Genomes and Genes
Samuel B Ho
- Characterization of the mouse Muc3 membrane bound intestinal mucin 5' coding and promoter regions: regulation by inflammatory cytokinesLaurie L Shekels
Department of Medicine, University of Minnesota and VA Medical Center, Research 151, 1 Veterans Drive, Minneapolis, MN 55417, USA
Biochim Biophys Acta 1627:90-100. 2003..TNF alpha and IFN gamma showed lesser stimulation. These data indicate that cytokines and growth factors are capable of regulating Muc3 gene expression, suggesting that this protein may play an active role in intestinal mucosal defense...
- Neutrophil elastase induces mucus cell metaplasia in mouse lungJudith A Voynow
Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
Am J Physiol Lung Cell Mol Physiol 287:L1293-302. 2004..The addition of AAPV-CMK reduced these measures of inflammation to control levels. These experiments suggest that NE proteolytic activity initiates an inflammatory process leading to goblet cell metaplasia...
- Prospective multicenter study of eligibility for antiviral therapy among 4,084 U.S. veterans with chronic hepatitis C virus infectionEdmund J Bini
VA New York Harbor Healthcare System and NYU School of Medicine, New York, New York 10010, USA
Am J Gastroenterol 100:1772-9. 2005..The aims of this study were to determine the proportion of HCV-infected veterans who were eligible for interferon alfa and ribavirin therapy and to evaluate barriers to HCV treatment...
- Alcohol use and treatment of hepatitis C virus: results of a national multicenter studyBhupinder S Anand
Department of Medicine, Michael E DeBakey VA Medical Center, Houston, Texas, USA
Gastroenterology 130:1607-16. 2006..The aim of the study was to determine the impact of alcohol use on HCV treatment outcomes...
- Clinical implications of hepatic steatosis in patients with chronic hepatitis C: a multicenter study of U.S. veteransKe Qin Hu
Loma Linda VA Medical Center, Loma Linda, CA, USA
Dig Dis Sci 52:570-8. 2007..We found that steatosis is independently associated with stage III-IV fibrosis. However, only HCV genotype, and not steatosis, obesity, or stage III-IV fibrosis, was associated with SVR to interferon alpha-2b and ribavirin treatment...
- Efficacy of Sofosbuvir Plus Ribavirin in Veterans With Hepatitis C Virus Genotype 2 Infection, Compensated Cirrhosis, and Multiple ComorbiditiesSamuel B Ho
Veterans Affairs San Diego Healthcare System, San Diego, California Electronic address
Clin Gastroenterol Hepatol . 2016..This population is often excluded from clinical studies...
- Integrated Care Increases Treatment and Improves Outcomes of Patients With Chronic Hepatitis C Virus Infection and Psychiatric Illness or Substance AbuseSamuel B Ho
Gastroenterology Section, Medicine Service, VA San Diego Healthcare System, San Diego, California Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, California Electronic address
Clin Gastroenterol Hepatol 13:2005-14.e1-3. 2015....
- Intestinal goblet cells and mucins in health and disease: recent insights and progressYoung S Kim
Genemed Biotechnologies, 458 Carlton Court, South San Francisco, CA 94080, USA
Curr Gastroenterol Rep 12:319-30. 2010..Further elucidation of the regulatory mechanisms involved in mucin changes in cancer and inflammation may lead to the development of novel therapeutic approaches...
- Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healingSamuel B Ho
Department of Medicine, Veterans Affairs Medical Center and University of Minnesota, Minneapolis, Minnesota, USA
Gastroenterology 131:1501-17. 2006..Muc3 intestinal mucin contains an extracellular cysteine-rich domain with 2 epidermal growth factor (EGF)-like motifs. The aim of this study was to determine the functional properties of Muc3 proteins...
- U.S. multicenter pilot study of daily consensus interferon (CIFN) plus ribavirin for "difficult-to-treat" HCV genotype 1 patientsSamuel B Ho
VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Dig Dis Sci 56:880-8. 2011..The purpose of this pilot study was to determine the efficacy and safety of daily CIFN + RBV for initial treatment of patients with HCV-1 infection...
- Activity of recombinant cysteine-rich domain proteins derived from the membrane-bound MUC17/Muc3 family mucinsSamuel B Ho
Department of Medicine, University of California San Diego, San Diego, CA, USA
Biochim Biophys Acta 1800:629-38. 2010..The purpose of this study was to determine the effect of size, recombinant host source, and external tags on mucin CRD1-L-CRD2 protein activity...
- Outcomes of a Hepatitis C screening program at a large urban VA medical centerHolly Groom
Department of Medicine, University of Minnesota, Minneapolis, MN, USA
J Clin Gastroenterol 42:97-106. 2008..To determine the outcomes of implementing clinical care guidelines for Hepatitis C screening, evaluation, and treatment in a large urban Veterans Affairs Medical Center...
- Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitisYing Luu
Department of Medicine, VA San Diego Healthcare System and University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, United States
Int J Biochem Cell Biol 42:996-1006. 2010..The purpose of this study was to determine the functional activity of human MUC17 membrane-bound mucin...
- Suicidal ideation during interferon-alpha2b and ribavirin treatment of patients with chronic hepatitis CEric Dieperink
Department of Medicine, Veterans Affairs Medical Center, Minneapolis, MN, USA
Gen Hosp Psychiatry 26:237-40. 2004..No subjects attempted suicide. Although SI in some form is common in hepatitis C patients, in most cases it is mild in nature. With adequate support most patients can successfully complete a full course of antiviral treatment...
- The effect of pegylated interferon-alpha2b and ribavirin on posttraumatic stress disorder symptomsEric Dieperink
Dept of Psychiatry and the Hepatitis C Resource Center at the VA Medical Center, Minneapolis, MN 55417, USA
Psychosomatics 49:225-9. 2008..Patients with chronic psychiatric diagnoses have a prevalence of chronic hepatitis C (HCV) approximately 11 times higher than the general American population. Posttraumatic stress disorder (PTSD) is particularly common among HCV patients...
- Increasing antiviral treatment through integrated hepatitis C care: a randomized multicenter trialErik J Groessl
VA San Diego Healthcare System, USA
Contemp Clin Trials 35:97-107. 2013..The Integrated Care intervention has the potential to transform HCV antiviral treatment by increasing the number of HCV-infected individuals that can be successfully treated. ..
- Significant reductions in drinking following brief alcohol treatment provided in a hepatitis C clinicEric Dieperink
Minneapolis Hepatitis C Resource Center, Minneapolis VA Medical Center, University of Minnesota School of Medicine, Minnesota, USA
Psychosomatics 51:149-56. 2010..Although the hepatitis C virus (HCV) alone increases the risk of cirrhosis, alcohol use is thought to act synergistically with HCV to significantly hasten the development of fibrosis...
- Integrated psychiatric/medical care in a chronic hepatitis C clinic: effect on antiviral treatment evaluation and outcomesAstrid Knott
Hepatitis C Resource Center, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
Am J Gastroenterol 101:2254-62. 2006..We evaluated the effect of integrating psychiatric and medical care on evaluation for and initiation of antiviral treatment in a cohort of 184 patients with chronic hepatitis C...
- Cost-effectiveness of a mailed educational reminder to increase colorectal cancer screeningJeffrey K Lee
Department of Medicine, VA San Diego Healthcare System and University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
BMC Gastroenterol 11:93. 2011..2% among U.S. Veterans. The aim of our study was to assess the costs and cost-effectiveness of a mailed educational reminder on fecal occult blood test (FOBT) adherence...
- Integrating hepatitis prevention services into a substance use disorder clinicHildi Hagedorn
Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
J Subst Abuse Treat 32:391-8. 2007..The importance of providing comprehensive educational sessions and recommendations for how patients with substance use disorders can access hepatitis screening, vaccination, and treatment resources are stressed...
- Development of the hepatitis C self-management programErik J Groessl
Health Services Research and Development, VA San Diego Healthcare System, San Diego, CA 92161, USA
Patient Educ Couns 83:252-5. 2011..Herein, we describe a recently developed self-management program designed to assist HCV-infected patients with adherence and improve their health-related quality of life (HRQOL)...
- National patterns and predictors of liver biopsy use for management of hepatitis CErik J Groessl
VA San Diego Healthcare System, San Diego, CA 92161, USA
J Hepatol 57:252-9. 2012..To identify the factors that influence the use of liver biopsy for HCV patients, we describe variations in liver biopsy use at the delivery system and patient level in a national VA sample...
- The hepatitis C self-management program: sustainability of primary outcomes at 1 yearErik J Groessl
1VA San Diego Healthcare System, San Diego, CA, USA
Health Educ Behav 40:730-40. 2013..Our objective was to evaluate whether the effects of the HCV self-management program were sustained at the 12-month follow-up assessment...
- Characteristics and impact of methamphetamine use in patients with chronic hepatitis CDana E Riley
From the Departments of Medicine DER, BC, SBH, Health Services Research and Development LL, EJG, and Psychiatry SR, VA San Diego Healthcare System, San Diego, CA and Departments of Family and Preventive Medicine LL, EJG, Medicine BC, SBH, and Psychiatry SR, University of California, San Diego
J Addict Med 8:25-32. 2014..The purpose of this study was to determine the characteristics and HCV infection outcomes of patients with a history of MA use...
- A prospective study of neuropsychiatric symptoms associated with interferon-alpha-2b and ribavirin therapy for patients with chronic hepatitis CEric Dieperink
Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
Psychosomatics 44:104-12. 2003..The control group of 13 untreated subjects showed little change over the 24-week period. All symptom scales were highly intercorrelated, suggesting that use of one is sufficient for monitoring symptoms...
- Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integritySilvia Resta-Lenert
Department of Medicine, University of California San Diego, USA
Am J Physiol Gastrointest Liver Physiol 300:G1144-55. 2011..In conclusion, these data suggest that both native and exogenous MUC17 play a role in attachment and invasion of EIEC in colonic cell lines and in maintaining epithelial barrier function...
- Long-term outcomes and prognostic factors for patients with endoscopy-negative iron deficiencyAnny Soon
Department of Medicine, Gastroenterology 111D, VA San Diego Healthcare System and University of California, San Diego, 3550 La Jolla Village Drive, San Diego, CA 92161, USA
Dig Dis Sci 58:488-95. 2013..The purpose of this study was to determine the long-term outcomes and predictors of gastrointestinal pathology and death in patients with endoscopy-negative IDA...
- Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial TranslocationLirui Wang
Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA Department of Medicine, VA San Diego Healthcare System, San Diego, CA 92161, USA
Cell Host Microbe 19:227-39. 2016..Thus, alcohol appears to impair control of the mucosa-associated microbiota, and subsequent breach of the mucosal barrier facilitates progression of alcoholic liver disease...
- Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesityPhillipp Hartmann
Department of Medicine, University of California San Diego, La Jolla, California
Am J Physiol Gastrointest Liver Physiol 310:G310-22. 2016..Our findings indicate that absence of the intestinal mucus layer activates the mucosal immune system. Higher IL-22 levels protect mice from diet-induced features of the metabolic syndrome. ..
- Improving the effectiveness of fecal occult blood testing in a primary care clinic by direct colonoscopy referral for positive testsErik Van Kleek
University of California, San Diego, CA, USA
J Healthc Qual 32:62-9. 2010..Inappropriate use of FOBT was observed in 49% of patients, indicating that further interventions in primary care clinics to improve the quality of FOBT screening are necessary...
- Improving fecal occult blood testing compliance using a mailed educational reminderJeffrey K Lee
Department of Medicine, VA San Diego Healthcare System and University of California, San Diego, CA 92161, USA
J Gen Intern Med 24:1192-7. 2009..Randomized controlled trials have shown that annual screening fecal occult blood testing (FOBT) reduces CRC mortality and incidence. However, patient compliance with FOBT is low...
- All-cause mortality and liver-related outcomes following successful antiviral treatment for chronic hepatitis CEric Dieperink
Department of Psychiatry 116A, Minneapolis Veterans Affairs Health Care System, One Veterans Drive, Minneapolis, MN, 55417, USA
Dig Dis Sci 59:872-80. 2014..Few studies are available from populations with multiple medical and psychiatric comorbidities where the impact of successful antiviral therapy might be limited...
- Management of chronic hepatitis C in veterans: the potential of integrated care modelsSamuel B Ho
Department of Medicine, VA San Diego Healthcare System and University of California, San Diego, California 92161, USA
Am J Gastroenterol 103:1810-23. 2008....
- Organizational change in management of hepatitis C: evaluation of a CME programJudith Garrard
Division of Health Services Research, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
J Contin Educ Health Prof 26:145-60. 2006..We describe a continuing medical education (CME) program for clinicians in a nationwide health care system, with emphasis on current treatment practices, multispecialty collaboration, and organizational change...
- Cost-Effectiveness of the Hepatitis C Self-Management ProgramErik J Groessl
VA San Diego Healthcare System, San Diego, CA, USA University of California, San Diego, CA, USA
Health Educ Behav . 2016..Self-management interventions can educate HCV-infected persons, improve their quality of life, and prepare them for treatment...
- Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in micePhillipp Hartmann
Department of Medicine, University of California San Diego, La Jolla, CA, USA
Hepatology 58:108-19. 2013..Consequently, Muc2(-/-) mice showed increased killing of commensal bacteria and prevented intestinal bacterial overgrowth...
- Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in bloodAkiko Eguchi
Department of Pediatrics, University of California San Diego, La Jolla, CA
Hepatology . 2016..Blood EV level (P < 0.01) and three miRNAs (P < 0.05) were significantly increased in patients with ambulatory mild ALD as compared to nonalcoholics...
- Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in micePeng Chen
Department of Medicine, University of California San Diego, La Jolla, CA
Hepatology 61:883-94. 2015..Using MLCK-deficient mice, we further demonstrate a partial contribution of MLCK to intestinal barrier dysfunction and liver disease after chronic alcohol feeding...
- Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in micePeng Chen
Department of Medicine, University of California San Diego, La Jolla, California
Gastroenterology 148:203-214.e16. 2015..However, little is known about how alterations to the microbiome contribute to pathogenesis of alcoholic liver disease...
- Living with hepatitis C: qualitative interviews with hepatitis C-infected veteransErik J Groessl
Health Services Research and Development, VA San Diego Healthcare System, San Diego, CA
J Gen Intern Med 23:1959-65. 2008..Chronic hepatitis C (HCV) infection affects millions of people in the USA and prevalence rates are higher in US veterans. The consequences of HCV infection include reduced quality of life, liver damage, and reduced longevity...
- Efficacy of daily induction dosing vs standard thrice weekly dosing of interferon-alpha2B for initial treatment of chronic hepatitis CHernando J Gonzalez
Veterans Affairs Medical Center and the University of Minnesota, Minneapolis, 55417, USA
Dig Dis Sci 47:784-92. 2002..9%) in the induction group compared with 13/68 (19.1%) in the noninduction group. These results indicate that an initial four week period of daily interferon confers no benefit in the treatment of patients with chronic hepatitis C...
- Quality of polyp resection during colonoscopy: are we achieving polyp clearance?Shanglei Liu
Gastroenterology, Department of Medicine, VA San Diego Healthcare System and University of California, San Diego, San Diego, CA 92161, USA
Dig Dis Sci 57:1786-91. 2012..The primary aim of this study was to determine the incidence of an incomplete polyp resection despite a perceived complete polypectomy...
- Spectrum of disease in U.S. veteran patients with hepatitis CHuy A Nguyen
Department of Medicine, Veterans Affairs Medical Center, University of Minnesota, Minneapolis 55417, USA
Am J Gastroenterol 97:1813-20. 2002..The purpose of this study was to examine the risk factors, psychiatric and substance abuse conditions, and severity of liver disease in veterans with HCV...
- Use of alveolar carbon monoxide to measure the effect of ribavirin on red blood cell survivalMark A Virtue
Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Am J Hematol 76:107-13. 2004..We conclude that RBV-associated anemia consistently is associated with reduced RBC survival as determined from breath CO measurements and that this reduced survival frequently is not associated with an elevated reticulocyte count...
- The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteinsSamuel B Ho
Department of Medicine, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota 55417, USA
Dig Dis Sci 49:1598-606. 2004..The physical stratification of mucin proteins may confer increased strength to the mucous layer or represent independent and redundant protection...
- Glycosyltransferase function in core 2-type protein O glycosylationErica L Stone
Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
Mol Cell Biol 29:3770-82. 2009..Although the absence of C2GnT and C4GnT activities is tolerable in vivo, core 2 O glycosylation exerts a significant influence on O-glycan biosynthesis and is important in multiple physiological processes...
- Coffee Consumption and the Incidence of Colorectal Cancer in WomenErik J Groessl
University of California, San Diego, La Jolla, CA, USA VA San Diego Healthcare System, San Diego, CA, USA
J Cancer Epidemiol 2016:6918431. 2016..Brew method results are novel and warrant further research. ..
- A Simple Dietary Questionnaire Correlates With Formal Dietitian Evaluation and Frequently Identifies Specific Clinical Interventions in an Outpatient Gastroenterology ClinicSterling M Dubin
Departments of Medicine, Nutrition, and Health Services Research and Development, VA San Diego Healthcare System Department of Medicine, University of California, San Diego, CA
J Clin Gastroenterol 50:e71-6. 2016..The spectrum of gastroenterology-related diseases related to obesity is growing. Few clinical tools exist to aid in clinician-guided dietary counseling...
- Opportunities for Improvement in the Care of Patients Hospitalized for Inflammatory Bowel Disease-Related ColitisNoel S Lee
VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA
Dig Dis Sci 61:1003-12. 2016..The degree to which providers adhere to these algorithms is unknown. This study evaluated the quality of care in IBD patients hospitalized for disease-associated exacerbations and factors correlated with higher degrees of care...
- Evaluating follow-up of positive fecal occult blood test results: lessons learnedZ John Chen
Minnesota Gastroenterology, P A, Minneapolis, MN, USA
J Healthc Qual 29:16-20, 34. 2007..Primary care providers often lacked knowledge regarding appropriate follow-up testing. More direct follow-up of positive FOBT results is recommended...
- Quantification of colorectal cancer micrometastases in lymph nodes by nested and real-time reverse transcriptase-PCR analysis for carcinoembryonic antigenSamuel B Ho
Departments of Medicine, Surgery, and Laboratory Medicine, Veterans Affairs Medical Center, Minneapolis, MN, USA
Clin Cancer Res 10:5777-84. 2004..These assays are not quantitative and can be confounded by false-positive results. The purpose of this study was to determine whether quantification of CEA in lymph nodes could more readily identify clinically relevant groups...
- Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levelsKoichi Hashimoto
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
J Allergy Clin Immunol 116:550-7. 2005....
- Expression of mucins in mucoid otitis mediaJizhen Lin
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
J Assoc Res Otolaryngol 4:384-93. 2003..Further study indicated that the mucin hyperproduction was significantly linked to CD4+ and CD8+ T cells and/or CD68+ monocyte macrophages. It suggests that MUC5B and MUC4 expression may be regulated by the products of these cells...
- Optimizing the dose and duration of therapy for chronic hepatitis CNipaporn Pichetshote
Department of Medicine, Health Services Research and Development, VA San Diego Healthcare System, and University of California, San Diego, CA and Hepatitis C Resource Center, VA Medical Center, San Francisco, CA, USA
Gut Liver 3:1-13. 2009..Individualized treatment based on viral genotype, viral load, the presence of advanced fibrosis, and initial virologic response can improve therapy for some patients and save resources in others...
- Chronic hepatitis C in Latinos: natural history, treatment eligibility, acceptance, and outcomesRamsey C Cheung
VA Palo Alto Healthcare System and Stanford University School of Medicine, Palo Alto, California 94304, USA
Am J Gastroenterol 100:2186-93. 2005..The natural history of chronic hepatitis C and treatment response are different between blacks and Caucasians, but little comparable data is available about Latinos...
- Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma modelLong P Nguyen
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, 4800 Calhoun, Houston, TX 77204 5037, USA
Am J Respir Cell Mol Biol 38:256-62. 2008..Similar to heart failure, our results provide a second disease model in which beta-blockers producing an acutely detrimental effect may provide a therapeutically beneficial effect with chronic administration...
- Expression of MUC2 and MUC4 proteins and cytokines: early markers of intestinal graft rejectionNir Wasserberg
Department of Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
Transplantation 75:1249-55. 2003..Alterations in mucin levels have been demonstrated in bowel diseases. The aim of this study was to detect early markers of intestinal graft rejection based on mucin and cytokine levels...
- Surveillance for hepatocellular carcinomaBashar A Aqel
Division of Gastroenterology and Hepatology, Hepatitis C Resource Center, Veterans Affairs Medical Center, University of Minnesota, Minneapolis 55417, USA
Postgrad Med 119:19-24. 2006
- Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virusNicholas W Lukacs
Department of Pathology, University of Michigan Medical School, 1301 Catherine St, Ann Arbor, MI 48109 0602, USA
Am J Pathol 169:977-86. 2006..These data demonstrate that different RSV strains of the same antigenic subgroup can elicit differential immune responses that impact the phenotypic expression of RSV-induced illness...
- Selective induction of mucin-3 by hypoxia in intestinal epitheliaNancy A Louis
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
J Cell Biochem 99:1616-27. 2006..Taken together, these studies implicate the HIF-1alpha mediated hypoxic induced expression of mucin 3 and associated ITF in the maintenance of intestinal barrier function under hypoxic conditions...
- Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5Koichi Hashimoto
Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA
Am J Respir Crit Care Med 170:306-12. 2004..The impact of virus infection combined with allergic inflammation on mucus production may partially explain the more severe disease and airway hyperresponsiveness associated with RSV in the setting of atopy...
- Can we predict the degree of fibrosis in chronic hepatitis C patients using routine blood tests in our daily practice?Ramsey C Cheung
VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA
J Clin Gastroenterol 42:827-34. 2008..To determine the validity of fibrosis indexes based on simple laboratory tests in daily practice...