Patrick J Pagano

Summary

Affiliation: Henry Ford Hospital
Country: USA

Publications

  1. ncbi request reprint Resistance of endothelium-dependent relaxation to elevation of O(-)(2) levels in rabbit carotid artery
    P J Pagano
    Vascular Biology Unit, Boston Medical Center, Boston, Massachusetts 02118, USA
    Am J Physiol 277:H2109-14. 1999
  2. pmc NO-mediated regulation of NAD(P)H oxidase by laminar shear stress in human endothelial cells
    Nicole Duerrschmidt
    University of Technology Dresden, Medical Faculty Carl Gustav Carus, Department of Vascular Endothelium and Microcirculation, Fetscherstr 74, D 01307 Dresden, Germany
    J Physiol 576:557-67. 2006
  3. ncbi request reprint Depolarization of the macula densa induces superoxide production via NAD(P)H oxidase
    Ruisheng Liu
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 292:F1867-72. 2007
  4. ncbi request reprint Perivascular superoxide anion contributes to impairment of endothelium-dependent relaxation: role of gp91(phox)
    Federico E Rey
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Circulation 106:2497-502. 2002
  5. pmc The adventitia: the outs and ins of vascular disease
    Patrick J Pagano
    Cardiovasc Res 75:636-9. 2007
  6. ncbi request reprint Adventitial fibroblast reactive oxygen species as autacrine and paracrine mediators of remodeling: bellwether for vascular disease?
    Mounir J Haurani
    Henry Ford Hospital, Detroit, Department of General Surgery, MI 48202 2689, USA
    Cardiovasc Res 75:679-89. 2007
  7. ncbi request reprint Comparison of H2O2-induced vasoconstriction in the abdominal aorta and mesenteric artery of the mouse
    Noelia Ardanaz
    Hypertension and Vascular Research Division, Henry Ford Health System, Detroit, MI 48202 2689, USA
    Vascul Pharmacol 47:288-94. 2007
  8. ncbi request reprint Vascular cell locomotion: osteopontin, NADPH oxidase, and matrix metalloproteinase-9
    Patrick J Pagano
    Circ Res 98:1453-5. 2006
  9. ncbi request reprint Hydrogen peroxide as a paracrine vascular mediator: regulation and signaling leading to dysfunction
    Noelia Ardanaz
    Hypertension and Vascular Research Division, RM 7044, E and R Building, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    Exp Biol Med (Maywood) 231:237-51. 2006
  10. ncbi request reprint Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: involvement of Nox2 (gp91phox)-containing NADPH oxidase
    Min Zhang
    Cardiovascular Division, King s College London, London, United Kingdom
    Circulation 113:1235-43. 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Resistance of endothelium-dependent relaxation to elevation of O(-)(2) levels in rabbit carotid artery
    P J Pagano
    Vascular Biology Unit, Boston Medical Center, Boston, Massachusetts 02118, USA
    Am J Physiol 277:H2109-14. 1999
    ..These findings support the hypothesis that peroxynitrite is the relaxing agent that resists high O(-)(2) in the carotid artery...
  2. pmc NO-mediated regulation of NAD(P)H oxidase by laminar shear stress in human endothelial cells
    Nicole Duerrschmidt
    University of Technology Dresden, Medical Faculty Carl Gustav Carus, Department of Vascular Endothelium and Microcirculation, Fetscherstr 74, D 01307 Dresden, Germany
    J Physiol 576:557-67. 2006
    ..This mechanism might contribute to the regulation of endothelial NO/.O(2)(-) balance and the vasoprotective potential of physiological levels of laminar shear stress...
  3. ncbi request reprint Depolarization of the macula densa induces superoxide production via NAD(P)H oxidase
    Ruisheng Liu
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 292:F1867-72. 2007
    ..We conclude that increasing luminal NaCl induces O(2)(-) production during tubuloglomerular feedback. O(2)(-) generated by the macula densa is primarily derived from NAD(P)H oxidase and is induced by depolarization...
  4. ncbi request reprint Perivascular superoxide anion contributes to impairment of endothelium-dependent relaxation: role of gp91(phox)
    Federico E Rey
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Circulation 106:2497-502. 2002
    ..and adventitial NAD(P)H oxidase-derived O2- contributes to impairment of endothelium-dependent relaxation (EDR)...
  5. pmc The adventitia: the outs and ins of vascular disease
    Patrick J Pagano
    Cardiovasc Res 75:636-9. 2007
  6. ncbi request reprint Adventitial fibroblast reactive oxygen species as autacrine and paracrine mediators of remodeling: bellwether for vascular disease?
    Mounir J Haurani
    Henry Ford Hospital, Detroit, Department of General Surgery, MI 48202 2689, USA
    Cardiovasc Res 75:679-89. 2007
    ..We will also survey other signaling pathways involving adventitial NAD(P)H oxidase ultimately leading to changes in vascular phenotype...
  7. ncbi request reprint Comparison of H2O2-induced vasoconstriction in the abdominal aorta and mesenteric artery of the mouse
    Noelia Ardanaz
    Hypertension and Vascular Research Division, Henry Ford Health System, Detroit, MI 48202 2689, USA
    Vascul Pharmacol 47:288-94. 2007
    ..Furthermore, we found that p38, ERK 1/2 and Rho-kinase play a role in H(2)O(2) constriction, which may be critical pathways involved in H(2)O(2)-induced constriction across vascular beds...
  8. ncbi request reprint Vascular cell locomotion: osteopontin, NADPH oxidase, and matrix metalloproteinase-9
    Patrick J Pagano
    Circ Res 98:1453-5. 2006
  9. ncbi request reprint Hydrogen peroxide as a paracrine vascular mediator: regulation and signaling leading to dysfunction
    Noelia Ardanaz
    Hypertension and Vascular Research Division, RM 7044, E and R Building, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    Exp Biol Med (Maywood) 231:237-51. 2006
    ..Taken together, these findings seem consistent with a paracrine effect of H(2)O(2) across the vascular wall...
  10. ncbi request reprint Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: involvement of Nox2 (gp91phox)-containing NADPH oxidase
    Min Zhang
    Cardiovascular Division, King s College London, London, United Kingdom
    Circulation 113:1235-43. 2006
    ..However, the effects of early-glycated proteins, such as glycated serum albumin (Gly-BSA), are poorly defined. In this study, we investigated the effects of Gly-BSA on reactive oxygen species (ROS) production by cardiomyocytes...
  11. ncbi request reprint Targeting reactive oxygen species in hypertension
    M Eugenia Cifuentes
    Hypertension and Vascular Research Division, Henry Ford Health System, Detroit, Michigan 48202, USA
    Curr Opin Nephrol Hypertens 15:179-86. 2006
    ..NADPH oxidase, the primary source of reactive oxygen species in the cardiovascular system, is a strong candidate for the development of therapeutic agents to ameliorate hypertension and end-organ damage...
  12. ncbi request reprint Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries
    Matthias Keller
    Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    FASEB J 20:702-4. 2006
    ..Our results indicate a mandatory role for Sk1/S1P in mediating pressure-induced, NADPH oxidase-derived ROS formation. In turn, ROS generation appears to increase Ca2+ sensitivity, necessary for full myogenic vasoconstriction...
  13. ncbi request reprint Reduced NAD(P)H oxidase in low renin hypertension: link among angiotensin II, atherogenesis, and blood pressure
    Ming Sheng Zhou
    Veterans Affairs Medical Center, Division of Nephrology and Hypertension, Vascular Biology Institute, University of Miami Miller School of Medicine, Miami, FL, USA
    Hypertension 47:81-6. 2006
    ..Our findings support the notion that in SS hypertension, activation of NAD(P)H oxidase promotes ED and atherogenesis via decreased nitric oxide bioactivity and increased LOX-1 and MCP-1, independent of blood pressure...
  14. ncbi request reprint Lack of inducible NO synthase reduces oxidative stress and enhances cardiac response to isoproterenol in mice with deoxycorticosterone acetate-salt hypertension
    Ying Sun
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Health System, Wayne State University, Detroit, MI 48202 2689, USA
    Hypertension 46:1355-61. 2005
    ....
  15. ncbi request reprint Perivascular gene transfer of NADPH oxidase inhibitor suppresses angioplasty-induced neointimal proliferation of rat carotid artery
    Hector M Dourron
    Division of Vascular Surgery, Henry Ford Health System, Detroit, Michigan, USA
    Am J Physiol Heart Circ Physiol 288:H946-53. 2005
    ....
  16. ncbi request reprint Cloning and sequencing of rabbit leukocyte NADPH oxidase genes reveals a unique p67(phox) homolog
    Katherine A Gauss
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, 59717, USA
    J Leukoc Biol 71:319-28. 2002
    ..These studies contribute to our understanding of the nature of the leukocyte NADPH oxidase in different species and will be valuable in future research using the rabbit model...
  17. ncbi request reprint Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II
    Rhian M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Canada
    Circ Res 90:1205-13. 2002
    ..These novel findings provide insight into the molecular regulation of NAD(P)H oxidase by Ang II in HVSMCs. Furthermore, we identify differences in gp91phox homologue expression in VSMCs from rats and human small and large arteries...
  18. ncbi request reprint Rac-dependent monocyte chemoattractant protein-1 production is induced by nutrient deprivation
    Neuza H M Lopes
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circ Res 91:798-805. 2002
    ..In conclusion, ND, an important component of ischemia, is sufficient to induce MCP-1 production by HAECs, and such production requires a functional Rac1, redox-dependent pathway...
  19. ncbi request reprint Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis
    Masuko Ushio-Fukai
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 91:1160-7. 2002
    ....
  20. ncbi request reprint The reactive adventitia: fibroblast oxidase in vascular function
    Federico E Rey
    Department of Microbiology, University of Iowa, Iowa City, USA
    Arterioscler Thromb Vasc Biol 22:1962-71. 2002
    ..A clearer understanding of the molecular mechanisms involved will likely lead to therapeutic strategies aimed at preventing vascular dysfunction in diseases such as atherosclerosis, in which these pathways are activated...
  21. ncbi request reprint Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension
    Lixin Li
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
    Circulation 107:1053-8. 2003
    ..However, the mechanisms underlying superoxide production in low-renin hypertension are undefined...
  22. ncbi request reprint Novel NAD(P)H oxidase inhibitor suppresses angioplasty-induced superoxide and neointimal hyperplasia of rat carotid artery
    Gary M Jacobson
    Hypertension and Vascular Research Division, Henry Ford Health System, Detroit, Mich, USA
    Circ Res 92:637-43. 2003
    ..Our data indicate that in response to balloon injury of the rat carotid artery, NAD(P)H oxidase activity contributes to neointimal hyperplasia and is involved in vascular cell proliferation and migration during restenosis...
  23. ncbi request reprint NAD(P)H oxidase mediates angiotensin II-induced vascular macrophage infiltration and medial hypertrophy
    Jianhua Liu
    Hypertension and Vascular Research Division and the Biostatistics Department, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, Mich 48202 2689, USA
    Arterioscler Thromb Vasc Biol 23:776-82. 2003
    ....
  24. ncbi request reprint c-Src and smooth muscle NAD(P)H oxidase: assembling a path to hypertrophy
    M Eugenia Cifuentes
    Arterioscler Thromb Vasc Biol 23:919-21. 2003
  25. ncbi request reprint Gene transfer of NAD(P)H oxidase inhibitor to the vascular adventitia attenuates medial smooth muscle hypertrophy
    Jianhua Liu
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Circ Res 95:587-94. 2004
    ..After treatment with Ad-gp91ds-eGFP, 4-HNE generation was normalized. Thus NAD(P)H oxidases in adventitial fibroblasts and macrophages appear to modulate Ang II-induced medial hypertrophy...
  26. doi request reprint Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration
    Mounir J Haurani
    Department of General Surgery, Hypertension and Vascular Research Division, Room 7044, E and R Building, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Hypertension 52:143-9. 2008
    ..05). Our data suggest that Nox4 promotes Ang II-induced myofibroblast migration via an H(2)O(2)-dependent pathway. The data also suggest that Nox4 causes feedback inhibition of its own expression in adventitial myofibroblasts...