Andrew E Evan

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Nondestructive analysis of urinary calculi using micro computed tomography
    Chad A Zarse
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    BMC Urol 4:15. 2004
  2. ncbi Renal disease potentiates the injury caused by SWL
    A P Evan
    Department of Anatomy, Indiana University, School of Medicine, Indianapolis 46202 5120, USA
    J Endourol 13:619-28. 1999
  3. pmc Role of interstitial apatite plaque in the pathogenesis of the common calcium oxalate stone
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    Semin Nephrol 28:111-9. 2008
  4. doi Renal intratubular crystals and hyaluronan staining occur in stone formers with bypass surgery but not with idiopathic calcium oxalate stones
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46223, USA
    Anat Rec (Hoboken) 291:325-34. 2008
  5. ncbi Crystal-associated nephropathy in patients with brushite nephrolithiasis
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46220, USA
    Kidney Int 67:576-91. 2005
  6. ncbi Independent assessment of a wide-focus, low-pressure electromagnetic lithotripter: absence of renal bioeffects in the pig
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    BJU Int 101:382-8. 2008
  7. ncbi Renal inter-alpha-trypsin inhibitor heavy chain 3 increases in calcium oxalate stone-forming patients
    A P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46223, USA
    Kidney Int 72:1503-11. 2007
  8. ncbi Mechanism of formation of human calcium oxalate renal stones on Randall's plaque
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University, School of Medicine, Indianapolis, Indiana 46223, USA
    Anat Rec (Hoboken) 290:1315-23. 2007
  9. ncbi Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46220, USA
    Kidney Int 68:145-54. 2005
  10. ncbi Insights on the pathology of kidney stone formation
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University, School of Medicine, Indianapolis, IN, USA
    Urol Res 33:383-9. 2005

Collaborators

Detail Information

Publications82

  1. pmc Nondestructive analysis of urinary calculi using micro computed tomography
    Chad A Zarse
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    BMC Urol 4:15. 2004
    ..We tested the idea that micro CT might also be used to identify the mineral composition of urinary stones non-destructively...
  2. ncbi Renal disease potentiates the injury caused by SWL
    A P Evan
    Department of Anatomy, Indiana University, School of Medicine, Indianapolis 46202 5120, USA
    J Endourol 13:619-28. 1999
    ..The present study tested the hypothesis that renal disease potentiates the structural/functional changes induced by a clinical dose of shockwaves...
  3. pmc Role of interstitial apatite plaque in the pathogenesis of the common calcium oxalate stone
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    Semin Nephrol 28:111-9. 2008
    ..This process generates an attached stone fixed to the side of a papilla, allowing the ever-changing urine to dictate stone growth and composition...
  4. doi Renal intratubular crystals and hyaluronan staining occur in stone formers with bypass surgery but not with idiopathic calcium oxalate stones
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46223, USA
    Anat Rec (Hoboken) 291:325-34. 2008
    ..002 and place the lower limit of their size at the resolution of the optics (<0.2 mu). The tiny deposits in bypass patients may be the initial crystal lesion...
  5. ncbi Crystal-associated nephropathy in patients with brushite nephrolithiasis
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46220, USA
    Kidney Int 67:576-91. 2005
    ..We contrasted these with biopsies of 15 calcium oxalate stone formers, three stone formers with intestinal bypass, and four normal subjects...
  6. ncbi Independent assessment of a wide-focus, low-pressure electromagnetic lithotripter: absence of renal bioeffects in the pig
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    BJU Int 101:382-8. 2008
    ..Ltd., Suzhou, PRC)...
  7. ncbi Renal inter-alpha-trypsin inhibitor heavy chain 3 increases in calcium oxalate stone-forming patients
    A P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46223, USA
    Kidney Int 72:1503-11. 2007
    ..This is consistent with studies linking inter-alpha-trypsin inhibitor components to human stone disease, although their role is still unclear. Heavy chain 3 may also play a role in stabilizing hyaluronan in the renal interstitial matrix...
  8. ncbi Mechanism of formation of human calcium oxalate renal stones on Randall's plaque
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University, School of Medicine, Indianapolis, Indiana 46223, USA
    Anat Rec (Hoboken) 290:1315-23. 2007
    ..Over time, urine calcium and oxalate ions gradually overgrow on the large crystals forming the attached stone...
  9. ncbi Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46220, USA
    Kidney Int 68:145-54. 2005
    ..Thus our purpose here is to detail the structure of the interstitial and membrane-bound plaque and explore the relationship of plaque apatite to osteopontin, a well-known crystal-associated urine protein...
  10. ncbi Insights on the pathology of kidney stone formation
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University, School of Medicine, Indianapolis, IN, USA
    Urol Res 33:383-9. 2005
    ....
  11. ncbi Renal injury during shock wave lithotripsy is significantly reduced by slowing the rate of shock wave delivery
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    BJU Int 100:624-7; discussion 627-8. 2007
    ....
  12. ncbi Renal histopathology of stone-forming patients with distal renal tubular acidosis
    A P Evan
    Department of Anatomy and Cell Biology, Indiana University, School of Medicine, and Department of Urology, Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, Indiana 46223, USA
    Kidney Int 71:795-801. 2007
    ..In all, dRTA SF have a more diffuse papillary renal disease than other SF thus studied, and are also unusual for the degree of interstitial fibrosis...
  13. ncbi Randall's plaque: pathogenesis and role in calcium oxalate nephrolithiasis
    A Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, 46220, USA
    Kidney Int 69:1313-8. 2006
    ..We believe our approach to studying stone disease will provide insights into the pathogenesis of stone formation for each type of SF that will lead to improved clinical treatment...
  14. doi Histopathology and surgical anatomy of patients with primary hyperparathyroidism and calcium phosphate stones
    Andrew E Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46223, USA
    Kidney Int 74:223-9. 2008
    ....
  15. ncbi Renal crystal deposits and histopathology in patients with cystine stones
    A P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46220, USA
    Kidney Int 69:2227-35. 2006
    ..The pattern of IMCD dilation, and loss of medullary structures is most compatible with such obstruction, either from BD lumen plugs or urinary tract obstruction from stones themselves...
  16. pmc Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46220, USA
    J Clin Invest 111:607-16. 2003
    ..Non-stone formers also do not form plaque. Plaque is specific to certain kinds of stone-forming patients and is initiated specifically in thin-limb basement membranes by mechanisms that remain to be elucidated...
  17. pmc Intra-tubular deposits, urine and stone composition are divergent in patients with ileostomy
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46223, USA
    Kidney Int 76:1081-8. 2009
    ..They are, however, unlike these bypass patients in having interstitial apatite plaque. IMCD plugging with sodium and ammonium acid urate has not been found previously and appears to correlate with formation of uric acid stones...
  18. pmc Comparison of the pathology of interstitial plaque in human ICSF stone patients to NHERF-1 and THP-null mice
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5055S, Indianapolis, IN 46223, USA
    Urol Res 38:439-52. 2010
    ..This may be due to the different morphology of the human versus mouse papillary region. Both mouse models appear to be important to characterize further in order to determine how well they mimic human kidney stone disease...
  19. pmc Physiopathology and etiology of stone formation in the kidney and the urinary tract
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Ms 5055, Indianapolis, IN 46220, USA
    Pediatr Nephrol 25:831-41. 2010
    ....
  20. pmc Renal histopathology and crystal deposits in patients with small bowel resection and calcium oxalate stone disease
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46223, USA
    Kidney Int 78:310-7. 2010
    ..However, the mechanisms for the presence of IMCD apatite remain unknown...
  21. ncbi Sequential analysis of kidney stone formation in the Aprt knockout mouse
    A P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Kidney Int 60:910-23. 2001
    ..Aprt heterozygous and wild-type mice were used as controls...
  22. pmc Assessment of renal injury with a clinical dual head lithotriptor delivering 240 shock waves per minute
    Rajash K Handa
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Urol 181:884-9. 2009
    ....
  23. doi Renal functional effects of simultaneous bilateral single-tract percutaneous access in pigs
    Rajash K Handa
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    BJU Int 105:125-8. 2010
    ....
  24. ncbi Percutaneous stone implantation in the pig kidney: a new animal model for lithotripsy research
    Ryan F Paterson
    Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, Indiana 46202, USA
    J Endourol 16:543-7. 2002
    ..This report describes a new animal model for research on the parameters of shockwave delivery and the mechanisms of shockwave action in SWL...
  25. ncbi Helical computed tomography accurately reports urinary stone composition using attenuation values: in vitro verification using high-resolution micro-computed tomography calibrated to fourier transform infrared microspectroscopy
    Chad A Zarse
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Urology 63:828-33. 2004
    ..Recent advances in CT make this a viable prospect, but the heterogeneity of most stones is a complicating factor...
  26. pmc Localization of renal oxidative stress and inflammatory response after lithotripsy
    Daniel L Clark
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    BJU Int 103:1562-8. 2009
    ..Furthermore, the differing patterns of markers of injury for ESWL and ischaemia-reperfusion suggest that ischaemia is not the principal cause of the injury response after ESWL...
  27. ncbi Reducing shock number dramatically decreases lesion size in a juvenile kidney model
    Bret A Connors
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Endourol 20:607-11. 2006
    ..If increasing SW number is known to increase renal injury and functional impairment, will reducing SW number below typical treatment levels significantly decrease kidney damage and hemodynamic changes?..
  28. pmc Detection of significant variation in acoustic output of an electromagnetic lithotriptor
    Yuri A Pishchalnikov
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    J Urol 176:2294-8. 2006
    ..This instability had a form that was not detected by routine assessment, but rather was observed only by collecting many consecutive shock waves in nonstop regimen...
  29. ncbi Calcium oxalate calculi found attached to the renal papilla: Preliminary evidence for early mechanisms in stone formation
    James C Williams
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    J Endourol 20:885-90. 2006
    ..Calculi are commonly found attached to the renal papilla in calcium oxalate (CaOx) stone formers, but the mechanisms by which stones form in this manner are not well established...
  30. ncbi Acute effects of percutaneous tract dilation on renal function and structure
    Rajash K Handa
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Endourol 20:1030-40. 2006
    ..Little is known of the acute impact of tract dilation procedures on renal function...
  31. doi Glomerular permeability to macromolecules in the Necturus kidney
    George A Tanner
    Department of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Dr, MS 332, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 296:F1269-78. 2009
    ..Electron microscopic studies revealed many cell processes within the GBM. Macromolecules that penetrated the GBM were taken up by mesangial cells and endothelial cells, suggesting that these cells help to prevent clogging of the filter...
  32. pmc Dual-head lithotripsy in synchronous mode: acute effect on renal function and morphology in the pig
    Rajash K Handa
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indiana Kidney Stone Institute, Indianapolis, IN, USA
    BJU Int 99:1134-42. 2007
    ....
  33. ncbi In vitro assessment of a novel dual probe ultrasonic intracorporeal lithotriptor
    Samuel C Kim
    Methodist Hospital Institute for Kidney Stone Disease and Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Urol 177:1363-5. 2007
    ..We compared this device to the LithoClast(R) Ultra, which we previously noted is the most efficient commercially available intracorporeal lithotripsy device...
  34. doi Micro-computed tomography for analysis of urinary calculi
    James C Williams
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive MS 5055Y, Indianapolis, IN 46202 5120, USA
    Urol Res 38:477-84. 2010
    ..Finally, micro CT has become a powerful tool to help investigate events in stone formation that distinguish different kinds of stone disease...
  35. pmc Effect of initial shock wave voltage on shock wave lithotripsy-induced lesion size during step-wise voltage ramping
    Bret A Connors
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BJU Int 103:104-7. 2009
    ..To determine if the starting voltage in a step-wise ramping protocol for extracorporeal shock wave lithotripsy (SWL) alters the size of the renal lesion caused by the SWs...
  36. doi Renal functional effects of multiple-tract percutaneous access
    Rajash K Handa
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    J Endourol 23:1951-6. 2009
    ..The present study examined whether multiple percutaneous accesses results in a more severe reduction in renal function than that after single-percutaneous access...
  37. pmc The acute and long-term adverse effects of shock wave lithotripsy
    James A McAteer
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    Semin Nephrol 28:200-13. 2008
    ....
  38. pmc Extracorporeal shock wave lithotripsy at 60 shock waves/min reduces renal injury in a porcine model
    Bret A Connors
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianopolis, IN 46202, USA
    BJU Int 104:1004-8. 2009
    ..To determine if extracorporeal shock wave lithotripsy (ESWL) at 60 shock waves (SWs)/min reduces renal damage and haemodynamic impairment compared to treatment at 120 SWs/min...
  39. doi Potential for cavitation-mediated tissue damage in shockwave lithotripsy
    Brian R Matlaga
    Indiana University School of Medicine, and Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN 46202, USA
    J Endourol 22:121-6. 2008
    ..We describe experiments that promote cavitation during SWL and estimate the spatial distribution of the resulting hemorrhagic lesion in a large-animal (porcine) model of clinical lithotripsy...
  40. pmc Treatment protocols to reduce renal injury during shock wave lithotripsy
    James A McAteer
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    Curr Opin Urol 19:192-5. 2009
    ..Growing concern over the acute and long-term adverse effects associated with shock wave lithotripsy calls for treatment strategies to reduce renal injury and improve the efficiency of stone breakage in shock wave lithotripsy...
  41. ncbi Ultracal-30 gypsum artificial stones for research on the mechanisms of stone breakage in shock wave lithotripsy
    James A McAteer
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Dr MS 5055, Indianapolis, IN 46202 5120, USA
    Urol Res 33:429-34. 2005
    ..U-30 stones provide a convenient, reproducible model for SWL research...
  42. ncbi Shockwave lithotripsy: dose-related effects on renal structure, hemodynamics, and tubular function
    Lynn R Willis
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Endourol 19:90-101. 2005
    ....
  43. ncbi Stone formation is proportional to papillary surface coverage by Randall's plaque
    Samuel C Kim
    Methodist Hospital Institute for Kidney Stone Disease, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Urol 173:117-9; discussion 119. 2005
    ..We measured plaque areas in idiopathic CaOx stone formers and nonstone formers (NSF), and identified significant relationships with quantified stone histories...
  44. ncbi Renal nerves mediate changes in contralateral renal blood flow after extracorporeal shockwave lithotripsy
    Bret A Connors
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Ind 46202, USA
    Nephron Physiol 95:p67-75. 2003
    ..These observations suggest that renal nerves play a pivotal role in modulating the vascular response of the contralateral unshocked kidney to SWL, but only a partial role, if any, in modulating that response in the shocked kidney...
  45. ncbi Endoscopic renal papillary biopsies: a tissue retrieval technique for histological studies in patients with nephrolithiasis
    Ramsay L Kuo
    Methodist Hospital Institute for Kidney Stone Disease and Indiana University School of Medicine, Indianapolis, USA
    J Urol 170:2186-9. 2003
    ..To determine changes occurring in the human kidney during active stone disease we used an endoscopic renal papillary biopsy protocol in calcium stone formers undergoing percutaneous nephrolithotomy...
  46. ncbi Prevention of lithotripsy-induced renal injury by pretreating kidneys with low-energy shock waves
    Lynn R Willis
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, and Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN 46202, USA
    J Am Soc Nephrol 17:663-73. 2006
    ..The threshold for the protection may be <100 SW...
  47. ncbi Atubular glomeruli in a rat model of polycystic kidney disease
    George A Tanner
    Department of Cellular and Integrative Physiology, Indiana UniversitySchool of Medicine, Indianapolis, Indiana, USA
    Kidney Int 62:1947-57. 2002
    ..Autosomal-dominant polycystic kidney disease (ADPKD) is associated with a progressive decline in glomerular filtration rate (GFR) that often leads to end-stage renal disease. The basis for this decline in GFR is poorly understood...
  48. pmc Effect of shock wave number on renal oxidative stress and inflammation
    Daniel L Clark
    Department of Anatomy and Cell Biology, and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    BJU Int 107:318-22. 2011
    ..However, it is not known if the HO-1 response is beneficial or deleterious; determining that will inform us whether SWL-induced renal injury can be assessed by quantifying markers of oxidative stress and inflammation...
  49. doi Time-course for recovery of renal function after unilateral (single-tract) percutaneous access in the pig
    Rajash K Handa
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Endourol 24:283-8. 2010
    ..The immediate (1-5 hours) response to percutaneous renal access (PERC) in pigs is vasoconstriction in the treated kidney. The present study determined the longer-term (72 hours) consequences of this surgical procedure...
  50. ncbi Kidney damage and renal functional changes are minimized by waveform control that suppresses cavitation in shock wave lithotripsy
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, USA
    J Urol 168:1556-62. 2002
    ..Experiments were also performed in isolated red blood cells, an in vitro test system that is a sensitive indicator of cavitation mediated shock wave damage...
  51. ncbi Stone fragmentation during shock wave lithotripsy is improved by slowing the shock wave rate: studies with a new animal model
    Ryan F Paterson
    Department of Anatomy and Cell Biology, Indiana University School of Medicine and Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, Indiana, USA
    J Urol 168:2211-5. 2002
    ..We tested the effect of the shock wave rate on stone comminution in a new animal model...
  52. ncbi Calcium oxalate crystal localization and osteopontin immunostaining in genetic hypercalciuric stone-forming rats
    Andrew P Evan
    Anatomy Department, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 65:154-61. 2004
    ..The present study was designed to determine the localization of stone formation and if this solid phase resulted in pathologic changes to the kidneys...
  53. pmc Pretreatment with low-energy shock waves induces renal vasoconstriction during standard shock wave lithotripsy (SWL): a treatment protocol known to reduce SWL-induced renal injury
    Rajash K Handa
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    BJU Int 103:1270-4. 2009
    ....
  54. ncbi In vitro assessment of ultrasonic lithotriptors
    Ramsay L Kuo
    Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, Indiana, USA
    J Urol 170:1101-4. 2003
    ..To date a comparative assessment of current units has not been accomplished without potential operator bias. An objective testing environment is required for optimal appraisal of the efficiency of ultrasonic lithotriptors...
  55. ncbi Shockwave lithotripsy: anecdotes and insights
    James E Lingeman
    Clarian Health Partners, Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, Indiana, USA
    J Endourol 17:687-93. 2003
    ..It appears likely that most tissue damage from shockwaves is caused by cavitation. As the understanding of SWL matures, new lithotripter designs may emerge that truly represent an improvement on the original Dornier HM3 machine...
  56. ncbi Urine calcium and volume predict coverage of renal papilla by Randall's plaque
    Ramsay L Kuo
    The Methodist Hospital Institute for Kidney Stone Disease and Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 64:2150-4. 2003
    ..To test this, we measured papillary plaque areas in both idiopathic calcium oxalate stone formers and nonstone formers and examined 24-hour urine data to identify significant correlations...
  57. ncbi Endoscopic evidence of calculus attachment to Randall's plaque
    Brian R Matlaga
    Methodist Hospital Institute for Kidney Stone Disease, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Urol 175:1720-4; discussion 1724. 2006
    ..In this study we used endoscopic examination of renal papillae in stone formers undergoing percutaneous nephrolithotomy to investigate both issues...
  58. ncbi Continuous infusion of oxalate by minipumps induces calcium oxalate nephrocalcinosis
    Susan Ruth Marengo
    Department of Urology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4931, USA
    Urol Res 34:200-10. 2006
    ..Adjustments in the length of treatment and level of hyperoxaluria may allow this model to also be used to study the oxalate driven CaOx-nephrolithiasis common in patients with hyperoxaluria due to other causes...
  59. ncbi The role of Randall's plaques in the pathogenesis of calcium stones
    Brian R Matlaga
    Methodist Hospital Institute for Kidney Stone Disease, Indiana University School of Medicine, International Kidney Stone Institute, Indianapolis, Indiana 46202, USA
    J Urol 177:31-8. 2007
    ..We reviewed in vivo data that have further defined the role of Randall's plaques in stone disease...
  60. pmc Shock wave lithotripsy: advances in technology and technique
    James E Lingeman
    Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, USA
    Nat Rev Urol 6:660-70. 2009
    ..New technologies have begun to address many of these issues, and hold considerable promise for the future...
  61. pmc Profile of the brushite stone former
    Amy E Krambeck
    Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, Indiana 46202, USA
    J Urol 184:1367-71. 2010
    ..The incidence of brushite stones has increased during the last 3 decades and we report our experience with brushite stone formers...
  62. ncbi The pathogenesis of calyceal diverticular calculi
    Brian R Matlaga
    Methodist Hospital Institute for Kidney Stone Disease, Indiana University School of Medicine, 1801 North Senate Boulevard, Suite 220, Indianapolis, IN 46202, USA
    Urol Res 35:35-40. 2007
    ..Taken together, it seems likely that calyceal diverticular calculi arise from a combination of metabolic abnormalities and urinary stasis...
  63. doi A new world revealed: early experience with digital ureteroscopy
    Mitchell R Humphreys
    International Kidney Stone Institute, Clarian Methodist Hospital, Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Urol 179:970-5. 2008
    ..Southborough, Massachusetts) offers image quality that greatly exceeds current analog image capabilities. The purpose of this report was to document the applicability of this device in studying the earliest stages of stone formation...
  64. ncbi Evidence that postprandial reduction of renal calcium reabsorption mediates hypercalciuria of patients with calcium nephrolithiasis
    Elaine M Worcester
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Renal Physiol 292:F66-75. 2007
    ..Parathyroid hormone is not likely to be a sufficient explanation for this difference...
  65. ncbi Prefocal alignment improves stone comminution in shockwave lithotripsy
    Dahlia L Sokolov
    Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle 98105, USA
    J Endourol 16:709-15. 2002
    ..In clinical practice, however, stones are aligned with F2...
  66. ncbi Gender- and age-dependent changes in kidney androgen protein mRNA expression in a knockout mouse model for nephrolithiasis
    Eleni G Tzortzaki
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
    J Histochem Cytochem 50:1663-9. 2002
    ..Kap expression is under multihormonal control, and hormonal changes in DHA-induced nephrolithiasis may account for the decreased Kap expression in APRT-deficient mice...
  67. ncbi Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, Veterans Affairs Medical Center in Manhattan, 423 E23 St, Rm 18064S, New York, NY 10010, USA
    Am J Physiol Renal Physiol 293:F1935-43. 2007
    ....
  68. ncbi Impaired expression of an organic cation transporter, IMPT1, in a knockout mouse model for kidney stone disease
    Eleni G Tzortzaki
    Department of Genetics, Rutgers University, 604 Allison Road, NJ 08854 8082, Piscataway, USA
    Urol Res 31:257-61. 2003
    ....
  69. ncbi Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6
    Zhirong Jiang
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Genet 38:474-8. 2006
    ..We conclude that the anion exchanger SLC26A6 has a major constitutive role in limiting net intestinal absorption of oxalate, thereby preventing hyperoxaluria and calcium oxalate urolithiasis...
  70. ncbi Morphological changes induced in the pig kidney by extracorporeal shock wave lithotripsy: nephron injury
    Youzhi Shao
    Department of Histology, Jinzhou Medical College, Jinzhou, Liaoning Province, People s Republic of China
    Anat Rec A Discov Mol Cell Evol Biol 275:979-89. 2003
    ..The initial injury caused by SWL was cellular fragmentation and necrosis. Cellular vacuolization, membrane blebbing, and disorganization of apical brush borders appear to be secondary changes related to hypoxia...
  71. pmc Cavitation bubble cluster activity in the breakage of kidney stones by lithotripter shockwaves
    Yuriy A Pishchalnikov
    Department of Acoustics, Physics Faculty, M V Lomonosov Moscow State University, Moscow, Russia
    J Endourol 17:435-46. 2003
    ..Cavitation control may thus be a way to improve lithotripsy...
  72. ncbi Nephrolithiasis and nephrocalcinosis in rats with small bowel resection
    R Corey O'Connor
    Department of Urology, University of Chicago, Chicago, IL, USA
    Urol Res 33:105-15. 2005
    ..The model allows further studies of the mechanisms of renal crystal formation, and possible therapeutic interventions...
  73. ncbi Pathogenesis of renal calculi
    Nicole L Miller
    Clarian Health Partners, USA
    Urol Clin North Am 34:295-313. 2007
    ..These data suggest there are individual stone-forming phenotypes with unique surgical anatomy, histology, and metabolic profiles...
  74. ncbi Clinical implications of abundant calcium phosphate in routinely analyzed kidney stones
    Joan H Parks
    Nephrology Section, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 66:777-85. 2004
    ..Our purpose was to inform clinicians and highlight areas that seem to deserve further research...
  75. ncbi Aprt/Opn double knockout mice: osteopontin is a modifier of kidney stone disease severity
    Hilary J Vernon
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    Kidney Int 68:938-47. 2005
    ..We examined the role of OPN in adenine phosphoribosyltransferase (Aprt) knockout mice, in which inflammation and formation of 2,8-dihydroxyadenine (DHA) kidney stones are prominent features, by generating Aprt/Opn double knockout mice...
  76. ncbi In vitro assessment of lithoclast ultra intracorporeal lithotripter
    Ramsay L Kuo
    Methodist Hospital Institute for Kidney Stone Disease
    J Endourol 18:153-6. 2004
    ..We evaluated the effectiveness of this unit using a hands-free in vitro testing system...
  77. pmc A cumulative shear mechanism for tissue damage initiation in shock-wave lithotripsy
    Jonathan B Freund
    Department of Mechanical Science and Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Ultrasound Med Biol 33:1495-503. 2007
    ..Implications of the model are that slower delivery rates and broader focal zones should both decrease injury, consistent with some recent observations...
  78. ncbi Reduced renal function and benefits of treatment in cystinuria vs other forms of nephrolithiasis
    Elaine M Worcester
    Renal Section, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    BJU Int 97:1285-90. 2006
    ..Other interesting findings are also presented...
  79. ncbi Cavitation detection during shock-wave lithotripsy
    Michael R Bailey
    Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105, USA
    Ultrasound Med Biol 31:1245-56. 2005
    ..The finding that cavitation occurs in kidney tissue is a critical step toward determining the mechanisms of tissue injury in SWL...
  80. ncbi Shock wave lithotripsy of stones implanted in the proximal ureter of the pig
    Ryan F Paterson
    Department of Surgery, Division of Urology, University of British Columbia, Vancouver, British Columbia, Canada
    J Urol 173:1391-4. 2005
    ..However, push-back is invasive and not always possible. Since there are few clues to suggest how best to treat ureteral stones with SWs in situ, we developed an animal model for research on lithotripsy for ureteral stones...
  81. ncbi Calcium oxalate stone formation in genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine, Strong Memorial Hospital, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Kidney Int 61:975-87. 2002
    ....
  82. ncbi A new animal model of hyperoxaluria and nephrolithiasis in rats with small bowel resection
    Elaine M Worcester
    Nephrology Section, MC 5100, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Urol Res 33:380-2. 2005
    ..Further studies are required to better characterize the causes and consequences of hyperoxaluria in this animal model...

Research Grants4

  1. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  2. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Risk for Renal Injury Caused by Shock Wave Lithotripsy
    Andrew Evan; Fiscal Year: 2008
    ..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..
  4. IKSI: 2nd International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2008
    ..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..