Juqun Shen

Summary

Affiliation: ImClone Systems
Country: USA

Publications

  1. ncbi request reprint An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody
    Juqun Shen
    ImClone Systems Incorporated, New York, NY 10014, USA
    Biochem Biophys Res Commun 357:1142-7. 2007
  2. ncbi request reprint Catumaxomab, a rat/murine hybrid trifunctional bispecific monoclonal antibody for the treatment of cancer
    Juqun Shen
    ImClone Systems Inc, 180 Varick Street, New York, NY 10014 USA
    Curr Opin Mol Ther 10:273-84. 2008
  3. ncbi request reprint Single variable domain-IgG fusion. A novel recombinant approach to Fc domain-containing bispecific antibodies
    Juqun Shen
    Department of Antibody Technology, ImClone Systems Inc, New York, New York 10014, USA
    J Biol Chem 281:10706-14. 2006
  4. ncbi request reprint Single variable domain antibody as a versatile building block for the construction of IgG-like bispecific antibodies
    Juqun Shen
    Department of Antibody Technology, Department of Cell Engineering and Expression, ImClone Systems Incorporation, 180 Varick Street, New York, NY 10014, USA
    J Immunol Methods 318:65-74. 2007
  5. pmc Development of a fully human anti-PDGFRbeta antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody
    Juqun Shen
    ImClone Systems, New York, NY 10014, USA
    Neoplasia 11:594-604. 2009
  6. ncbi request reprint Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity
    Dan Lu
    Departments of Antibody Technology, Molecular and Cell Biology, and Research, ImClone Systems Incorporated, New York, New York 10014, USA
    J Biol Chem 278:43496-507. 2003
  7. ncbi request reprint Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys
    Haijun D Sun
    ImClone Systems Inc, 180 Varick St, New York, NY 10014, USA
    Am J Physiol Endocrinol Metab 292:E964-76. 2007

Collaborators

Detail Information

Publications7

  1. ncbi request reprint An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody
    Juqun Shen
    ImClone Systems Incorporated, New York, NY 10014, USA
    Biochem Biophys Res Commun 357:1142-7. 2007
    ..Taken together, these results lend great support to use PDGFRbeta antagonists in combinations with other antitumor and/or anti-angiogenic agents in the treatment of a variety of cancers...
  2. ncbi request reprint Catumaxomab, a rat/murine hybrid trifunctional bispecific monoclonal antibody for the treatment of cancer
    Juqun Shen
    ImClone Systems Inc, 180 Varick Street, New York, NY 10014 USA
    Curr Opin Mol Ther 10:273-84. 2008
    ..Catumaxomab is currently undergoing phase II clinical trials in patients with malignant ascites, ovarian and stomach cancer...
  3. ncbi request reprint Single variable domain-IgG fusion. A novel recombinant approach to Fc domain-containing bispecific antibodies
    Juqun Shen
    Department of Antibody Technology, ImClone Systems Inc, New York, New York 10014, USA
    J Biol Chem 281:10706-14. 2006
    ..This design and expression of Fc domain-containing, IgG-like BsAb should be applicable to the construction of similar BsAb from antibodies recognizing any pair of antigens...
  4. ncbi request reprint Single variable domain antibody as a versatile building block for the construction of IgG-like bispecific antibodies
    Juqun Shen
    Department of Antibody Technology, Department of Cell Engineering and Expression, ImClone Systems Incorporation, 180 Varick Street, New York, NY 10014, USA
    J Immunol Methods 318:65-74. 2007
    ..This format of BsAb should be readily applicable to the production of other BsAb recognizing any pairs of antigens...
  5. pmc Development of a fully human anti-PDGFRbeta antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody
    Juqun Shen
    ImClone Systems, New York, NY 10014, USA
    Neoplasia 11:594-604. 2009
    ..Taken together, these results lend great support to the use of PDGFRbeta antagonists in combination with other antiangiogenic agents in the treatment of a broad range of human cancers...
  6. ncbi request reprint Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity
    Dan Lu
    Departments of Antibody Technology, Molecular and Cell Biology, and Research, ImClone Systems Incorporated, New York, New York 10014, USA
    J Biol Chem 278:43496-507. 2003
    ..Taken together, our observation suggests that clone 1121 may have great clinical potential in anti-angiogenesis therapy. It further underscores the efforts to identify antibodies of high affinity for enhanced biological activities...
  7. ncbi request reprint Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys
    Haijun D Sun
    ImClone Systems Inc, 180 Varick St, New York, NY 10014, USA
    Am J Physiol Endocrinol Metab 292:E964-76. 2007
    ..Our data suggest that FGF signaling through FGFR1c may play a physiological role in hypothalamic feeding circuit and that blocking it leads to hypophagia and weight loss...