Binquan Luan

Summary

Affiliation: IBM Research
Country: USA

Publications

  1. doi request reprint Complete wetting of graphene by biological lipids
    Binquan Luan
    Department of Physics, Zhejiang University, Hangzhou, 310027, China and IBM Research at T J Watson Center, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA
    Nanoscale 8:5750-4. 2016
  2. doi request reprint Controlled transport of DNA through a Y-shaped carbon nanotube in a solid membrane
    Binquan Luan
    IBM Research at T J Watson Center, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA
    Nanoscale 6:11479-83. 2014
  3. doi request reprint Dynamics of DNA translocation in a solid-state nanopore immersed in aqueous glycerol
    Binquan Luan
    IBM T J Watson Research Center, Yorktown Heights, 10598, USA
    Nanotechnology 23:455102. 2012
  4. pmc Characterizing and controlling the motion of ssDNA in a solid-state nanopore
    Binquan Luan
    IBM T J Watson Research Center, Yorktown Heights, New York, USA
    Biophys J 101:2214-22. 2011
  5. pmc Slowing and controlling the translocation of DNA in a solid-state nanopore
    Binquan Luan
    IBM Research, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA
    Nanoscale 4:1068-77. 2012
  6. pmc Tribological effects on DNA translocation in a nanochannel coated with a self-assembled monolayer
    Binquan Luan
    IBM T J Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, New York 10598, USA
    J Phys Chem B 114:17172-6. 2010
  7. pmc Control and reversal of the electrophoretic force on DNA in a charged nanopore
    Binquan Luan
    T J Watson Research Center, IBM, 1101 Kitchawan Road, Yorktown Heights, NY, USA
    J Phys Condens Matter 22:454123. 2010
  8. doi request reprint Electrochemical characterization of thin film electrodes toward developing a DNA transistor
    Stefan Harrer
    IBM T J Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, New York 10598, United States
    Langmuir 26:19191-8. 2010
  9. pmc Electrochemical protection of thin film electrodes in solid state nanopores
    Stefan Harrer
    IBM T J Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA
    Nanotechnology 22:275304. 2011
  10. pmc Base-by-base ratcheting of single stranded DNA through a solid-state nanopore
    Binquan Luan
    IBM T J Watson Research Center, PO Box 218, Yorktown Heights, New York 10598, USA
    Phys Rev Lett 104:238103. 2010

Collaborators

  • Ruhong Zhou
  • Aleksei Aksimentiev
  • Stefan Harrer
  • Martin Caffrey
  • Chao Wang
  • Jingyuan Li
  • Bo Zhou
  • Deqiang Wang
  • Phil De Luna
  • Mei Feng
  • Jingwei Bai
  • Hongbo Peng
  • Gustavo Stolovitzky
  • Christopher Maffeo
  • Edward H Sargent
  • Jagotamoy Das
  • Shana O Kelley
  • Sahar S Mahshid
  • Hongsuk Kang
  • Zaixing Yang
  • Eric Joseph
  • Stanislav Polonsky
  • Lynn Gignac
  • Robert Bruce
  • Sung Wook Nam
  • S Papa Rao
  • Stephen Rossnagel
  • Phil Waggoner
  • Venkat Balagurusamy
  • Mike Guillorn
  • Ali Afzali-Ardakani
  • Kathleen Reuter
  • Young Kwark
  • Yann Astier
  • Ajay Royyuru
  • Ernst Kratschmer
  • Markus Brink

Detail Information

Publications27

  1. doi request reprint Complete wetting of graphene by biological lipids
    Binquan Luan
    Department of Physics, Zhejiang University, Hangzhou, 310027, China and IBM Research at T J Watson Center, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA
    Nanoscale 8:5750-4. 2016
    ..Our simulation results suggest that biological lipids can completely wet the concave, flat or even convex (with a small curvature) surface of a graphene sheet. ..
  2. doi request reprint Controlled transport of DNA through a Y-shaped carbon nanotube in a solid membrane
    Binquan Luan
    IBM Research at T J Watson Center, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA
    Nanoscale 6:11479-83. 2014
    ..The controlled motion of DNA in the Y-CNT is expected to enhance the accuracy of nanopore-based DNA sequencing. ..
  3. doi request reprint Dynamics of DNA translocation in a solid-state nanopore immersed in aqueous glycerol
    Binquan Luan
    IBM T J Watson Research Center, Yorktown Heights, 10598, USA
    Nanotechnology 23:455102. 2012
    ..Simulation results of slowing ssDNA translocation were confirmed in our nanopore experiment...
  4. pmc Characterizing and controlling the motion of ssDNA in a solid-state nanopore
    Binquan Luan
    IBM T J Watson Research Center, Yorktown Heights, New York, USA
    Biophys J 101:2214-22. 2011
    ..The simulated translocation of ssDNA in the DNA transistor was theoretically characterized using Fokker-Planck analysis...
  5. pmc Slowing and controlling the translocation of DNA in a solid-state nanopore
    Binquan Luan
    IBM Research, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA
    Nanoscale 4:1068-77. 2012
    ..In this article, we review computational studies on how to slow down and control the DNA translocation through a solid-state nanopore...
  6. pmc Tribological effects on DNA translocation in a nanochannel coated with a self-assembled monolayer
    Binquan Luan
    IBM T J Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, New York 10598, USA
    J Phys Chem B 114:17172-6. 2010
    ..This work also demonstrates that traditional tribology methods can be deployed to study a biological or biomimetic transport process...
  7. pmc Control and reversal of the electrophoretic force on DNA in a charged nanopore
    Binquan Luan
    T J Watson Research Center, IBM, 1101 Kitchawan Road, Yorktown Heights, NY, USA
    J Phys Condens Matter 22:454123. 2010
    ..Our work suggests a physical mechanism to control DNA transport in a nanopore by chemical, electrical or electrochemical modification of the nanopore surface...
  8. doi request reprint Electrochemical characterization of thin film electrodes toward developing a DNA transistor
    Stefan Harrer
    IBM T J Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, New York 10598, United States
    Langmuir 26:19191-8. 2010
    ..These results are applicable to any system that requires nanoelectrodes placed in aqueous solution at voltages that can activate electrochemical processes...
  9. pmc Electrochemical protection of thin film electrodes in solid state nanopores
    Stefan Harrer
    IBM T J Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA
    Nanotechnology 22:275304. 2011
    ..The use of a protective self-assembled monolayer of hexadecylphosphonic acid (HDPA) was also investigated...
  10. pmc Base-by-base ratcheting of single stranded DNA through a solid-state nanopore
    Binquan Luan
    IBM T J Watson Research Center, PO Box 218, Yorktown Heights, New York 10598, USA
    Phys Rev Lett 104:238103. 2010
    ..The controlled ratcheting motion of DNA could potentially enhance the signal-to-noise ratio for nanoelectronic DNA sensing technologies...
  11. pmc Regulating the transport of DNA through biofriendly nanochannels in a thin solid membrane
    Deqiang Wang
    1 IBM T J Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, NY, 10598, USA 2
    Sci Rep 4:3985. 2014
    ..Our method to control the DNA motion inside a nanopore may find its applications in nanopore-based DNA sequencing devices. ..
  12. doi request reprint Potential Interference of Protein-Protein Interactions by Graphyne
    Binquan Luan
    Computational Biological Center, IBM Thomas J Watson Research, Yorktown Heights, New York 10598, United States
    J Phys Chem B 120:2124-31. 2016
    ..Our results help to elucidate the mechanism of interaction between graphyne and ppI networks within a biological cell and provide insights for its hazard reduction. ..
  13. pmc Electro-osmotic screening of the DNA charge in a nanopore
    Binquan Luan
    Department of Physics, University of Illinois at Urbana Champaign, 1110 West Green Street, Urbana, Illinois 61801, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 78:021912. 2008
    ..Using this relationship, we suggest a method for determining the effective driving force on DNA in a nanopore that does not require a direct force measurement...
  14. pmc An electro-hydrodynamics-based model for the ionic conductivity of solid-state nanopores during DNA translocation
    Binquan Luan
    IBM Research, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA
    Nanotechnology 24:195702. 2013
    ....
  15. pmc End-to-end attraction of duplex DNA
    Christopher Maffeo
    Department of Physics, University of Illinois at Urbana Champaign, 1110 W Green Street, Urbana, IL 61801, USA
    Nucleic Acids Res 40:3812-21. 2012
    ..The relation between the stacking free energy and end-to-end attraction is discussed as well as possible roles of the end-to-end interaction in biological and nanotechnological systems...
  16. pmc DNA attraction in monovalent and divalent electrolytes
    Binquan Luan
    University of Illinois at Urbana Champaign, Department of Physics, 1110 West Green Street, Urbana, Illinois 61801, USA
    J Am Chem Soc 130:15754-5. 2008
    ..The effective force in divalent electrolytes was predominantly attractive, reaching a maximum of 42 pN per one turn of a DNA helix...
  17. pmc Strain softening in stretched DNA
    Binquan Luan
    Department of Physics, University of Illinois at Urbana Champaign, 1110 W Green Street, Urbana, Illinois 61801, USA
    Phys Rev Lett 101:118101. 2008
    ..The simulations revealed that strain softening may occur in the process of stretching torsionally constrained DNA. The latter observation was qualitatively reconciled with available experimental data using a random-field Ising model...
  18. pmc The effect of calcium on the conformation of cobalamin transporter BtuB
    Binquan Luan
    Department of Physics, University of Illinois, Urbana, Illinois 61801, USA
    Proteins 78:1153-62. 2010
    ..Finally, we characterize conformation dynamics of the TonB box in different X-ray structures and find an interesting correlation between the stability of the TonB box structure and calcium binding...
  19. doi request reprint Simplified TiO2 force fields for studies of its interaction with biomolecules
    Binquan Luan
    IBM T J Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, New York 10598, USA
    J Chem Phys 142:234102. 2015
    ..We demonstrate that these simulation results are consistent with experimental data/observations. We expect that simulations will help to better understand the interaction between TiO2 and molecules. ..
  20. doi request reprint Nanopore-Based Sensors for Ligand-Receptor Lead Optimization
    Binquan Luan
    Computational Biology Center, IBM Thomas J Watson Research, Yorktown Heights, New York 10598, United States
    J Phys Chem Lett 6:331-7. 2015
    ..It is expected that the application of this single-molecule technology could help to accelerate the drug discovery, particularly for processes of the narrow screening and further lead optimization. ..
  21. doi request reprint Nanomechanics of Protein Unfolding Outside a Generic Nanopore
    Binquan Luan
    Computational Biological Center, IBM Thomas J Watson Research, Yorktown Heights, New York 10598, United States
    ACS Nano 10:317-23. 2016
    ..Simulation results also unveiled different nanomechanics, tearing fracture vs shearing friction, in these two distinct types of mechanical unfoldings. ..
  22. pmc Structure refinement of the OpcA adhesin using molecular dynamics
    Binquan Luan
    Department of Physics, University of Illinois, Urbana, Illinois, USA
    Biophys J 93:3058-69. 2007
    ..The loops form a funnel that leads to the base of the beta-barrel and that includes Tyr-169 on its exposed surface, which has been implicated in proteoglycan binding...
  23. doi request reprint Potential toxicity of graphene to cell functions via disrupting protein-protein interactions
    Binquan Luan
    Computational Biological Center, IBM Thomas J Watson Research, Yorktown Heights, New York 10598, United States
    ACS Nano 9:663-9. 2015
    ..The forced separation of two functional proteins can disrupt the cell's metabolism and even lead to the cell's mortality. ..
  24. doi request reprint Potential disruption of protein-protein interactions by graphene oxide
    Mei Feng
    Department of Physics, Institute of Quantitative Biology, Zhejiang University, Hangzhou 310027, China
    J Chem Phys 144:225102. 2016
    ..This study helps to better understand the toxicity of GO to cell functions which could shed light on how to improve its biocompatibility and biosafety for its wide potential biomedical applications. ..
  25. doi request reprint High-Curvature Nanostructuring Enhances Probe Display for Biomolecular Detection
    Phil De Luna
    Computational Biology Center, IBM Thomas J Watson Research Center, Yorktown Heights, New York 10598, United States
    Nano Lett . 2017
    ....
  26. doi request reprint Controlling the motion of DNA in a nanochannel with transversal alternating electric voltages
    Binquan Luan
    IBM T J Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, 10598, USA
    Nanotechnology 25:265101. 2014
    ..It is expected that achieving the controlled motion of DNA in the channel can advance studies and applications of a nanochannel-based sensor for analyzing DNA (e.g., DNA sequencing). ..
  27. doi request reprint Fabrication of sub-20 nm nanopore arrays in membranes with embedded metal electrodes at wafer scales
    Jingwei Bai
    IBM T J Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA
    Nanoscale 6:8900-6. 2014
    ..This fabrication approach can potentially pave the way to manufacturable nanopore arrays with the ability to electrically control the movement of single or double-stranded DNA inside the pore with embedded electrodes...