Xin Xiao Zheng

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance
    Xin Xiao Zheng
    Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Immunity 19:503-14. 2003
  2. pmc Requirements for induction and maintenance of peripheral tolerance in stringent allograft models
    Masayuki Sho
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:13230-5. 2005
  3. pmc Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation
    Christophe Mariat
    Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Immunol 182:1379-85. 2009
  4. pmc An antagonist mutant IL-15/Fc promotes transplant tolerance
    Xin Xiao Zheng
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Transplantation 81:109-16. 2006
  5. pmc Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice
    Nicolas Degauque
    Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:735-41. 2008
  6. ncbi request reprint Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size
    Masayuki Sho
    Department of Medicine, Children s Hospital, Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:3744-51. 2002
  7. ncbi request reprint Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol
    Christoph Domenig
    Transplantation Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 175:51-60. 2005
  8. pmc CD8(+) T cells resistant to costimulatory blockade are controlled by an antagonist interleukin-15/Fc protein
    Sylvie Ferrari-Lacraz
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Transplantation 82:1510-7. 2006
  9. ncbi request reprint The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    Chen Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1245-52. 2005
  10. ncbi request reprint Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    Catherine A Sabatos
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1102-10. 2003

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance
    Xin Xiao Zheng
    Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Immunity 19:503-14. 2003
    ....
  2. pmc Requirements for induction and maintenance of peripheral tolerance in stringent allograft models
    Masayuki Sho
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:13230-5. 2005
    ..These results provide insight into the mechanisms of tolerance in stringent models and provide a rational basis for innovative tolerogenic strategies in humans...
  3. pmc Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation
    Christophe Mariat
    Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Immunol 182:1379-85. 2009
    ....
  4. pmc An antagonist mutant IL-15/Fc promotes transplant tolerance
    Xin Xiao Zheng
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Transplantation 81:109-16. 2006
    ..To inhibit IL-15 function and to target IL-15 receptor (IL-15R) bearing cells, we have generated a unique lytic antagonistic mutant IL-15/Fc fusion protein (mIL-15/Fc)...
  5. pmc Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice
    Nicolas Degauque
    Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:735-41. 2008
    ..The reciprocal effects of agonist Tim-1-specific mAbs upon effector T cells and Tregs serve to prevent allogeneic transplant tolerance...
  6. ncbi request reprint Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size
    Masayuki Sho
    Department of Medicine, Children s Hospital, Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:3744-51. 2002
    ..These data demonstrate that cytokine regulation, CTLA-4 negative signaling, and T cell apoptosis play critical roles in regulating alloimmunity, especially under conditions where the alloreactive T cell clone size is relatively small...
  7. ncbi request reprint Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol
    Christoph Domenig
    Transplantation Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 175:51-60. 2005
    ..In this model, both deletional and immunoregulatory mechanisms are active during the induction and/or maintenance of allograft tolerance through creation of MC using a potentially clinically applicable regimen...
  8. pmc CD8(+) T cells resistant to costimulatory blockade are controlled by an antagonist interleukin-15/Fc protein
    Sylvie Ferrari-Lacraz
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Transplantation 82:1510-7. 2006
    ....
  9. ncbi request reprint The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    Chen Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1245-52. 2005
    ..These data suggest that the Tim-3-galectin-9 pathway may have evolved to ensure effective termination of effector T(H)1 cells...
  10. ncbi request reprint Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    Catherine A Sabatos
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1102-10. 2003
    ..These data indicate that interaction of Tim-3 with Tim-3 ligand may serve to inhibit effector T(H)1 cells during a normal immune response and may be crucial for the induction of peripheral tolerance...
  11. pmc TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines
    William D Hastings
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 39:2492-501. 2009
    ..These results suggest that TIM-3 is a negative regulator of human T cells and regulates Th1 and Th17 cytokine secretion...
  12. pmc Specificity of CD4+CD25+ regulatory T cell function in alloimmunity
    Alberto Sanchez-Fueyo
    Department of Medicine, Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 176:329-34. 2006
    ..Taken together, our results indicate that in transplantation, TReg function is dependent on TCR stimulation, providing definitive evidence for their specificity in the regulation of alloimmune responses...
  13. ncbi request reprint Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis
    Sylvie Ferrari-Lacraz
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 173:5818-26. 2004
    ..Our study suggests that the effective targeting of IL-15R-triggered events with CRB-15 can be of therapeutic importance in the treatment of rheumatoid arthritis...
  14. pmc Regulation of T cell dependent immune responses by TIM family members
    Christophe Mariat
    Department of Medicine, Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Philos Trans R Soc Lond B Biol Sci 360:1681-5. 2005
    ..In contrast, TIM-1 appears to be an activation molecule for all T cells, although the mechanisms through which TIM-1 activates T cells remain to be elicited...
  15. pmc Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins
    Nicolas Degauque
    Division of Transplant Immunology, Harvard Medical School, and Transplant Research Center, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Transplantation 84:S12-6. 2007
    ..Likewise, it is tempting to speculate that Tim proteins might also modulate the function of other T helper cell subsets such as TH3, TR1 and TH17 cells, among others...
  16. pmc On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response
    Gulcin Demirci
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 168:4382-90. 2002
    ....
  17. pmc The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression
    Alberto Sanchez-Fueyo
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Transplantation 74:898-900. 2002
    ..In this study, we sought to test the role of complement dependent cytotoxicity (CDC) immune effector mechanism in MR1 anti-CD154 induced immunosuppression...
  18. pmc Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates
    Timothy Millington
    Massachusetts General Hospital Transplant Center, Massachusetts General Hospital, Boston, MA, USA
    J Heart Lung Transplant 31:427-35. 2012
    ..To tilt the immunologic balance toward tolerance and away from rejection, non-human primate recipients of cardiac allografts were treated with interleukin (IL)-2/Fc, mutant (m) antagonist type mIL-15/Fc, and sirolimus...
  19. ncbi request reprint The balance of deletion and regulation in allograft tolerance
    Xin Xiao Zheng
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA
    Immunol Rev 196:75-84. 2003
    ..Whilst in a model in which the regulation mechanism plays a critical role, e.g. donor-specific transfusion plus MR1-induced allograft tolerance, a deletional mechanism lowers the threshold for effective Treg action...
  20. pmc New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses
    Dong Zhang
    Transplantation Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Blood 109:4071-9. 2007
    ..This pathway provides a novel, cell-based, therapeutic approach for preventing allograft rejection...
  21. ncbi request reprint Tracking the immunoregulatory mechanisms active during allograft tolerance
    Alberto Sanchez-Fueyo
    Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 168:2274-81. 2002
    ....
  22. pmc Functional Th1 cells are required for surgical adhesion formation in a murine model
    Arthur O Tzianabos
    Department of Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:6970-6. 2008
    ..These data demonstrate that the CD4(+) T cells orchestrating adhesion formation are of the Th1 phenotype and delineate the central role of T-bet, Tim-3, IFN-gamma, and IL-16 in mediating this pathogenic tissue response...
  23. ncbi request reprint Proteomic analysis of the allograft response
    Basset El Essawy
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Transplantation 82:267-74. 2006
    ..As transcriptional profiling techniques appear to provide a useful means to evaluate the allograft response, we have now initiated an attempt to use proteomics to examine the allograft response...
  24. pmc Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts
    Maria Koulmanda
    Department of Surgery, Harvard Medical School, and Islet Transplantation Research Laboratory, Massachusetts General Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:13074-9. 2007
    ..Thus, this triple-therapy regimen, possessing both tolerance-inducing and select antiinflammatory properties, may represent a prototype for therapies able to restore euglycemia and self-tolerance in T1DM...
  25. ncbi request reprint Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
    Alberto Sanchez-Fueyo
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Immunol 4:1093-101. 2003
    ..Our data indicate that the Tim-3 pathway provides an important mechanism to down-regulate T(H)1-dependent immune responses and to facilitate the development of immunological tolerance...
  26. ncbi request reprint TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation
    Jennifer Hartt Meyers
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:455-64. 2005
    ..These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation...
  27. pmc On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes
    Yingyos Avihingsanon
    Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA, USA
    J Am Soc Nephrol 16:1542-8. 2005
    ..The transcriptional profiling data provide absolutely essential data to the predictive models, particularly with respect to AR and renal function 6 mo posttransplantation...
  28. ncbi request reprint Cytokines in the treatment and prevention of autoimmune responses-a role of IL-15
    Xin Xiao Zheng
    Beth Israel Deaconess Medical Centre, Boston, Massachusetts, USA
    Adv Exp Med Biol 520:87-95. 2003
  29. ncbi request reprint Bystander central memory but not effector memory CD8+ T cells suppress allograft rejection
    Ni Wan
    Center for Biomedical Research, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 180:113-21. 2008
    ..Thus, bystander TCM, but not TEM, CD8+ T cells are potent suppressors rather than bystanders. This new finding will have an impact on cellular immunology and may have clinic implications for tolerance induction...
  30. ncbi request reprint Mast cells are essential intermediaries in regulatory T-cell tolerance
    Li Fan Lu
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    Nature 442:997-1002. 2006
    ..Finally, immunohistochemical analysis clearly demonstrates the existence of this novel T(Reg)-IL-9-mast cell relationship within tolerant allografts...
  31. ncbi request reprint CTLA4 engagement is required for induction of murine liver transplant spontaneous tolerance
    Wei Li
    Department of Surgery, Division of Transplantation, University of Washington Medical Center, Seattle, WA, USA
    Am J Transplant 5:978-86. 2005
    ..CTLA4 blockade promotes donor specific T-cell activation, cytotoxicity and Th1 polarization; protects alloreactive T cells from apoptotic death and induces liver allograft acute rejection...
  32. ncbi request reprint Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance
    Yon Su Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int Immunol 18:1771-7. 2006
    ..These findings highlight the capacity of CD4(+)DC to modulate alloimmune responses, and suggest therapeutic approaches for the induction of donor-specific tolerance...