Bernardetta Nardelli

Summary

Affiliation: Human Genome Sciences
Country: USA

Publications

  1. ncbi Dendritic cells and MPIF-1: chemotactic activity and inhibition of endogenous chemokine production by IFN-gamma and CD40 ligation
    B Nardelli
    Human Genome Sciences, Inc, Rockville, Maryland 20850, USA
    J Leukoc Biol 65:822-8. 1999
  2. ncbi Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system
    Bernardetta Nardelli
    Human Genome Sciences, Rockville, MD 20850, USA
    J Immunol 169:4822-30. 2002
  3. ncbi B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases
    Bernardetta Nardelli
    Human Genome Sciences, Inc, Rockville, MD, USA
    Leuk Lymphoma 43:1367-73. 2002
  4. ncbi Synthesis and release of B-lymphocyte stimulator from myeloid cells
    B Nardelli
    Human Genome Sciences, Inc, Rockville, MD 20850, USA
    Blood 97:198-204. 2001
  5. ncbi Osteostat/tumor necrosis factor superfamily 18 inhibits osteoclastogenesis and is selectively expressed by vascular endothelial cells
    Bernardetta Nardelli
    Human Genome Sciences, Inc, Rockville, Maryland 20850, USA
    Endocrinology 147:70-8. 2006
  6. ncbi An IFN-beta-albumin fusion protein that displays improved pharmacokinetic and pharmacodynamic properties in nonhuman primates
    Cynthia Sung
    Human Genome Sciences, Inc, Rockville, MD 20850, USA
    J Interferon Cytokine Res 23:25-36. 2003
  7. pmc Selective induction of tumor necrosis receptor factor 6/decoy receptor 3 release by bacterial antigens in human monocytes and myeloid dendritic cells
    Sunghee Kim
    Human Genome Sciences Inc, Rockville, Maryland 20850, USA
    Infect Immun 72:89-93. 2004
  8. ncbi BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases
    Viktor Roschke
    Department of Antibody Development, Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    J Immunol 169:4314-21. 2002
  9. ncbi Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in cynomolgus monkeys
    Blaire L Osborn
    Human Genome Sciences, Inc, 9410 Key West Avenue, Rockville, MD 20850, USA
    J Pharmacol Exp Ther 303:540-8. 2002
  10. pmc DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    Mikhail B Litinskiy
    Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:822-9. 2002

Collaborators

Detail Information

Publications14

  1. ncbi Dendritic cells and MPIF-1: chemotactic activity and inhibition of endogenous chemokine production by IFN-gamma and CD40 ligation
    B Nardelli
    Human Genome Sciences, Inc, Rockville, Maryland 20850, USA
    J Leukoc Biol 65:822-8. 1999
    ..Thus, in dendritic cells the regulation of the production and release of MPIF-1 is distinct in comparison to other CC and CXC chemokines...
  2. ncbi Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system
    Bernardetta Nardelli
    Human Genome Sciences, Rockville, MD 20850, USA
    J Immunol 169:4822-30. 2002
    ..The pattern of cytokines induced by IFN-kappa in monocytes, coupled with the unique induction of IFN-kappa mRNA by IFN-gamma, indicates a potential role for IFN-kappa in the regulation of immune cell functions...
  3. ncbi B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases
    Bernardetta Nardelli
    Human Genome Sciences, Inc, Rockville, MD, USA
    Leuk Lymphoma 43:1367-73. 2002
    ..This review discusses the therapeutic potential of BLyS in the context of BLyS structure, function and receptor specificity...
  4. ncbi Synthesis and release of B-lymphocyte stimulator from myeloid cells
    B Nardelli
    Human Genome Sciences, Inc, Rockville, MD 20850, USA
    Blood 97:198-204. 2001
    ..These results provide further support for an important role for BLyS expressed in myeloid cells in B-cell expansion and antibody responses...
  5. ncbi Osteostat/tumor necrosis factor superfamily 18 inhibits osteoclastogenesis and is selectively expressed by vascular endothelial cells
    Bernardetta Nardelli
    Human Genome Sciences, Inc, Rockville, Maryland 20850, USA
    Endocrinology 147:70-8. 2006
    ..These findings demonstrate that Osteostat is a novel regulator of osteoclast generation and substantiate the major role played by the endothelium in bone physiology...
  6. ncbi An IFN-beta-albumin fusion protein that displays improved pharmacokinetic and pharmacodynamic properties in nonhuman primates
    Cynthia Sung
    Human Genome Sciences, Inc, Rockville, MD 20850, USA
    J Interferon Cytokine Res 23:25-36. 2003
    ..The enhanced in vivo pharmacologic properties of IFN-beta when fused to serum albumin suggest a clinical opportunity for improved IFN-beta therapy...
  7. pmc Selective induction of tumor necrosis receptor factor 6/decoy receptor 3 release by bacterial antigens in human monocytes and myeloid dendritic cells
    Sunghee Kim
    Human Genome Sciences Inc, Rockville, Maryland 20850, USA
    Infect Immun 72:89-93. 2004
    ..In agreement with the in vitro data, TR6 levels in serum were significantly elevated in patients with bacterial infections. Overall, these data suggest a novel role for TR6 in immune responses to bacteria...
  8. ncbi BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases
    Viktor Roschke
    Department of Antibody Development, Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    J Immunol 169:4314-21. 2002
    ..These findings raise the possibility that active BLyS/APRIL heterotrimers may play a role in rheumatic and other autoimmune diseases and that other members of the TNF ligand superfamily may also form active soluble heterotrimers...
  9. ncbi Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in cynomolgus monkeys
    Blaire L Osborn
    Human Genome Sciences, Inc, 9410 Key West Avenue, Rockville, MD 20850, USA
    J Pharmacol Exp Ther 303:540-8. 2002
    ....
  10. pmc DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    Mikhail B Litinskiy
    Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:822-9. 2002
    ..By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses...
  11. ncbi Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases
    Patrizia Scapini
    Department of Pathology, University of Verona, Verona, Italy
    Blood 105:830-7. 2005
    ..Collectively, our data uncover a novel mechanism that might dramatically exacerbate the release of BLyS by neutrophils during pathologic inflammatory responses...
  12. ncbi Analysis of IFN-kappa expression in pathologic skin conditions: downregulation in psoriasis and atopic dermatitis
    Claudia Scarponi
    Laboratory of Immunology and Allergology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    J Interferon Cytokine Res 26:133-40. 2006
    ..Given the difference in IFN-kappa expression levels in the skin disorders examined, IFN-kappa presence or deficiency might have different pathogenetic consequences depending also on other disease-specific intrinsic alterations...
  13. pmc G-CSF-stimulated neutrophils are a prominent source of functional BLyS
    Patrizia Scapini
    Department of Pathology, University of Verona, 37134 Verona, Italy
    J Exp Med 197:297-302. 2003
    ..Collectively, our findings suggest that neutrophils, through the production of BLyS, might play an unsuspected role in the regulation of B cell homeostasis...
  14. ncbi Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis
    Marco A Cassatella
    Department of Pathology, Division of General Pathology, University of Verona, Verona, Italy
    J Immunol 178:7325-33. 2007
    ....