K D Brandt

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis
    J D Bradley
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Rheumatol 28:1073-6. 2001
  2. ncbi request reprint Studies in animal models of osteoarthritis as predictors of a structure-modifying effect of diacerhein in humans with osteoarthritis
    Kenneth D Brandt
    Indiana University School of Medicine, Division of Rheumatology, Indianapolis, IN 46202, USA
    Biorheology 43:589-94. 2006
  3. pmc Chondrocalcinosis, osteophytes and osteoarthritis
    K D Brandt
    Indiana University School of Medicine, Indianapolis 46202, USA
    Ann Rheum Dis 62:499-500. 2003
  4. ncbi request reprint Animal models of osteoarthritis
    Kenneth D Brandt
    Rheumatology Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biorheology 39:221-35. 2002
  5. pmc Non-surgical treatment of osteoarthritis: a half century of "advances"
    K D Brandt
    Indiana University School of Medicine and Indiana University Multipurpose Arthritis and Musculoskeletal Diseases Center, 1110 West Michigan Street, Room 545, Indianapolis IN 46202, USA
    Ann Rheum Dis 63:117-22. 2004
  6. ncbi request reprint Hyaluronan injection affects neither osteoarthritis progression nor loading of the OA knee in dogs
    Kenneth D Brandt
    Rheumatology Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biorheology 41:493-502. 2004
  7. ncbi request reprint Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial
    Kenneth D Brandt
    Indiana University School of Medicine, Rheumatology Division, Indianapolis, IN 46202 5100, USA
    Arthritis Rheum 52:2015-25. 2005
  8. ncbi request reprint Response of joint structures to inactivity and to reloading after immobilization
    Kenneth D Brandt
    Indiana University School of Medicine and Indiana University Multipurpose Arthritis and Musculoskeletal Diseases Center, Indianapolis, Indiana, USA
    Arthritis Rheum 49:267-71. 2003
  9. ncbi request reprint [Paracetamol in the treatment of osteoarthritis pain]
    Kenneth Brandt
    Départements de Rhumatologie et de Chirurgie Orthopédique, Faculté de Médecine de l Université d Indiana et Centre pluridisciplinaire des maladies rhumatismales et ostéoarticulaires de l Université d Indiana, Etats Unis
    Drugs 63:23-41. 2003
  10. ncbi request reprint A comparison of lower extremity muscle strength, obesity, and depression scores in elderly subjects with knee pain with and without radiographic evidence of knee osteoarthritis
    K D Brandt
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Rheumatol 27:1937-46. 2000

Detail Information

Publications54

  1. ncbi request reprint Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis
    J D Bradley
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Rheumatol 28:1073-6. 2001
    ..CONCLUSION: Our data suggest that acetaminophen and ibuprofen are comparably effective in treating knee OA pain, even when the pain is severe...
  2. ncbi request reprint Studies in animal models of osteoarthritis as predictors of a structure-modifying effect of diacerhein in humans with osteoarthritis
    Kenneth D Brandt
    Indiana University School of Medicine, Division of Rheumatology, Indianapolis, IN 46202, USA
    Biorheology 43:589-94. 2006
  3. pmc Chondrocalcinosis, osteophytes and osteoarthritis
    K D Brandt
    Indiana University School of Medicine, Indianapolis 46202, USA
    Ann Rheum Dis 62:499-500. 2003
  4. ncbi request reprint Animal models of osteoarthritis
    Kenneth D Brandt
    Rheumatology Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biorheology 39:221-35. 2002
    ..Indeed, it should not be assumed a priori that reduction in the rate of progression of joint damage in OA will be associated with a reduction in joint pain...
  5. pmc Non-surgical treatment of osteoarthritis: a half century of "advances"
    K D Brandt
    Indiana University School of Medicine and Indiana University Multipurpose Arthritis and Musculoskeletal Diseases Center, 1110 West Michigan Street, Room 545, Indianapolis IN 46202, USA
    Ann Rheum Dis 63:117-22. 2004
  6. ncbi request reprint Hyaluronan injection affects neither osteoarthritis progression nor loading of the OA knee in dogs
    Kenneth D Brandt
    Rheumatology Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biorheology 41:493-502. 2004
    ..A significant correlation was noted between the severity of chondropathy and the magnitude of the vertical ground reaction forces generated by the unstable limb...
  7. ncbi request reprint Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial
    Kenneth D Brandt
    Indiana University School of Medicine, Rheumatology Division, Indianapolis, IN 46202 5100, USA
    Arthritis Rheum 52:2015-25. 2005
    ..To confirm preclinical data suggesting that doxycycline can slow the progression of osteoarthritis (OA). The primary outcome measure was joint space narrowing (JSN) in the medial tibiofemoral compartment...
  8. ncbi request reprint Response of joint structures to inactivity and to reloading after immobilization
    Kenneth D Brandt
    Indiana University School of Medicine and Indiana University Multipurpose Arthritis and Musculoskeletal Diseases Center, Indianapolis, Indiana, USA
    Arthritis Rheum 49:267-71. 2003
  9. ncbi request reprint [Paracetamol in the treatment of osteoarthritis pain]
    Kenneth Brandt
    Départements de Rhumatologie et de Chirurgie Orthopédique, Faculté de Médecine de l Université d Indiana et Centre pluridisciplinaire des maladies rhumatismales et ostéoarticulaires de l Université d Indiana, Etats Unis
    Drugs 63:23-41. 2003
    ..This paper discusses the relative positioning of APAP, NSAIDs and coxibs in the management of OA, on the basis of considerations of tolerability, efficacy and costs...
  10. ncbi request reprint A comparison of lower extremity muscle strength, obesity, and depression scores in elderly subjects with knee pain with and without radiographic evidence of knee osteoarthritis
    K D Brandt
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Rheumatol 27:1937-46. 2000
    ....
  11. ncbi request reprint Lessons learned from nine clinical trials of disease-modifying osteoarthritis drugs
    Kenneth D Brandt
    Rheumatology Division, Indiana University School of Medicine, 1110 West Michigan Street, Rm LO 545, Indianapolis, IN 46202 5100, USA
    Arthritis Rheum 52:3349-59. 2005
  12. ncbi request reprint Experience with a placebo-controlled randomized clinical trial of a disease-modifying drug for osteoarthritis: the doxycycline trial
    Kenneth D Brandt
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5100, USA
    Rheum Dis Clin North Am 32:217-34, xi-xii. 2006
    ....
  13. pmc Comparison of quantitative and semiquantitative indicators of joint space narrowing in subjects with knee osteoarthritis
    S A Mazzuca
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202 5100, USA
    Ann Rheum Dis 65:64-8. 2006
    ..To compare quantitative estimates of change in joint space width (JSW) with semiquantitative ratings of the progression of joint space narrowing (JSN) with respect to sensitivity to change over time...
  14. ncbi request reprint Effects of synovial fluid hyaluronan concentration and molecular size on clearance of protein from the canine knee
    S L Myers
    Rheumatology Division, Indiana University School of Medicine, Indianapolis 46202 5103, USA
    J Rheumatol 22:1732-9. 1995
    ....
  15. pmc Risk factors for progression of tibiofemoral osteoarthritis: an analysis based on fluoroscopically standardised knee radiography
    S A Mazzuca
    Indiana University School of Medicine, Department of Medicine, Rheumatology Division, Long Hospital Room 545, 1110 W Michigan St, Indianapolis, IN 46202 5100, USA
    Ann Rheum Dis 65:515-9. 2006
    ..To evaluate risk factors for progressive radiographic changes of knee osteoarthritis using a standardised fluoroscopically assisted protocol for knee radiography...
  16. pmc Urinary levels of type II collagen C-telopeptide crosslink are unrelated to joint space narrowing in patients with knee osteoarthritis
    S A Mazzuca
    Indiana University School of Medicine, Department of Medicine, Rheumatology Division, Long Hospital Room 545, 1110 W Michigan St, Indianapolis, IN 46202 5100, USA
    Ann Rheum Dis 65:1055-9. 2006
    ..To determine whether urinary concentrations of the cross linked C-telopeptide of type II collagen (CTx-II) distinguish subjects with progressive radiographic or symptomatic knee osteoarthritis from those with stable disease...
  17. pmc Development of radiographic changes of osteoarthritis in the "Chingford knee" reflects progression of disease or non-standardised positioning of the joint rather than incident disease
    S A Mazzuca
    Department of Medicine, Indiana University School of Medicine, USA
    Ann Rheum Dis 62:1061-5. 2003
    ....
  18. ncbi request reprint Effect of intraarticular hyaluronan injection on synovial fluid hyaluronan in the early stage of canine post-traumatic osteoarthritis
    G N Smith
    Rheumatology Division, Department of Medicine, and Department of Anatomy, Indiana University School of Medicine, Room 545, 1110 W. Michigan Street, Indianapolis, IN 46202-5103, USA
    J Rheumatol 28:1341-6. 2001
    ..1 +/- 0.01 mg/ml, respectively; p = 0.04). CONCLUSION: Intraarticular injection of HA did not alter the volume of SF or molecular weight of HA in SF of OA canine knees, nor did it restore the HA concentration to that of normal canine SF...
  19. pmc Varus malalignment negates the structure-modifying benefits of doxycycline in obese women with knee osteoarthritis
    S A Mazzuca
    Indiana University School of Medicine, Indianapolis, IN, USA
    Osteoarthritis Cartilage 18:1008-11. 2010
    ....
  20. ncbi request reprint Severity of medial meniscus damage in the canine knee after anterior cruciate ligament transection
    G N Smith
    Rheumatology Division, Department of Medicine, and Department of Anatomy, Indiana University School of Medicine, Indianapolis, IN 46202 5103, USA
    Osteoarthritis Cartilage 10:321-6. 2002
    ..To examine the relationship between the severity of cartilage damage and the severity of meniscus damage after transection of the anterior cruciate ligament (ACLT) in adult dogs...
  21. ncbi request reprint Effect of alignment of the medial tibial plateau and x-ray beam on apparent progression of osteoarthritis in the standing anteroposterior knee radiograph
    S A Mazzuca
    Indiana University School of Medicine, Department of Medicine, Long Hospital, Indianapolis 46202-5100, USA
    Arthritis Rheum 44:1786-94. 2001
    ....
  22. ncbi request reprint Accelerated clearance of albumin from the osteoarthritic knee: implications for interpretation of concentrations of "cartilage markers" in synovial fluid
    S L Myers
    Rheumatology Division, Indiana University School of Medicine, Indiana University Multipurpose Arthritis and Musculoskeletal Diseases Center, Indianapolis, USA
    J Rheumatol 23:1744-8. 1996
    ....
  23. ncbi request reprint Inhibition of recombinant human neutrophil collagenase by doxycycline is pH dependent
    G N Smith
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202 5103, USA
    J Rheumatol 24:1769-73. 1997
    ....
  24. ncbi request reprint Educational program for nursing home physicians and staff to reduce use of non-steroidal anti-inflammatory drugs among nursing home residents: a randomized controlled trial
    C M Stein
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Med Care 39:436-45. 2001
    ..5%) and intervention (35.4%) groups had worsening of their arthritis pain score (P = 0.81). CONCLUSIONS: An educational intervention effectively reduced NSAID use in nursing homes without worsening of arthritis pain...
  25. ncbi request reprint Periosteal new bone formation in a canine neuropathic model of osteoarthritis
    S L Myers
    Indiana University School of Medicine, and Indiana University Multipurpose Arthritis and Musculoskeletal Diseases Center, Indianapolis, USA
    Arthritis Rheum 40:1756-9. 1997
    ..To characterize, for the first time, periosteal new bone formation in a well-established canine model of accelerated osteoarthritis (OA) with features of neuropathic arthropathy...
  26. ncbi request reprint Hypothesis: can type IX collagen "glue" together intersecting type II fibers in articular cartilage matrix? A proposed mechanism
    G N Smith
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202 5103
    J Rheumatol 19:14-7. 1992
    ..We propose that both type IX collagen and an intermediary molecule are necessary for network stabilization and that proteoglycans are likely candidates for the role of intermediary...
  27. ncbi request reprint Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis
    L Stefan Lohmander
    Lund University, Lund, Sweden
    Arthritis Rheum 52:3160-7. 2005
    ..To determine whether baseline or serial plasma concentrations of stromelysin (matrix metalloproteinase 3 [MMP-3]) protein might distinguish subjects with progressive radiographic knee osteoarthritis (OA) from those with stable disease...
  28. ncbi request reprint Severity of joint pain and Kellgren-Lawrence grade at baseline are better predictors of joint space narrowing than bone scintigraphy in obese women with knee osteoarthritis
    Steven A Mazzuca
    Department of Medicine, Indiana University School of Medicine IUSM, Indianapolis, 46202, USA
    J Rheumatol 32:1540-6. 2005
    ....
  29. ncbi request reprint The randomized clinical trial of doxycycline in knee osteoarthritis: comment on the editorial by Dieppe
    Kenneth D Brandt
    Arthritis Rheum 54:684. 2006
  30. ncbi request reprint Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
    Daniel O Clegg
    Division of Rheumatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    N Engl J Med 354:795-808. 2006
    ..The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis...
  31. ncbi request reprint Detection of radiographic joint space narrowing in subjects with knee osteoarthritis: longitudinal comparison of the metatarsophalangeal and semiflexed anteroposterior views
    Steven A Mazzuca
    Indiana University School of Medicine, Department of Medicine, Rheumatology Division, Long Hospital Room 545, 1110 West Michigan Street, Indianapolis, IN 46202 5100, USA
    Arthritis Rheum 48:385-90. 2003
    ..The present study was undertaken to compare the metatarsophalangeal (MTP) view and the semiflexed anteroposterior (AP) view with respect to sensitivity to JSN in knee OA...
  32. ncbi request reprint Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees
    Kenneth D Brandt
    Department of Medicine, Rheumatology Division, Indiana University School of Medicine, Indianapolis, IN 46202 5100, USA
    Rheumatology (Oxford) 45:1389-94. 2006
    ....
  33. pmc Risk factors for early radiographic changes of tibiofemoral osteoarthritis
    Steven A Mazzuca
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5100, USA
    Ann Rheum Dis 66:394-9. 2007
    ..To evaluate the risk factors for early radiographic changes of knee osteoarthritis...
  34. ncbi request reprint Effects of strength training on the incidence and progression of knee osteoarthritis
    Alan E Mikesky
    Indiana University Purdue University, Indianapolis, IN, USA
    Arthritis Rheum 55:690-9. 2006
    ..Quadriceps weakness is a risk factor for incident knee osteoarthritis (OA). We describe a randomized controlled trial of effects of lower-extremity strength training on incidence and progression of knee OA...
  35. ncbi request reprint Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing
    Ivan G Otterness
    School of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA
    Arthritis Rheum 56:3644-9. 2007
    ....
  36. doi request reprint Etiopathogenesis of osteoarthritis
    Kenneth D Brandt
    Kansas University Medical Center, 5755 Windsor Drive, Fairway, Kansas City, KS 66205, USA
    Rheum Dis Clin North Am 34:531-59. 2008
    ..Because the body's innate mechanisms for repairing the damaged tissues cannot be effective in the face of the overwhelming mechanical abnormality, they cannot solve the problem of OA...
  37. ncbi request reprint Tidal irrigation as treatment for knee osteoarthritis: a sham-controlled, randomized, double-blinded evaluation
    John D Bradley
    Indiana University School of Medicine, Indianapolis 46202, USA
    Arthritis Rheum 46:100-8. 2002
    ..To evaluate the effectiveness of tidal irrigation (TI) in comparison with a well-matched sham irrigation (SI) procedure as a treatment for knee osteoarthritis (OA)...
  38. ncbi request reprint Field test of the reproducibility of the semiflexed metatarsophalangeal view in repeated radiographic examinations of subjects with osteoarthritis of the knee
    Steven A Mazzuca
    Indiana University School of Medicine, Department of Medicine, Indianapolis 46202 5100, USA
    Arthritis Rheum 46:109-13. 2002
    ....
  39. ncbi request reprint Is a strong quadriceps muscle bad for a patient with knee osteoarthritis?
    Kenneth D Brandt
    Ann Intern Med 138:678-9. 2003
  40. ncbi request reprint Measurement of radiographic joint space width in the tibiofemoral compartment of the osteoarthritic knee: comparison of standing anteroposterior and Lyon schuss views
    Eric Vignon
    Claude Bernard University, Lyon, France
    Arthritis Rheum 48:378-84. 2003
    ..To evaluate progression of joint space narrowing in radiographs of osteoarthritic (OA) knees imaged in both the standing anteroposterior (AP) and the Lyon schuss positions, using alternative methods to measure joint space width (JSW)...
  41. ncbi request reprint Knee pain reduces joint space width in conventional standing anteroposterior radiographs of osteoarthritic knees
    Steven A Mazzuca
    Department of Medicine, Rheumatology Division, Indiana University School of Medicine, Indianapolis 46202, USA
    Arthritis Rheum 46:1223-7. 2002
    ....
  42. ncbi request reprint Is knee radiography useful for studying the efficacy of a disease-modifying osteoarthritis drug in humans?
    Steven A Mazzuca
    Division of Rheumatology, Department of Medicine, Indiana University School of Medicine, Long Hospital, Room 545, 1110 West Michigan Street, Indianapolis, IN 46202 5100, USA
    Rheum Dis Clin North Am 29:819-30. 2003
    ....
  43. ncbi request reprint Which is the best radiographic protocol for a clinical trial of a structure modifying drug in patients with knee osteoarthritis?
    Kenneth D Brandt
    Rheumatology Division, Indiana University School of Medicine, Indianapolis 46202 5100, USA
    J Rheumatol 29:1308-20. 2002
  44. ncbi request reprint Bone scintigraphy is not a better predictor of progression of knee osteoarthritis than Kellgren and Lawrence grade
    Steven A Mazzuca
    Department of Medicine, Department of Orthopaedic Surgery, Indiana University School of Medicine IUSM, Indianapolis, Indiana 46202 5100, USA
    J Rheumatol 31:329-32. 2004
    ....
  45. ncbi request reprint Neuromuscular aspects of osteoarthritis: a perspective
    Kenneth D Brandt
    Multipurpose Arthritis and Musculoskeletal Diseases Center, Indiana University School of Medicine, 1110 West Michigan Street, Indianapolis, IN 46202 5100, USA
    Novartis Found Symp 260:49-58; discussion 58-63, 100-4, 277-9. 2004
    ..Individuals vary with respect to how they load their joints, perhaps because of genetic differences in central program generators...
  46. ncbi request reprint Simple analgesics versus NSAID
    Kenneth D Brandt
    J Rheumatol 29:640-2. 2002
  47. ncbi request reprint Pitfalls in the accurate measurement of joint space narrowing in semiflexed, anteroposterior radiographic imaging of the knee
    Steven A Mazzuca
    Department of Medicine, Indiana University, Indianapolis 46202 5100, USA
    Arthritis Rheum 50:2508-15. 2004
    ....
  48. ncbi request reprint Pilot study of the effects of a heat-retaining knee sleeve on joint pain, stiffness, and function in patients with knee osteoarthritis
    Steven A Mazzuca
    Indiana University School of Medicine, Indianapolis, IN 46202 5100, USA
    Arthritis Rheum 51:716-21. 2004
    ..To identify changes in joint pain, stiffness, and functional ability in patients with knee osteoarthritis (OA) after use of a knee sleeve that prevents loss of body heat by the joint...
  49. ncbi request reprint Subject retention and adherence in a randomized placebo-controlled trial of a disease-modifying osteoarthritis drug
    Steven A Mazzuca
    Indiana University School of Medicine, Indianapolis, 46202 5100, USA
    Arthritis Rheum 51:933-40. 2004
    ..To describe the methods by which remarkable levels of subject retention and adherence were achieved in a 30-month multicenter randomized placebo-controlled trial (RCT) of a disease-modifying osteoarthritis drug (DMOAD)...
  50. ncbi request reprint Effect of intraarticular hyaluronan injection on vertical ground reaction force and progression of osteoarthritis after anterior cruciate ligament transection
    Gerald Smith
    Rheumatology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Rheumatol 32:325-34. 2005
    ..To determine if intraarticular (IA) injection of hyaluronan (HA) into the canine knee after anterior cruciate ligament transection (ACLT) alters the progression of osteoarthritis (OA) and the perception of pain in this model...
  51. ncbi request reprint Associations between joint space narrowing and molecular markers of collagen and proteoglycan turnover in patients with knee osteoarthritis
    Steven A Mazzuca
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Rheumatol 33:1147-51. 2006
    ....
  52. ncbi request reprint What is important in treating osteoarthritis? Whom should we treat and how should we treat them?
    Paul Dieppe
    Medical Research Council, Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Canyge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Rheum Dis Clin North Am 29:687-716. 2003
    ..The authors also believe that the academic community striving to provide help for people who have OA should bear in mind the concept that there is "too much medicine" [37]...
  53. ncbi request reprint Osteoarthritis. Preface
    Kenneth D Brandt
    Rheum Dis Clin North Am 29:ix-xiii. 2003
  54. ncbi request reprint Translating osteoarthritis into numbers: the importance of alignment in knee radiography for clinical trials of structure-modifying drugs
    Kenneth D Brandt
    Arthritis Rheum 52:1343-5. 2005