Steven N Kalkanis

Summary

Affiliation: Henry Ford Hospital
Country: USA

Publications

  1. pmc The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Steven N Kalkanis
    Department of Neurosurgery, Henry Ford Health System, 2799 West Grand Blvd, K 11, Detroit, MI 48202, USA
    J Neurooncol 96:33-43. 2010
  2. pmc The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Laurie E Gaspar
    Department of Radiation Oncology, University of Colorado Denver, Denver, CO, USA
    J Neurooncol 96:17-32. 2010
  3. pmc The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Mark E Linskey
    Department of Neurosurgery, University of California Irvine Medical Center, Orange, CA, USA
    J Neurooncol 96:45-68. 2010
  4. pmc The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline
    Mario Ammirati
    Department of Neurosurgery, Ohio State University Medical Center, Columbus, OH, USA
    J Neurooncol 96:85-96. 2010
  5. pmc Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells
    Xin Hong
    Department of Neurology, Henry Ford Health Science Center, Detroit, MI, USA
    J Exp Clin Cancer Res 27:23. 2008
  6. pmc The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline
    Tom Mikkelsen
    Department of Neurology, Henry Ford Health System, Detroit, MI, USA
    J Neurooncol 96:97-102. 2010
  7. pmc Intracellular free calcium mediates glioma cell detachment and cytotoxicity after photodynamic therapy
    Xin Hong
    Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Lasers Med Sci 24:777-86. 2009
  8. doi request reprint The role of targeted therapies in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
    J Neurooncol 118:557-99. 2014
  9. pmc The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline
    Timothy C Ryken
    Department of Neurosurgery, Iowa Spine and Brain Institute, Iowa City, IA, USA
    J Neurooncol 96:103-14. 2010
  10. pmc The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
    J Neurooncol 96:115-42. 2010

Collaborators

Detail Information

Publications33

  1. pmc The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Steven N Kalkanis
    Department of Neurosurgery, Henry Ford Health System, 2799 West Grand Blvd, K 11, Detroit, MI 48202, USA
    J Neurooncol 96:33-43. 2010
    ..There is insufficient evidence to make a recommendation for patients with poor performance scores, advanced systemic disease, or multiple brain metastases...
  2. pmc The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Laurie E Gaspar
    Department of Radiation Oncology, University of Colorado Denver, Denver, CO, USA
    J Neurooncol 96:17-32. 2010
    ..Should patients with newly-diagnosed metastatic brain tumors undergo open surgical resection versus whole brain radiation therapy (WBRT) and/or other treatment modalities such as radiosurgery, and in what clinical settings?..
  3. pmc The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Mark E Linskey
    Department of Neurosurgery, University of California Irvine Medical Center, Orange, CA, USA
    J Neurooncol 96:45-68. 2010
    ....
  4. pmc The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline
    Mario Ammirati
    Department of Neurosurgery, Ohio State University Medical Center, Columbus, OH, USA
    J Neurooncol 96:85-96. 2010
    ..What evidence is available regarding the use of whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS), surgical resection or chemotherapy for the treatment of recurrent/progressive brain metastases?..
  5. pmc Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells
    Xin Hong
    Department of Neurology, Henry Ford Health Science Center, Detroit, MI, USA
    J Exp Clin Cancer Res 27:23. 2008
    ..Focal adhesion kinase (FAK) and extracellular signal-regulated kinase 1 (ERK1) signaling were not altered by heparanase-overexpression. These results indicate that heparanase has pleiotropic effects on tumor cells...
  6. pmc The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline
    Tom Mikkelsen
    Department of Neurology, Henry Ford Health System, Detroit, MI, USA
    J Neurooncol 96:97-102. 2010
    ..Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment?..
  7. pmc Intracellular free calcium mediates glioma cell detachment and cytotoxicity after photodynamic therapy
    Xin Hong
    Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Lasers Med Sci 24:777-86. 2009
    ..Our findings indicated that internal calcium store-derived [Ca(2+)](i) plays an important role in PDT-induced enzymatic cell detachment decrease and cytotoxicity. Cell migration may be affected by these changes...
  8. doi request reprint The role of targeted therapies in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
    J Neurooncol 118:557-99. 2014
    ..What is the influence of targeted medical therapies on disease control and survival in the adult patient with progressive glioblastoma?..
  9. pmc The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline
    Timothy C Ryken
    Department of Neurosurgery, Iowa Spine and Brain Institute, Iowa City, IA, USA
    J Neurooncol 96:103-14. 2010
    ..2) comparison of different doses of steroid therapy...
  10. pmc The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
    J Neurooncol 96:115-42. 2010
    ..What evidence is available regarding the emerging and investigational therapies for the treatment of metastatic brain tumors?..
  11. doi request reprint Raman molecular imaging of brain frozen tissue sections
    Rachel E Kast
    Electrical and Computer Engineering, Wayne State University, Detroit, MI, 48202, USA
    J Neurooncol 120:55-62. 2014
    ..Raman spectroscopy can successfully provide label-free imaging of tissue characteristics with high accuracy. It can be translated to a surgical or laboratory tool for rapid, non-destructive imaging of tumor margins...
  12. pmc Combination therapy with antiangiogenic treatment and photodynamic therapy for the nude mouse bearing U87 glioblastoma
    Feng Jiang
    Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
    Photochem Photobiol 84:128-37. 2008
    ....
  13. doi request reprint The role of cytotoxic chemotherapy in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
    J Neurooncol 118:501-55. 2014
    ..What is the impact of cytotoxic chemotherapy on disease control and survival in the adult patient with progressive glioblastoma?..
  14. doi request reprint The role of cytoreductive surgery in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline
    Timothy Charles Ryken
    Department of Neurosurgery, Iowa Spine and Brain Institute, Waterloo, IA, USA
    J Neurooncol 118:479-88. 2014
    ..Should patients with previously diagnosed malignant glioma who are suspected of experiencing progression of the neoplasm process undergo repeat open surgical resection?..
  15. doi request reprint Through the patient's eyes: the value of a comprehensive brain tumor center
    Adam M Robin
    Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI, 48202, USA
    J Neurooncol 119:465-72. 2014
    ..Our comments are not meant to be exclusive to our experience and should be interpreted as representative of the growing movement in neurosurgery to provide comprehensive, multidisciplinary, patient-centered care. ..
  16. doi request reprint Identification of regions of normal grey matter and white matter from pathologic glioblastoma and necrosis in frozen sections using Raman imaging
    Rachel Kast
    Department of Surgery, Wayne State University, Detroit, MI, 48202, USA
    J Neurooncol 125:287-95. 2015
    ..This method can be applied to either surgical or laboratory tools for rapid, non-destructive imaging of grey and white matter...
  17. doi request reprint The role of surgery in the management of patients with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline
    Manish K Aghi
    Department of Neurosurgery, University of California, 505 Parnassus Avenue, Room M779, San Francisco, CA, 94143 0112, USA
    J Neurooncol 125:503-30. 2015
    ..Should patients with imaging suggestive of low grade glioma (LGG) undergo observation versus treatment involving a surgical procedure?..
  18. doi request reprint The role of imaging in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline
    Timothy Charles Ryken
    Department of Neurosurgery, Iowa Spine and Brain Institute, Waterloo, IA, USA
    J Neurooncol 118:435-60. 2014
    ..Which imaging techniques most accurately differentiate true tumor progression from pseudo-progression or treatment related changes in patients with previously diagnosed glioblastoma?..
  19. doi request reprint Heparanase expression is associated with histone modifications in glioblastoma
    Xin Hong
    Department of Neurosurgery, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Int J Oncol 40:494-500. 2012
    ..Overexpression of both heparanase and NFκB p65 may be the result of excessive histone modifications...
  20. doi request reprint The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells
    Stephanie L Lomonaco
    Department of Neurosurgery, William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Int J Cancer 125:717-22. 2009
    ..Collectively, these results indicate that the induction of autophagy contributes to the radioresistance of these cells and autophagy inhibitors may be employed to increase the sensitivity of CD133+ GSCs to gamma-radiation...
  21. doi request reprint Antitumor treatment using interleukin- 12-secreting marrow stromal cells in an invasive glioma model
    Xin Hong
    Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    Neurosurgery 64:1139-46; discussion 1146-7. 2009
    ..In the present study, C57/B16 mice were implanted with the highly invasive Ast11.9-2 glioma cell line to investigate the potential therapeutic effects of interleukin-12 (IL-12)-secreting MSCs...
  22. doi request reprint Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline
    Brian V Nahed
    Department of Neurosurgery, Massachusetts General Hospital, 15 Parkman Street, Wang 745, Boston, MA, 02114, USA
    J Neurooncol 125:609-30. 2015
    ..These recommendations apply to adult patients with recurrent low-grade glioma (LGG) with initial pathologic diagnosis of a WHO grade II infiltrative glioma (oligodendroglioma, astrocytoma, or oligo-astrocytoma)...
  23. doi request reprint The role of initial chemotherapy for the treatment of adults with diffuse low grade glioma : A systematic review and evidence-based clinical practice guideline
    Mateo Ziu
    Department of Neurosurgery, Seton Brain and Spine Institute, 1400 N IH 35, Suite 300, Austin, TX, 78701, USA
    J Neurooncol 125:585-607. 2015
    ..Adult patients (older than 18 years of age) with newly diagnosed World Health Organization (WHO) Grade II gliomas (Oligodendroglioma, astrocytoma, mixed oligoastrocytoma)...
  24. doi request reprint The role of neuropathology in the management of patients with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline
    Daniel P Cahill
    Department of Neurosurgery, Massachusetts General Hospital, 32 Fruit Street, Yankey 9E, Boston, MA, 02114, USA
    J Neurooncol 125:531-49. 2015
    ..Adult patients (age ≥18 years) who have suspected low-grade diffuse glioma...
  25. doi request reprint The role of radiotherapy in the management of patients with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline
    Timothy C Ryken
    Department of Neurosurgery, Kansas University Medical Center, Kansas City, KS, USA
    J Neurooncol 125:551-83. 2015
    ..g., age, volume, extent of resection, genetic subtype) identify subgroups with better outcomes following radiation therapy than the general population of adults with newly diagnosed low-grade gliomas?..
  26. doi request reprint It is time to reevaluate the management of patients with brain metastases
    Douglas Kondziolka
    Departments of Neurosurgery and Radiation Oncology, NYU Langone Medical Center, New York, New York Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan Department of Radiation Oncology, University of Maryland, Baltimore, Maryland Department of Medicine Neuro Oncology, Cleveland Clinic Foundation, Cleveland, Ohio Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts
    Neurosurgery 75:1-9. 2014
    ..The conduct and findings of past clinical research have led to conceptions that affect clinical care yet appear limiting...
  27. doi request reprint Glioblastoma cell line-derived spheres in serum‑containing medium versus serum-free medium: a comparison of cancer stem cell properties
    Xin Hong
    Department of Neurosurgery, Henry Ford Health System, Detroit, MI 48202, USA
    Int J Oncol 41:1693-700. 2012
    ..U251n cells are distinguished from other tumor cells due to their potential for multilineage differentiation...
  28. doi request reprint Evidence-based guidelines for the management of brain metastases
    Sandeep S Bhangoo
    Department of Neurosurgery, Henry Ford Health System, Hermelin Brain Tumor Center, 2799 West Grand Boulevard, K 11, Detroit, MI 48202, USA
    Neurosurg Clin N Am 22:97-104, viii. 2011
    ..The roles of radiotherapy, surgical resection, and stereotactic radiosurgery along with combination therapies are reviewed. Other topics include the role of chemotherapy, anticonvulsants, steroids, and investigational therapies...
  29. doi request reprint Through the patient's eyes: an emphasis on patient-centered values in operative decision making in the management of malignant glioma
    Adam M Robin
    Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI, 48202, USA
    J Neurooncol 119:473-9. 2014
    ..Herein, we present the philosophy and practice of the Hermelin Brain Tumor Center at the Henry Ford Health System as one type of approach to caring for the patient with a malignant glioma. ..
  30. doi request reprint Raman spectroscopy to distinguish grey matter, necrosis, and glioblastoma multiforme in frozen tissue sections
    Steven N Kalkanis
    Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI, 48202, USA
    J Neurooncol 116:477-85. 2014
    ..Future work will develop mapped images of diffuse glioma and neoplastic margins toward development of an intraoperative surgical tool...
  31. doi request reprint Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles
    David D Gonda
    Department of Neurosurgery, University of California, San Diego, CA, USA
    Neurosurgery 72:501-10. 2013
    ..We review the normal physiology of these extracellular vesicles, their pertinence to tumor biology, and directions for research in this field...
  32. doi request reprint Heparanase expression of glioma in human and animal models
    Xin Hong
    Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Neurosurg 113:261-9. 2010
    ..However, heparanase expression in gliomas has not been well analyzed. To clarify its expression in gliomas, human glioma tissues and glioma animal models were investigated...
  33. ncbi request reprint Decrease of endogenous vascular endothelial growth factor may not affect glioma cell proliferation and invasion
    Xin Hong
    Department of Neurosurgery, Henry Ford Health Science Center, Detroit, MI 48202, USA
    J Exp Ther Oncol 6:219-29. 2007
    ..Our data indicate that the decrease of endogenous VEGF expression may not affect glioma cell proliferation and invasion...