms that responds to oxidative DNA damage. Lesion-specific DNA repair enzymes include hOgg1, hMYH, hNTH and hMTH...
  6. ncbi request reprint Disparity between DNA base excision repair in yeast and mammals: translational implications
    Mark R Kelley
    Department of Pediatrics, Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer Res 63:549-54. 2003
    ..cerevisiae to humans, it is worth keeping these differences in mind if yeast continues to be used as a model or primary system in the screening for potential new human therapeutics...
  7. pmc DNA repair proteins as molecular targets for cancer therapeutics
    Mark R Kelley
    Department of Pediatrics, Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St R4 W302C, Indianapolis, IN 46202, USA
    Anticancer Agents Med Chem 8:417-25. 2008
    ....
  8. ncbi request reprint Genomic structure and characterization of the Drosophila S3 ribosomal/DNA repair gene and mutant alleles
    M R Kelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    DNA Cell Biol 19:149-56. 2000
    ....
  9. pmc Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1
    Mark R Kelley
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 980 West Walnut Street, Indianapolis, IN 46202, USA
    Antioxid Redox Signal 14:1387-401. 2011
    ..This progress in synthesizing and isolating biologically active novel E3330 analogues that effectively inhibit the APE1 redox function validates the utility of further translational anticancer therapeutic development...
  10. ncbi request reprint Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1
    M R Kelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Antioxid Redox Signal 3:671-83. 2001
    ..These findings suggest that the Apel/ref-1 protein may be much more intimately regulated at the posttranslational level than initially imagined...
  11. ncbi request reprint Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer
    M R Kelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 702 Barnhill Drive, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 7:824-30. 2001
    ..Given these results, we conclude that Ape1/ref-1 may be a diagnostic marker for early prostate cancer and play a role, through its repair, redox, or both functions, in the physiology of the early development of prostate cancer...
  12. ncbi request reprint The Drosophila S3 multifunctional DNA repair/ribosomal protein protects Fanconi anemia cells against oxidative DNA damaging agents
    M R Kelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, 702 Barnhill Dr, Room 2600, Indianapolis, IN 46202, USA
    Mutat Res 485:107-19. 2001
    ..Based on these findings, we would predict other oxidative repair proteins, or oxidative scavengers, could serve as protective agents against the oxidative DNA damage that occurs in FA...
  13. ncbi request reprint Constitutional polymorphisms of prostate cancer: prognostic and diagnostic implications
    Noah M Hahn
    Indiana University Melvin and Bren Simon Cancer Center, Indiana Cancer Pavilion Room RT415, 535 Barnhill Drive, Indianapolis, Indiana 46202, USA
    Future Oncol 3:665-82. 2007
    ....
  14. pmc Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis
    Melissa L Fishel
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 980 W Walnut, Indianapolis, IN 46202, USA
    Exp Hematol 38:1178-88. 2010
    ....
  15. ncbi request reprint Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin
    Ying Guo
    The Walther Oncology Center, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, Indiana, USA
    Stem Cells 22:259-64. 2004
    ..These data imply that ES cell transcription factors are differentially sensitive to oxidation and that Thioredoxin may differentially regulate ES cell transcription factors...
  16. ncbi request reprint Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance
    Sarah Freitas
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 9:4689-94. 2003
    ..The purpose of this study is to determine whether APE/ref-1 expression differs with ovarian cancer progression and metastasis and in platinum-resistant disease...
  17. ncbi request reprint DNA repair in neurons: so if they don't divide what's to repair?
    Melissa L Fishel
    Department of Pediatrics, Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut, Room 302C, Indianapolis, IN 46202, USA
    Mutat Res 614:24-36. 2007
    ..Studies of DNA repair may help our understanding of how those cells that are not dividing could succumb to neurotoxicity with the clinical manifestations discussed in the following article...
  18. pmc Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation
    April M Reed
    Department of Pediatrics, Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Future Oncol 5:713-26. 2009
    ....
  19. ncbi request reprint Implication of p53 in base excision DNA repair: in vivo evidence
    Young R Seo
    Indiana University Cancer Center, Department of Microbiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Oncogene 21:731-7. 2002
    ..Our findings demonstrate an in vivo requirement for p53 in regulating the base excision repair response, a novel finding of great potential importance in understanding the DNA repair branch of the p53 pathway...
  20. ncbi request reprint The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target
    Melissa L Fishel
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Mol Aspects Med 28:375-95. 2007
    ..In this review, we will provide an overview of Ape1/Ref-1's activities and explore the potential of this protein as a target in cancer treatment as well as its role in chemoprevention...
  21. ncbi request reprint Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents
    Shanbao Cai
    Section of Hematology Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut, R4 302C, Indianapolis, IN 46202, USA
    Cancer Res 65:3319-27. 2005
    ....
  22. pmc Going ape as an approach to cancer therapeutics
    Aditi Bapat
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Antioxid Redox Signal 11:651-68. 2009
    ..Therefore, selective inhibition of Ape1's DNA repair activity is a promising avenue to develop novel cancer therapeutics...
  23. ncbi request reprint Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition
    Dong Wang
    Section of Hematology Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, 1044 W Walnut, R4 302C, Indianapolis, IN 46202, USA
    Mol Cancer Ther 3:679-86. 2004
    ..The APE1-siRNA results demonstrate the feasibility for the therapeutic modulation of APE1 using a variety of molecules and approaches...
  24. pmc Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1
    Meihua Luo
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Antioxid Redox Signal 10:1853-67. 2008
    ..Here we discuss small-molecule inhibition of Ape1 redox and its effect on both cancer and endothelial cells...
  25. ncbi request reprint Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide
    Melissa L Fishel
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 13:260-7. 2007
    ....
  26. pmc Redox regulation of DNA repair: implications for human health and cancer therapeutic development
    Meihua Luo
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indiana, USA
    Antioxid Redox Signal 12:1247-69. 2010
    ..Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair...
  27. pmc Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions
    Yanlin Jiang
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, United States
    DNA Repair (Amst) 8:1273-82. 2009
    ..Our results demonstrate that the DNA repair function of APE1 contributes to the survival of nondividing post-mitotic cells following oxidative DNA damage...
  28. pmc Role of Ape1 and base excision repair in the radioresponse and heat-radiosensitization of HeLa Cells
    Christopher N Batuello
    Indiana University, Department of Radiation Oncology, Indianapolis, Indiana 46202, USA
    Anticancer Res 29:1319-25. 2009
    ..We determined whether base excision repair (BER) is involved in heat-radiosensitization and report novel findings that provide insight regarding the role of BER in the radiation response of HeLa cells...
  29. ncbi request reprint Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain
    Gang Ming Zou
    Department of Pediatrics Section of Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1917-22. 2007
    ..In summary, these data indicate Ape1 is required in normal embryonic hematopoiesis and that the redox function, but not the repair endonuclease activity, of Ape1 is critical in normal embryonic hematopoietic development...
  30. pmc Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons
    Yanlin Jiang
    Department of Pediatrics, Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer Res 68:6425-34. 2008
    ....
  31. ncbi request reprint Escherichia coli FPG and human OGG1 reduce DNA damage and cytotoxicity by BCNU in human lung cells
    Ying hui He
    Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Lung Cell Mol Physiol 282:L50-5. 2002
    ..Gene transfer of FPG/hOGG1 reduced BCNU-induced DNA damage and cytotoxicity of cultured lung cells and may suggest a new mechanism to reduce BCNU pulmonary toxicity...
  32. pmc Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth
    Melissa L Fishel
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    DNA Repair (Amst) 7:177-86. 2008
    ..Ape1's role in DNA repair and redox signaling is important to our basic understanding of ovarian cancer cell growth and these findings strongly support Ape1 as a therapeutic target...
  33. pmc Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression
    Yanlin Jiang
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Walnut, Indianapolis 46202, USA
    Cancer Invest 28:885-95. 2010
    ..Endogenous cell cycle inhibitors increase when APE1/ Ref-1 is reduced, demonstrating its importance to proliferation and growth of pancreatic cancer...
  34. pmc Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library
    LaTeca S Glass
    Department of Chemistry and Chemical Biology, Purdue School of Science, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Bioorg Med Chem Lett 20:1685-8. 2010
    ..In addition, the general screening strategy described may find broader impact toward the rapid discovery of DNA targeted agents with biological activity...
  35. ncbi request reprint Frontiers of mutagenesis and DNA repair: a workshop
    Mark R Kelley
    Herman B Wells Center for Pediatric Research, Cancer Research Institute, Indianapolis, Indiana, USA
    Cancer Res 64:3357-60. 2004
  36. ncbi request reprint Update on late relapse of germ cell tumor: a clinical and molecular analysis
    David W George
    Department of Medicine, and Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University Medical Center, Indianapolis, IN, USA
    J Clin Oncol 21:113-22. 2003
    ..Analysis of patients with late relapse (LR) of germ cell tumor (GCT) with reports on clinical characteristics, outcomes, and molecular and cytogenetic features...
  37. ncbi request reprint The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress
    Michael R Vasko
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, 1044 W Walnut, Room 302C, Indianapolis, IN 46202, USA
    DNA Repair (Amst) 4:367-79. 2005
    ..These data support the notion that both of functions of Ape1, redox and repair are necessary for optimal levels of neuronal cell survival...
  38. ncbi request reprint Identification of the human HEX1/hExo1 gene promoter and characterization of elements responsible for promoter activity
    Paula D Ladd
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    DNA Repair (Amst) 2:187-98. 2003
    ..Mutation of either the CREB-1 or Sp1/Sp3 binding sites dramatically reduces HEX1/hExo1 promoter activity and elimination of both elements abolishes promoter activity...
  39. ncbi request reprint Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing
    Melissa L Fishel
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer Res 63:608-15. 2003
    ....
  40. ncbi request reprint Protection of human lung cells against hyperoxia using the DNA base excision repair genes hOgg1 and Fpg
    Min Wu
    Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Am J Respir Crit Care Med 166:192-9. 2002
    ..Our data suggest that increased expression of DNA base excision repair genes might represent a new approach for protecting critical lung cells from the toxic effects of hyperoxia...
  41. pmc Selenomethionine regulation of p53 by a ref1-dependent redox mechanism
    Young R Seo
    Department of Microbiology, Walther Oncology Center, and Walther Cancer Institute, Indiana University School of Medicine, Indianapolis, IN 46208, USA
    Proc Natl Acad Sci U S A 99:14548-53. 2002
    ..The evidence suggests that the DNA repair branch of the p53 pathway was activated. The central relevance of DNA repair to cancer prevention is discussed...
  42. ncbi request reprint Human-yeast chimeric repair protein protects mammalian cells against alkylating agents: enhancement of MGMT protection
    Timothy J Roth
    Department of Physiology and Biophysics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 702 Barnhill Dr, Room 2600, Indianapolis, Indiana 46202, USA
    Cancer Gene Ther 10:603-10. 2003
    ....
  43. ncbi request reprint Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone
    Meihua Luo
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Anticancer Res 24:2127-34. 2004
    ..Given these initial findings, it would be of interest to further develop lucanthone as an APE1 inhibitor through the use of structure-function studies as a means of enhancing the sensitization of tumors to chemotherapeutic agents...
  44. ncbi request reprint Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells
    Mikael Rinne
    Herman B Wells Center for Pediatric Research, 1044 West Walnut, Building R4, Room 302C, Indianapolis, IN 46202, USA
    Mol Cancer Ther 3:955-67. 2004
    ..These data establish transient MPG overexpression as a potential therapeutic approach for increasing cellular sensitivity to alkylating agent chemotherapy...
  45. ncbi request reprint Effect of S. cerevisiae APN1 protein on mammalian DNA base excision repair
    Massimo Bogliolo
    DNA Repair Unit, Mutagenesis Laboratory, Istituto Nazionale Ricerca Cancro, 16132 Genova, Italy
    Anticancer Res 22:2797-804. 2002
    ..The inability of APN1 to increase the efficiency of BER initiated by bifunctional glycosylases indicates that removal of 3' blocking fragments is not the rate limiting step of this repair pathway...
  46. ncbi request reprint Targeting human 8-oxoguanine glycosylase to mitochondria of oligodendrocytes protects against menadione-induced oxidative stress
    Nadiya M Druzhyna
    Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama 36688, USA
    Glia 42:370-8. 2003
    ..Therefore, targeting of DNA repair enzymes to mitochondria appears to be a viable approach for the protection of cells against some of the deleterious effects of oxidative stress...
  47. ncbi request reprint Drosophila S3 ribosomal protein accelerates repair of 8-oxoguanine performed by human and mouse cell extracts
    Enrico Cappelli
    DNA Repair Unit, Mutagenesis Laboratory Istituto Nazionale Ricerca Cancro, Genova, Italy
    Environ Mol Mutagen 42:50-8. 2003
    ..removal of 3' blocking fragments). No stimulating effect was observed on the BER of uracil, natural AP sites, and beta-lyase-cleaved AP sites. Heterologous expression of Drosophila S3 may be used to enhance 8-oxoG repair in human cells...
  48. ncbi request reprint Repair of 8 oxoguanine in mammalian cells expressing the Drosophila S3 ribosomal/repair protein
    Enrico Cappelli
    DNA Repair Unit, Mutagenesis Laboratory, Istituto Nazionale Ricerca Cancro, Genova, Italy
    Teratog Carcinog Mutagen . 2003
    ..The cells synthesized both S3 mRNA and protein but no improved repair of 8 oxoguanine was observed. Factors important for the proper expression of Drosophila genes in mammalian cells are discussed...
  49. ncbi request reprint Accelerated repair and reduced mutagenicity of oxidative DNA damage in human bladder cells expressing the E. coli FPG protein
    Monica Ropolo
    Department of Translational Oncology, Experimental Oncology B Laboratory, Istituto Nazionale Ricerca Cancro, Largo Rosanna Benzi n 10, 16132 Genova, Italy
    Int J Cancer 118:1628-34. 2006
    ..FPG may stably protect human cells from some harmful effects of oxidative DNA damage...
  50. ncbi request reprint Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death
    Allison W Dobson
    Department of Cell Biology and Neuroscience, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    Am J Physiol Lung Cell Mol Physiol 283:L205-10. 2002
    ..These findings show that mtDNA damage is a direct cause of cell death in XO-treated PAECs...
  51. pmc Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents
    Jason F Harrison
    Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama 36688, USA
    Glia 55:1416-25. 2007
    ..Consequently, this unique characteristic of astrocytes may be responsible, in part, for resistance of astrocytomas to chemotherapeutic agents...
  52. ncbi request reprint Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria
    Lyudmila I Rachek
    Department of Cell Biology and Neuroscience, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 277:44932-7. 2002
    ..Functional studies revealed that cells containing recombinant OGG1 were more proficient at repairing oxidative damage in their mtDNA, and this increased repair led to increased cellular survival following oxidative stress...
  53. ncbi request reprint Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop
    Alex Pines
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy
    Free Radic Res 39:269-81. 2005
    ....
  54. ncbi request reprint [Effect of adenoviral N-methylpurine DNA glycosylase overexpression on chemosensitivity of human osteosarcoma cells]
    Dong Wang
    Cancer Center and Department of Pathology, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Zhonghua Bing Li Xue Za Zhi 35:352-6. 2006
    ..In an effort to improve the efficacy of cancer chemotherapy, we have constructed adenoviral vector of MPG, to study its ability to sensitize human osteosarcoma cell HOS to DNA damage agents...
  55. ncbi request reprint Targeting DNA repair proteins to mitochondria
    Allison W Dobson
    Department of Cell Biology and Neuroscience, University of South Alabama College of Medicine, Mobile, AL, USA
    Methods Mol Biol 197:351-62. 2002
  56. ncbi request reprint Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas
    Fabio Puglisi
    Clinica Oncologica, Policlinico Universitario, Piazzale S M Misericordia I 33100 Udine, Italy
    Oncol Rep 9:11-7. 2002
    ..014) and Cox proportional hazard model analysis identified APE/Ref-1 as an independent prognostic factor. The results suggest that subcellular localisation of APE/Ref-1 may influence the aggressiveness of breast carcinomas...
  57. ncbi request reprint Redox effector factor-1 regulates the activity of thyroid transcription factor 1 by controlling the redox state of the N transcriptional activation domain
    Gianluca Tell
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Via Giorgieri 1, Universita degli Studi di Trieste, Trieste 34127, Italy
    J Biol Chem 277:14564-74. 2002
    ..Having previously demonstrated that Ref-1 is able to modulate the transcriptional activity of another thyroid-specific transcription factor (Pax-8), our data suggest that Ref-1 plays a central role in the regulation of thyroid cells...
  58. pmc Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Nucleic Acids Res 33:4379-94. 2005
    ..Our data provide new insights into the complex mechanisms regulating APE1/Ref-1 functions...
  59. ncbi request reprint Repression of cyclin D1 as a target for germ cell tumors
    Sarah J Freemantle
    Department of Pharmacology and Toxicology, Dartmouth Medical School, HB 7650, Hanover, NH 03755, USA
    Int J Oncol 30:333-40. 2007
    ..This inhibited proliferation in RA and cisplatin sensitive and resistant EC cells. Taken together, these findings implicate cyclin D1 targeting agents for the treatment of GCTs...
  60. ncbi request reprint Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress
    Marta Deganuto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 212:223-35. 2007
    ..These data, suggesting that GD cells display an impairment in the cellular redox state and in the adaptive cellular response to oxidative stress, may open new perspectives in the comprehension of GD pathogenesis...
  61. ncbi request reprint Effect of S. cerevisiae APN1 protein on mammalian DNA base excision repair
    Massimo Bogliolo
    DNA Repair Unit, Mutagenesis Laboratory, Istituto Nazionale Ricerca Cancro, 16132 Genova, Italy
    Anticancer Res 23:3727-34. 2003
    ..The inability of APN1 to increase the efficiency of BER initiated by bifunctional glycosylases indicates that removal of 3' blocking fragments is not the rate-limiting step of this repair pathway...
  62. pmc Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress
    Renee Ho
    Department of Cell Biology and Neuroscience, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    J Neurochem 102:13-24. 2007
    ..Therefore, these results reveal that the expression of Apn1 in neurons may be of potential therapeutic benefit for treating patients with specific neurodegenerative diseases...
  63. ncbi request reprint The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
    Antioxid Redox Signal 7:367-84. 2005
    ..In the present review, we tried to put together a growing body of information concerning APE1/Ref-1's different functions, shedding new light on present and future directions to understand fully this unique molecule...
  64. pmc Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress
    Cara A Rabik
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    J Pharmacol Exp Ther 327:442-52. 2008
    ..These data indicate GADD153 up-regulation plays an important role in BG-enhanced cisplatin cytotoxicity and apoptosis...

Research Grants3

  1. OXIDATIVE DNA DAMAGE AND REPAIR IN CNS CELLS
    Mark Kelley; Fiscal Year: 2003
    ..abstract_text> ..
  2. Therapeutic/Mechanistic Role of Ape1 in Germ Cell Tumors
    Mark Kelley; Fiscal Year: 2007
    ..If any mutants are shown to sensitize the GCT cell lines to chemo-/IR agents, as expected, this will set the stage for future gene therapy approaches to sensitize GCT's to therapy. ..
  3. Imbalancing DNA BER to enhance Ovarian Tumor Sensitivity
    Mark Kelley; Fiscal Year: 2008
    ..abstract_text> ..