Robert L Copeland

Summary

Affiliation: Howard University
Country: USA

Publications

  1. ncbi request reprint Cytotoxicity of 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone in androgen-dependent and -independent prostate cancer cell lines
    Robert L Copeland
    Department of Pharmacology, College of Medicine and Cancer Center, Howard University, Washington, DC 20059, USA
    Anticancer Res 27:1537-46. 2007
  2. ncbi request reprint Biological evaluation of 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone as an anti-breast cancer agent
    Yasmine M Kanaan
    Department of Pharmacologycer, and Howard University, Washington, DC 20059, USA
    Anticancer Res 29:191-9. 2009
  3. pmc Cytotoxic effects of N-(3-chloro-1,4-dioxo 1,4-dihydro-naphthalen-2-yl)-benzamide on androgen-dependent and -independent prostate cancer cell lines
    Yasmine M Kanaan
    Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA
    Anticancer Res 30:519-27. 2010
  4. ncbi request reprint Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicity
    Robert L Copeland
    Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
    Neurotox Res 12:61-9. 2007
  5. pmc Vitamin D receptor genetic polymorphisms are associated with PSA level, Gleason score and prostate cancer risk in African-American men
    Emmanuel Y Jingwi
    Cancer Center, Howard University, Washington, DC, U S A
    Anticancer Res 35:1549-58. 2015
  6. pmc Synthesis and cytotoxic activities of some 2-arylnaphtho[2,3-d]oxazole-4,9-dione derivatives on androgen-dependent (LNCaP) and androgen-independent (PC3) human prostate cancer cell lines
    Yakini Brandy
    Department of Chemistry, Howard University, Washington, DC 20059, USA
    Invest New Drugs 30:1709-14. 2012
  7. ncbi request reprint Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell
    Yousef Tizabi
    Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
    Alcohol Alcohol 42:413-6. 2007
  8. ncbi request reprint Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens
    Yousef Tizabi
    Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
    Alcohol Clin Exp Res 26:394-9. 2002
  9. doi request reprint Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines
    Emmanuel S Akinboye
    Department of Chemistry, Howard University, 525 College St NW, Washington, DC 20059, USA The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins School of Medicine, 1650 Orleans St, Baltimore, MD 21231, USA
    Bioorg Med Chem 23:5839-45. 2015
  10. ncbi request reprint Use of tanning potential as a predictor for prostate cancer risk in African-American men
    Desta Beyene
    Howard University Cancer Center, College of Medicine, Howard University, Washington, DC, U S A
    In Vivo 28:1181-7. 2014

Collaborators

  • Oladapo Bakare
  • Y Tizabi
  • Yanfei Zhou
  • Bernard Kwabi-Addo
  • Robert Williams
  • Yasmine M Kanaan
  • Desta Beyene
  • Zebalda D Bamji
  • Tammey J Naab
  • Emmanuel Y Jingwi
  • Emmanuel S Akinboye
  • Luisel Ricks-Santi
  • Agnes Day
  • Olakunle O Kassim
  • Samuel R Denmeade
  • Yakini Brandy
  • Jharna R Das
  • Solomon Berhe
  • Georgia M Dunston
  • Muneer Abbas
  • Danyelle Winchester
  • Kareem N Washington
  • Emmanuel Akinboye
  • David Ejeh
  • Wayne Frederick
  • Kwesi W Blackman
  • Luisel J Ricks-Santi
  • Victor Apprey
  • Edward Gabrielson
  • Brante P Sampey
  • Robert L DeWitty
  • Sylvia Dasi
  • Ashwini K Esnakula
  • Mohammad Daremipouran
  • Innocent Ononiwu
  • Vonetta Williams
  • Yasmine Kanaan
  • Dwayne A Wright
  • Ray J Butcher
  • Dolapo Adedeji
  • Claudia Mouamba
  • Hillaire Kenguele
  • Agnes A Day
  • Douglas F White
  • Vonita Williams
  • Nkechi M Enwerem

Detail Information

Publications13

  1. ncbi request reprint Cytotoxicity of 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone in androgen-dependent and -independent prostate cancer cell lines
    Robert L Copeland
    Department of Pharmacology, College of Medicine and Cancer Center, Howard University, Washington, DC 20059, USA
    Anticancer Res 27:1537-46. 2007
    ..DU-145) human prostate cancer cell lines, and/or a normal bone marrow cell line (HS-5). Moreover, the in vitro activity of this compound on cell cycle regulation and apoptosis was evaluated...
  2. ncbi request reprint Biological evaluation of 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone as an anti-breast cancer agent
    Yasmine M Kanaan
    Department of Pharmacologycer, and Howard University, Washington, DC 20059, USA
    Anticancer Res 29:191-9. 2009
    ..Moreover, the in vitro activity of this compound on cell cycle regulation and apoptosis were evaluated...
  3. pmc Cytotoxic effects of N-(3-chloro-1,4-dioxo 1,4-dihydro-naphthalen-2-yl)-benzamide on androgen-dependent and -independent prostate cancer cell lines
    Yasmine M Kanaan
    Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA
    Anticancer Res 30:519-27. 2010
    ..Specifically, the in vitro activity of this compound on cell cycle regulation and apoptosis was evaluated...
  4. ncbi request reprint Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicity
    Robert L Copeland
    Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
    Neurotox Res 12:61-9. 2007
    ..Hence, nicotinic agonists in combination with other antiapoptotic agents may be of substantial benefit in at least a subpopulation of Parkinson patients...
  5. pmc Vitamin D receptor genetic polymorphisms are associated with PSA level, Gleason score and prostate cancer risk in African-American men
    Emmanuel Y Jingwi
    Cancer Center, Howard University, Washington, DC, U S A
    Anticancer Res 35:1549-58. 2015
    ..To investigate whether VDR SNPs are associated with PCa risk in African-American (AA) men, nine VDR SNPs were analyzed in a case-control study...
  6. pmc Synthesis and cytotoxic activities of some 2-arylnaphtho[2,3-d]oxazole-4,9-dione derivatives on androgen-dependent (LNCaP) and androgen-independent (PC3) human prostate cancer cell lines
    Yakini Brandy
    Department of Chemistry, Howard University, Washington, DC 20059, USA
    Invest New Drugs 30:1709-14. 2012
    ..The meta-substituted 2-(3-Chloro-phenyl)-naphtho[2,3-d]oxazole-4,9-dione (10) appear to display the best cytotoxicity on both cell lines with an IC(50) of 0.03 μM on LNCaP and 0.08 μM on PC3 after 5 days of exposure...
  7. ncbi request reprint Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell
    Yousef Tizabi
    Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
    Alcohol Alcohol 42:413-6. 2007
    ..Moreover, to also investigate whether nicotinic receptors may be mediating these effects of alcohol and nicotine, the effects of mecamylamine, a nicotinic receptor antagonist was also evaluated...
  8. ncbi request reprint Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens
    Yousef Tizabi
    Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
    Alcohol Clin Exp Res 26:394-9. 2002
    ....
  9. doi request reprint Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines
    Emmanuel S Akinboye
    Department of Chemistry, Howard University, 525 College St NW, Washington, DC 20059, USA The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins School of Medicine, 1650 Orleans St, Baltimore, MD 21231, USA
    Bioorg Med Chem 23:5839-45. 2015
    ..079 ± 0.003 μM) on day 7 of treatment. Consequently, it appears that S-alkylation of compound 1 leads to a more stable dithiocarbamate ester derivative that resulted in lower anticancer activity in the prostate cancer cell lines...
  10. ncbi request reprint Use of tanning potential as a predictor for prostate cancer risk in African-American men
    Desta Beyene
    Howard University Cancer Center, College of Medicine, Howard University, Washington, DC, U S A
    In Vivo 28:1181-7. 2014
    ....
  11. ncbi request reprint Apoptotic Effects of Novel Dithiocarbamate Analogs of Emetine in Prostate Cancer Cell Lines
    Zebalda D Bamji
    Division of Medical Genetics, Department of Pediatrics and Child Health, College of Medicine, Howard University, Washington, DC, U S A
    Anticancer Res 35:4723-32. 2015
    ..The leading key compounds, EMTDTC-55 and EMTDTC-56 were studied...
  12. ncbi request reprint Metabolic profile of triple-negative breast cancer in African-American women reveals potential biomarkers of aggressive disease
    Yasmine M Kanaan
    Howard University, Washington, DC, U S A
    Cancer Genomics Proteomics 11:279-94. 2014
    ..These studies demonstrate that TNBC tumors have metabolic signatures that distinguish them from ER(+) tumors and suggest that distinctive metabolic characteristics of these tumors might offer new targets for treatment...
  13. ncbi request reprint Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson's disease
    Robert L Copeland
    Department of Pharmacology and Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA
    Neurotox Res 8:289-93. 2005
    ..It is suggested that selective nicotinic agonists may be of therapeutic potential in at least a subpopulation of Parkinsonian patients...